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Conserved domains on  [gi|157743267|ref|NP_001099046|]
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ankyrin repeat domain-containing protein SOWAHD [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
148-229 3.31e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.80  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743267 148 GYSVLHWLAKHGrHEELIlvhDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVGAlGADATRRDHSGHRACHY 227
Cdd:COG0666  153 GNTPLHLAAANG-NLEIV---KLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDL 225


                 ..
gi 157743267 228 LR 229
Cdd:COG0666  226 AA 227
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
148-229 3.31e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.80  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743267 148 GYSVLHWLAKHGrHEELIlvhDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVGAlGADATRRDHSGHRACHY 227
Cdd:COG0666  153 GNTPLHLAAANG-NLEIV---KLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDL 225


                 ..
gi 157743267 228 LR 229
Cdd:COG0666  226 AA 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
148-218 4.16e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 4.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743267  148 GYSVLHWLAKHGRHEELILVHDFALRRGlrldvsapGSGGLTPLHLAALQGHDMVIKVLVgALGADATRRD 218
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEHADVNL--------KDNGRTALHYAARSGHLEIVKLLL-EKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 148-221 7.58e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 7.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157743267 148 GYSVLHWLAKHGRHEELILvhDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVgALGADATRRDHSG 221
Cdd:PHA03095 222 GNTPLHSMATGSSCKRSLV--LPLLIAGI--SINARNRYGQTPLHYAAVFNNPRACRRLI-ALGADINAVSSDG 290
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
148-229 3.31e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.80  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743267 148 GYSVLHWLAKHGrHEELIlvhDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVGAlGADATRRDHSGHRACHY 227
Cdd:COG0666  153 GNTPLHLAAANG-NLEIV---KLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDL 225


                 ..
gi 157743267 228 LR 229
Cdd:COG0666  226 AA 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
148-227 7.55e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 7.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743267 148 GYSVLHWLAKHGrHEELIlvhDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVGAlGADATRRDHSGHRACHY 227
Cdd:COG0666  120 GETPLHLAAYNG-NLEIV---KLLLEAGA--DVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHL 192
Ank_2 pfam12796
Ankyrin repeats (3 copies);
148-218 4.16e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 4.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743267  148 GYSVLHWLAKHGRHEELILVHDFALRRGlrldvsapGSGGLTPLHLAALQGHDMVIKVLVgALGADATRRD 218
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEHADVNL--------KDNGRTALHYAARSGHLEIVKLLL-EKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
148-207 1.58e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743267  148 GYSVLHWLAKHGRHEELILVHDFalrrglRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV 207
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK------GADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
148-227 5.41e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 38.01  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743267 148 GYSVLHWLAKHGRHEelilVHDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVgALGADATRRDHSGHRACHY 227
Cdd:COG0666  186 GETPLHLAAENGHLE----IVKLLLEAGA--DVNAKDNDGKTALDLAAENGNLEIVKLLL-EAGADLNAKDKDGLTALLL 258
PHA03095 PHA03095
ankyrin-like protein; Provisional
 148-221 7.58e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 7.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157743267 148 GYSVLHWLAKHGRHEELILvhDFALRRGLrlDVSAPGSGGLTPLHLAALQGHDMVIKVLVgALGADATRRDHSG 221
Cdd:PHA03095 222 GNTPLHSMATGSSCKRSLV--LPLLIAGI--SINARNRYGQTPLHYAAVFNNPRACRRLI-ALGADINAVSSDG 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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