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Conserved domains on  [gi|161085803|ref|NP_001097666|]
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secretory pathway calcium atpase, isoform D [Drosophila melanogaster]

Protein Classification

calcium-transporting ATPase type 2C( domain architecture ID 11550604)

calcium-transporting ATPase type 2C is an ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
132-977 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1515.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 132 RAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKK 211
Cdd:cd02085    1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 212 LVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNvKDHSN 291
Cdd:cd02085   81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASN-GDLTT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 292 MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLS 371
Cdd:cd02085  160 RSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 372 EMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITsdgym 451
Cdd:cd02085  240 EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT----- 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 452 advtgagyndqgeihirhcnnvemaktnitnlleiGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEY 531
Cdd:cd02085  315 -----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEI 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 532 PFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQT-VPLTKQNEAEFLAEAYEIGRKGLRVLALAKGR 610
Cdd:cd02085  360 PFSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGP 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 611 SMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVA 690
Cdd:cd02085  440 ELGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVV 519
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 691 NNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEE 770
Cdd:cd02085  520 RKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEE 599
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 771 GKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMI 850
Cdd:cd02085  600 GKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPIL 679
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 851 TKSVVVNVLLSASIIVLGTLWVFQREMADGtlGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVA 930
Cdd:cd02085  680 TRSLILNVLLSAAIIVSGTLWVFWKEMSDD--NVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVG 757
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*..
gi 161085803 931 FSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK 977
Cdd:cd02085  758 GSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
132-977 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1515.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 132 RAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKK 211
Cdd:cd02085    1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 212 LVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNvKDHSN 291
Cdd:cd02085   81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASN-GDLTT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 292 MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLS 371
Cdd:cd02085  160 RSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 372 EMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITsdgym 451
Cdd:cd02085  240 EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT----- 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 452 advtgagyndqgeihirhcnnvemaktnitnlleiGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEY 531
Cdd:cd02085  315 -----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEI 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 532 PFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQT-VPLTKQNEAEFLAEAYEIGRKGLRVLALAKGR 610
Cdd:cd02085  360 PFSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGP 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 611 SMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVA 690
Cdd:cd02085  440 ELGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVV 519
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 691 NNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEE 770
Cdd:cd02085  520 RKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEE 599
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 771 GKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMI 850
Cdd:cd02085  600 GKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPIL 679
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 851 TKSVVVNVLLSASIIVLGTLWVFQREMADGtlGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVA 930
Cdd:cd02085  680 TRSLILNVLLSAAIIVSGTLWVFWKEMSDD--NVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVG 757
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*..
gi 161085803 931 FSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK 977
Cdd:cd02085  758 GSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
103-984 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1189.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  103 ESSTHSASEVAGRLQVDVRTGLKWT-EAKYRAKIIGHNELLLVAEDPTWKKYIEQF-RNPLILLLLGSALVSVIMKQFDD 180
Cdd:TIGR01522   3 QYCELSVEETCSKLQTDLQNGLNSSqEASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNIDD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  181 AVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLS 260
Cdd:TIGR01522  83 AVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVDLS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  261 IDESSFTGETEPARKITDVLLNNTNVkDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKS 340
Cdd:TIGR01522 163 IDESNLTGETTPVSKVTAPIPAATNG-DLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQKS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  341 MDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETL 420
Cdd:TIGR01522 242 MDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVETL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  421 GCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQN--G 498
Cdd:TIGR01522 322 GSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNeaD 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  499 TLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNkeEIFFAKGALETLLPQCTKYQFGT-Q 577
Cdd:TIGR01522 402 TLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHRQDRS--EMCFMKGAYEQVLKYCTYYQKKDgK 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  578 TVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETAL 657
Cdd:TIGR01522 480 TLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAV 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  658 AIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIG 737
Cdd:TIGR01522 560 SIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIG 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  738 IAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWIN 817
Cdd:TIGR01522 640 VAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWIN 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  818 IIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLgkTKRDTTMTFTCFV 897
Cdd:TIGR01522 720 ILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVI--TARDTTMTFTCFV 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  898 FFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK 977
Cdd:TIGR01522 798 FFDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRK 877

                  ....*..
gi 161085803  978 WFERTME 984
Cdd:TIGR01522 878 KVERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
97-985 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 971.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  97 MLLSTSESSTHSASEVAGRLQVDvRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMK 176
Cdd:COG0474    1 MATALKDWHALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 177 QFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEA 256
Cdd:COG0474   80 DWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 257 VDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMkniAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTP 336
Cdd:COG0474  160 KDLQVDESALTGESVPVEKSADPLPEDAPLGDRGNM---VFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEKTP 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 337 LQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPT 416
Cdd:COG0474  237 LQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPA 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 417 VETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMaDVTGAGYNDQGEihirhcnnvemaktnitnLLEIGAVCNNAYIQ 496
Cdd:COG0474  317 VETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY-EVTGEFDPALEE------------------LLRAAALCSDAQLE 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 497 NGTLLGQPTEGALVAVAMKNGMYATA--ENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFfAKGALETLLPQCTKYQF 574
Cdd:COG0474  378 EETGLGDPTEGALLVAAAKAGLDVEElrKEYPRVDEIPFDSERKRMST--VHEDPDGKRLLI-VKGAPEVVLALCTRVLT 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 575 GTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRS-----------MQDLIYCGLVGITDPPRPLVRESIEMLMQSGV 643
Cdd:COG0474  455 GGGVVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELpadpeldseddESDLTFLGLVGMIDPPRPEAKEAIAECRRAGI 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 644 RVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGD 723
Cdd:COG0474  535 RVKMITGDHPATARAIARQLGLGDDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGD 614
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 724 GVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMD 803
Cdd:COG0474  615 GVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLG 694
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 804 IANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGtlG 883
Cdd:COG0474  695 LPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALARG--A 772
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 884 KTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLV 963
Cdd:COG0474  773 SLALARTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLIL 852
                        890       900
                 ....*....|....*....|..
gi 161085803 964 SLTSSVLVVSEIKKWFERTMER 985
Cdd:COG0474  853 GLALLYLLLVELVKLLRRRFGR 874
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
122-788 8.11e-90

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 307.00  E-value: 8.11e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 122 TGLKWTEAKYRAKIIGHNELllVAEDPT--WKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQE 199
Cdd:PRK10517  66 EGLNEAEVESAREQHGENEL--PAQKPLpwWVHLWVCYRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQE 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 200 YRSEKSLEELKKLVPPECHCLR------EGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPA 273
Cdd:PRK10517 144 ARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPV 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 274 RKITDVL-LNNTNVKDhsnMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYS 352
Cdd:PRK10517 224 EKFATTRqPEHSNPLE---CDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFM 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 353 FLIIGVIMLL-GWLQGKpLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKT 431
Cdd:PRK10517 301 LVMAPVVLLInGYTKGD-WWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKT 379
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 432 GTLTKNEmtatIIITSDgymADVTGAgyNDQGEIHIRHCNNveMAKTNITNLLEIgAVcnnayiqngtllgqpTEGALVA 511
Cdd:PRK10517 380 GTLTQDK----IVLENH---TDISGK--TSERVLHSAWLNS--HYQTGLKNLLDT-AV---------------LEGVDEE 432
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 512 VAMKngmyaTAENYVRIQEYPFSSEQKMMAVkCIHKYNNNKEEIffAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLA 591
Cdd:PRK10517 433 SARS-----LASRWQKIDEIPFDFERRRMSV-VVAENTEHHQLI--CKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKR 504
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 592 EAYEIGRKGLRVLALAKgRSM------------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAI 659
Cdd:PRK10517 505 VTDTLNRQGLRVVAVAT-KYLparegdyqradeSDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKV 583
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 660 ANLIGIDtiHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIA 739
Cdd:PRK10517 584 CHEVGLD--AGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGIS 661
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 161085803 740 MgKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLST 788
Cdd:PRK10517 662 V-DGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASS 709
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
807-979 4.15e-52

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 180.13  E-value: 4.15e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  807 PLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTK 886
Cdd:pfam00689   3 PLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISESQ 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  887 RDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLT 966
Cdd:pfam00689  83 NAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLA 162
                         170
                  ....*....|...
gi 161085803  967 SSVLVVSEIKKWF 979
Cdd:pfam00689 163 LVVLLVVELRKLL 175
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
108-175 2.28e-07

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 49.12  E-value: 2.28e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161085803   108 SASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIM 175
Cdd:smart00831   8 SLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
132-977 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1515.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 132 RAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKK 211
Cdd:cd02085    1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 212 LVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNvKDHSN 291
Cdd:cd02085   81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASN-GDLTT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 292 MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLS 371
Cdd:cd02085  160 RSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 372 EMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITsdgym 451
Cdd:cd02085  240 EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT----- 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 452 advtgagyndqgeihirhcnnvemaktnitnlleiGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEY 531
Cdd:cd02085  315 -----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEI 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 532 PFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQT-VPLTKQNEAEFLAEAYEIGRKGLRVLALAKGR 610
Cdd:cd02085  360 PFSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGP 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 611 SMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVA 690
Cdd:cd02085  440 ELGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVV 519
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 691 NNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEE 770
Cdd:cd02085  520 RKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEE 599
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 771 GKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMI 850
Cdd:cd02085  600 GKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPIL 679
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 851 TKSVVVNVLLSASIIVLGTLWVFQREMADGtlGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVA 930
Cdd:cd02085  680 TRSLILNVLLSAAIIVSGTLWVFWKEMSDD--NVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVG 757
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*..
gi 161085803 931 FSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK 977
Cdd:cd02085  758 GSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
103-984 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1189.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  103 ESSTHSASEVAGRLQVDVRTGLKWT-EAKYRAKIIGHNELLLVAEDPTWKKYIEQF-RNPLILLLLGSALVSVIMKQFDD 180
Cdd:TIGR01522   3 QYCELSVEETCSKLQTDLQNGLNSSqEASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNIDD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  181 AVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLS 260
Cdd:TIGR01522  83 AVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVDLS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  261 IDESSFTGETEPARKITDVLLNNTNVkDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKS 340
Cdd:TIGR01522 163 IDESNLTGETTPVSKVTAPIPAATNG-DLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQKS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  341 MDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETL 420
Cdd:TIGR01522 242 MDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVETL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  421 GCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQN--G 498
Cdd:TIGR01522 322 GSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNeaD 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  499 TLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNkeEIFFAKGALETLLPQCTKYQFGT-Q 577
Cdd:TIGR01522 402 TLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHRQDRS--EMCFMKGAYEQVLKYCTYYQKKDgK 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  578 TVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETAL 657
Cdd:TIGR01522 480 TLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAV 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  658 AIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIG 737
Cdd:TIGR01522 560 SIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIG 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  738 IAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWIN 817
Cdd:TIGR01522 640 VAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWIN 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  818 IIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLgkTKRDTTMTFTCFV 897
Cdd:TIGR01522 720 ILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVI--TARDTTMTFTCFV 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  898 FFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK 977
Cdd:TIGR01522 798 FFDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRK 877

                  ....*..
gi 161085803  978 WFERTME 984
Cdd:TIGR01522 878 KVERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
97-985 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 971.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  97 MLLSTSESSTHSASEVAGRLQVDvRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMK 176
Cdd:COG0474    1 MATALKDWHALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 177 QFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEA 256
Cdd:COG0474   80 DWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 257 VDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMkniAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTP 336
Cdd:COG0474  160 KDLQVDESALTGESVPVEKSADPLPEDAPLGDRGNM---VFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEKTP 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 337 LQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPT 416
Cdd:COG0474  237 LQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPA 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 417 VETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMaDVTGAGYNDQGEihirhcnnvemaktnitnLLEIGAVCNNAYIQ 496
Cdd:COG0474  317 VETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY-EVTGEFDPALEE------------------LLRAAALCSDAQLE 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 497 NGTLLGQPTEGALVAVAMKNGMYATA--ENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFfAKGALETLLPQCTKYQF 574
Cdd:COG0474  378 EETGLGDPTEGALLVAAAKAGLDVEElrKEYPRVDEIPFDSERKRMST--VHEDPDGKRLLI-VKGAPEVVLALCTRVLT 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 575 GTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRS-----------MQDLIYCGLVGITDPPRPLVRESIEMLMQSGV 643
Cdd:COG0474  455 GGGVVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELpadpeldseddESDLTFLGLVGMIDPPRPEAKEAIAECRRAGI 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 644 RVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGD 723
Cdd:COG0474  535 RVKMITGDHPATARAIARQLGLGDDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGD 614
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 724 GVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMD 803
Cdd:COG0474  615 GVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLG 694
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 804 IANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGtlG 883
Cdd:COG0474  695 LPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALARG--A 772
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 884 KTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLV 963
Cdd:COG0474  773 SLALARTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLIL 852
                        890       900
                 ....*....|....*....|..
gi 161085803 964 SLTSSVLVVSEIKKWFERTMER 985
Cdd:COG0474  853 GLALLYLLLVELVKLLRRRFGR 874
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
123-977 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 738.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRS 202
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFGVVLINAIIGYIQEGKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 203 EKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLN 282
Cdd:cd02080   81 EKALAAIKNMLSPEATVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQIDESALTGESVPVEKQEGPLEE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 283 NTNVKDHSNMkniAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL 362
Cdd:cd02080  161 DTPLGDRKNM---AYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLIVILVLAALTFVF 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 363 GWL-QGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTA 441
Cdd:cd02080  238 GLLrGDYSLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 442 TIIITsdgymadvtgagyndqgeihirhcnnvemaktnitnlleigaVCNNAYIQNG----TLLGQPTEGALVAVAMKNG 517
Cdd:cd02080  318 QAIVT------------------------------------------LCNDAQLHQEdghwKITGDPTEGALLVLAAKAG 355
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 518 MYATAEN--YVRIQEYPFSSEQKMMAVkcIHKYNNnkEEIFFAKGALETLLPQCTKYQFGTQTVPLTKqneAEFLAEAYE 595
Cdd:cd02080  356 LDPDRLAssYPRVDKIPFDSAYRYMAT--LHRDDG--QRVIYVKGAPERLLDMCDQELLDGGVSPLDR---AYWEAEAED 428
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 596 IGRKGLRVLALAKgRSMQD-------------LIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANL 662
Cdd:cd02080  429 LAKQGLRVLAFAY-REVDSeveeidhadleggLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQ 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 663 IGIdTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGK 742
Cdd:cd02080  508 LGL-GDGKKVLTGAELDALDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGI 586
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 743 NGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDG 822
Cdd:cd02080  587 KGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAI 666
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 823 PPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRdtTMTFTCFVFFDMF 902
Cdd:cd02080  667 TLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLFLWALDRGYSLETAR--TMAVNTIVVAQIF 744
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161085803 903 NALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYD--IFFLVSLtsSVLVVSEIKK 977
Cdd:cd02080  745 YLFNCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDwaIILLVGI--VVFIVVELEK 819
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
123-843 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 711.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSItIAILIVVTV-AFIQEYR 201
Cdd:cd02089    1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGEYVDAIVI-IAIVILNAVlGFVQEYK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 202 SEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLL 281
Cdd:cd02089   80 AEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEESSLTGESEPVEKDADTLL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 282 N-NTNVKDHSNMkniAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIM 360
Cdd:cd02089  160 EeDVPLGDRKNM---VFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAIAALIICALVF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 361 LLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT 440
Cdd:cd02089  237 ALGLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKMT 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 441 ATIIITsdgymadvtgagyndqgeihirhcnnvemaktnitnlleigavcnnayiqngtlLGQPTEGALVAVAMKNGMYA 520
Cdd:cd02089  317 VEKIYT------------------------------------------------------IGDPTETALIRAARKAGLDK 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 521 T--AENYVRIQEYPFSSEQKMMAVkcIHKYNNNKeeIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGR 598
Cdd:cd02089  343 EelEKKYPRIAEIPFDSERKLMTT--VHKDAGKY--IVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSE 418
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 599 KGLRVLALA-------KGRSM----QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDT 667
Cdd:cd02089  419 EALRVLAVAykpldedPTESSedleNDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILE 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 668 IHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDV 747
Cdd:cd02089  499 DGDKALTGEELDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDV 578
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 748 CKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQS 827
Cdd:cd02089  579 AKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALA 658
                        730
                 ....*....|....*.
gi 161085803 828 LGVEPVDHDVLKQKPR 843
Cdd:cd02089  659 LGVEPAEPDIMDRKPR 674
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
106-981 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 627.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 106 THSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELllVAEDPT--WKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVS 183
Cdd:cd02083    2 SKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNEL--PAEEGKslWELVLEQFDDLLVRILLLAAIISFVLALFEEGEE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 184 ITIA-------ILIVV---TVAFIQEYRSEKSLEELKKLVPPECHCLREGR-LDTFLARELVPGDIVHLNVGDRVPADVR 252
Cdd:cd02083   80 GVTAfvepfviLLILIanaVVGVWQERNAEKAIEALKEYEPEMAKVLRNGKgVQRIRARELVPGDIVEVAVGDKVPADIR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 253 L--FEAVDLSIDESSFTGETEPARKITDVLLNNTNVKdhSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAE 330
Cdd:cd02083  160 IieIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVN--QDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAET 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 331 EAPKTPLQKSMDILGAQLSfysfLIIGVIMLL----------------GWLQGKplSEMFNISVSLAVAAIPEGLPIVVT 394
Cdd:cd02083  238 EEEKTPLQQKLDEFGEQLS----KVISVICVAvwainighfndpahggSWIKGA--IYYFKIAVALAVAAIPEGLPAVIT 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 395 VTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMAD-------VTGAGYNDQGEIHI 467
Cdd:cd02083  312 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDDsslnefeVTGSTYAPEGEVFK 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 468 RHCNNVEMAKTNITNLLEIGAVCNNAYIQ-NGTL-----LGQPTEGALVAVAMKNGMYATAENYVRIQEYP--------- 532
Cdd:cd02083  392 NGKKVKAGQYDGLVELATICALCNDSSLDyNESKgvyekVGEATETALTVLVEKMNVFNTDKSGLSKRERAnacndvieq 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 533 ---------FSSEQKMMAVKCIHKyNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNE-AEFLAEAYEIGRKGLR 602
Cdd:cd02083  472 lwkkeftleFSRDRKSMSVYCSPT-KASGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIkILILKKVWGYGTDTLR 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 603 VLALA------KGRSM------------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIG 664
Cdd:cd02083  551 CLALAtkdtppKPEDMdledstkfykyeTDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIG 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 665 I-----DTIHHqTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIA 739
Cdd:cd02083  631 IfgedeDTTGK-SYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIA 709
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 740 MGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINII 819
Cdd:cd02083  710 MG-SGTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLV 788
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 820 MDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSASiIVLGTLWVFQR------------------- 875
Cdd:cd02083  789 TDGLPATALGFNPPDLDIMKKPPRKPDEPLISgwlffRYLAIGTYVGLA-TVGAFAWWFMYyeegpqvsfyqlthfmqcs 867
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 876 EMADGTLG------KTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVF 949
Cdd:cd02083  868 SWEPNFEGvdceifEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIF 947
                        970       980       990
                 ....*....|....*....|....*....|..
gi 161085803 950 QTEALTPYDIFFLVSLTSSVLVVSEIKKWFER 981
Cdd:cd02083  948 QITPLSFAEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
154-981 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 585.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  154 IEQFRNPLILLLLGSALVSVIMKQFDDAVSITIA---------ILIV-VTVAFIQEYRSEKSLEELKKLVPPECHCLREG 223
Cdd:TIGR01116   2 LEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAfvepfvillILVAnAIVGVWQERNAEKAIEALKEYESEHAKVLRDG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  224 RLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVkdHSNMKNIAFMGTLVR 303
Cdd:TIGR01116  82 RWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTESVPDERAV--NQDKKNMLFSGTLVV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  304 CGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL------------GWLQGKPLS 371
Cdd:TIGR01116 160 AGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVInighfndpalggGWIQGAIYY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  372 emFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT--IIITSDG 449
Cdd:TIGR01116 240 --FKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCkvVALDPSS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  450 YMA---DVTGAGYNDQGEIhIRHCNNVEMAKT-NITNLLEIGAVCNNAYI----QNGTL--LGQPTEGALVAVAMKNGMY 519
Cdd:TIGR01116 318 SSLnefCVTGTTYAPEGGV-IKDDGPVAGGQDaGLEELATIAALCNDSSLdfneRKGVYekVGEATEAALKVLVEKMGLP 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  520 AT------------------AENYVRIQEYPFSSEQKMMAVKCIHKYNNNkeeiFFAKGALETLLPQCTKYQFGTQT-VP 580
Cdd:TIGR01116 397 ATkngvsskrrpalgcnsvwNDKFKKLATLEFSRDRKSMSVLCKPSTGNK----LFVKGAPEGVLERCTHILNGDGRaVP 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  581 LTKQNEAEFLAEAYEIG-RKGLRVLALAKGRSMQ------------------DLIYCGLVGITDPPRPLVRESIEMLMQS 641
Cdd:TIGR01116 473 LTDKMKNTILSVIKEMGtTKALRCLALAFKDIPDpreedllsdpanfeaiesDLTFIGVVGMLDPPRPEVADAIEKCRTA 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  642 GVRVKMVTGDAQETALAIANLIGI----DTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNI 717
Cdd:TIGR01116 553 GIRVIMITGDNKETAEAICRRIGIfspdEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELLQEQGEI 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  718 VGMTGDGVNDGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIA 797
Cdd:TIGR01116 633 VAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIF 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  798 LATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGT----LWVF 873
Cdd:TIGR01116 712 LTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATvggfVWWY 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  874 Q--REMADGTLGKTKRD----------------TTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIG 935
Cdd:TIGR01116 792 LltHFTGCDEDSFTTCPdfedpdcyvfegkqpaRTISLSVLVVIEMFNALNALSEDQSLLRMPPWVNKWLIGAICLSMAL 871
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*.
gi 161085803  936 QMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFER 981
Cdd:TIGR01116 872 HFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
123-981 4.41e-160

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 495.05  E-value: 4.41e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRS 202
Cdd:cd02086    1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFAVKDWIEGGVIAAVIALNVIVGFIQEYKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 203 EKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLN 282
Cdd:cd02086   81 EKTMDSLRNLSSPNAHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIKDAELVFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 283 ---NTNVKDHSNMkniAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQ----AEEAPK--------------------- 334
Cdd:cd02086  161 keeDVSVGDRLNL---AYSSSTVTKGRAKGIVVATGMNTEIGKIAKALRgkggLISRDRvkswlygtlivtwdavgrflg 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 335 ----TPLQKSMDILgAQLSFYSFLIIGVIMLlgwlqgkpLSEMFNI-------SVSLAVAAIPEGLPIVVTVTLALGVMR 403
Cdd:cd02086  238 tnvgTPLQRKLSKL-AYLLFFIAVILAIIVF--------AVNKFDVdneviiyAIALAISMIPESLVAVLTITMAVGAKR 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 404 MAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymadvtgagyndQGEIHIRHCNNVEMAKTNITnl 483
Cdd:cd02086  309 MVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVR-------------------QVWIPAALCNIATVFKDEET-- 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 484 leigavcnnayiQNGTLLGQPTEGALVAVAMKNGM------YATAENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFF 557
Cdd:cd02086  368 ------------DCWKAHGDPTEIALQVFATKFDMgknaltKGGSAQFQHVAEFPFDSTVKRMSV--VYYNNQAGDYYAY 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 558 AKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKgRSM---------------------QDLI 616
Cdd:cd02086  434 MKGAVERVLECCSSMYGKDGIIPLDDEFRKTIIKNVESLASQGLRVLAFAS-RSFtkaqfnddqlknitlsradaeSDLT 512
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 617 YCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGI----------DTIHHQTLSGQEMDQMNEHQL 686
Cdd:cd02086  513 FLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGIlppnsyhysqEIMDSMVMTASQFDGLSDEEV 592
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 687 DKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIA 766
Cdd:cd02086  593 DALPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVN 672
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 767 AIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIAN-----PLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQK 841
Cdd:cd02086  673 AIEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRP 752
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 842 PRNVKQPMITKSVVVNVLLSASII---VLGTLWVFQREMADGTLGK------------TKRDTTMTFTCFVFFDMFNALS 906
Cdd:cd02086  753 PHDLKVGIFTRELIIDTFVYGTFMgvlCLASFTLVIYGIGNGDLGSdcnesynsscedVFRARAAVFATLTWCALILAWE 832
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 907 CRSQTKSVFTIGLTT-------------NRMFLLAVAFSIIGQMLVVYFPPL-QMVFQTEALTPYDIFFLVSLTSSVLVV 972
Cdd:cd02086  833 VVDMRRSFFNMHPDTdspvksffktlwkNKFLFWSVVLGFVSVFPTLYIPVInDDVFKHTGIGWEWGLVIACTVAFFAGV 912

                 ....*....
gi 161085803 973 sEIKKWFER 981
Cdd:cd02086  913 -ELWKAGKR 920
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
132-853 8.21e-145

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 448.96  E-value: 8.21e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 132 RAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIM---KQFDDA---------VSITIAILIVVTVAFIQE 199
Cdd:cd02081    4 RREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLgfyTPFGEGegktgwiegVAILVAVILVVLVTAGND 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 200 YRSEKSLEEL-KKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD 278
Cdd:cd02081   84 YQKEKQFRKLnSKKEDQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDPIKKTPD 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 279 vllnntnvkdHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSfLIIGV 358
Cdd:cd02081  164 ----------NQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVG-LIVAA 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 359 IMLLG------------------WLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETL 420
Cdd:cd02081  233 LTFIVliirfiidgfvndgksfsAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETM 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 421 GCVNVICSDKTGTLTKNEMTATiiitsdgymadvtgagyndqgeihirhcnnvemaktnitnlleigavcnNAYIqngtl 500
Cdd:cd02081  313 GNATAICSDKTGTLTQNRMTVV-------------------------------------------------QGYI----- 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 501 lGQPTEGALVAVAMKNGM---YATAENYVRI-QEYPFSSEQKMMAVkcIHKYNNNKEEIFfAKGALETLLPQCTKYQFGT 576
Cdd:cd02081  339 -GNKTECALLGFVLELGGdyrYREKRPEEKVlKVYPFNSARKRMST--VVRLKDGGYRLY-VKGASEIVLKKCSYILNSD 414
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 577 QT-VPLTKQNEAEFLAEAYEIGRKGLRVLALAKGR------------------SMQDLIYCGLVGITDPPRPLVRESIEM 637
Cdd:cd02081  415 GEvVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDfspdeeptaerdwddeedIESDLTFIGIVGIKDPLRPEVPEAVAK 494
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 638 LMQSGVRVKMVTGDAQETALAIANLIGIdtIHHQ------------TLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKL 705
Cdd:cd02081  495 CQRAGITVRMVTGDNINTARAIARECGI--LTEGedglvlegkefrELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKY 572
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 706 EIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQ 785
Cdd:cd02081  573 TLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQ 652
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161085803 786 LSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKS 853
Cdd:cd02081  653 LTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRT 720
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
156-831 4.05e-138

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 428.37  E-value: 4.05e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 156 QFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLRE--GRLDTFLAREL 233
Cdd:cd07539   35 QLELPPVALLGLAAGASASTGGGVDAVLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRApaGRTQTVPAESL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 234 VPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLlNNTNVKDHSNMkniAFMGTLVRCGNGKGIVVS 313
Cdd:cd07539  115 VPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQVAPT-PGAPLADRACM---LYEGTTVVSGQGRAVVVA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 314 TGERSEFGEVFKMMQAEEApKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVV 393
Cdd:cd07539  191 TGPHTEAGRAQSLVAPVET-ATGVQAQLRELTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLPLVA 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 394 TVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMtatiiitsdgymadvtgagyndqgeihirhcnnv 473
Cdd:cd07539  270 TLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRL---------------------------------- 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 474 emaktnitnlleigavcnnayiqngtllgqptegALVAVAmkngmyataenyVRIQEYPFSSEQKMMAVkcIHKYNNnkE 553
Cdd:cd07539  316 ----------------------------------RVVQVR------------PPLAELPFESSRGYAAA--IGRTGG--G 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 554 EIFFA-KGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA-----------KGRSMQDLIYCGLV 621
Cdd:cd07539  346 IPLLAvKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNELLAGQGLRVLAVAyrtldagtthaVEAVVDDLELLGLL 425
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 622 GITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDtIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSP 701
Cdd:cd07539  426 GLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLP-RDAEVVTGAELDALDEEALTGLVADIDVFARVSP 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 702 RHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNF 781
Cdd:cd07539  505 EQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDA 584
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|
gi 161085803 782 VRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVE 831
Cdd:cd07539  585 VHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
123-860 6.04e-132

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 412.99  E-value: 6.04e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRS 202
Cdd:cd07538    1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQEWRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 203 EKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLN 282
Cdd:cd07538   81 ERALEALKNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGESVPVWKRIDGKAM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 283 NTNVKDHsnmKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL 362
Cdd:cd07538  161 SAPGGWD---KNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCALAALVFCALIVAV 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 363 GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT 442
Cdd:cd07538  238 YGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLTKNQMEVV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 443 iiitsdgymadvtgagyndqgeihirhcnnvemaktnitnlleigavcnnayiqngtllgqptegalvavamkngmyata 522
Cdd:cd07538      --------------------------------------------------------------------------------
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 523 ENYVRIQEYPFSSEQKMMAvkciHKYNNNKEEIFFAKGALETLLPQCTkyqfgtqtvpLTKQNEAEFLAEAYEIGRKGLR 602
Cdd:cd07538  318 ELTSLVREYPLRPELRMMG----QVWKRPEGAFAAAKGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAGEGLR 383
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 603 VLALAKGRSMQD----------LIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHhQT 672
Cdd:cd07538  384 VLAVAACRIDESflpddledavFIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGLDNTD-NV 462
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 673 LSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAA 752
Cdd:cd07538  463 ITGQELDAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREAS 542
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 753 DMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEP 832
Cdd:cd07538  543 DIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEP 622
                        730       740
                 ....*....|....*....|....*...
gi 161085803 833 VDHDVLKQKPRNVKQPMITKSVVVNVLL 860
Cdd:cd07538  623 AERDIMRRPPRPPDEPLFGPRLVIKAIL 650
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
109-942 8.79e-132

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 421.88  E-value: 8.79e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  109 ASEVAGRLQVDVRTGLKWTEAKY--RAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFD------- 179
Cdd:TIGR01517  45 AEGIATKLKTDLNEGVRLSSSTLerREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVpsvgedk 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  180 --------DAVSITIAILIVVTVAFIQEYRSEKSLEEL-KKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPAD 250
Cdd:TIGR01517 125 adtetgwiEGVAILVSVILVVLVTAVNDYKKELQFRQLnREKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPAD 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  251 VRLFEAVDLSIDESSFTGETEPARKitdvllnnTNVKDhsnmkNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAE 330
Cdd:TIGR01517 205 GVFISGLSLEIDESSITGESDPIKK--------GPVQD-----PFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQA 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  331 EAPKTPLQKSMDILGAQLSFY---SFLIIGVIMLLGWL---------------QGKPLSEMFNISVSLAVAAIPEGLPIV 392
Cdd:TIGR01517 272 GEEETPLQEKLSELAGLIGKFgmgSAVLLFLVLSLRYVfriirgdgrfedteeDAQTFLDHFIIAVTIVVVAVPEGLPLA 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  393 VTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsDGYMADVTgagYNDQGEIHIRhcnN 472
Cdd:TIGR01517 352 VTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVV-----QGYIGEQR---FNVRDEIVLR---N 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  473 VEMAKTNItnLLEIGAVCNNAYI-----QNGTLLGQPTEGALVAVAMKNGMYATAENYVR-----IQEYPFSSEQKMMAV 542
Cdd:TIGR01517 421 LPAAVRNI--LVEGISLNSSSEEvvdrgGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRaeekvVKIYPFNSERKFMSV 498
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  543 KCIHKYNNNKeeiFFAKGALETLLPQCTKY-QFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAkGRSMQD------- 614
Cdd:TIGR01517 499 VVKHSGGKYR---EFRKGASEIVLKPCRKRlDSNGEATPISEDDKDRCADVIEPLASDALRTICLA-YRDFAPeefprkd 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  615 -----LIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKV 689
Cdd:TIGR01517 575 ypnkgLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGGLAMEGKEFRSLVYEEMDPI 654
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  690 ANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIE 769
Cdd:TIGR01517 655 LPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVK 734
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  770 EGKGIFYNIRNFVRFQLSTSIAALALIALATLM--DIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQ 847
Cdd:TIGR01517 735 WGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCIssSHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNA 814
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  848 PMITKSVVVNVLLSAS--IIVLGTL------WVFQREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRS--QTKSVFTi 917
Cdd:TIGR01517 815 PLISRSMWKNILGQAGyqLVVTFILlfaggsIFDVSGPDEITSHQQGELNTIVFNTFVLLQLFNEINARKlyEGMNVFE- 893
                         890       900
                  ....*....|....*....|....*
gi 161085803  918 GLTTNRMFLLAVAFSIIGQMLVVYF 942
Cdd:TIGR01517 894 GLFKNRIFVTIMGFTFGFQVIIVEF 918
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
123-788 2.20e-126

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 402.01  E-value: 2.20e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVI--------MKQFDDAVSITIAILIVVTV 194
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFtdvllapgEFDLVGALIILLMVLISGLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 195 AFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLA-RELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPA 273
Cdd:cd02077   81 DFIQEIRSLKAAEKLKKMVKNTATVIRDGSKYMEIPiDELVPGDIVYLSAGDMIPADVRIIQSKDLFVSQSSLTGESEPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 274 RKITDVllNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQaEEAPKTPLQKSMDILGAQLSFYSF 353
Cdd:cd02077  161 EKHATA--KKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSIT-EKRPETSFDKGINKVSKLLIRFML 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 354 LIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGT 433
Cdd:cd02077  238 VMVPVVFLINGLTKGDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTDKTGT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 434 LTknemtatiiitsdgymadvtgagyndQGEIHIRHCNNVEMaKTNItNLLEIGAVcnNAYIQNGtlLGQPTEGALVAVA 513
Cdd:cd02077  318 LT--------------------------QDKIVLERHLDVNG-KESE-RVLRLAYL--NSYFQTG--LKNLLDKAIIDHA 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 514 MKNGMYATAENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFfAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEA 593
Cdd:cd02077  366 EEANANGLIQDYTKIDEIPFDFERRRMSV--VVKDNDGKHLLI-TKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQV 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 594 YEIGRKGLRVLALAKgRSMQ------------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIAN 661
Cdd:cd02077  443 EELNREGLRVLAIAY-KKLPapegeysvkdekELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICK 521
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 662 LIGIDTihHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMg 741
Cdd:cd02077  522 QVGLDI--NRVLTGSEIEALSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISV- 598
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*..
gi 161085803 742 KNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLST 788
Cdd:cd02077  599 DSAVDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASS 645
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
123-844 1.31e-122

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 395.95  E-value: 1.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSALVSV---IMKQFDDAVS-------ITIAILIV 191
Cdd:cd02608    1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQlFGGFSMLLWIGAILCFLaygIQAATEEEPSndnlylgIVLAAVVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 192 VT--VAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGE 269
Cdd:cd02608   81 VTgcFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 270 TEPARKITDVllnntnvkDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD---- 342
Cdd:cd02608  161 SEPQTRSPEF--------THENpleTKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEhfih 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 343 -ILGAQLSF-YSFLIIGVIMLLGWLQgkplSEMFNISVslAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETL 420
Cdd:cd02608  233 iITGVAVFLgVSFFILSLILGYTWLE----AVIFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETL 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 421 GCVNVICSDKTGTLTKNEMTAT------IIITSDgYMADVTGAGYNdqgeihirhcnnvemaKTNIT--NLLEIGAVCNN 492
Cdd:cd02608  307 GSTSTICSDKTGTLTQNRMTVAhmwfdnQIHEAD-TTEDQSGASFD----------------KSSATwlALSRIAGLCNR 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 493 AYIQNG---------TLLGQPTEGAL---VAVAMKNGMyATAENYVRIQEYPFSSEQKMMAvkCIHKYNNNKEE--IFFA 558
Cdd:cd02608  370 AEFKAGqenvpilkrDVNGDASESALlkcIELSCGSVM-EMRERNPKVAEIPFNSTNKYQL--SIHENEDPGDPryLLVM 446
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 559 KGALETLLPQCTKYQFGTQTVPLTKQNEAEFlAEAY-EIGRKGLRVLALA----------KGRS---------MQDLIYC 618
Cdd:cd02608  447 KGAPERILDRCSTILINGKEQPLDEEMKEAF-QNAYlELGGLGERVLGFChlylpddkfpEGFKfdtdevnfpTENLCFV 525
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 619 GLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIdtihhqtlsgqemdqmnehqldkvannvSVFYR 698
Cdd:cd02608  526 GLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI----------------------------IVFAR 577
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 699 VSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNI 778
Cdd:cd02608  578 TSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNL 657
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161085803 779 RNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRN 844
Cdd:cd02608  658 KKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRN 723
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
183-789 8.08e-122

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 382.82  E-value: 8.08e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  183 SITIAILIVVTVAFIQEYRSEKSLEELKKLV--PPECHCLREGrLDTFLARELVPGDIVHLNVGDRVPADVRLFEAvDLS 260
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLvnTATVLVLRNG-WKEISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  261 IDESSFTGETEPARKITDvllnntnvkdhsNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKS 340
Cdd:TIGR01494  79 VDESSLTGESLPVLKTAL------------PDGDAVFAGTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSK 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  341 MDILGAQLSFYSFLIIGVIMLLGWL----QGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPT 416
Cdd:TIGR01494 147 ADKFENFIFILFLLLLALAVFLLLPiggwDGNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNA 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  417 VETLGCVNVICSDKTGTLTKNEMTatiiitsdgymadvtgagyndqgeihIRHCNNVEMAKTNITNLLEIgAVCNNAyiq 496
Cdd:TIGR01494 227 LEELGKVDVICFDKTGTLTTNKMT--------------------------LQKVIIIGGVEEASLALALL-AASLEY--- 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  497 ngtLLGQPTEGALV-AVAMKNGMYATAENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEiFFAKGALETLLPQCTkyqfg 575
Cdd:TIGR01494 277 ---LSGHPLERAIVkSAEGVIKSDEINVEYKILDVFPFSSVLKRMGV--IVEGANGSDL-LFVKGAPEFVLERCN----- 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  576 tqtvpltkqNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQET 655
Cdd:TIGR01494 346 ---------NENDYDEKVDEYARQGLRVLAFASKKLPDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLT 416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  656 ALAIANLIGIDtihhqtlsgqemdqmnehqldkvannvsVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKAD 735
Cdd:TIGR01494 417 AKAIAKELGID----------------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKAD 468
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 161085803  736 IGIAMGknGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTS 789
Cdd:TIGR01494 469 VGIAMG--SGDVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYN 520
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
106-943 3.85e-121

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 395.92  E-value: 3.85e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   106 THSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSIT 185
Cdd:TIGR01523    9 SDIADEAAEFIGTSIPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMHDWIEGGVIS 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   186 IAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESS 265
Cdd:TIGR01523   89 AIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTDEAL 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   266 FTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAE---------EAPK-- 334
Cdd:TIGR01523  169 LTGESLPVIKDAHATFGKEEDTPIGDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAAGLQGDgglfqrpekDDPNkr 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   335 ------------------------TPLQKSMDILgAQLSFYSFLIIGVIMLLgwlqgkplSEMFNI-------SVSLAVA 383
Cdd:TIGR01523  249 rklnkwilkvtkkvtgaflglnvgTPLHRKLSKL-AVILFCIAIIFAIIVMA--------AHKFDVdkevaiyAICLAIS 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   384 AIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEM-TATIIITSDGYMA---------- 452
Cdd:TIGR01523  320 IIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMiARQIWIPRFGTISidnsddafnp 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   453 ---DVTG--------AGYNDQGEIHIRHCNNVEMAKTNITN---------LLEIGAVCNNAYIQNGT------LLGQPTE 506
Cdd:TIGR01523  400 negNVSGiprfspyeYSHNEAADQDILKEFKDELKEIDLPEdidmdlfikLLETAALANIATVFKDDatdcwkAHGDPTE 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   507 GAL-----------VAVAMKNGMYATAEN----------------YVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFFAK 559
Cdd:TIGR01523  480 IAIhvfakkfdlphNALTGEEDLLKSNENdqsslsqhnekpgsaqFEFIAEFPFDSEIKRMAS--IYEDNHGETYNIYAK 557
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   560 GALETLLPQCTKY--QFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA--------------------KGRSMQDLIY 617
Cdd:TIGR01523  558 GAFERIIECCSSSngKDGVKISPLEDCDRELIIANMESLAAEGLRVLAFAsksfdkadnnddqlknetlnRATAESDLEF 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   618 CGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGI---DTIHHQ-------TLSGQEMDQMNEHQLD 687
Cdd:TIGR01523  638 LGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIippNFIHDRdeimdsmVMTGSQFDALSDEEVD 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   688 KVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAA 767
Cdd:TIGR01523  718 DLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNA 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   768 IEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIAN-----PLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKP 842
Cdd:TIGR01523  798 IEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLP 877
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   843 RNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREM-----------ADGTLGKTKRD---------TTMTFTCFV----- 897
Cdd:TIGR01523  878 HDNEVGIFQKELIIDMFAYGFFLGGSCLASFTGILygfgsgnlghdCDAHYHAGCNDvfkarsaafATMTFCALIlavev 957
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|..
gi 161085803   898 ------FFDMFNALSCRSQTKSVFTiGLTTNRMFLLAVAFSIIGQMLVVYFP 943
Cdd:TIGR01523  958 kdfdnsFFNLHGIPDGDSNFKEFFH-SIVENKFLAWAIAFAAVSAFPTIYIP 1008
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
108-853 9.84e-117

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 382.60  E-value: 9.84e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  108 SASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSALVSV---IMKQFDDAVS 183
Cdd:TIGR01106  21 SLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQlFGGFSMLLWIGAILCFLaygIQASTEEEPQ 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  184 -------ITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLF 254
Cdd:TIGR01106 101 ndnlylgVVLSAVVIITgcFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRII 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  255 EAVDLSIDESSFTGETEPARKITDVllnntnvkDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEE 331
Cdd:TIGR01106 181 SAQGCKVDNSSLTGESEPQTRSPEF--------THENpleTRNIAFFSTNCVEGTARGIVVNTGDRTVMGRIASLASGLE 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  332 APKTPLQKSMD-----ILGAQLSF-YSFLIIGVIMLLGWLQgkplSEMFNISVslAVAAIPEGLPIVVTVTLALGVMRMA 405
Cdd:TIGR01106 253 NGKTPIAIEIEhfihiITGVAVFLgVSFFILSLILGYTWLE----AVIFLIGI--IVANVPEGLLATVTVCLTLTAKRMA 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  406 KRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTgagyNDQgeihirhcNNVEMAKTNIT--N 482
Cdd:TIGR01106 327 RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTvAHMWFDNQIHEADTT----EDQ--------SGVSFDKSSATwlA 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  483 LLEIGAVCNNAYIQNG---------TLLGQPTEGAL---VAVAMKNGMyATAENYVRIQEYPFSSEQKMMAvkCIHKYNN 550
Cdd:TIGR01106 395 LSRIAGLCNRAVFKAGqenvpilkrAVAGDASESALlkcIELCLGSVM-EMRERNPKVVEIPFNSTNKYQL--SIHENED 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  551 NKEEIFF--AKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA----------KGRS------- 611
Cdd:TIGR01106 472 PRDPRHLlvMKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFChlylpdeqfpEGFQfdtddvn 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  612 --MQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQT----------------- 672
Cdd:TIGR01106 552 fpTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETvediaarlnipvsqvnp 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  673 -------LSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKN 743
Cdd:TIGR01106 632 rdakacvVHGSDLKDMTSEQLDEILKYHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  744 GTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGP 823
Cdd:TIGR01106 712 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMV 791
                         810       820       830
                  ....*....|....*....|....*....|....*.
gi 161085803  824 PAQSLGVEPVDHDVLKQKPRN------VKQPMITKS 853
Cdd:TIGR01106 792 PAISLAYEKAESDIMKRQPRNpktdklVNERLISMA 827
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
123-941 5.56e-114

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 369.25  E-value: 5.56e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNELllvaEDPT---WKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQE 199
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNEL----PEKKenpILKFLSFFWGPIPWMLEAAAILAAALGDWVDFAIILLLLLINAGIGFIEE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 200 YRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKitdv 279
Cdd:cd02076   77 RQAGNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTK---- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 280 llnntnvkdHSNmkNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEaPKTPLQKSMDILGAQLSFYSFLIIGVI 359
Cdd:cd02076  153 ---------HPG--DEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAE-EQGHLQKVLNKIGNFLILLALILVLII 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 360 MLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEM 439
Cdd:cd02076  221 VIVALYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKL 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 440 TATIIITSDGYMAD---VTGAGYNDQgeihiRHCNNVEMaktnitnlleigAVCNNAyiqngtllgqptegalvavamkn 516
Cdd:cd02076  301 SLDEPYSLEGDGKDellLLAALASDT-----ENPDAIDT------------AILNAL----------------------- 340
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 517 GMYATAENYVRIQEY-PFSSEQKMMAVKCIhkyNNNKEEIFFAKGALETLLPQCTKYQFGTQTVpltkQNEAEFLAEaye 595
Cdd:cd02076  341 DDYKPDLAGYKQLKFtPFDPVDKRTEATVE---DPDGERFKVTKGAPQVILELVGNDEAIRQAV----EEKIDELAS--- 410
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 596 igrKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDT--IHHQTL 673
Cdd:cd02076  411 ---RGYRSLGVARKEDGGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMGTniLSAERL 487
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 674 S-GQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMgKNGTDVCKEAA 752
Cdd:cd02076  488 KlGGGGGGMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAV-SGATDAARAAA 566
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 753 DMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGpPAQSLGvep 832
Cdd:cd02076  567 DIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAETLRILVFFTLGILILNFYPLPLIMIVLIAILNDG-ATLTIA--- 642
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 833 VDHDVLKQKPRNVKQPMITK-SVVVNVLLSASIIVL-----GTLWVFQREMADGTLgktkrdTTMTFTCFVFFDMFNALS 906
Cdd:cd02076  643 YDNVPPSPRPVRWNMPELLGiATVLGVVLTISSFLLlwlldDQGWFEDIVLSAGEL------QTILYLQLSISGHLTIFV 716
                        810       820       830
                 ....*....|....*....|....*....|....*
gi 161085803 907 CRsqTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVY 941
Cdd:cd02076  717 TR--TRGPFWRPRPSPLLFIAVVLTQILATLLAVY 749
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
123-787 2.14e-108

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 353.94  E-value: 2.14e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  123 GLKWTEAKYRAKIIGHNELLLVAEDPtWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRS 202
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELPEKKVSP-LLKFLGFFWNPLSWVMEAAAIIAIALENWVDFVIILGLLLLNATIGFIEENKA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  203 EKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDvlln 282
Cdd:TIGR01647  80 GNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKKTG---- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  283 ntnvkdhsnmkNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL 362
Cdd:TIGR01647 156 -----------DIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIVLIGVLVLIELVV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  363 GWLQ-GKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT- 440
Cdd:TIGR01647 225 LFFGrGESFREGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSi 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  441 ATIIITSDGYMADvtgagyndqgeihirhcnnvemaktnitNLLEIGAvcnnayiqngtlLGQPTEGALVAVAMKNGMYA 520
Cdd:TIGR01647 305 DEILPFFNGFDKD----------------------------DVLLYAA------------LASREEDQDAIDTAVLGSAK 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  521 T----AENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIffAKGALETLLPQCTKYqfgtqtVPLTKQNEAEFLaeayEI 596
Cdd:TIGR01647 345 DlkeaRDGYKVLEFVPFDPVDKRTEATVEDPETGKRFKV--TKGAPQVILDLCDNK------KEIEEKVEEKVD----EL 412
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  597 GRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDT--IHHQTLS 674
Cdd:TIGR01647 413 ASRGYRALGVARTDEEGRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTniYTADVLL 492
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  675 GQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMgKNGTDVCKEAADM 754
Cdd:TIGR01647 493 KGDNRDDLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAV-AGATDAARSAADI 571
                         650       660       670
                  ....*....|....*....|....*....|...
gi 161085803  755 ILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLS 787
Cdd:TIGR01647 572 VLTEPGLSVIVDAILESRKIFQRMKSYVIYRIA 604
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
107-789 3.38e-93

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 315.65  E-value: 3.38e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  107 HSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITI 186
Cdd:TIGR01524  17 QMGKETLLRKLGVHETGLTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYLTDDLEATVIIAL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  187 AILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLR------EGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLS 260
Cdd:TIGR01524  97 MVLASGLLGFIQESRAERAAYALKNMVKNTATVLRvinengNGSMDEVPIDALVPGDLIELAAGDIIPADARVISARDLF 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  261 IDESSFTGETEPARKITDvllnNTNVKDHS--NMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMqAEEAPKTPLQ 338
Cdd:TIGR01524 177 INQSALTGESLPVEKFVE----DKRARDPEilERENLCFMGTNVLSGHAQAVVLATGSSTWFGSLAIAA-TERRGQTAFD 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  339 KSMDILGAQLSFYSFLIIGVIMLL-GWLQGKPLsEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTV 417
Cdd:TIGR01524 252 KGVKSVSKLLIRFMLVMVPVVLMInGLMKGDWL-EAFLFALAVAVGLTPEMLPMIVSSNLAKGAINMSKKKVIVKELSAI 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  418 ETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADvtgagyndqgeiHIRHCNNVemaktnitnlleigavcnNAYIQN 497
Cdd:TIGR01524 331 QNFGAMDILCTDKTGTLTQDKIELEKHIDSSGETSE------------RVLKMAWL------------------NSYFQT 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  498 GtlLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKeeiFFAKGALETLLPQCTKYQFGTQ 577
Cdd:TIGR01524 381 G--WKNVLDHAVLAKLDESAARQTASRWKKVDEIPFDFDRRRLSVVVENRAEVTR---LICKGAVEEMLTVCTHKRFGGA 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  578 TVPLTKQNEAEFLAEAYEIGRKGLRVLALA----KGRSM-------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVK 646
Cdd:TIGR01524 456 VVTLSESEKSELQDMTAEMNRQGIRVIAVAtktlKVGEAdftktdeEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVK 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  647 MVTGDAQETALAIANLIGIDTihHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVN 726
Cdd:TIGR01524 536 VLTGDNEIVTARICQEVGIDA--NDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGIN 613
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161085803  727 DGVALKKADIGIAMgKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTS 789
Cdd:TIGR01524 614 DAPALRKADVGISV-DTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSN 675
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
122-788 8.11e-90

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 307.00  E-value: 8.11e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 122 TGLKWTEAKYRAKIIGHNELllVAEDPT--WKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQE 199
Cdd:PRK10517  66 EGLNEAEVESAREQHGENEL--PAQKPLpwWVHLWVCYRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQE 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 200 YRSEKSLEELKKLVPPECHCLR------EGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPA 273
Cdd:PRK10517 144 ARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPV 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 274 RKITDVL-LNNTNVKDhsnMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYS 352
Cdd:PRK10517 224 EKFATTRqPEHSNPLE---CDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFM 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 353 FLIIGVIMLL-GWLQGKpLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKT 431
Cdd:PRK10517 301 LVMAPVVLLInGYTKGD-WWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKT 379
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 432 GTLTKNEmtatIIITSDgymADVTGAgyNDQGEIHIRHCNNveMAKTNITNLLEIgAVcnnayiqngtllgqpTEGALVA 511
Cdd:PRK10517 380 GTLTQDK----IVLENH---TDISGK--TSERVLHSAWLNS--HYQTGLKNLLDT-AV---------------LEGVDEE 432
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 512 VAMKngmyaTAENYVRIQEYPFSSEQKMMAVkCIHKYNNNKEEIffAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLA 591
Cdd:PRK10517 433 SARS-----LASRWQKIDEIPFDFERRRMSV-VVAENTEHHQLI--CKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKR 504
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 592 EAYEIGRKGLRVLALAKgRSM------------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAI 659
Cdd:PRK10517 505 VTDTLNRQGLRVVAVAT-KYLparegdyqradeSDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKV 583
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 660 ANLIGIDtiHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIA 739
Cdd:PRK10517 584 CHEVGLD--AGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGIS 661
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 161085803 740 MgKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLST 788
Cdd:PRK10517 662 V-DGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASS 709
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
425-828 5.80e-86

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 279.34  E-value: 5.80e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 425 VICSDKTGTLTKNEMTATIIItsdgymadvtgagyndqgeihirhcnnvemaktnitnlleigavcnnayiqngtllgqp 504
Cdd:cd01431    1 VICSDKTGTLTKNGMTVTKLF----------------------------------------------------------- 21
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 505 tegalvavamkngmyataenyvrIQEYPFSSEQKMMAVKCIhkynNNKEEIFFAKGALETLLPQCTKyqfgtqtvPLTKQ 584
Cdd:cd01431   22 -----------------------IEEIPFNSTRKRMSVVVR----LPGRYRAIVKGAPETILSRCSH--------ALTEE 66
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 585 NEAEFLAEAYEIGRKGLRVLALAKGRSMQ---------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQET 655
Cdd:cd01431   67 DRNKIEKAQEESAREGLRVLALAYREFDPetskeavelNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLT 146
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 656 ALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKAD 735
Cdd:cd01431  147 AIAIAREIGIDTKASGVILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQAD 226
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 736 IGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILW 815
Cdd:cd01431  227 VGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILW 306
                        410
                 ....*....|...
gi 161085803 816 INIIMDGPPAQSL 828
Cdd:cd01431  307 INLVTDLIPALAL 319
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
123-778 1.20e-85

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 295.40  E-value: 1.20e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 123 GLKWTEAKYRAKIIGHNElllVAED---PTWKKYIEQFRNPLILLLLGSALVSVIM--------KQFDDAVSITIaILIV 191
Cdd:PRK15122  45 GLTEEDAAERLQRYGPNE---VAHEkppHALVQLLQAFNNPFIYVLMVLAAISFFTdywlplrrGEETDLTGVII-ILTM 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 192 VTVA----FIQEYRSEKSLEELKKLVPPECHCLR------EGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSI 261
Cdd:PRK15122 121 VLLSgllrFWQEFRSNKAAEALKAMVRTTATVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFI 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 262 DESSFTGETEPARKItDVL-------LNNTNVKDHS--NMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEvfkmmqaeea 332
Cdd:PRK15122 201 SQAVLTGEALPVEKY-DTLgavagksADALADDEGSllDLPNICFMGTNVVSGTATAVVVATGSRTYFGS---------- 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 333 pktpLQKSmdILG--AQLSF------YSFLIIG--------VIMLLGWLQGKPLSE-MFNISVslAVAAIPEGLPIVVTV 395
Cdd:PRK15122 270 ----LAKS--IVGtrAQTAFdrgvnsVSWLLIRfmlvmvpvVLLINGFTKGDWLEAlLFALAV--AVGLTPEMLPMIVSS 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 396 TLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEmtatiIITSDGYmaDVtgAGYNDQgeihirhcnnvem 475
Cdd:PRK15122 342 NLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDR-----IILEHHL--DV--SGRKDE------------- 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 476 aktnitNLLEIGAVcnNAYIQNG--TLLGQptegALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVkcIHKyNNNKE 553
Cdd:PRK15122 400 ------RVLQLAWL--NSFHQSGmkNLMDQ----AVVAFAEGNPEIVKPAGYRKVDELPFDFVRRRLSV--VVE-DAQGQ 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 554 EIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA------KGRSMQ-------DLIYCGL 620
Cdd:PRK15122 465 HLLICKGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAYNADGFRVLLVAtreipgGESRAQystaderDLVIRGF 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 621 VGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTihHQTLSGQEMDQMNEHQLDKVANNVSVFYRVS 700
Cdd:PRK15122 545 LTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTAKICREVGLEP--GEPLLGTEIEAMDDAALAREVEERTVFAKLT 622
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 701 PRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMgKNGTDVCKEAADMILVNDDfhtiIAAIEEG--KG--IFY 776
Cdd:PRK15122 623 PLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGISV-DSGADIAKESADIILLEKS----LMVLEEGviKGreTFG 697

                 ..
gi 161085803 777 NI 778
Cdd:PRK15122 698 NI 699
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
186-862 2.62e-76

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 263.76  E-value: 2.62e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 186 IAILIVVTV-AFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDES 264
Cdd:cd02609   62 LGVIIVNTViGIVQEIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDES 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 265 SFTGETEPARKITDVLLnntnvkdhsnmkniaFMGTLVRCGNGKGIVVSTGERSefgevFKMMQAEEAPK-----TPLQK 339
Cdd:cd02609  142 LLTGESDLIPKKAGDKL---------------LSGSFVVSGAAYARVTAVGAES-----YAAKLTLEAKKhklinSELLN 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 340 SMDILgaqLSFYSFLII--GVIMLLG--WLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLP 415
Cdd:cd02609  202 SINKI---LKFTSFIIIplGLLLFVEalFRRGGGWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELY 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 416 TVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAgyndqgeihirhcnnvemaktnitnllEIGAVCNNAYI 495
Cdd:cd02609  279 SIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAEAAA---------------------------ALAAFVAASED 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 496 QNGTllgqptegalvAVAMKNGMYATaENYVRIQEYPFSSEQKMMAV--KCIHKYnnnkeeiffAKGALETLLpqctkyq 573
Cdd:cd02609  332 NNAT-----------MQAIRAAFFGN-NRFEVTSIIPFSSARKWSAVefRDGGTW---------VLGAPEVLL------- 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 574 fgtqtvpltKQNEAEFLAEAYEIGRKGLRVLALAKGRS-------MQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVK 646
Cdd:cd02609  384 ---------GDLPSEVLSRVNELAAQGYRVLLLARSAGaltheqlPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVK 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 647 MVTGDAQETALAIANLIGIDtihhqtlsGQEMD-----QMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMT 721
Cdd:cd02609  455 VISGDNPVTVSAIAKRAGLE--------GAESYidastLTTDEELAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMT 526
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 722 GDGVNDGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATL 801
Cdd:cd02609  527 GDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVI 605
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161085803 802 MDIANPLNAMQILWINIIMDGPPAQSLGVEPvdhdvlkqkprNVKQpmITKSVVVNVLLSA 862
Cdd:cd02609  606 TALPFPFLPIQITLISLFTIGIPSFFLALEP-----------NKRR--IEGGFLRRVLTKA 653
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
178-782 2.77e-56

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 208.07  E-value: 2.77e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 178 FDDAVSITIAILIVvtvAFIQEY---RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLF 254
Cdd:COG2217  176 FEAAAMIIFLLLLG---RYLEARakgRARAAIRALLSLQPKTARVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVL 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 255 EAvDLSIDESSFTGETEPARKITDvllnnTNVkdhsnmkniaFMGTLvrcgNGKG-IVV---STGERSEFGEVFKMMQAE 330
Cdd:COG2217  253 EG-ESSVDESMLTGESLPVEKTPG-----DEV----------FAGTI----NLDGsLRVrvtKVGSDTTLARIIRLVEEA 312
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 331 EAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGL----PIVVTVtlALGvmRMAK 406
Cdd:COG2217  313 QSSKAPIQRLADRIARYFVPAVLAIAALTFLVWLLFGGDFSTALYRAVAVLVIACPCALglatPTAIMV--GTG--RAAR 388
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 407 RNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYmadvtgagynDQGEIhirhcnnVEMAKTnitnlLEI 486
Cdd:COG2217  389 RGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDGL----------DEDEL-------LALAAA-----LEQ 446
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 487 G-------AVCNNAYIQNGTLLgQPTEgaLVAVAMKnGMYATAENyvriqeypfsseqkmmavkcihkynnnkEEIFFAK 559
Cdd:COG2217  447 GsehplarAIVAAAKERGLELP-EVED--FEAIPGK-GVEATVDG----------------------------KRVLVGS 494
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 560 GALetllpqctkyqFGTQTVPLTkqneAEFLAEAYEIGRKGLRVLALAKGRSmqdliYCGLVGITDPPRPLVRESIEMLM 639
Cdd:COG2217  495 PRL-----------LEEEGIDLP----EALEERAEELEAEGKTVVYVAVDGR-----LLGLIALADTLRPEAAEAIAALK 554
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 640 QSGVRVKMVTGDAQETALAIANLIGIDTIHhqtlsgqemdqmnehqldkvANnvsvfyrVSPRHKLEIVKSLQRSGNIVG 719
Cdd:COG2217  555 ALGIRVVMLTGDNERTAEAVARELGIDEVR--------------------AE-------VLPEDKAAAVRELQAQGKKVA 607
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161085803 720 MTGDGVNDGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR-NFV 782
Cdd:COG2217  608 MVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIRqNLF 670
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
168-782 3.01e-52

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 192.85  E-value: 3.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  168 SALVSVIMKQFDDAVSItiaILIVVTVAFIQEY---RSEKSLEELKKLVPPECHCLR-EGRLDTFLARELVPGDIVHLNV 243
Cdd:TIGR01525   8 AAIAAYAMGLVLEGALL---LFLFLLGETLEERaksRASDALSALLALAPSTARVLQgDGSEEEVPVEELQVGDIVIVRP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  244 GDRVPAD--VRLFEAvdlSIDESSFTGETEP-ARKITDvllnntnvkdhsnmknIAFMGTLVRCGNGKGIVVSTGERSEF 320
Cdd:TIGR01525  85 GERIPVDgvVISGES---EVDESALTGESMPvEKKEGD----------------EVFAGTINGDGSLTIRVTKLGEDSTL 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  321 GEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALG 400
Cdd:TIGR01525 146 AQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALGLATPVAILVA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  401 VMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymaDVTGAGYNDQGEIhirhcnnvemaktni 480
Cdd:TIGR01525 226 IGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVV----------DIEPLDDASEEEL--------------- 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  481 tnLLEIGAvcnnayiqngtlLGQPTEGALvAVAMKNgmYATAENYVRIQEypfssEQKMMAVKCIHKYNNNKEEIFFAKG 560
Cdd:TIGR01525 281 --LALAAA------------LEQSSSHPL-ARAIVR--YAKERGLELPPE-----DVEEVPGKGVEATVDGGREVRIGNP 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  561 ALetllpqCTKYQFGTQTVpltkQNEAEFLAEAYEIGRKGLRVLALAKgrsmqdliYCGLVGITDPPRPLVRESIEMLMQ 640
Cdd:TIGR01525 339 RF------LGNRELAIEPI----SASPDLLNEGESQGKTVVFVAVDGE--------LLGVIALRDQLRPEAKEAIAALKR 400
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  641 SGV-RVKMVTGDAQETALAIANLIGIDTIhhqtlsgqemdqmnehqldkvannvsVFYRVSPRHKLEIVKSLQRSGNIVG 719
Cdd:TIGR01525 401 AGGiKLVMLTGDNRSAAEAVAAELGIDDE--------------------------VHAELLPEDKLAIVKKLQEEGGPVA 454
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161085803  720 MTGDGVNDGVALKKADIGIAMGKnGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR-NFV 782
Cdd:TIGR01525 455 MVGDGINDAPALAAADVGIAMGS-GSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKqNLA 517
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
807-979 4.15e-52

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 180.13  E-value: 4.15e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  807 PLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTK 886
Cdd:pfam00689   3 PLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISESQ 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  887 RDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLT 966
Cdd:pfam00689  83 NAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLA 162
                         170
                  ....*....|...
gi 161085803  967 SSVLVVSEIKKWF 979
Cdd:pfam00689 163 LVVLLVVELRKLL 175
E1-E2_ATPase pfam00122
E1-E2 ATPase;
211-407 1.13e-51

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 179.30  E-value: 1.13e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  211 KLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDlSIDESSFTGETEPARKitdvllnntnvkdhs 290
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  291 NMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPL 370
Cdd:pfam00122  65 KKGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPP 144
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 161085803  371 SEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKR 407
Cdd:pfam00122 145 LRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
178-782 2.30e-51

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 191.66  E-value: 2.30e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 178 FDDAVSITIAILIVvtvAFIQEY---RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLF 254
Cdd:cd02079   88 FEEAAMLLFLFLLG---RYLEERarsRARSALKALLSLAPETATVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVV 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 255 EAVDlSIDESSFTGETEPARKITD--VllnntnvkdhsnmkniaFMGTLvrcgNGKGI----VVSTGERSEFGEVFKMMQ 328
Cdd:cd02079  165 SGES-SVDESSLTGESLPVEKGAGdtV-----------------FAGTI----NLNGPltieVTKTGEDTTLAKIIRLVE 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 329 AEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRN 408
Cdd:cd02079  223 EAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLALYRALAVLVVACPCALGLATPTAIVAGIGRAARKG 302
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 409 SIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADvtgagyndqgeihirhcnnvemaktnitNLLEIGA 488
Cdd:cd02079  303 ILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEPLEGFSED----------------------------ELLALAA 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 489 vcnnaYIQNGTllGQPtegalVAVAmkngmyataenyvrIQEYpfsSEQKmmavkcihkynnNKEEIFFAKgaLETLLPQ 568
Cdd:cd02079  355 -----ALEQHS--EHP-----LARA--------------IVEA---AEEK------------GLPPLEVED--VEEIPGK 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 569 CTKYQFGTQTVPLTKQN--EAEFLAEAYEIGRKGLRVLALAKGRSMQdliYCGLVGITDPPRPLVRESIEMLMQSGVRVK 646
Cdd:cd02079  392 GISGEVDGREVLIGSLSfaEEEGLVEAADALSDAGKTSAVYVGRDGK---LVGLFALEDQLRPEAKEVIAELKSGGIKVV 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 647 MVTGDAQETALAIANLIGIDTIHhqtlsgqemdqmnehqldkvannvsvfYRVSPRHKLEIVKSLQRSGNIVGMTGDGVN 726
Cdd:cd02079  469 MLTGDNEAAAQAVAKELGIDEVH---------------------------AGLLPEDKLAIVKALQAEGGPVAMVGDGIN 521
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 161085803 727 DGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR-NFV 782
Cdd:cd02079  522 DAPALAQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKqNLA 577
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
176-782 2.30e-49

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 184.40  E-value: 2.30e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  176 KQFDDAVSITIAILIVVTvaFIQEY---RSEKSLEELKKLVPPECHCLR-EGRLDTFLARELVPGDIVHLNVGDRVPADV 251
Cdd:TIGR01511  51 HTFFDASAMLITFILLGR--WLEMLakgRASDALSKLAKLQPSTATLLTkDGSIEEVPVALLQPGDIVKVLPGEKIPVDG 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  252 RLFEAvDLSIDESSFTGETEPARKITDvllnntnvkdhsnmkNIAFMGTLvrcgNGKGIVV----STGERSEFGEVFKMM 327
Cdd:TIGR01511 129 TVIEG-ESEVDESLVTGESLPVPKKVG---------------DPVIAGTV----NGTGSLVvratATGEDTTLAQIVRLV 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  328 QAEEAPKTPLQKSMDILgAQLSFYSFLIIGVIMLLGWLQGkplsemFNISVSLAVAAIPEGL----PIVVTVtlalGVMR 403
Cdd:TIGR01511 189 RQAQQSKAPIQRLADKV-AGYFVPVVIAIALITFVIWLFA------LEFAVTVLIIACPCALglatPTVIAV----ATGL 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  404 MAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymaDVTGAGYNDQGEIhirhcnnVEMAKTnitnl 483
Cdd:TIGR01511 258 AAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVT----------DVHVFGDRDRTEL-------LALAAA----- 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  484 LEIGAvcnnayiqngtllGQPtegalVAVAMKNgmYATAENYVRIQEYPFSSEQKMmAVKCihKYNNnkeeiffakgale 563
Cdd:TIGR01511 316 LEAGS-------------EHP-----LAKAIVS--YAKEKGITLVTVSDFKAIPGI-GVEG--TVEG------------- 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  564 tllpqcTKYQFGTQTvpLTKQNEAEFLAEAyeiGRKGLRVLALAKGRsmqdliYCGLVGITDPPRPLVRESIEMLMQSGV 643
Cdd:TIGR01511 360 ------TKIQLGNEK--LLGENAIKIDGKA---GQGSTVVLVAVNGE------LAGVFALEDQLRPEAKEVIQALKRRGI 422
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  644 RVKMVTGDAQETALAIANLIGIDtihhqtlsgqemdqmnehqldkvannvsVFYRVSPRHKLEIVKSLQRSGNIVGMTGD 723
Cdd:TIGR01511 423 EPVMLTGDNRKTAKAVAKELGID----------------------------VRAEVLPDDKAALIKKLQEKGPVVAMVGD 474
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  724 GVNDGVALKKADIGIAMGKnGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR-NFV 782
Cdd:TIGR01511 475 GINDAPALAQADVGIAIGA-GTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKqNLL 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
191-782 2.49e-49

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 186.14  E-value: 2.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 191 VVTVAFIQ-----EYRS-EKSLEELKKLV---PPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAvDLSI 261
Cdd:cd02094  106 AVIITFILlgkylEARAkGKTSEAIKKLLglqPKTARVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEG-ESSV 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 262 DESSFTGETEPARKitdvllnntNVKDHsnmkniAFMGTLvrcgNGKGIVV----STGERSEFGEVFKMMQAEEAPKTPL 337
Cdd:cd02094  185 DESMLTGESLPVEK---------KPGDK------VIGGTI----NGNGSLLvratRVGADTTLAQIIRLVEEAQGSKAPI 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 338 QKSMDilgaQLSFYsF----LIIGVIMLLGWL---QGKPLSEMFNISVSLAVAAIPEGL----PIVVTVtlalGVMRMAK 406
Cdd:cd02094  246 QRLAD----RVSGV-FvpvvIAIAILTFLVWLllgPEPALTFALVAAVAVLVIACPCALglatPTAIMV----GTGRAAE 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 407 RNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymaDVTGAGYNDQGEIhirhcnnVEMAKTnitnlLEI 486
Cdd:cd02094  317 LGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT----------DVVPLPGDDEDEL-------LRLAAS-----LEQ 374
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 487 G-------AVCNNAYiQNGTLLGQPTEgaLVAVAMKnGMYATAENY-VRIqeypfsSEQKMMAVKCIhkynnnkeeiffa 558
Cdd:cd02094  375 GsehplakAIVAAAK-EKGLELPEVED--FEAIPGK-GVRGTVDGRrVLV------GNRRLMEENGI------------- 431
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 559 kgaletllpqctkyqfgtqtvpltkqNEAEFLAEAYEIGRKGLRVLALAKgrsmqDLIYCGLVGITDPPRPLVRESIEML 638
Cdd:cd02094  432 --------------------------DLSALEAEALALEEEGKTVVLVAV-----DGELAGLIAVADPLKPDAAEAIEAL 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 639 MQSGVRVKMVTGDAQETALAIANLIGIDTihhqtlsgqemdqmnehqldkvannvsVFYRVSPRHKLEIVKSLQRSGNIV 718
Cdd:cd02094  481 KKMGIKVVMLTGDNRRTARAIAKELGIDE---------------------------VIAEVLPEDKAEKVKKLQAQGKKV 533
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161085803 719 GMTGDGVNDGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR-NFV 782
Cdd:cd02094  534 AMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIKqNLF 597
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
128-875 6.44e-49

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 186.69  E-value: 6.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 128 EAKYRAKIIGHNELLlVAEDPTWKKYIEQFRNPLILLLlgsaLVSVIMKQFDDAVSITIAILIV-VTVAFIQEYRSEKSL 206
Cdd:cd07542    2 EQSDRRLIYGPNEID-VPLKSILKLLFKEVLNPFYVFQ----LFSVILWSSDDYYYYAACIVIIsVISIFLSLYETRKQS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 207 EELKKLVppECHC----LREGRLDTFLARELVPGDIVHL-NVGDRVPADVRLFEAvDLSIDESSFTGETEPARKI----- 276
Cdd:cd07542   77 KRLREMV--HFTCpvrvIRDGEWQTISSSELVPGDILVIpDNGTLLPCDAILLSG-SCIVNESMLTGESVPVTKTplpde 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 277 -TDVLLNNTNVKDHSnmKNIAFMGTLV------RCGNGKGIVVSTGERSEFGE-VFKMMQAEEAPKTPLQKSMDILG--A 346
Cdd:cd07542  154 sNDSLWSIYSIEDHS--KHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILYPKPVDFKFYRDSMKFILflA 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 347 QLSFYSFLIIGVIMLLgwlQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMaKRNSIVKKLP-TVETLGCVNV 425
Cdd:cd07542  232 IIALIGFIYTLIILIL---NGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRL-KKKGIFCISPqRINICGKINL 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 426 ICSDKTGTLTKNEMTATIIITSDGymadvtgagyNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPT 505
Cdd:cd07542  308 VCFDKTGTLTEDGLDLWGVRPVSG----------NNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSLTLIDGELVGDPL 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 506 EgalvaVAMKNgmyATAENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFFAKGALETLLPQCTKyqfgtQTVPLTKQN 585
Cdd:cd07542  378 D-----LKMFE---FTGWSLEILRQFPFSSALQRMSV--IVKTPGDDSMMAFTKGAPEMIASLCKP-----ETVPSNFQE 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 586 EAEFLAeayeigRKGLRVLALAkGRSMQ----------------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVT 649
Cdd:cd07542  443 VLNEYT------KQGFRVIALA-YKALEsktwllqklsreevesDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVT 515
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 650 GDAQETALAIANLIGI-------DTIHHQTLSGQEMDQMNEHQLdkvaNNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTG 722
Cdd:cd07542  516 GDNLLTAISVARECGMispskkvILIEAVKPEDDDSASLTWTLL----LKGTVFARMSPDQKSELVEELQKLDYTVGMCG 591
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 723 DGVNDGVALKKADIGIAMGKNGTDVckeAADMILVNDDFHTIIAAIEEGK-------GIF-----YNIRNFVRFQLstsi 790
Cdd:cd07542  592 DGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPTVIKEGRaalvtsfSCFkymalYSLIQFISVLI---- 664
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 791 aalalialatLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKP-RNVKQPMITKSVVVNVLLSASIIVLGT 869
Cdd:cd07542  665 ----------LYSINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPpASLVSPPVLVSLLGQIVLILLFQVIGF 734

                 ....*.
gi 161085803 870 LWVFQR 875
Cdd:cd07542  735 LIVRQQ 740
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
168-772 3.77e-48

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 180.60  E-value: 3.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  168 SALVSVIMKQFDDAVSItiaILIVVTVAFIQEY---RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVG 244
Cdd:TIGR01512   8 AALGAVAIGEYLEGALL---LLLFSIGETLEEYasgRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGDVVVVKPG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  245 DRVPAD--VRLFEAvdlSIDESSFTGETEPARKITDvllnntnvkdhsnmkNIAFMGTLvrcgNGKGI----VVSTGERS 318
Cdd:TIGR01512  85 ERVPVDgeVLSGTS---SVDESALTGESVPVEKAPG---------------DEVFAGAI----NLDGVltieVTKLPADS 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  319 EFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGK-PLSEMFNISVSLAVAAIPEGLPIVVTVTL 397
Cdd:TIGR01512 143 TIAKIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPLLGAgPFLEWIYRALVLLVVASPCALVISAPAAY 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  398 ALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMAD--VTGAGYNDQGEIHirhcnnvem 475
Cdd:TIGR01512 223 LSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGHSESevLRLAAAAEQGSTH--------- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  476 aktnitnlleigavcnnayiqngtllgqPTEGALVAVAMKNGMYATAENYvriQEYPfsseqkmmavkcihkynnnkeei 555
Cdd:TIGR01512 294 ----------------------------PLARAIVDYARARELAPPVEDV---EEVP----------------------- 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  556 ffAKGAletllpqctKYQFGTQTVPLTKQN--EAEFLAEAYEIGRKGLR-VLALAKGRsmqdliYCGLVGITDPPRPLVR 632
Cdd:TIGR01512 320 --GEGV---------RAVVDGGEVRIGNPRslSEAVGASIAVPESAGKTiVLVARDGT------LLGYIALSDELRPDAA 382
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  633 ESIEMLMQSGV-RVKMVTGDAQETALAIANLIGIDTIHHQTLsgqemdqmnehqldkvannvsvfyrvsPRHKLEIVKSL 711
Cdd:TIGR01512 383 EAIAELKALGIkRLVMLTGDRRAVAEAVARELGIDEVHAELL---------------------------PEDKLEIVKEL 435
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161085803  712 QRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGK 772
Cdd:TIGR01512 436 REKAGPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLAR 496
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
206-769 1.17e-47

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 180.96  E-value: 1.17e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 206 LEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAvDLSIDESSFTGETEPARKitdvllnntN 285
Cdd:cd07552  122 LKKLAELLPKTAHLVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEG-ESSVNESMVTGESKPVEK---------K 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 286 VKDhsnmKNIAfmGTLvrcgNGKGI----VVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDiLGAQLSFYSFLIIGVIML 361
Cdd:cd07552  192 PGD----EVIG--GSV----NGNGTlevkVTKTGEDSYLSQVMELVAQAQASKSRAENLAD-KVAGWLFYIALGVGIIAF 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 362 LGWLQGKPLSEMFNISVSLAVAAIPEGL----PIVVTVTLALGvmrmAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKN 437
Cdd:cd07552  261 IIWLILGDLAFALERAVTVLVIACPHALglaiPLVVARSTSIA----AKNGLLIRNREALERARDIDVVLFDKTGTLTEG 336
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 438 EMTATIIITSDGYmadvtgagynDQGEIhirhcnnvemaktnitnLLEIGAVCNNAyiqngtllGQPTEGALVAVAMKNG 517
Cdd:cd07552  337 KFGVTDVITFDEY----------DEDEI-----------------LSLAAALEAGS--------EHPLAQAIVSAAKEKG 381
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 518 MyataenyvriqEYPFSSEQKMMAVKCIHKYNNNKeeiffakgaletllpqctKYQFGTQTVpLTKQNEAEFLAEAYEIG 597
Cdd:cd07552  382 I-----------RPVEVENFENIPGVGVEGTVNGK------------------RYQVVSPKY-LKELGLKYDEELVKRLA 431
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 598 RKGLRVLALAKGRSMQdliycGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQtlsgqe 677
Cdd:cd07552  432 QQGNTVSFLIQDGEVI-----GAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGIDEYFAE------ 500
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 678 mdqmnehqldkvannvsvfyrVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKnGTDVCKEAADMILV 757
Cdd:cd07552  501 ---------------------VLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIGA-GTDVAIESADVVLV 558
                        570
                 ....*....|..
gi 161085803 758 NDDFHTIIAAIE 769
Cdd:cd07552  559 KSDPRDIVDFLE 570
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
187-740 2.08e-46

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 181.02  E-value: 2.08e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   187 AILIVVTVAFIQE--YRSEKSLEELKKLV--PPECHCLREGRLDTFLARELVPGDIVHLNV--GDRVPADVRLFEAvDLS 260
Cdd:TIGR01657  197 LCIVFMSSTSISLsvYQIRKQMQRLRDMVhkPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SCI 275
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   261 IDESSFTGETEPARK--ITDVLLNNTNV-KDHSNMKNIAFMGTLV-------RCGNGKGIVVSTGERSEFGE-VFKMMQA 329
Cdd:TIGR01657  276 VNESMLTGESVPVLKfpIPDNGDDDEDLfLYETSKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQlVRSILYP 355
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   330 EEAPKTPLQKSMDILGAqLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMaKRNS 409
Cdd:TIGR01657  356 KPRVFKFYKDSFKFILF-LAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARL-KKKG 433
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   410 IVKKLP-TVETLGCVNVICSDKTGTLTKNEMtatiiitsdgymaDVTGAGYNDQGEIHIRHCNNveMAKTNITNLLEIGA 488
Cdd:TIGR01657  434 IFCTSPfRINFAGKIDVCCFDKTGTLTEDGL-------------DLRGVQGLSGNQEFLKIVTE--DSSLKPSITHKALA 498
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   489 VCNNAYIQNGTLLGQPTEGALV------------------AVAMKNGMYATAENYVrIQEYPFSSEQKMMAVKCihKYNN 550
Cdd:TIGR01657  499 TCHSLTKLEGKLVGDPLDKKMFeatgwtleeddesaeptsILAVVRTDDPPQELSI-IRRFQFSSALQRMSVIV--STND 575
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   551 NKEEIFFAKGALETLLPQCTKyqfgtQTVPltkqneAEFLAEAYEIGRKGLRVLALA----------KGRSMQ------D 614
Cdd:TIGR01657  576 ERSPDAFVKGAPETIQSLCSP-----ETVP------SDYQEVLKSYTREGYRVLALAykelpkltlqKAQDLSrdavesN 644
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   615 LIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGI----DTI----HHQTLSGQ---------- 676
Cdd:TIGR01657  645 LTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIvnpsNTLilaeAEPPESGKpnqikfevid 724
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   677 --------------------EMDQMNEH------------------QLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIV 718
Cdd:TIGR01657  725 sipfastqveipyplgqdsvEDLLASRYhlamsgkafavlqahspeLLLRLLSHTTVFARMAPDQKETLVELLQKLDYTV 804
                          650       660
                   ....*....|....*....|..
gi 161085803   719 GMTGDGVNDGVALKKADIGIAM 740
Cdd:TIGR01657  805 GMCGDGANDCGALKQADVGISL 826
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
169-768 6.75e-43

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 166.27  E-value: 6.75e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 169 ALVSVIMKQFDDAvsiTIAILIVVTVAFIQEY---RSEKSLEELKKLVPPECHCL-REGRLDTFLARELVPGDIVHLNVG 244
Cdd:cd07551   66 AIGAAAIGYWAEG---ALLIFIFSLSHALEDYamgRSKRAITALMQLAPETARRIqRDGEIEEVPVEELQIGDRVQVRPG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 245 DRVPADVRLFEAVDlSIDESSFTGETEPARKIT--DVllnntnvkdhsnmkniaFMGTLvrcgNGKG--IVVSTGERSE- 319
Cdd:cd07551  143 ERVPADGVILSGSS-SIDEASITGESIPVEKTPgdEV-----------------FAGTI----NGSGalTVRVTKLSSDt 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 320 -FGEVFKMMQAEEAPKTPLQKSMD---------ILGAQLsfysFLIIGVIMLLGWlqgkPLSEMFNISVSLAVAAIPEGL 389
Cdd:cd07551  201 vFAKIVQLVEEAQSEKSPTQSFIErferiyvkgVLLAVL----LLLLLPPFLLGW----TWADSFYRAMVFLVVASPCAL 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 390 PIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymaDVTGAGYNDQGEIhIRH 469
Cdd:cd07551  273 VASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVT----------DVIPAEGVDEEEL-LQV 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 470 CNNVEMAKTNitnllEIGAVCNNAYIQNGTLLGQPTEgaLVAVAMKnGMYATAEN-YVRIQEYPFsseqkmmavkcihky 548
Cdd:cd07551  342 AAAAESQSEH-----PLAQAIVRYAEERGIPRLPAIE--VEAVTGK-GVTATVDGqTYRIGKPGF--------------- 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 549 nnnkeeiffakgaletllpqctkyqFGTQTVPLTKQNEAEFLAEAyeigrkGLRVLALAKGRSMQdliycGLVGITDPPR 628
Cdd:cd07551  399 -------------------------FGEVGIPSEAAALAAELESE------GKTVVYVARDDQVV-----GLIALMDTPR 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 629 PLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIhhqtlsgqemdqmnehqldkVANnvsvfyrVSPRHKLEIV 708
Cdd:cd07551  443 PEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGIDEV--------------------VAN-------LLPEDKVAII 495
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 709 KSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAI 768
Cdd:cd07551  496 RELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAI 554
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
204-744 1.34e-41

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 164.48  E-value: 1.34e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 204 KSLEELKKL--VPPECHCLREGRLDTFLARELVPGDIV---HLNVGDRVPADVRLFEAVDLsIDESSFTGETEPARKITD 278
Cdd:cd07543   73 KNLSEFRTMgnKPYTIQVYRDGKWVPISSDELLPGDLVsigRSAEDNLVPCDLLLLRGSCI-VNEAMLTGESVPLMKEPI 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 279 VLLNNTNVKDHSNM--KNIAFMGTLV-------RC------GNGKGIVVSTGERSEFGEVFKMM--QAEEAPKTPLQKSM 341
Cdd:cd07543  152 EDRDPEDVLDDDGDdkLHVLFGGTKVvqhtppgKGglkppdGGCLAYVLRTGFETSQGKLLRTIlfSTERVTANNLETFI 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 342 DILgaqlsfysFLIIGVIMLLG--WLQGKPLSEMFN---ISVSLAVAA-IPEGLPIVVTVTLALGVMRMAKRNSIVKKLP 415
Cdd:cd07543  232 FIL--------FLLVFAIAAAAyvWIEGTKDGRSRYklfLECTLILTSvVPPELPMELSLAVNTSLIALAKLYIFCTEPF 303
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 416 TVETLGCVNVICSDKTGTLTKNEMTatiiitsdgymadVTGAGYNDQGEIHIRHcnnvemAKTNITNLLEIGAVCNN-AY 494
Cdd:cd07543  304 RIPFAGKVDICCFDKTGTLTSDDLV-------------VEGVAGLNDGKEVIPV------SSIEPVETILVLASCHSlVK 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 495 IQNGTLLGQPTEGALVA-----VAMKNGMYATAENYVR---IQEYPFSSEQKMMAVKCIHK--YNNNKEEIFFAKGALET 564
Cdd:cd07543  365 LDDGKLVGDPLEKATLEavdwtLTKDEKVFPRSKKTKGlkiIQRFHFSSALKRMSVVASYKdpGSTDLKYIVAVKGAPET 444
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 565 L---LPQCTKYQFGTQTvpltkqneaeflaeayEIGRKGLRVLALA----------KGRSMQ------DLIYCGLVGITD 625
Cdd:cd07543  445 LksmLSDVPADYDEVYK----------------EYTRQGSRVLALGykelghltkqQARDYKredvesDLTFAGFIVFSC 508
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 626 PPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKvanNVSVFYRVSPRHKL 705
Cdd:cd07543  509 PLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGIVDKPVLILILSEEGKSNEWKLIP---HVKVFARVAPKQKE 585
                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 161085803 706 EIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNG 744
Cdd:cd07543  586 FIITTLKELGYVTLMCGDGTNDVGALKHAHVGVALLKLG 624
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
201-782 7.61e-40

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 156.67  E-value: 7.61e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 201 RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLsIDESSFTGETEPARKITDVL 280
Cdd:cd07550   86 KSEKALLDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEKREGDL 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 281 LnntnvkdhsnmkniaFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIM 360
Cdd:cd07550  165 V---------------FASTVVEEGQLVIRAERVGRETRAARIAELIEQSPSLKARIQNYAERLADRLVPPTLGLAGLVY 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 361 LLGWLQGKPLSeMFNISVSLAVaaipeGLPIVVTVtlaLGVMRMAKRNSI-VKKLPTVETLGCVNVICSDKTGTLTKNEM 439
Cdd:cd07550  230 ALTGDISRAAA-VLLVDFSCGI-----RLSTPVAV---LSALNHAARHGIlVKGGRALELLAKVDTVVFDKTGTLTEGEP 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 440 TATIIITSDGYMADVTGAGYNDQGEIHIRHcnnvemaktnitnlleigavcnnayiqngtllgqPTEGALVAVAMKNGMY 519
Cdd:cd07550  301 EVTAIITFDGRLSEEDLLYLAASAEEHFPH----------------------------------PVARAIVREAEERGIE 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 520 ATAENYVriqEYPFSseqKMMAVKcIHKynnnkeeiffakgalETLLPQCTKYQFGTQTVPLTKQNEaefLAEAYEIGRK 599
Cdd:cd07550  347 HPEHEEV---EYIVG---HGIAST-VDG---------------KRIRVGSRHFMEEEEIILIPEVDE---LIEDLHAEGK 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 600 GLrvLALAKGRSMQdliycGLVGITDPPRPLVRESIEMLMQSGV-RVKMVTGDAQETALAIANLIGIDTIHHQtlsgqem 678
Cdd:cd07550  402 SL--LYVAIDGRLI-----GVIGLSDPLRPEAAEVIARLRALGGkRIIMLTGDHEQRARALAEQLGIDRYHAE------- 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 679 dqmnehqldkvannvsvfyrVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKnGTDVCKEAADMILVN 758
Cdd:cd07550  468 --------------------ALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISMRG-GTDIARETADVVLLE 526
                        570       580
                 ....*....|....*....|....*
gi 161085803 759 DDFHTIIAAIEEGKGIFYNI-RNFV 782
Cdd:cd07550  527 DDLRGLAEAIELARETMALIkRNIA 551
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
128-740 2.24e-38

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 154.29  E-value: 2.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 128 EAKYRAKIIGHNELLLVAEDpTWKKYIEQFRNPLILLLlgsaLVSVIMKQFDDAVSITIAILiVVTVAFIQE--YRSEKS 205
Cdd:cd02082    1 RVDQLLAYYGKNEIEINVPS-FLTLMWREFKKPFNFFQ----YFGVILWGIDEYVYYAITVV-FMTTINSLSciYIRGVM 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 206 LEELKK--LVPPECHCLREGR-LDTFLARELVPGDIVHLNV-GDRVPADVRLFEAvDLSIDESSFTGETEPARK------ 275
Cdd:cd02082   75 QKELKDacLNNTSVIVQRHGYqEITIASNMIVPGDIVLIKRrEVTLPCDCVLLEG-SCIVTEAMLTGESVPIGKcqiptd 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 276 -ITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNG-KGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILgaQLSFYSF 353
Cdd:cd02082  154 sHDDVLFKYESSKSHTLFQGTQVMQIIPPEDDIlKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKF--TLLLATL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 354 LIIGVIMLLGWLQGKPLSEMFNI--SVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKT 431
Cdd:cd02082  232 ALIGFLYTLIRLLDIELPPLFIAfeFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKT 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 432 GTLTKNEMtatiiitsdgymaDVTG-AGYNDQGEIHIRHCnnveMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALV 510
Cdd:cd02082  312 GTLTEDKL-------------DLIGyQLKGQNQTFDPIQC----QDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMA 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 511 AVAMKNGMYAT-AENYVR---------IQEYPFSSEQKMMAVKCIHKYNNNKE--EIFFAKGALETLLPQCTkyqfgtqT 578
Cdd:cd02082  375 EASTWDLDYDHeAKQHYSksgtkrfyiIQVFQFHSALQRMSVVAKEVDMITKDfkHYAFIKGAPEKIQSLFS-------H 447
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 579 VPLTKQNEAEflaeayEIGRKGLRVLALAKGRSMQDLI----------------YCGLVGITDPPRPLVRESIEMLMQSG 642
Cdd:cd02082  448 VPSDEKAQLS------TLINEGYRVLALGYKELPQSEIdafldlsreaqeanvqFLGFIIYKNNLKPDTQAVIKEFKEAC 521
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 643 VRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMdqMNEHQLDKVAN-----NVSVFYRVSPRHKLEIVKSLQRSGNI 717
Cdd:cd02082  522 YRIVMITGDNPLTALKVAQELEIINRKNPTIIIHLL--IPEIQKDNSTQwiliiHTNVFARTAPEQKQTIIRLLKESDYI 599
                        650       660
                 ....*....|....*....|...
gi 161085803 718 VGMTGDGVNDGVALKKADIGIAM 740
Cdd:cd02082  600 VCMCGDGANDCGALKEADVGISL 622
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
201-786 2.76e-37

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 149.09  E-value: 2.76e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 201 RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDlSIDESSFTGETEP-ARKITDV 279
Cdd:cd07546   85 RARSGVKALMALVPETALREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPvEKAAGDK 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 280 LlnntnvkdhsnmkniaFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGaqlSFYSFLIIG-- 357
Cdd:cd07546  164 V----------------FAGSINVDGVLRIRVTSAPGDNAIDRILHLIEEAEERRAPIERFIDRFS---RWYTPAIMAva 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 358 --VIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLT 435
Cdd:cd07546  225 llVIVVPPLLFGADWQTWIYRGLALLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTTVAFDKTGTLT 304
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 436 KNEMTATIIITSDGYmadvtgagynDQGEIhIRHCNNVEMAKTNitnlleigavcnnayiqngtllgqPTEGALVAVAMK 515
Cdd:cd07546  305 RGKPVVTDVVPLTGI----------SEAEL-LALAAAVEMGSSH------------------------PLAQAIVARAQA 349
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 516 NGMyataenyvriqEYPFSSEQKMMAVKCIhKYNNNKEEIFFAKGaletllpqctkyQFGTQTVPLTKQNEAEFLAEAye 595
Cdd:cd07546  350 AGL-----------TIPPAEEARALVGRGI-EGQVDGERVLIGAP------------KFAADRGTLEVQGRIAALEQA-- 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 596 iGRKglRVLALAKGRSMqdliycGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDtIHHQTLsg 675
Cdd:cd07546  404 -GKT--VVVVLANGRVL------GLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGLD-FRAGLL-- 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 676 qemdqmnehqldkvannvsvfyrvsPRHKLEIVKSLQRSGNiVGMTGDGVNDGVALKKADIGIAMGkNGTDVCKEAADMI 755
Cdd:cd07546  472 -------------------------PEDKVKAVRELAQHGP-VAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAA 524
                        570       580       590
                 ....*....|....*....|....*....|.
gi 161085803 756 LVNDDFHTIIAAIEEGKGIFYNIRNFVRFQL 786
Cdd:cd07546  525 LTHNRLGGVAAMIELSRATLANIRQNITIAL 555
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
186-774 1.22e-34

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 141.63  E-value: 1.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 186 IAILIVVTVAF------IQEYRSE---KSLEELKKLVppECHCLRE-GRLDTFLARELVPGDIVHLNVGDRVPADVRLFE 255
Cdd:cd02078   59 VSLWLWFTVLFanfaeaIAEGRGKaqaDSLRKTKTET--QAKRLRNdGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIE 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 256 AVdLSIDESSFTGETEPA-RKITDvllnntnvkDHSNMKNiafmGTLVRCGNGKgIVVStgerSEFGEVF--KMMQAEEA 332
Cdd:cd02078  137 GV-ASVDESAITGESAPViRESGG---------DRSSVTG----GTKVLSDRIK-VRIT----ANPGETFldRMIALVEG 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 333 P---KTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMfnISVSLAVAAIPeglpivvTVTLAL-------GVM 402
Cdd:cd02078  198 AsrqKTPNEIALTILLVGLTLIFLIVVATLPPFAEYSGAPVSVT--VLVALLVCLIP-------TTIGGLlsaigiaGMD 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 403 RMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYmadvtgagyndqgeihirhcnnvemaktnitN 482
Cdd:cd02078  269 RLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLGNRQATEFIPVGGV-------------------------------D 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 483 LLEIGAVCNNAYIQNGTllgqpTEG-ALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCihkynNNKEEIffAKGA 561
Cdd:cd02078  318 EKELADAAQLASLADET-----PEGrSIVILAKQLGGTERDLDLSGAEFIPFSAETRMSGVDL-----PDGTEI--RKGA 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 562 LETLLpqcTKYQFGTQTVPltkqneaEFLAEAY-EIGRKGLRVLALAKGrsmqDLIYcGLVGITDPPRPLVRESIEMLMQ 640
Cdd:cd02078  386 VDAIR---KYVRSLGGSIP-------EELEAIVeEISKQGGTPLVVAED----DRVL-GVIYLKDIIKPGIKERFAELRK 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 641 SGVRVKMVTGDAQETALAIANLIGIDtihhqtlsgqemdqmnehqlDKVANnvsvfyrVSPRHKLEIVKSLQRSGNIVGM 720
Cdd:cd02078  451 MGIKTVMITGDNPLTAAAIAAEAGVD--------------------DFLAE-------AKPEDKLELIRKEQAKGKLVAM 503
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....
gi 161085803 721 TGDGVNDGVALKKADIGIAMgKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGI 774
Cdd:cd02078  504 TGDGTNDAPALAQADVGVAM-NSGTQAAKEAGNMVDLDSDPTKLIEVVEIGKQL 556
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
169-768 1.43e-32

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 134.47  E-value: 1.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 169 ALVSVIMKQFDDAVSITIAIL------------IVVTVAFIQEY-------RSEKSLEELKKLVPPECHCLREGRLDTFL 229
Cdd:cd07545   31 GWRNLIRRNFDMKTLMTIAVIgaaligewpeaaMVVFLFAISEAleaysmdRARRSIRSLMDIAPKTALVRRDGQEREVP 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 230 ARELVPGDIVHLNVGDRVPADVRLFEAVDlSIDESSFTGETEPARKitdvllnntNVKDHsnmkniAFMGTLvrcgNGKG 309
Cdd:cd07545  111 VAEVAVGDRMIVRPGERIAMDGIIVRGES-SVNQAAITGESLPVEK---------GVGDE------VFAGTL----NGEG 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 310 I----VVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGaqlSFYSFLIIGVIMLLG-----WLQGKPLSEMFNiSVSL 380
Cdd:cd07545  171 AlevrVTKPAEDSTIARIIHLVEEAQAERAPTQAFVDRFA---RYYTPVVMAIAALVAivpplFFGGAWFTWIYR-GLAL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 381 AVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymaDVtgAGYN 460
Cdd:cd07545  247 LVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVT----------DV--VVLG 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 461 DQGEihirhcnnvemaktniTNLLEIGAVcnnayiqngtlLGQPTEGALVAVAMKngmyaTAENyvriQEYPFSSEQKMM 540
Cdd:cd07545  315 GQTE----------------KELLAIAAA-----------LEYRSEHPLASAIVK-----KAEQ----RGLTLSAVEEFT 358
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 541 AVKcihkynnnkeeiffAKGALETLlpQCTKYQFGTQTVpLTKQNEAEFLAEAYEIG---RKGLRVLALAKGRSmqdliY 617
Cdd:cd07545  359 ALT--------------GRGVRGVV--NGTTYYIGSPRL-FEELNLSESPALEAKLDalqNQGKTVMILGDGER-----I 416
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 618 CGLVGITDPPRPLVRESIEMLMQSGV-RVKMVTGDAQETALAIANLIGIDTIHHQTLsgqemdqmnehqldkvannvsvf 696
Cdd:cd07545  417 LGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQVGVSDIRAELL----------------------- 473
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161085803 697 yrvsPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAI 768
Cdd:cd07545  474 ----PQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAV 541
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
197-769 1.48e-32

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 134.37  E-value: 1.48e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 197 IQEYRSEKSLEELKKL---VPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLfEAVDLSIDESSFTGETEPA 273
Cdd:cd07544   89 LEDYAQRRASRELTALldrAPRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEV-VSGTATLDESSLTGESKPV 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 274 RKitdvllnntnvkdhsnmkniaFMGTLVRCG--NGKGIVV----STGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQ 347
Cdd:cd07544  168 SK---------------------RPGDRVMSGavNGDSALTmvatKLAADSQYAGIVRLVKEAQANPAPFVRLADRYAVP 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 348 LSFYSFLIIGVimllGWL-QGKPLSemfniSVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVI 426
Cdd:cd07544  227 FTLLALAIAGV----AWAvSGDPVR-----FAAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTV 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 427 CSDKTGTLTKNEMTATIIITSDGYMAD--VTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAyiqngtllGQP 504
Cdd:cd07544  298 AFDKTGTLTYGQPKVVDVVPAPGVDADevLRLAASVEQYSSHVLARAIVAAARERELQLSAVTELTEVP--------GAG 369
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 505 TEGALvavamkngmyataenyvriqeypfssEQKMMAVkcihkynnnkeeiffakgaletllpqcTKYQFgtqtvPLTKQ 584
Cdd:cd07544  370 VTGTV--------------------------DGHEVKV---------------------------GKLKF-----VLARG 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 585 NEAEFLAEAYEigrKGLRVLALAKGRsmqdliYCGLVGITDPPRPLVRESIEMLMQSGV-RVKMVTGDAQETALAIANLI 663
Cdd:cd07544  392 AWAPDIRNRPL---GGTAVYVSVDGK------YAGAITLRDEVRPEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEV 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 664 GIDTIHhqtlsgqeMDQMnehqldkvannvsvfyrvsPRHKLEIVKSLQRSGnIVGMTGDGVNDGVALKKADIGIAMGKN 743
Cdd:cd07544  463 GIDEVR--------AELL-------------------PEDKLAAVKEAPKAG-PTIMVGDGVNDAPALAAADVGIAMGAR 514
                        570       580
                 ....*....|....*....|....*.
gi 161085803 744 GTDVCKEAADMILVNDDFHTIIAAIE 769
Cdd:cd07544  515 GSTAASEAADVVILVDDLDRVVDAVA 540
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
229-772 1.27e-28

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 122.62  E-value: 1.27e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 229 LARELVPGDIVHLNVGDRVPADVRLFEAvDLSIDESSFTGETEParkitdvllnntnVKDHSNMKniAFMGTLVRCGNGK 308
Cdd:cd07553  142 RADQIKSGDVYLVASGQRVPVDGKLLSE-QASIDMSWLTGESLP-------------RIVERGDK--VPAGTSLENQAFE 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 309 GIVVSTGERSEFGEVFKMMQAEEAPKTPLqksmDILGAQLSFYSFLIIGVIMLLG---WLqGKPLSEMFNISVSLAVAAI 385
Cdd:cd07553  206 IRVEHSLAESWSGSILQKVEAQEARKTPR----DLLADKIIHYFTVIALLIAVAGfgvWL-AIDLSIALKVFTSVLIVAC 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 386 PEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgymaDVTGAGYNDQGEI 465
Cdd:cd07553  281 PCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFV----------MVNPEGIDRLALR 350
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 466 HI----RHCNNvEMAKTNITNLLEIGAVcnnayiqngtllgQPTEGALVAVAMKnGMYATAE-NYVRIQEYPFSSEQKMM 540
Cdd:cd07553  351 AIsaieAHSRH-PISRAIREHLMAKGLI-------------KAGASELVEIVGK-GVSGNSSgSLWKLGSAPDACGIQES 415
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 541 AVkcihkynnnkeeiffakgaletllpqctkyqfgtqtvpltkqneaeflaeayEIGRKGLRVLALAkgrsmqdliycgl 620
Cdd:cd07553  416 GV----------------------------------------------------VIARDGRQLLDLS------------- 430
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 621 vgITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDtihhqtlsgqemdqmnehqldkvanNVSVFYRVS 700
Cdd:cd07553  431 --FNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLGLD-------------------------PRQLFGNLS 483
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161085803 701 PRHKLEIVKSLQrSGNIVgMTGDGVNDGVALKKADIGIAMgKNGTDVCKEAADMILVNDDFHTIIAAIEEGK 772
Cdd:cd07553  484 PEEKLAWIESHS-PENTL-MVGDGANDALALASAFVGIAV-AGEVGVSLEAADIYYAGNGIGGIRDLLTLSK 552
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
155-744 9.29e-25

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 111.11  E-value: 9.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 155 EQFRNPLILLLLGSALVSVImkQFDDAVS--ITIA-ILIVVTVAFIQE-------YRSEKSLEELKklvppeCHCLREGR 224
Cdd:cd02073   21 EQFRRVANLYFLFIAILQQI--PGISPTGpyTTLLpLLFVLGVTAIKEgyedirrHKSDNEVNNRP------VQVLRGGK 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 225 LDTFLARELVPGDIVHLNVGDRVPADVRLfeavdLS---------IDESSFTGETEpaRKITDVLLNNTNVKDHSNMKNI 295
Cdd:cd02073   93 FVKKKWKDIRVGDIVRVKNDEFVPADLLL-----LSssepdglcyVETANLDGETN--LKIRQALPETALLLSEEDLARF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 296 --------------AFMGTLVRCGNGK----------------------GIVVSTGERSefgevfKMMQaeEAPKTPLQK 339
Cdd:cd02073  166 sgeieceqpnndlyTFNGTLELNGGRElplspdnlllrgctlrntewvyGVVVYTGHET------KLML--NSGGTPLKR 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 340 S-------MDILGAQLSFYSFLIIGVIM--------------LLGWLQGKPLSEMFNISVSLAV---AAIPEGLPIVVTV 395
Cdd:cd02073  238 SsiekkmnRFIIAIFCILIVMCLISAIGkgiwlskhgrdlwyLLPKEERSPALEFFFDFLTFIIlynNLIPISLYVTIEV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 396 TLALGVMRM--------AKRNS--IVKKLPTVETLGCVNVICSDKTGTLTKNEMTATiiitsdgyMADVTGAGYNdqgei 465
Cdd:cd02073  318 VKFLQSFFInwdldmydEETDTpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFK--------KCSINGVDYG----- 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 466 hirhcnnvemaktnitnLLEIGAVCNNAYIQNGTLLGQ-------PTEGALVAVAMKNGM--YATAENYVRI------QE 530
Cdd:cd02073  385 -----------------FFLALALCHTVVPEKDDHPGQlvyqassPDEAALVEAARDLGFvfLSRTPDTVTInalgeeEE 447
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 531 Y------PFSSEQKMMAVkcIHKyNNNKEEIFFAKGALETLLPQCTKYQfgTQTVPLTKQNEAEFlaeayeiGRKGLRVL 604
Cdd:cd02073  448 YeilhilEFNSDRKRMSV--IVR-DPDGRILLYCKGADSVIFERLSPSS--LELVEKTQEHLEDF-------ASEGLRTL 515
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 605 ALAK-----------------------GRSM----------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGD 651
Cdd:cd02073  516 CLAYreiseeeyeewnekydeastalqNREElldevaeeieKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGD 595
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 652 AQETALAIA---NLIGIDTIHH------QTLSgQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNivGM 720
Cdd:cd02073  596 KQETAINIGyscRLLSEDMENLalvidgKTLT-YALDPELERLFLELALKCKavICCRVSPLQKALVVKLVKKSKK--AV 672
                        730       740
                 ....*....|....*....|....*...
gi 161085803 721 T---GDGVNDGVALKKADIGIA-MGKNG 744
Cdd:cd02073  673 TlaiGDGANDVSMIQEAHVGVGiSGQEG 700
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
201-779 5.28e-24

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 108.54  E-value: 5.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 201 RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAvDLSIDESSFTGETEPARKITD-- 278
Cdd:PRK11033 229 RARRGVSALMALVPETATRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVERATGek 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 279 VLLNNTNVKDHSNMKniafmgtlvrcgngkgiVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDilgaqlsFYSFLIIGV 358
Cdd:PRK11033 308 VPAGATSVDRLVTLE-----------------VLSEPGASAIDRILHLIEEAEERRAPIERFID-------RFSRIYTPA 363
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 359 IMLlgwlqgkplsemfnisVSLAVAAIP-------------EGL---------------PIVVTVTLALGvmrmAKRNSI 410
Cdd:PRK11033 364 IML----------------VALLVILVPpllfaapwqewiyRGLtllligcpcalvistPAAITSGLAAA----ARRGAL 423
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 411 VKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMAD--VTGAGYNDQGEIHirhcnnvemaktnitnlleiga 488
Cdd:PRK11033 424 IKGGAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATGISESelLALAAAVEQGSTH---------------------- 481
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 489 vcnnayiqngtllgqPTEGALVAVAMKNGMyataenyvriqEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLpq 568
Cdd:PRK11033 482 ---------------PLAQAIVREAQVRGL-----------AIPEAESQRALAGSGIEGQVNGERVLICAPGKLPPLA-- 533
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 569 ctkyqfgtqtvpltkqneAEFLAEAYEIGRKGLRVLALakgrsMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMV 648
Cdd:PRK11033 534 ------------------DAFAGQINELESAGKTVVLV-----LRNDDVLGLIALQDTLRADARQAISELKALGIKGVML 590
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 649 TGDAQETALAIANLIGIDtihhqtlsgqemdqmnehqldkvannvsvfYRVS--PRHKLEIVKSLQRSGNiVGMTGDGVN 726
Cdd:PRK11033 591 TGDNPRAAAAIAGELGID------------------------------FRAGllPEDKVKAVTELNQHAP-LAMVGDGIN 639
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 161085803 727 DGVALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR 779
Cdd:PRK11033 640 DAPAMKAASIGIAMG-SGTDVALETADAALTHNRLRGLAQMIELSRATHANIR 691
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
196-772 3.59e-22

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 102.31  E-value: 3.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 196 FIQEY---RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDlSIDESSFTGETEP 272
Cdd:cd07548   87 LFQDLaveRSRKSIKALLDIRPDYANLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGES-FLDTSALTGESVP 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 273 arkitdvllnnTNVKDHSNMkniaFMGTLvrcgNGKGI----VVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDilgaql 348
Cdd:cd07548  166 -----------VEVKEGSSV----LAGFI----NLNGVleikVTKPFKDSAVAKILELVENASARKAPTEKFIT------ 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 349 SF---YSFLIIGVIMLLGWLqgKPL-SEMFNISVSLAVAAI------PEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVE 418
Cdd:cd07548  221 KFaryYTPIVVFLALLLAVI--PPLfSPDGSFSDWIYRALVflviscPCALVISIPLGYFGGIGAASRKGILIKGSNYLE 298
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 419 TLGCVNVICSDKTGTLTKNEMTATIIITSDGYMAD--VTGAGYNDQGEIH-----IRHCNNVEMAKTNITNLLEIGAVCN 491
Cdd:cd07548  299 ALSQVKTVVFDKTGTLTKGVFKVTEIVPAPGFSKEelLKLAALAESNSNHpiarsIQKAYGKMIDPSEIEDYEEIAGHGI 378
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 492 NAYIQNGTLLgqptegalvavamkngmyatAENyvriqeypfsseQKMMavkcihkynnNKEEIFFAKGALEtllpqctk 571
Cdd:cd07548  379 RAVVDGKEIL--------------------VGN------------EKLM----------EKFNIEHDEDEIE-------- 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 572 yqfGTqtvpltkqneaeflaeayeigrkglrVLALAKgrsmqDLIYCGLVGITDPPRPLVRESIEMLMQSGV-RVKMVTG 650
Cdd:cd07548  409 ---GT--------------------------IVHVAL-----DGKYVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTG 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 651 DAQETALAIANLIGIDtihhqtlsgqemdqmnehqldkvannvSVFYRVSPRHKLEIVKSLQ-RSGNIVGMTGDGVNDGV 729
Cdd:cd07548  455 DRKSVAEKVAKKLGID---------------------------EVYAELLPEDKVEKVEELKaESKGKVAFVGDGINDAP 507
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 161085803 730 ALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGK 772
Cdd:cd07548  508 VLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAEAIKIAR 550
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
178-769 4.66e-21

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 98.58  E-value: 4.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 178 FDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLR-EGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEA 256
Cdd:cd02092   89 FDAAVMLLFFLLIGRYLDHRMRGRARSAAEELAALEARGAQRLQaDGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSG 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 257 VDLsIDESSFTGETEPARKITDVLLnntnvkdHSNMKNIAfmGTL-VRcgngkgiVVSTGERSEFGEVFKMMQAEEAPKT 335
Cdd:cd02092  169 TSE-LDRSLLTGESAPVTVAPGDLV-------QAGAMNLS--GPLrLR-------ATAAGDDTLLAEIARLMEAAEQGRS 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 336 plqKSMDILGAQLSFYSFLI--IGVIMLLGW-LQGKPLSEMFNISVSLAVAAIPEGL----PIVVTVtlALGvmRMAKRN 408
Cdd:cd02092  232 ---RYVRLADRAARLYAPVVhlLALLTFVGWvAAGGDWRHALLIAVAVLIITCPCALglavPAVQVV--ASG--RLFRRG 304
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 409 SIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNdqgeiHIRHcnnvemaktnitnlleiga 488
Cdd:cd02092  305 VLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHAISADLLALAAALAQ-----ASRH------------------- 360
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 489 vcnnayiqngtllgqPTEGALVAVAMkngmyATAENYVRIQEYPfssEQKMMAVkcihkynnnkeeiffAKGAletllpq 568
Cdd:cd02092  361 ---------------PLSRALAAAAG-----ARPVELDDAREVP---GRGVEGR---------------IDGA------- 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 569 ctKYQFGTqtvpltkqneAEFLAEAYEIGRKGlrVLALAKGRSMQDLIycglvGITDPPRPLVRESIEMLMQSGVRVKMV 648
Cdd:cd02092  396 --RVRLGR----------PAWLGASAGVSTAS--ELALSKGGEEAARF-----PFEDRPRPDAREAISALRALGLSVEIL 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 649 TGDAQETALAIANLIGIDTIHhqtlsgqemdqmnehqldkvANnvsvfyrVSPRHKLEIVKSLQRSGNIVGMTGDGVNDG 728
Cdd:cd02092  457 SGDREPAVRALARALGIEDWR--------------------AG-------LTPAEKVARIEELKAQGRRVLMVGDGLNDA 509
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 161085803 729 VALKKADIGIAMGkNGTDVCKEAADMILVNDDFHTIIAAIE 769
Cdd:cd02092  510 PALAAAHVSMAPA-SAVDASRSAADIVFLGDSLAPVPEAIE 549
copA PRK10671
copper-exporting P-type ATPase CopA;
201-779 5.33e-21

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 99.05  E-value: 5.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 201 RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAvDLSIDESSFTGETEPARKIT-DV 279
Cdd:PRK10671 309 RSSKALEKLLDLTPPTARVVTDEGEKSVPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGEgDS 387
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 280 LLNNTNVKDHSnmkniafmgTLVRCGngkgivvSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAqlSFYSFLI-IGV 358
Cdd:PRK10671 388 VHAGTVVQDGS---------VLFRAS-------AVGSHTTLSRIIRMVRQAQSSKPEIGQLADKISA--VFVPVVVvIAL 449
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 359 IMLLGWLQGKPLSEM---FNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLT 435
Cdd:PRK10671 450 VSAAIWYFFGPAPQIvytLVIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLT 529
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 436 KNEMTATIIITSDGYM-ADVTG-AGYNDQGEIH------IRHCNNVEMAKTNitnlleigavcnnayiQNGTLLGQPTEG 507
Cdd:PRK10671 530 EGKPQVVAVKTFNGVDeAQALRlAAALEQGSSHplaraiLDKAGDMTLPQVN----------------GFRTLRGLGVSG 593
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 508 ALVAVAMKNGmyataenyvriqeypfssEQKMMAvkcihkynnnkeeiffakgaletllpqctKYQFGTQTVPLTKQNEA 587
Cdd:PRK10671 594 EAEGHALLLG------------------NQALLN-----------------------------EQQVDTKALEAEITAQA 626
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 588 EflaeayeigrKGLR-VLALAKGRSMqdliycGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGID 666
Cdd:PRK10671 627 S----------QGATpVLLAVDGKAA------ALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGID 690
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 667 tihhQTLSGqemdqmnehqldkvannvsvfyrVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGkNGTD 746
Cdd:PRK10671 691 ----EVIAG-----------------------VLPDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSD 742
                        570       580       590
                 ....*....|....*....|....*....|...
gi 161085803 747 VCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR 779
Cdd:PRK10671 743 VAIETAAITLMRHSLMGVADALAISRATLRNMK 775
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
155-744 1.25e-20

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 98.22  E-value: 1.25e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   155 EQFRNPLILLLLGSALVsvimkQFDDAVSIT------IAILIVVTVAFIQE----YRSEKS-LEELKKLVppecHCLREG 223
Cdd:TIGR01652   23 EQFKRFANLYFLVVALL-----QQVPILSPTyrgtsiVPLAFVLIVTAIKEaiedIRRRRRdKEVNNRLT----EVLEGH 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   224 rlDTFLA---RELVPGDIVHLNVGDRVPADVRLFEAVDLS----IDESSFTGETE----PARKITDVLLNNTNVKDHS-- 290
Cdd:TIGR01652   94 --GQFVEipwKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDGETNlklrQALEETQKMLDEDDIKNFSge 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   291 ---------------NMK------------NIAFMGTLVRcgNGK---GIVVSTGersefGEVFKMMQAEEAP--KTPLQ 338
Cdd:TIGR01652  172 ieceqpnaslysfqgNMTingdrqyplspdNILLRGCTLR--NTDwviGVVVYTG-----HDTKLMRNATQAPskRSRLE 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   339 KSMDilgaQLSFYSFLIIGVIMLLG---------------W---LQGKPLSEMFNISVSLAVAAIPEG--LPIVVTVTLA 398
Cdd:TIGR01652  245 KELN----FLIIILFCLLFVLCLISsvgagiwndahgkdlWyirLDVSERNAAANGFFSFLTFLILFSslIPISLYVSLE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   399 L----------GVMRM--AKRNS--IVKKLPTVETLGCVNVICSDKTGTLTKNEMT---ATI------------------ 443
Cdd:TIGR01652  321 LvksvqayfinSDLQMyhEKTDTpaSVRTSNLNEELGQVEYIFSDKTGTLTQNIMEfkkCSIagvsygdgfteikdgire 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   444 ---IITSDGYMADVTGAGYNDQGEIHIRHCN-NVEMAKTnITNLLEIGAVCNNA---YIQNGTLL-----GQPTEGALVA 511
Cdd:TIGR01652  401 rlgSYVENENSMLVESKGFTFVDPRLVDLLKtNKPNAKR-INEFFLALALCHTVvpeFNDDGPEEityqaASPDEAALVK 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   512 VAMKNG--MYATAENYVRI--------QEY------PFSSEQKMMAVKCihkyNNNKEEI-FFAKGA------------- 561
Cdd:TIGR01652  480 AARDVGfvFFERTPKSISLliemhgetKEYeilnvlEFNSDRKRMSVIV----RNPDGRIkLLCKGAdtvifkrlssggn 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   562 --LETLLPQCTKYQ---FGTQTVPLTKQNEAEFLA--EAYEIGRKGLR----VLALAKGRSMQDLIYCGLVGITDPPRPL 630
Cdd:TIGR01652  556 qvNEETKEHLENYAsegLRTLCIAYRELSEEEYEEwnEEYNEASTALTdreeKLDVVAESIEKDLILLGATAIEDKLQEG 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   631 VRESIEMLMQSGVRVKMVTGDAQETALAIA---NLIGID--------------TIHHQTLSGQEMDQMNEHQLDKVANNV 693
Cdd:TIGR01652  636 VPETIELLRQAGIKIWVLTGDKVETAINIGyscRLLSRNmeqivitsdsldatRSVEAAIKFGLEGTSEEFNNLGDSGNV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803   694 S------------------VFY------------RVSPRHKLEIVKSLQRS-GNIVGMTGDGVNDGVALKKADIGIAM-G 741
Cdd:TIGR01652  716 AlvidgkslgyaldeelekEFLqlalkckaviccRVSPSQKADVVRLVKKStGKTTLAIGDGANDVSMIQEADVGVGIsG 795

                   ...
gi 161085803   742 KNG 744
Cdd:TIGR01652  796 KEG 798
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
222-814 1.71e-19

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 94.00  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 222 EGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVdLSIDESSFTGETEPARKITDVLLNNTnvkdhsnmkniaFMGTL 301
Cdd:PRK14010 112 DGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGL-ATVDESAITGESAPVIKESGGDFDNV------------IGGTS 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 302 VRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMdilgaqlsFYSFLIIGVIMLLGWLQGKPLSEM--FNISVS 379
Cdd:PRK14010 179 VASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNEIAL--------FTLLMTLTIIFLVVILTMYPLAKFlnFNLSIA 250
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 380 ----LAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITsdgymadvt 455
Cdd:PRK14010 251 mliaLAVCLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYGNRMADAFIP--------- 321
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 456 gagyndqgeihirhcnnveMAKTNITNLLEIGAVCNnayIQNGTllgqPTEGALVAVAMKNGMYATAEnyvRIQEYPFSS 535
Cdd:PRK14010 322 -------------------VKSSSFERLVKAAYESS---IADDT----PEGRSIVKLAYKQHIDLPQE---VGEYIPFTA 372
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 536 EQKMMAVkcihKYNNnkEEIFfaKGALETLLPQCTKyqfGTQTVPltkqneAEFLAEAYEIGRKGLRVLALakgrsMQDL 615
Cdd:PRK14010 373 ETRMSGV----KFTT--REVY--KGAPNSMVKRVKE---AGGHIP------VDLDALVKGVSKKGGTPLVV-----LEDN 430
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 616 IYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIhhqtlsgqemdqmnehqldkvannvsv 695
Cdd:PRK14010 431 EILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVDRF--------------------------- 483
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 696 FYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMgKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIF 775
Cdd:PRK14010 484 VAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAM-NSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLL 562
                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 161085803 776 YNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQIL 814
Cdd:PRK14010 563 MTRGSLTTFSIANDIAKYFAILPAMFMAAMPAMNHLNIM 601
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
177-744 1.46e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 84.96  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 177 QFDDAVSIT------IAILIVVTVAFIQE----YRSEKSLEELKKlvpPECHCLREGRLDTFLARELVPGDIVHLNVGDR 246
Cdd:cd07536   38 QFVPALKPGylyttwAPLIFILAVTMTKEaiddFRRFQRDKEVNK---KQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 247 VPADVRLFEAVDLS----IDESSFTGETE------------------------------PARKITD----VLLNNTNVKD 288
Cdd:cd07536  115 IPSDMVLLRTSEPQgscyVETAQLDGETDlklrvavsctqqlpalgdlmkisayvecqkPQMDIHSfegnFTLEDSDPPI 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 289 HSNM--KNIAFMGT-LVRCGNGKGIVVSTGERSefgevfKMMQAEEAPK---TPLQKSMDILGAQLsFYSFLIIGVIMLL 362
Cdd:cd07536  195 HESLsiENTLLRAStLRNTGWVIGVVVYTGKET------KLVMNTSNAKnkvGLLDLELNRLTKAL-FLALVVLSLVMVT 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 363 GWLQGKPLSEMFNISVSLAVAAIPEGL--------------PIVVTVTLALG-------VMRMAKRNSIVKKLPTV---- 417
Cdd:cd07536  268 LQGFWGPWYGEKNWYIKKMDTTSDNFGrnllrflllfsyiiPISLRVNLDMVkavyawfIMWDENMYYIGNDTGTVarts 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 418 ---ETLGCVNVICSDKTGTLTKNEMTatiiitsdgymadvtgagyndqgeihIRHCNnvemaktnitnlleIGAVCNNAY 494
Cdd:cd07536  348 tipEELGQVVYLLTDKTGTLTQNEMI--------------------------FKRCH--------------IGGVSYGGQ 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 495 IQNgtllgqptegalvavamkngmyataenYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFFAKGALETLLPQCTKYQF 574
Cdd:cd07536  388 VLS---------------------------FCILQLLEFTSDRKRMSV--IVRDESTGEITLYMKGADVAISPIVSKDSY 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 575 GTQTV-------------------PLTKQNEAEFLAEAYE----IGRKGLRVLALAKgRSMQDLIYCGLVGITDPPRPLV 631
Cdd:cd07536  439 MEQYNdwleeecgeglrtlcvakkALTENEYQEWESRYTEaslsLHDRSLRVAEVVE-SLERELELLGLTAIEDRLQAGV 517
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 632 RESIEMLMQSGVRVKMVTGDAQETALAIA------------NLIGIDTIHHQTLS------------GQEMD-------- 679
Cdd:cd07536  518 PETIETLRKAGIKIWMLTGDKQETAICIAkschlvsrtqdiHLLRQDTSRGERAAitqhahlelnafRRKHDvalvidgd 597
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161085803 680 ------QMNEHQLDKVA--NNVSVFYRVSPRHKLEIVKSLQ-RSGNIVGMTGDGVNDGVALKKADIGIAM-GKNG 744
Cdd:cd07536  598 slevalKYYRHEFVELAcqCPAVICCRVSPTQKARIVTLLKqHTGRRTLAIGDGGNDVSMIQAADCGVGIsGKEG 672
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
230-744 7.90e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 82.46  E-value: 7.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 230 ARELVPGDIVHLNVGDRVPADVRLFEAVDLS----IDESSFTGET-----------------------------EPARKI 276
Cdd:cd07541   96 SSDIKVGDLIIVEKNQRIPADMVLLRTSEKSgscfIRTDQLDGETdwklriavpctqklpeegilnsisavyaeAPQKDI 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 277 TD----VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGErsefgEVFKMMQAEEaPKTP---LQKSMDILgAQLS 349
Cdd:cd07541  176 HSfygtFTINDDPTSESLSVENTLWANTVVASGTVIGVVVYTGK-----ETRSVMNTSQ-PKNKvglLDLEINFL-TKIL 248
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 350 FYSFLIIGVIMLLgwLQGkPLSEMFnISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLP-TV-------ETLG 421
Cdd:cd07541  249 FCAVLALSIVMVA--LQG-FQGPWY-IYLFRFLILFSSIIPISLRVNLDMAKIVYSWQIEHDKNIPgTVvrtstipEELG 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 422 CVNVICSDKTGTLTKNEMTATIIitsdgYMADVTGAGYNDQGEIhirhcnnvemaktnitnlleigavcnnayiqngtll 501
Cdd:cd07541  325 RIEYLLSDKTGTLTQNEMVFKKL-----HLGTVSYGGQNLNYEI------------------------------------ 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 502 gqptegalvavamkngmyataenyvrIQEYPFSSEQKMMAVkcIHKYNNNKEEIFFAKGAlETLLPQCTKYQF------- 574
Cdd:cd07541  364 --------------------------LQIFPFTSESKRMGI--IVREEKTGEITFYMKGA-DVVMSKIVQYNDwleeecg 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 575 -----GTQTVPLTKQ--NEAEFLA--EAYEIGRKGL--RVLALAKGRSM--QDLIYCGLVGITDPPRPLVRESIEMLMQS 641
Cdd:cd07541  415 nmareGLRTLVVAKKklSEEEYQAfeKRYNAAKLSIhdRDLKVAEVVESleRELELLCLTGVEDKLQEDVKPTLELLRNA 494
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 642 GVRVKMVTGDAQETALAIA---NLIGIDTIHHQ----TLSGQEMDQMN------------------------EHQLDKVA 690
Cdd:cd07541  495 GIKIWMLTGDKLETATCIAkssKLVSRGQYIHVfrkvTTREEAHLELNnlrrkhdcalvidgeslevclkyyEHEFIELA 574
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161085803 691 NNVS--VFYRVSPRHKLEIVKSLQ-RSGNIVGMTGDGVNDGVALKKADIGIAM-GKNG 744
Cdd:cd07541  575 CQLPavVCCRCSPTQKAQIVRLIQkHTGKRTCAIGDGGNDVSMIQAADVGVGIeGKEG 632
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
488-572 1.44e-15

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 73.02  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  488 AVCNNAYIQNG------TLLGQPTEGALVAVAMKNGMYATA--ENYVRIQEYPFSSEQKMMAVkcIHKYNNNKEEIFFAK 559
Cdd:pfam13246   1 ALCNSAAFDENeekgkwEIVGDPTESALLVFAEKMGIDVEElrKDYPRVAEIPFNSDRKRMST--VHKLPDDGKYRLFVK 78
                          90
                  ....*....|...
gi 161085803  560 GALETLLPQCTKY 572
Cdd:pfam13246  79 GAPEIILDRCTTI 91
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
105-171 2.36e-09

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 54.49  E-value: 2.36e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161085803  105 STHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALV 171
Cdd:pfam00690   2 HALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
586-735 2.40e-09

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 57.98  E-value: 2.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  586 EAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGI 665
Cdd:pfam00702  58 KRDWLEELDILRGLVETLEAEGLTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGL 137
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  666 DtihhqtlsgqemdqmnEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKAD 735
Cdd:pfam00702 138 D----------------DYFDVVISGDDVGVGKPKPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
108-175 2.28e-07

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 49.12  E-value: 2.28e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161085803   108 SASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIM 175
Cdd:smart00831   8 SLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
629-770 6.13e-06

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 47.82  E-value: 6.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 629 PLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDT-----------------IHHQTLSGQEMDQMNEHqLDKVAN 691
Cdd:COG0561   22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDplitsngaliydpdgevLYERPLDPEDVREILEL-LREHGL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803 692 NVSVFYRvSPRHKLEIVKS-----------LQRSG----NIVGMtGDGVNDgVA-LKKADIGIAMGkNGTDVCKEAADMI 755
Cdd:COG0561  101 HLQVVVR-SGPGFLEILPKgvskgsalkklAERLGippeEVIAF-GDSGND-LEmLEAAGLGVAMG-NAPPEVKAAADYV 176
                        170
                 ....*....|....*
gi 161085803 756 LVNDDFHTIIAAIEE 770
Cdd:COG0561  177 TGSNDEDGVAEALEK 191
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
628-760 4.77e-05

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 46.11  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  628 RPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQemdqmNEHQLDKVANNVSvfyrvsprhKLEI 707
Cdd:TIGR00099 127 PKLEVVDIQYLPDDILKILLLFLDPEDLDLLIEALNKLELEENVSVVSS-----GPYSIEITAKGVS---------KGSA 192
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 161085803  708 VKSLQRSGNI----VGMTGDGVNDGVALKKADIGIAMGkNGTDVCKEAADMI--LVNDD 760
Cdd:TIGR00099 193 LQSLAEALGIsledVIAFGDGMNDIEMLEAAGYGVAMG-NADEELKALADYVtdSNNED 250
PLN03190 PLN03190
aminophospholipid translocase; Provisional
418-744 9.14e-05

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 46.43  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  418 ETLGCVNVICSDKTGTLTKNEMT---ATI--IITSDG----------YMADVTGAGYNDQGEIHI--------RHCNNVE 474
Cdd:PLN03190  448 EDLGQIKYVFSDKTGTLTENKMEfqcASIwgVDYSDGrtptqndhagYSVEVDGKILRPKMKVKVdpqllelsKSGKDTE 527
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  475 MAKtNITNLLEIGAVCN--------NAYIQNGTLLG----QPTEGALVAVAMKNGMYATAENYVRIQeYPFSSEQKMMAV 542
Cdd:PLN03190  528 EAK-HVHDFFLALAACNtivpivvdDTSDPTVKLMDyqgeSPDEQALVYAAAAYGFMLIERTSGHIV-IDIHGERQRFNV 605
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  543 KCIHKYNNNKEEI------------FFAKGA-----------LETLLPQCTKYQFGTQT--------VPLTKQNEAEF-- 589
Cdd:PLN03190  606 LGLHEFDSDRKRMsvilgcpdktvkVFVKGAdtsmfsvidrsLNMNVIRATEAHLHTYSslglrtlvVGMRELNDSEFeq 685
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  590 ------LAEAYEIGRKGLrvLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIA--- 660
Cdd:PLN03190  686 whfsfeAASTALIGRAAL--LRKVASNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGyss 763
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  661 --------------------------------NLIGIDTIHHQTLSGQE------------------MDQMNEHQLDKVA 690
Cdd:PLN03190  764 klltnkmtqiiinsnskescrksledalvmskKLTTVSGISQNTGGSSAaasdpvaliidgtslvyvLDSELEEQLFQLA 843
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 161085803  691 NNVSVFY--RVSPRHKLEIVKSLQ-RSGNIVGMTGDGVNDGVALKKADIGIAM-GKNG 744
Cdd:PLN03190  844 SKCSVVLccRVAPLQKAGIVALVKnRTSDMTLAIGDGANDVSMIQMADVGVGIsGQEG 901
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
676-760 1.60e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.45  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161085803  676 QEMDQMNEHQLDKVANNVSVFyrVSPRHKLEIV-------KSLQRSGNIVGMT-------GDGVNDGVALKKADIGIAMG 741
Cdd:pfam08282 152 EDLDELEKELKELFGSLITIT--SSGPGYLEIMpkgvskgTALKALAKHLNISleeviafGDGENDIEMLEAAGLGVAMG 229
                          90       100
                  ....*....|....*....|.
gi 161085803  742 kNGTDVCKEAADMIL--VNDD 760
Cdd:pfam08282 230 -NASPEVKAAADYVTdsNNED 249
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
722-760 1.66e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 41.05  E-value: 1.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 161085803 722 GDGVNDGVALKKADIGIAMGkNGTDVCKEAADMIL--VNDD 760
Cdd:cd07517  164 GDGLNDIEMLEAVGIGIAMG-NAHEELKEIADYVTkdVDED 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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