BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 334 VDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLE-NPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAM 412
Cdd:cd18315    2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELL 81

                 ....
gi 161078326 413 KIKG 416
Cdd:cd18315   82 QIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 334 VDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLE-NPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAM 412
Cdd:cd18315    2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELL 81

                 ....
gi 161078326 413 KIKG 416
Cdd:cd18315   82 QIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326   335 DVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENP--SSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAM 412
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 161078326   413 KIKGL--HTEKNLDSD 426
Cdd:smart00225  81 QIPGLveLCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 334 VDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLE-NPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAM 412
Cdd:cd18315    2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELL 81

                 ....
gi 161078326 413 KIKG 416
Cdd:cd18315   82 QIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326   335 DVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENP--SSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAM 412
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 161078326   413 KIKGL--HTEKNLDSD 426
Cdd:smart00225  81 QIPGLveLCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 319 NMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIF---LENPSSHPILLMaDVEASHMAGLLDFMYSGQV 395
Cdd:cd18250    7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFageLRESRADRVVLH-GVSAEILGLLLDFSYTGRV 85

                         90
                 ....*....|....*
gi 161078326 396 NVKYEDLPVFLKVAE 410
Cdd:cd18250   86 TVTQDNVEALLRAAD 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 315 NFHGNMcrgfHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLEN--PSSHPILLMADVEASHMAGLLDFMYS 392
Cdd:cd18238    1 DSFKVL----HQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaESKQDSITIKDIDEEAVELLVDFAYT 76

                 ...
gi 161078326 393 GQV 395
Cdd:cd18238   77 GKL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 322 RGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLEN--PSSHPILLMADVEASHMAGLLDFMYSGQVNVKY 399
Cdd:cd18257    7 QGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEFQCIDETALQAIVEYAYTGTVFISQ 86

                         90
                 ....*....|....*.
gi 161078326 400 EDLPVFLKVAEAMKIK 415
Cdd:cd18257   87 ATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 319 NMCRgfhsLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLE--NPSSHPILLMADVEASHMAGLLDFMYSGQVN 396
Cdd:cd18256   10 QLNK----LRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGgmSESSKDVVQIHGVEPDIFHILLDFIYTGVVE 85

                 .
gi 161078326 397 V 397
Cdd:cd18256   86 V 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 322 RGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSS-------HPILLMADVEASHMAGLLDFMYSGQ 394
Cdd:cd18203   14 RNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSelqvslmHSSRVVADLLLSCYTGALEFSVRDI 93

                 ..
gi 161078326 395 VN 396
Cdd:cd18203   94 VN 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 332 KMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHpILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEA 411
Cdd:cd18200   17 KFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNC-LVLPSVIEAAAFENLLQLIYSGRLTLCMDALPSHLLVASG 95

                 ...
gi 161078326 412 MKI 414
Cdd:cd18200   96 LQM 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 324 FHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENP--SSHPILLMADVEASHMAGLLDFMYSGQVNVKYED 401
Cdd:cd18215   10 LNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLknNVSVINLDPEIEPEGFRILLDFMYTSRLNLREGN 89

                         90
                 ....*....|...
gi 161078326 402 LPVFLKVAEAMKI 414
Cdd:cd18215   90 IMAVMATAMYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 323 GFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFL--ENPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYE 400
Cdd:cd18269   17 GLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLsdLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQ 96

                         90
                 ....*....|....*....
gi 161078326 401 DLPVFLKVAEAMKIKGLHT 419
Cdd:cd18269   97 NVQDIFALASRFQIPSIFT 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 323 GFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFL--ENPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYE 400
Cdd:cd18341   17 GLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLseESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDG 96

                         90
                 ....*....|....*....
gi 161078326 401 DLPVFLKVAEAMKIKGLHT 419
Cdd:cd18341   97 NVQDIFALASRFQIPSVFT 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 325 HSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLEN--PSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDL 402
Cdd:cd18339   13 NELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDmsESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV 92

                         90
                 ....*....|..
gi 161078326 403 PVFLKVAEAMKI 414
Cdd:cd18339   93 QVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 317 HG-NMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHPILLmADVEASHMAGLLDFMYSGQV 395
Cdd:cd18260    1 YGaNLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVEL-NDISPLGLATVITYAYTGKL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 319 NMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLEN--PSSHPILLMADVEASHMAGLLDFMYSGQVN 396
Cdd:cd18253    4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDhrESREMLVEINGILAEAMDCFLQYVYTGKVK 83

                         90       100
                 ....*....|....*....|.
gi 161078326 397 VKYEDLPVFLKVAEAMKIKGL 417
Cdd:cd18253   84 ITTENVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 327 LQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHPILLM--ADVEASHMAGLLDFMYSGQVNVKYEDLPV 404
Cdd:cd18332   13 LRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTlpSGLEARGFQLLLDFMYTSRLPLTPRTVPA 92

                         90
                 ....*....|.
gi 161078326 405 FLKVAEAMKIK 415
Cdd:cd18332   93 VLAAATYLQME 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 319 NMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHPILLMAD-VEASHMAGLLDFMYSGQVNV 397
Cdd:cd18278   17 NILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEeVTARGFGPLLQFAYTAKLLL 96

                         90       100
                 ....*....|....*....|
gi 161078326 398 KYEDLPVFLKVAEAMKIKGL 417
Cdd:cd18278   97 SRENIQEVIRCAEFLRMHNL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 322 RGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLEN---PSSHPILLmADVEASHMAGLLDFMYSGQVNVK 398
Cdd:cd18237   10 GVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmteSKSSEVEL-KDAEPDIIELLVEFAYTARISVN 88

                         90
                 ....*....|....*.
gi 161078326 399 YEDLPVFLKVAEAMKI 414
Cdd:cd18237   89 SNNVQSLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 327 LQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFL-ENPSSHPI-LLMADVEASHMAGLLDFMYSGQVNVKYEDLPV 404
Cdd:cd18249   17 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgELAESRQTeVTIRDIDERAMELLIDFAYTSQITVEEGNVQT 96

                 ....*
gi 161078326 405 FLKVA 409
Cdd:cd18249   97 LLPAA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 332 KMVDVTIAAGGKIFKAHKLVLSVCSPYFQ-QIFLENPSShpILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAE 410
Cdd:cd18210   20 KLCDISIHVQGRVFRAHRAVLAASSPYFHdQVLLKNMSS--ISLPGVMDPGAFESVLASAYTGKLTMLADEIVNYLTVGS 97

                 ....
gi 161078326 411 AMKI 414
Cdd:cd18210   98 VLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 328 QKDE-KMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFlENPSSHPILLMADVeASHMAGLLDFMYSGQVNVKYEDLPVFL 406
Cdd:cd18232   12 QREEgQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY-GDGTSGSVVLPESF-AEVFGLLLDFFYTGELALTRENRDRVL 89

                 ....*...
gi 161078326 407 KVAEAMKI 414
Cdd:cd18232   90 LAAKELRV 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 333 MVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSshpillMADVEASHMAGL---LDFMYSGQVNVKYEDLPVFLKVA 409
Cdd:cd18206   22 LCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKD------VVHLDISNAAGLgqvLEFMYTAKLSLSPENVDDVLAVA 95

                 ....*.
gi 161078326 410 EAMKIK 415
Cdd:cd18206   96 TFLQMQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 309 YLLSWNNFHGNMC-RGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLE--NPSSHPILLMADVEASHMAG 385
Cdd:cd18264    3 YFLAYSKSHGEAVlSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDytQESKARVIHLPVVSAAGLQR 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 161078326 386 LLDFMYSGQVNVKYEDLPV------FLKVAEAMKIKGLHTEKNLDSD 426
Cdd:cd18264   83 VLDFIYTSWLSLSLDTLEDtleaasYLQVTEAIGLCSQYLINNLAPE 129

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161078326 335 DVTIAAGGKIFKAHKLVLSVCSPYFQQIFL-ENPSS-----HPILLMADVEASHMAGLLDFMYSG 393
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLsSLLTSedavgCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 333 MVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHPIL-LMAD-VEASHMAGLLDFMYSGQvnVKYEDLPV------ 404
Cdd:cd18324   23 LCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVhLNSDiVTAPAFALLLEFMYEGK--LQFKDLPIedvlaa 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 161078326 405 --FLKVAEAMKI--KGLHTEKNLDSDASDISSPHESDGTECR 442
Cdd:cd18324  101 asYLHMYDIVKVckKKLKEKATTEADSTKKEEDASSCSDKVE 142

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 319 NMCRGFHSLQKDEKMVDVTIAA---GGKI-FKAHKLVLSVCSPYFQQIFLENPSS---HPILLMADVEASHMAGLLDFMY 391
Cdd:cd18211   11 NLLNEMHKLRLLGHLCDVTVQVehqGSKEeFSAHKAVLAASSKYFKEVFLNEKISdgkNTNVMLNEIYTADFASFLEFVY 90

                         90       100
                 ....*....|....*....|....*.
gi 161078326 392 SGQVNVKYEDLPVFLKVAEAMKIKGL 417
Cdd:cd18211   91 TAKVEVEEDRVQRMLEIAEKLKCLDL 116

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 322 RGFHSLQKDEKMVDVT-IAAGGKIFKAHKLVLSVCSPYFQQIFLenpSSHPILLMADVEASHMAGLLDFMYSGQVNVKYE 400
Cdd:cd18299    1 EDLRNLLHSPSCADVVfILQGGVRIFAHRIVLAAASSVFADLFL---MMTVVTLDSDITPEAFRRVLEFLYTGVLDENED 77

                         90
                 ....*....|....*..
gi 161078326 401 DLPVFLKVAEAMKIKGL 417
Cdd:cd18299   78 DLKELKDAAELLELFDL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161078326 327 LQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENP--SSHPILLMADVEASHMAGLLDFMYSGQVNVK 398
Cdd:cd18331   18 LRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLkcNLSVINLDPEINPEGFNILLDFMYTSRLNLR 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 327 LQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIfLENPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFL 406
Cdd:cd18218   12 LRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQ-LTNPNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRPLL 90

                         90
                 ....*....|.
gi 161078326 407 KVAEAMKIKGL 417
Cdd:cd18218   91 EAARALEVESL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 331 EKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQiFLENPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYED-------LP 403
Cdd:cd18221   16 DQFTDITLIVDGHQFKAHKAVLAACSQFFYK-FFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEeandvwkAA 94

                         90
                 ....*....|
gi 161078326 404 VFLKVAEAMK 413
Cdd:cd18221   95 EYLQMQEAIK 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078326 332 KMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIF---LENPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKV 408
Cdd:cd18207   26 RFCDVLLRVGEESFPAHRAVLAACSEYFESVFsaqEGDGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTA 105

                 ..
gi 161078326 409 AE 410
Cdd:cd18207  106 AK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.