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Conserved domains on  [gi|157787081|ref|NP_001099184|]
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proto-oncogene Wnt-1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 64-370 0e+00

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381707  Cd Length: 311  Bit Score: 605.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAP---GPHLFGKIVNRGCRETAFIFAITSAGVTHSVA 140
Cdd:cd19333    1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDsrgGPNVFGKILNRGCRETAFIYAITSAAVTHSVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 141 RSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKC 220
Cdd:cd19333   81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 221 HGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRAS-RAELLRLEPEDPAHKPPSPHDLVYFEKSPNFC 299
Cdd:cd19333  161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSrRAKKFLLEPENPNHKPPTSKDLVYFEESPNFC 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157787081 300 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:cd19333  241 EKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTCL 311
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 64-370 0e+00

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 605.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAP---GPHLFGKIVNRGCRETAFIFAITSAGVTHSVA 140
Cdd:cd19333    1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDsrgGPNVFGKILNRGCRETAFIYAITSAAVTHSVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 141 RSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKC 220
Cdd:cd19333   81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 221 HGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRAS-RAELLRLEPEDPAHKPPSPHDLVYFEKSPNFC 299
Cdd:cd19333  161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSrRAKKFLLEPENPNHKPPTSKDLVYFEESPNFC 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157787081 300 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:cd19333  241 EKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTCL 311
WNT1 smart00097
found in Wnt-1;
60-370 1.03e-179

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 500.69  E-value: 1.03e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081    60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSV 139
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081   140 ARSCSEGSIESCTCDYRRRGP-GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQEC 218
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRaGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKREC 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081   219 KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRaellrlePEDPAHKPPSPHDLVYFEKSPNF 298
Cdd:smart00097 161 KCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPV-------PKNSTFKPPTETDLVYLESSPDF 233

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787081   299 CTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:smart00097 234 CEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 60-370 2.47e-168

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 471.65  E-value: 2.47e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081   60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH-LFGKIVNRGCRETAFIFAITSAGVTHS 138
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKRpVFGKVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  139 VARSCSEGSIESCTCDYRRRG--PGGPDWHWGGCSDNIDFGRLFGREFVDSGEKG-RDLRFLMNLHNNEAGRTTVFSEMR 215
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGksSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKrRDARALMNLHNNEAGRKAVKSNMR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  216 QECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVlygNRGNNRASRaellrLEPEDPAHKPPSPHDLVYFEKS 295
Cdd:pfam00110 161 TECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKV---NRRRNKRGR-----LVPRNSRFKPPTKNDLVYLEKS 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157787081  296 PNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:pfam00110 233 PDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 64-370 0e+00

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 605.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAP---GPHLFGKIVNRGCRETAFIFAITSAGVTHSVA 140
Cdd:cd19333    1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDsrgGPNVFGKILNRGCRETAFIYAITSAAVTHSVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 141 RSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKC 220
Cdd:cd19333   81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 221 HGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRAS-RAELLRLEPEDPAHKPPSPHDLVYFEKSPNFC 299
Cdd:cd19333  161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSrRAKKFLLEPENPNHKPPTSKDLVYFEESPNFC 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157787081 300 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:cd19333  241 EKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTCL 311
WNT1 smart00097
found in Wnt-1;
60-370 1.03e-179

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 500.69  E-value: 1.03e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081    60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSV 139
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081   140 ARSCSEGSIESCTCDYRRRGP-GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQEC 218
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRaGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKREC 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081   219 KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRaellrlePEDPAHKPPSPHDLVYFEKSPNF 298
Cdd:smart00097 161 KCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPV-------PKNSTFKPPTETDLVYLESSPDF 233

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787081   299 CTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:smart00097 234 CEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 60-370 2.47e-168

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 471.65  E-value: 2.47e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081   60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH-LFGKIVNRGCRETAFIFAITSAGVTHS 138
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKRpVFGKVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  139 VARSCSEGSIESCTCDYRRRG--PGGPDWHWGGCSDNIDFGRLFGREFVDSGEKG-RDLRFLMNLHNNEAGRTTVFSEMR 215
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGksSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKrRDARALMNLHNNEAGRKAVKSNMR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  216 QECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVlygNRGNNRASRaellrLEPEDPAHKPPSPHDLVYFEKS 295
Cdd:pfam00110 161 TECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKV---NRRRNKRGR-----LVPRNSRFKPPTKNDLVYLEKS 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157787081  296 PNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:pfam00110 233 PDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 78-369 2.12e-147

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 418.23  E-value: 2.12e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  78 ILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRR 157
Cdd:cd13113    1 LMESIAEGAQLALKECQRQFANRRWNCSTFNEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 158 RGP-GGPDWHWGGCSDNIDFGRLFGREFVDSGEK--GRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWM 234
Cdd:cd13113   81 QGPeGQGDWTWGGCSDNIKFGIKFSRKFLDAREKkkGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 235 RLPTLRAVGDVLRDRFDGASRVLYGNRGNNrasraelLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRA 314
Cdd:cd13113  161 QLPSFREIGDYLKEKYDNAVKVKLNNNGSG-------LRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRE 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157787081 315 CNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd13113  234 CNPTSPGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 64-370 7.71e-146

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 415.08  E-value: 7.71e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPgpHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19338   13 LKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSR--KSFGKILKRDTRETAFVYAITSAGVTYSVTRAC 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRG-PGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGR-DLRFLMNLHNNEAGRTTVFSEMRQECKCH 221
Cdd:cd19338   91 SMGELLQCGCDKSKRGkSTEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRsDIRTLMNLHNNEAGRLAVKNNMRKECKCH 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 222 GMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNnrasraellRLEPEDPAHKPPSPHDLVYFEKSPNFCTY 301
Cdd:cd19338  171 GLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSNDGK---------SLIPEGKTIKPPTKEDLVYLEESPDFCEP 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157787081 302 SGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:cd19338  242 NKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 60-370 8.27e-133

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 382.05  E-value: 8.27e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSV 139
Cdd:cd19336    3 SLKGLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEPVFGKVLNQGTREAAFVHAISSAGVAHAV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 140 ARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGR----DLRFLMNLHNNEAGRTTVFSEMR 215
Cdd:cd19336   83 TRACSSGELEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFVDARERRKgrasSSRALMNLHNNEAGRKAIEKNMR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 216 QECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRasraellRLEPEDPAHKPPSPHDLVYFEKS 295
Cdd:cd19336  163 VECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRIGSRP-------VLVPKNPQFKPHTDADLVYLDSS 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157787081 296 PNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:cd19336  236 PDFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 64-363 1.69e-131

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 378.92  E-value: 1.69e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPG----PHLFGkIVNRGCRETAFIFAITSAGVTHSV 139
Cdd:cd19342   10 LTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSSLETknknPHTSP-ILSRGYRETAFAYAISAAGVAHQV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 140 ARSCSEGSIESCTCDYRRRGPGGP--DWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQE 217
Cdd:cd19342   89 ARACSLGKLLSCGCDRSRRGKRSSgnDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 218 CKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRAELLRlepedPAHKPPSPHDLVYFEKSPN 297
Cdd:cd19342  169 CKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQSNLNNGARRRRLTRR-----KRRRRPPKTDLVYYERSPN 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157787081 298 FCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHT 363
Cdd:cd19342  244 FCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTET 309
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 60-369 3.99e-131

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 377.89  E-value: 3.99e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH-LFGKIVNRGCRETAFIFAITSAGVTHS 138
Cdd:cd19335    6 SIPGLVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLsVFGPVLDKASRESAFVHAIASAGVAHA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 139 VARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQEC 218
Cdd:cd19335   86 VTRACAEGDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 219 KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGAS--RVLYgnrgnNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSP 296
Cdd:cd19335  166 KCHGLSGSCELKTCWWAQPDFRKIGDYLKDKYDSASemVVER-----HRESRGWVETLRPKYKLFKPPTERDLIYYEESP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157787081 297 NFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19335  241 NFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTC 313
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 60-369 3.71e-125

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 362.72  E-value: 3.71e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  60 SLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSV 139
Cdd:cd19337    3 QLRGLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVFGPVTNIGTREAAFTYAISAAGVVHAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 140 ARSCSEGSIESCTCDYRRRGPGGP-DWHWGGCSDNIDFGRLFGREFVDSGEKGRD--------LRFLMNLHNNEAGRTTV 210
Cdd:cd19337   83 ARACREGNLSTCGCSRERRPKDLPrDWLWGGCGDNIEYGYKFAKEFIDARERETNyprhsrelARVLMNLHNNEAGRRAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 211 FSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNnrasraellRLEPEDPAHKPPSPHDLV 290
Cdd:cd19337  163 YEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGT---------LLRRRNSRFNKPTKDDLV 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157787081 291 YFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19337  234 YLDDSPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHIC 312
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 64-369 9.29e-124

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 358.96  E-value: 9.29e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH-LFGKIVNRGCRETAFIFAITSAGVTHSVARS 142
Cdd:cd19334   12 LVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDAtVFGKVLLKGSREAAFVYAISSAGVVHAITRA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 143 CSEGSIESCTCDYRRRGPG---GPDWHWGGCSDNIDFGRLFGREFVDSGE-KGRDLRFLMNLHNNEAGRTTVFSEMRQEC 218
Cdd:cd19334   92 CSKGELLNCACDPTKRGKGrdsKGEFDWGGCSDNVKYGINFARKFVDARErRVRDARALMNLHNNRAGRKAVKKNLKLQC 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 219 KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNrasraellrLEPEDPAHKPPSPHDLVYFEKSPNF 298
Cdd:cd19334  172 KCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTN---------LLAANKGHKKPTRSDLVYFESSPDY 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157787081 299 CTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19334  243 CVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTC 313
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 64-369 1.98e-121

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 352.69  E-value: 1.98e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19344    1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGPD-WHWGGCSDNIDFGRLFGREFVDSGEK-----GRDLRFLMNLHNNEAGRTTVFSEMRQE 217
Cdd:cd19344   81 SAGNLTDCSCDSRRQGQSASEgWKWGGCSDNVDYGIWFARKFVDAPEKserkrSRDVRSLMNLHNNEVGRQAIARLMKVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 218 CKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYgNRGNNRASRAEllRLEPEDPAHKppspHDLVYFEKSPN 297
Cdd:cd19344  161 CRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIAT-KKSKRRLRRRE--RRKRKVPISK----DELVYIHKSPN 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787081 298 FCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19344  234 YCVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTC 305
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 64-369 1.02e-119

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 348.89  E-value: 1.02e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19339    8 LTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGERTVFGQELPVGSREAAFTYAITSAGVAYAITQAC 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGPD--WHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCH 221
Cdd:cd19339   88 SQGNLSDCGCDKSKKGYGKSDegWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCH 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 222 GMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLyGNRGnNRASRAELLRLEPEDPaHKPPSPHDLVYFEKSPNFCTY 301
Cdd:cd19339  168 GVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVE-PVRG-RRRRRPTFLKLKISRK-YKKPRPRDLVYLEKSPNYCEK 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 302 SGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19339  245 DPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTC 312
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 64-370 7.93e-115

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 336.15  E-value: 7.93e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPT---APGphlFGKIVNRGCRETAFIFAITSAGVTHSVA 140
Cdd:cd19343    1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSielAPN---FTPDLTRGTREQAFVYALSSAALTHTIA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 141 RSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEK-----GRDLRFLMNLHNNEAGRTTVFSEMR 215
Cdd:cd19343   78 RACASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTDAPEKkkkkkKRQARALMNLHNNRVGRKAVRDSLE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 216 QECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRasraellRLEPEDPAHKPPSPHDLVYFEKS 295
Cdd:cd19343  158 TQCKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRR-------KLVPKSLKVRPYTKDDLIYLTKS 230

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157787081 296 PNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
Cdd:cd19343  231 PDYCLPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 64-369 3.71e-101

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 301.85  E-value: 3.71e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH-LFGKIVNRGCRETAFIFAITSAGVTHSVARS 142
Cdd:cd19345   12 LVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHsLFGRLLLRSSRESAFVYAISSAGVVFAITRA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 143 CSEGSIESCTCDYRRRGPGGPD---WHWGGCSDNIDFGRLFGREFVDSGE-KGRDLRFLMNLHNNEAGRTTVFSEMRQEC 218
Cdd:cd19345   92 CSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAKErKGKDARALMNLHNNRAGRKAVKRFMTLEC 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 219 KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRAELLrlepedpahKPPSPHDLVYFEKSPNF 298
Cdd:cd19345  172 KCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHF---------KKPTKNDLVYFENSPDY 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787081 299 CTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRT-RTQRVTeRCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19345  243 CVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTsRVGRMT-KCECKFHWCCAVRCKDCHQQVDVHTC 313
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 64-361 1.70e-98

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 294.66  E-value: 1.70e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19347    7 LSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAISAAGVVNAVSRAC 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGP-DWHWGGCSDNIDFGRLFGREFVDSGEKGR--------DLRFLMNLHNNEAGRTTVFSEM 214
Cdd:cd19347   87 REGELSTCGCSRAARPKDLPrDWLWGGCGDNLEYGYRFAKEFVDAREREKiyqkgsyeSARTLMNLHNNEAGRRTVYNLA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 215 RQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGnnrasraellRLEPEDPAHKPPSPHDLVYFEK 294
Cdd:cd19347  167 DVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRG----------KLVQVNSRFNPPTTLDLVYIDP 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157787081 295 SPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCT 361
Cdd:cd19347  237 SPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCT 303
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 64-369 1.42e-97

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 292.60  E-value: 1.42e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH-LFGKIVNRGCRETAFIFAITSAGVTHSVARS 142
Cdd:cd19346   12 LVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHtVFGRVMLRSSREAAFVYAISSAGVVYAITRA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 143 CSEGSIESCTCDYRRRGPGGP---DWHWGGCSDNIDFGRLFGREFVDSGEKG-RDLRFLMNLHNNEAGRTTVFSEMRQEC 218
Cdd:cd19346   92 CSQGELKSCSCDPHKRGRSHDergEFDWGGCSDNINYGIKFAKAFVDAKEKKeKDARALMNLHNNRCGRMAVKRFMKLEC 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 219 KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASraellrlepEDPAHKPPSPHDLVYFEKSPNF 298
Cdd:cd19346  172 KCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTV---------ANKNFRKATKTDLVYFENSPDY 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787081 299 CTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRT-RTQRVTeRCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19346  243 CVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTtRVTRVT-KCECKFHWCCAVRCKECEETVDVHTC 313
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 81-369 4.71e-96

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 288.04  E-value: 4.71e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  81 SVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIvnRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP 160
Cdd:cd19340   12 SVAAGAQLAMEECQYQFKWDRWNCPESAFFSQKNNP--SATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSKKGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 161 -GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTL 239
Cdd:cd19340   90 kGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLAPF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 240 RAVGDVLRDRFDGASRVLYGNRGNNRASRAELLRLEPEdpahkppSPHDLVYFEKSPNFCTYSGRLGTAGTAGRAC---- 315
Cdd:cd19340  170 REIGTDLKRKYDRAVRVDYENGGLRETNGSRAIKLLNI-------KKNDLVYLEKSPNYCRANVTLGWPGTLGRQCsrdk 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 316 NSSSPALD--GCELLCCGRGHRTRTQRVTE--RCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19340  243 KESVSRWErkSCRRLCRACGLKVRKKVVEVtsSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 64-369 2.15e-95

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 286.49  E-value: 2.15e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLF---GKIVNRGCRETAFIFAITSAGVTHSVA 140
Cdd:cd19355   10 LTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSSLETRNKIpyeSVVFSRGFRESAFAYAIAAAGVVHAVS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 141 RSCSEGSIESCTCDyrrrgpggpdWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKC 220
Cdd:cd19355   90 NACAMGKLKACGCD----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 221 HGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNrasraellRLEPEDPAH-KPPSPHDLVYFEKSPNFC 299
Cdd:cd19355  160 HGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLIKPHNRNTG--------QLEPGHAPHrRRASINDLVYFEKSPDFC 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 300 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19355  232 EREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVC 301
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 64-361 9.41e-94

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 282.64  E-value: 9.41e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19348    7 LSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRAC 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGP-DWHWGGCSDNIDFGRLFGREFVDSGEKGRDL--------RFLMNLHNNEAGRTTVFSEM 214
Cdd:cd19348   87 REGELSTCGCSRAARPKDLPrDWLWGGCGDNVEYGYRFAKEFVDAREREKNYpkgseehaRTLMNLQNNEAGRRAVYNLA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 215 RQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGnnrasraellRLEPEDPAHKPPSPHDLVYFEK 294
Cdd:cd19348  167 DVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRKG----------KLELVNSRFNPPTAEDLVYIDP 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157787081 295 SPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCT 361
Cdd:cd19348  237 SPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCT 303
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 64-369 8.52e-91

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 275.39  E-value: 8.52e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19349   13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAAC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGPD--WHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCH 221
Cdd:cd19349   93 TQGNLSDCGCDKEKQGQYNQEegWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCH 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 222 GMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVlyGNRGNNRASRAELLRLEpEDPAHKPPSPHDLVYFEKSPNFCTY 301
Cdd:cd19349  173 GVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHV--EPVRASRNKRPTFLKIK-KPLSYRKPMDTDLVYIEKSPNYCEE 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 302 SGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19349  250 DPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTC 317
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 64-369 1.02e-90

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 274.55  E-value: 1.02e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCpTAPGPHLFgkIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19341    1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNC-SLGKYRIN--LLKKGYKETAFLYAISSAGLTHSVARAC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDyrrrGPGGPD-----WHWGGCSDNIDFGRLFGREFVDSGEKG-RDLRFLMNLHNNEAGRTTVFSEMRQE 217
Cdd:cd19341   78 SSGRLDRCTCD----ESFSLEenrqtWLWGGCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 218 CKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRAeLLRLEPEDPAHKPPSPHDLVYFEKSPN 297
Cdd:cd19341  154 CKCHGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGGSQL-RKGKSGSVKKKSRPRRKDLVYLEKSPS 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787081 298 FCTySGRLgTAGTAGRACNSSspalDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19341  233 FCR-STRY-SPGTKGRRCLKG----DNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTC 298
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 64-369 2.89e-87

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 266.49  E-value: 2.89e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19350   13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTVFGQELRVGSREAAFTYAITAAGVAHAVTAAC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGPD--WHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCH 221
Cdd:cd19350   93 SQGNLSNCGCDREKQGYYNQEegWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCH 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 222 GMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRgnNRASRAELLRLEpEDPAHKPPSPHDLVYFEKSPNFCTY 301
Cdd:cd19350  173 GVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRA--SRLRQPTFLKIK-KRRSYQKPMETDLVYIERSPNYCEE 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 302 SGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19350  250 DAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTC 317
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 64-369 2.32e-86

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 263.29  E-value: 2.32e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPG----PHlFGKIVNRGCRETAFIFAITSAGVTHSV 139
Cdd:cd19356   10 LSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSSLEGggklPH-DSAILKRGFRESAFSFSLLAAGVMHSV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 140 ARSCSEGSIESCTCDyrrrgpggpdWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECK 219
Cdd:cd19356   89 ATACSLGKLRGCGCE----------WEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 220 CHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVlygnRGNNRASRAELLRLEPEDPAhkppspHDLVYFEKSPNFC 299
Cdd:cd19356  159 CHGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFI----NSHNKNSGVFLPRLRPRRLA------RELVYFEKSPDFC 228

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 300 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19356  229 ERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVC 298
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 64-369 1.41e-81

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 250.97  E-value: 1.41e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGphlfGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19354    1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGR----GSLLKRGFKETAFLYAVSSAALTHSLAKAC 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGM 223
Cdd:cd19354   77 SSGRMERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 224 SGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLygNRGNNRASRAELLRLEPEDPAHKPPSPH--DLVYFEKSPNFCTY 301
Cdd:cd19354  157 SGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVH--SVTNDATGETELWSPERHGHTLKGHSPRstDLVYLEDSPSFCRP 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 302 SGRlgTAGTAGRACNSSSpaldGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19354  235 SKY--SPGTAGRTCSRET----NCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTC 296
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 81-369 1.16e-79

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 246.35  E-value: 1.16e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  81 SVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP 160
Cdd:cd19351   12 SVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRNGR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 161 -GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTL 239
Cdd:cd19351   92 tGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQLADF 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 240 RAVGDVLRDRFDGA-------SRVLYGNRGNNRASRAEllrlepedpAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAG 312
Cdd:cd19351  172 REIGNYLKVKHDQAlklemdkRRMRAGNSADNRGAIAE---------AFGSVAETELIYLEDSPDYCTKNASLGLQGTEG 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157787081 313 RACNSSSPALD-----GCELLC--CGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19351  243 RECLQSGKNLSqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 64-369 7.66e-79

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 244.18  E-value: 7.66e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  64 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCpTAPGPHLfGKIVNRGCRETAFIFAITSAGVTHSVARSC 143
Cdd:cd19353    1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNC-TLEGRYR-ASLLKRGFKETAFLYAISSAGLTHAMAKAC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 144 SEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVdSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGM 223
Cdd:cd19353   79 SAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFL-GRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 224 SGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVlyGNRGNNRASRAELLRLEPEDPAHKPPSPH--DLVYFEKSPNFCTY 301
Cdd:cd19353  158 SGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKV--GSTTNEATGEGDISPPKKSGAGHSDQIPRttDLVYIDDSPSFCLM 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 302 SGRlgTAGTAGRACNSSSpaldGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19353  236 SRF--SPGTSGRRCYKDK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTC 297
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 81-369 3.75e-75

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 234.92  E-value: 3.75e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081  81 SVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP 160
Cdd:cd19352   13 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 161 -GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTL 239
Cdd:cd19352   93 lGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787081 240 RAVGDVLRDRFDGASRV-LYGNRGNNRASRAELLRlepedpAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSS 318
Cdd:cd19352  173 REVGNYLKEKYHRALKVdLLQGAGNSAASRGAIAE------TFRSISKKELVHLEDSPDYCLENKTLGLLGTEGRECLKR 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157787081 319 SPALD-----GCELLC--CGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHEC 369
Cdd:cd19352  247 GKALSkwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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