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Conserved domains on  [gi|161077207|ref|NP_001097360|]
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uncharacterized protein Dmel_CG34195 [Drosophila melanogaster]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549439)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens tRNA N(3)-methylcytidine methyltransferase METTL6

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-175 5.30e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 49.67  E-value: 5.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077207   87 FEVGCGVGNLVFPLLEEqtseegcfsNSRFFFYACDFSPRAVEF----VRSNPLYDPSQISAFQCDITTQqvhdhiPPSS 162
Cdd:pfam08242   1 LEIGCGTGTLLRALLEA---------LPGLEYTGLDISPAALEAarerLAALGLLNAVRVELFQLDLGEL------DPGS 65

                          90
                  ....*....|...
gi 161077207  163 VDICTLIFVLSAI 175
Cdd:pfam08242  66 FDVVVASNVLHHL 78
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-175 5.30e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 49.67  E-value: 5.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077207   87 FEVGCGVGNLVFPLLEEqtseegcfsNSRFFFYACDFSPRAVEF----VRSNPLYDPSQISAFQCDITTQqvhdhiPPSS 162
Cdd:pfam08242   1 LEIGCGTGTLLRALLEA---------LPGLEYTGLDISPAALEAarerLAALGLLNAVRVELFQLDLGEL------DPGS 65

                          90
                  ....*....|...
gi 161077207  163 VDICTLIFVLSAI 175
Cdd:pfam08242  66 FDVVVASNVLHHL 78
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-175 5.30e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 49.67  E-value: 5.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077207   87 FEVGCGVGNLVFPLLEEqtseegcfsNSRFFFYACDFSPRAVEF----VRSNPLYDPSQISAFQCDITTQqvhdhiPPSS 162
Cdd:pfam08242   1 LEIGCGTGTLLRALLEA---------LPGLEYTGLDISPAALEAarerLAALGLLNAVRVELFQLDLGEL------DPGS 65

                          90
                  ....*....|...
gi 161077207  163 VDICTLIFVLSAI 175
Cdd:pfam08242  66 FDVVVASNVLHHL 78
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 88-190 9.97e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 43.32  E-value: 9.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077207   88 EVGCGVGNLVFPLLEEQTSEegcfsnsrffFYACDFSPRAVEFVRSNPLYDPSQISAFQCDITTQQVHDHippsSVDICT 167
Cdd:pfam13649   3 DLGCGTGRLTLALARRGGAR----------VTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDG----SFDLVV 68

                          90       100
                  ....*....|....*....|...
gi 161077207  168 LIFVLSAIHPQKFKDVVQNLGKL 190
Cdd:pfam13649  69 SSGVLHHLPDPDLEAALREIARV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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