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Conserved domains on  [gi|161082607|ref|NP_001097560|]
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metal response element-binding transcription Factor-1, isoform C [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-498 2.01e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  319 YESSDEALSRYRCNYENCYRSYSTIGNLRTHLKT--HTGDYS--FKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVS 394
Cdd:COG5048   278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLL 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  395 GCDKAFN------TRYRLHAHLRLHNGETFNCELCQKCFTTLSD--LKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTH 466
Cdd:COG5048   358 NSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437

                         170       180       190
                  ....*....|....*....|....*....|..
gi 161082607  467 RRTHTGEKPYPCqedSCQKSFSTSHSLKSHKK 498
Cdd:COG5048   438 KKIHTNHAPLLC---SILKSFRRDLDLSNHGK 466
PRK14954 super family cl33039
DNA polymerase III subunits gamma and tau; Provisional
 863-941 9.94e-03

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14954:

Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.93  E-value: 9.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  863 VKPAPSGGGCC---GEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKG 939
Cdd:PRK14954  380 VAPSPAGSPDVkkkAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASGKP 459


                  ..
gi 161082607  940 EV 941
Cdd:PRK14954  460 GV 461
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-498 2.01e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  319 YESSDEALSRYRCNYENCYRSYSTIGNLRTHLKT--HTGDYS--FKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVS 394
Cdd:COG5048   278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLL 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  395 GCDKAFN------TRYRLHAHLRLHNGETFNCELCQKCFTTLSD--LKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTH 466
Cdd:COG5048   358 NSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437

                         170       180       190
                  ....*....|....*....|....*....|..
gi 161082607  467 RRTHTGEKPYPCqedSCQKSFSTSHSLKSHKK 498
Cdd:COG5048   438 KKIHTNHAPLLC---SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-458 2.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.59e-06
                           10        20
                   ....*....|....*....|....*..
gi 161082607   432 DLKKHMRTHTQERPYKCPEddCGKAFT 458
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
ZnF_C2H2 smart00355
zinc finger;
418-440 3.39e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 3.39e-03
                            10        20
                    ....*....|....*....|...
gi 161082607    418 FNCELCQKCFTTLSDLKKHMRTH 440
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 863-941 9.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.93  E-value: 9.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  863 VKPAPSGGGCC---GEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKG 939
Cdd:PRK14954  380 VAPSPAGSPDVkkkAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASGKP 459


                  ..
gi 161082607  940 EV 941
Cdd:PRK14954  460 GV 461
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-498 2.01e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  319 YESSDEALSRYRCNYENCYRSYSTIGNLRTHLKT--HTGDYS--FKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVS 394
Cdd:COG5048   278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLL 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  395 GCDKAFN------TRYRLHAHLRLHNGETFNCELCQKCFTTLSD--LKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTH 466
Cdd:COG5048   358 NSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437

                         170       180       190
                  ....*....|....*....|....*....|..
gi 161082607  467 RRTHTGEKPYPCqedSCQKSFSTSHSLKSHKK 498
Cdd:COG5048   438 KKIHTNHAPLLC---SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-458 2.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.59e-06
                           10        20
                   ....*....|....*....|....*..
gi 161082607   432 DLKKHMRTHTQERPYKCPEddCGKAFT 458
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
416-500 8.16e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 8.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  416 ETFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKS 495
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111


                  ....*
gi 161082607  496 HKKTH 500
Cdd:COG5048   112 SSSSN 116
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
418-511 2.22e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  418 FNCELCQKCFTTLSDLKKHMRT--HTQE--RPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCqksfSTSHSL 493
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNS----SSKFSP 365

                          90
                  ....*....|....*...
gi 161082607  494 KSHKKTHQRQLQNKGRKK 511
Cdd:COG5048   366 LLNNEPPQSLQQYKDLKN 383
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 4.18e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.13  E-value: 4.18e-05
                           10        20
                   ....*....|....*....|...
gi 161082607   418 FNCELCQKCFTTLSDLKKHMRTH 440
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-519 4.35e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 4.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161082607  442 QERPYKCPEddCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKTQQT 519
Cdd:COG5048    30 APRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
318-448 4.58e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  318 AYESSDEALSRYRCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVH-----TKVKPYECE 392
Cdd:COG5048   311 SVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETL 390

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 161082607  393 VSGCDKAFNTRYRLHAHLRLH---NGETFNCELCQKCFTTLSDLKKHMRTHTQERPYKC 448
Cdd:COG5048   391 SNSCIRNFKRDSNLSLHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-489 5.57e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 5.57e-05
                           10        20
                   ....*....|....*....|....*...
gi 161082607   462 HLKTHRRTHTGEKPYPCQEdsCQKSFST 489
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 387-471 1.13e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  387 KPYECEVSGCDKAFNTRYRLHAHlRLHNGetfncelCQKCFTTLSDLKKHMRTHTQERPYKCPEddCGKAFTASHHLKTH 466
Cdd:COG5189   348 KPYKCPVEGCNKKYKNQNGLKYH-MLHGH-------QNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGLKYH 417


                  ....*
gi 161082607  467 RRTHT 471
Cdd:COG5189   418 RKHSH 422
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
358-448 2.66e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.63  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  358 SFKCPEDGCHKAFLTSYSLKIHVRV-HTKVKPYECevSGCDKAFNTRYRLHAH--LRLHN-----GETFN----CELCQK 425
Cdd:COG5236   151 SFKCPKSKCHRRCGSLKELKKHYKAqHGFVLCSEC--IGNKKDFWNEIRLFRSstLRDHKnggleEEGFKghplCIFCKI 228

                          90       100
                  ....*....|....*....|...
gi 161082607  426 CFTTLSDLKKHMRTHtQERPYKC 448
Cdd:COG5236   229 YFYDDDELRRHCRLR-HEACHIC 250
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-402 6.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.86e-04
                           10        20
                   ....*....|....*....|....*...
gi 161082607   375 SLKIHVRVHTKVKPYECEVsgCDKAFNT 402
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-372 8.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 8.52e-04
                           10        20
                   ....*....|....*....|....*...
gi 161082607   345 NLRTHLKTHTGDYSFKCPEdgCHKAFLT 372
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 446-470 1.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.69e-03
                           10        20
                   ....*....|....*....|....*
gi 161082607   446 YKCPedDCGKAFTASHHLKTHRRTH 470
Cdd:pfam00096    1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
332-503 3.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 3.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  332 NYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLR 411
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  412 LHNGETFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPE--DDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFST 489
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVST 194

                         170
                  ....*....|....
gi 161082607  490 SHSLKSHKKTHQRQ 503
Cdd:COG5048   195 SIPSSSENSPLSSS 208
ZnF_C2H2 smart00355
zinc finger;
418-440 3.39e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 3.39e-03
                            10        20
                    ....*....|....*....|...
gi 161082607    418 FNCELCQKCFTTLSDLKKHMRTH 440
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 418-440 5.36e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 5.36e-03
                           10        20
                   ....*....|....*....|...
gi 161082607   418 FNCELCQKCFTTLSDLKKHMRTH 440
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 443-498 6.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 6.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161082607  443 ERPYKCPEDDCGKAFTASHHLKTHR-------RTH------------TGEKPYPCQedSCQKSFSTSHSLKSHKK 498
Cdd:COG5189   347 GKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCE--VCDKRYKNLNGLKYHRK 419
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 863-941 9.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.93  E-value: 9.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161082607  863 VKPAPSGGGCC---GEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKG 939
Cdd:PRK14954  380 VAPSPAGSPDVkkkAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASGKP 459


                  ..
gi 161082607  940 EV 941
Cdd:PRK14954  460 GV 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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