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Conserved domains on  [gi|161076464|ref|NP_001097244|]
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Not1, isoform E [Drosophila melanogaster]

Protein Classification

CCR4-NOT transcription complex subunit 1( domain architecture ID 13872481)

CCR4-NOT transcription complex subunit 1 is a scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1831-2187 0e+00

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


:

Pssm-ID: 427680  Cd Length: 365  Bit Score: 575.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1831 FMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILvQIPGQKGWPLYAQLLQDLFKYLAP 1910
Cdd:pfam04054    1 LCELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLL-RLPDQKGWPLYTKLLIDLLKFLGE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1911 FLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSD 1990
Cdd:pfam04054   80 YLKKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1991 SSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELRGHLQVTS-------EPGTRYNMALMNALVMYVGTQAIAL 2063
Cdd:pfam04054  160 IRQAPKILYDPVADLQEAGLKKPVDNYLRSIPSESLLATILHALYLSEyketgfgFVPISVNVKLINALVLYVGIHAVAE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  2064 IRNKNFVPNTSniAHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEA----IQEQIT 2139
Cdd:pfam04054  240 AQKKGSSAVFN--PKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPeeteIQEQIT 317

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 161076464  2140 RVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLF 2187
Cdd:pfam04054  318 RVLLERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
CDC39 super family cl34904
Cell division control protein, negative regulator of transcription [Cell division and ...
 624-2205 2.08e-171

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


The actual alignment was detected with superfamily member COG5103:

Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 578.50  E-value: 2.08e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  624 SKEVEDEVNSYFQRIYNHQpnptLSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLFGGI 703
Cdd:COG5103   598 EIDIEEEASSYIQQIYNSQ----RGIESSINQLKEFLRSENPRDKELFSCIFHALLEEYGFFYDYPLSALALTAVLFGSL 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  704 IDRNLVPtFVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYVEygmhgq 783
Cdd:COG5103   674 IKFRLLP-KPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEKLPSYPSYCSEVLEIPTLNNRILIYKSIVE------ 746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  784 epppqkliglsntipsaissgpgtepiyrnssmlgnmpAATPGSGPKSNAAVSHAtrMKSIANATNIDTLLVANQEEKvt 863
Cdd:COG5103   747 --------------------------------------MDSNENTEVEKANPTHP--MLPLEDFVRLIVKCDANNEGR-- 784

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  864 vpPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKET 943
Cdd:COG5103   785 --ATEVVKSILFAINNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSKDLYLRFSRKT 862

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  944 LRNIKVLLrsDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQqeLLFVVPFVAKILESSAKS 1023
Cdd:COG5103   863 LEFLKMLL--DYRCESPSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRR--ILFVVPFVSKFLRQASCS 938

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1024 RIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPnrthriEEQMSQPKPKQLEPVAS 1103
Cdd:COG5103   939 IIFKPPNPWVMGILKLLSELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNH------LVLKSRLEKELPEDVLN 1012

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1104 ApalpreqqspaqpppppqqqqppqqqvpPPPSSADVDAQNAAAMmmaagganstpgsvSSPNLPTDssQVALPPPEPRy 1183
Cdd:COG5103  1013 A----------------------------KFPDGTDYLAQYIIED--------------SSQITVTD--LVARHVGSPK- 1047

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1184 syvdvnvsnfqligqqlvlppntpflhanPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRM 1263
Cdd:COG5103  1048 -----------------------------PAIKNLTQLALDLSVREICGAVVEKSCGIAIQTTMALFKKDFAMEVEKSML 1098

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1264 RTAAHQMVRNLAAGMAMITGKDEIARAISQNLHKALLSGLNGMPSMAEiqaAAMQLASENVELVCAFIQKTSAEKAAAEI 1343
Cdd:COG5103  1099 YVAARNMVVNLAKFLALVTAQEPLKACISGNVRSYAMKLCSVLDFSAE---KVDKIAMENQDVACRLIERAGVSKVSESI 1175

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1344 DRRLSTDFETRKIAREE--GNRFVDAQILTYQQErLPEAVRIKVGAAPATLYAVYSEFAR----SIPGFQQMSDRDIALF 1417
Cdd:COG5103  1176 SAEIEHMIVERVRHRKTtpNLPFVDPAAANLSLN-LPSSLELSIGKATPQQFSLYEDFDRlslsTIMGHIEKIAINAIDT 1254

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1418 VPKPTDLSQPNVFANDDSMVYGELASKMEAFMNTAIGvPTLQIQASKMHMLLNALIAtrrlrDQESafNLLTRAVEGLTE 1497
Cdd:COG5103  1255 DSADSTDALNNNLNNTVENEANQTALEYQENLLIIKA-QLVQLSKKIPYSSKKNVIA-----DEEH--GLLKEGKNQFET 1326

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1498 GLVNMHENMEQ-----MKMYQNIhLRILGLLNNSfgaPNTERAVTKCF-------FDIREEV-----------RYNVEAA 1554
Cdd:COG5103  1327 VFRRILESIASsddkdLECIQLC-RYILGHLSKS---PSKEEVLSRCLekickisFKTQKEVlgwliysndprKFNIPLI 1402

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1555 RALITSHFVNLNQFDGMLRDCMDNGNNYVaISFGIALLERLIMDDRVINIVSDneFMATVELLGrltqhrhrypecivna 1634
Cdd:COG5103  1403 GSLIEHNLINVVEYDQALSRKIPLADGNV-TDFAIALLASLVTAEVPICTVYD--FICTLEMLA---------------- 1463

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1635 idtlwsgnfnSSSDYSPFNGNDRYLSGASHYIHSGMHHVRScdtddppglqEKTEFLLKDWVALYtqQNQQSTRDARNfg 1714
Cdd:COG5103  1464 ----------GSSDPKVKDFFQKISNTMMHIVAKGNKQQLN----------DQIIIVFSEWVELL--RNCRFNDTVPE-- 1519

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1715 AFVQKMNTYGILKTDDLITRFFRqathICTDVVYRMFAEpSLPINQaknkIFQWIDAFVHLIAMLVRHSGEAGNptTKIN 1794
Cdd:COG5103  1520 MFLPQLMERGDYSASLDIRSFFK----VSLEHFIRAFHE-RIPTAY----CYLKIDALPSLIKNRLYEEGSTEG--TVSV 1588

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1795 LLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLEL 1874
Cdd:COG5103  1589 LFRKIIKDILFVFAEAHRKRAEFVHNYLFFRLFSRILIETLDVIDEDTSCFVNNRSVVYSIFEALQPSRFPGFTFAWLEL 1668

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1875 ISHRvFLGRILVQIPGQKGWPLYAQLLQDLFKYLApfLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTI 1954
Cdd:COG5103  1669 LSHK-FLLPKVLLVNNDKINDLFSEGLMSFLKFLD--LSEEGVVLVMEALYCGFLRTILVYLHDFPGFLITQIYQLFRRN 1745

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1955 PPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPvTFLSELRGHL 2034
Cdd:COG5103  1746 PLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQFRDRIVPLEGQNSFFDLEACLRSALQ-NRTSVKVTDL 1824

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 2035 QVTSEPGTRYNMA---LMNALVMYVGTQAIAlirNKNFVPNTSniahSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYP 2111
Cdd:COG5103  1825 YIGKNTPLWVYLIdnlNEMDAVSHTVVESIK---FMIERFMHK----SEILTMLWIRMRAGGPPKRYFLLTAILAQLRYP 1897

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 2112 NSHTHYFSCAVLHLF--AEANSEA--IQEQITRVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLF 2187
Cdd:COG5103  1898 EIHTYDFSRVFLKSFksHGYNPQKllIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLF 1977

                        1610
                  ....*....|....*...
gi 161076464 2188 ESVARSCLAKSNVTQQLN 2205
Cdd:COG5103  1978 DSLHEHVMAPSSANNVST 1995
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 291-446 1.26e-47

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


:

Pssm-ID: 465113  Cd Length: 146  Bit Score: 167.39  E-value: 1.26e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   291 QDLFNQLIPTFLGNHPNSNVILASAWSSNnfqlRSNIMNAMSEWYLRgnefDQVKLSRILDLAQDLKALSALLNARSFLF 370
Cdd:pfam16418    1 QELIDELFPLFLQGHPNSDLVLHSLWEVD----PQLLLKRLVDYYAR----DPLNLSRILDVAQELKILDELLNLLPFNF 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161076464   371 IIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAKVPEDqlPPKQAQLLPETVTTMINCLQ 446
Cdd:pfam16418   73 ALDLAALASRRGYLDLEKWLQDKLKEHGEPFAQALLDFLEIKAKLELEVQANQP--EPSSVPLSVETVHTLLKVLQ 146
 
Name Accession Description Interval E-value
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1831-2187 0e+00

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 427680  Cd Length: 365  Bit Score: 575.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1831 FMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILvQIPGQKGWPLYAQLLQDLFKYLAP 1910
Cdd:pfam04054    1 LCELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLL-RLPDQKGWPLYTKLLIDLLKFLGE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1911 FLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSD 1990
Cdd:pfam04054   80 YLKKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1991 SSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELRGHLQVTS-------EPGTRYNMALMNALVMYVGTQAIAL 2063
Cdd:pfam04054  160 IRQAPKILYDPVADLQEAGLKKPVDNYLRSIPSESLLATILHALYLSEyketgfgFVPISVNVKLINALVLYVGIHAVAE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  2064 IRNKNFVPNTSniAHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEA----IQEQIT 2139
Cdd:pfam04054  240 AQKKGSSAVFN--PKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPeeteIQEQIT 317

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 161076464  2140 RVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLF 2187
Cdd:pfam04054  318 RVLLERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 624-2205 2.08e-171

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 578.50  E-value: 2.08e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  624 SKEVEDEVNSYFQRIYNHQpnptLSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLFGGI 703
Cdd:COG5103   598 EIDIEEEASSYIQQIYNSQ----RGIESSINQLKEFLRSENPRDKELFSCIFHALLEEYGFFYDYPLSALALTAVLFGSL 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  704 IDRNLVPtFVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYVEygmhgq 783
Cdd:COG5103   674 IKFRLLP-KPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEKLPSYPSYCSEVLEIPTLNNRILIYKSIVE------ 746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  784 epppqkliglsntipsaissgpgtepiyrnssmlgnmpAATPGSGPKSNAAVSHAtrMKSIANATNIDTLLVANQEEKvt 863
Cdd:COG5103   747 --------------------------------------MDSNENTEVEKANPTHP--MLPLEDFVRLIVKCDANNEGR-- 784

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  864 vpPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKET 943
Cdd:COG5103   785 --ATEVVKSILFAINNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSKDLYLRFSRKT 862

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  944 LRNIKVLLrsDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQqeLLFVVPFVAKILESSAKS 1023
Cdd:COG5103   863 LEFLKMLL--DYRCESPSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRR--ILFVVPFVSKFLRQASCS 938

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1024 RIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPnrthriEEQMSQPKPKQLEPVAS 1103
Cdd:COG5103   939 IIFKPPNPWVMGILKLLSELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNH------LVLKSRLEKELPEDVLN 1012

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1104 ApalpreqqspaqpppppqqqqppqqqvpPPPSSADVDAQNAAAMmmaagganstpgsvSSPNLPTDssQVALPPPEPRy 1183
Cdd:COG5103  1013 A----------------------------KFPDGTDYLAQYIIED--------------SSQITVTD--LVARHVGSPK- 1047

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1184 syvdvnvsnfqligqqlvlppntpflhanPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRM 1263
Cdd:COG5103  1048 -----------------------------PAIKNLTQLALDLSVREICGAVVEKSCGIAIQTTMALFKKDFAMEVEKSML 1098

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1264 RTAAHQMVRNLAAGMAMITGKDEIARAISQNLHKALLSGLNGMPSMAEiqaAAMQLASENVELVCAFIQKTSAEKAAAEI 1343
Cdd:COG5103  1099 YVAARNMVVNLAKFLALVTAQEPLKACISGNVRSYAMKLCSVLDFSAE---KVDKIAMENQDVACRLIERAGVSKVSESI 1175

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1344 DRRLSTDFETRKIAREE--GNRFVDAQILTYQQErLPEAVRIKVGAAPATLYAVYSEFAR----SIPGFQQMSDRDIALF 1417
Cdd:COG5103  1176 SAEIEHMIVERVRHRKTtpNLPFVDPAAANLSLN-LPSSLELSIGKATPQQFSLYEDFDRlslsTIMGHIEKIAINAIDT 1254

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1418 VPKPTDLSQPNVFANDDSMVYGELASKMEAFMNTAIGvPTLQIQASKMHMLLNALIAtrrlrDQESafNLLTRAVEGLTE 1497
Cdd:COG5103  1255 DSADSTDALNNNLNNTVENEANQTALEYQENLLIIKA-QLVQLSKKIPYSSKKNVIA-----DEEH--GLLKEGKNQFET 1326

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1498 GLVNMHENMEQ-----MKMYQNIhLRILGLLNNSfgaPNTERAVTKCF-------FDIREEV-----------RYNVEAA 1554
Cdd:COG5103  1327 VFRRILESIASsddkdLECIQLC-RYILGHLSKS---PSKEEVLSRCLekickisFKTQKEVlgwliysndprKFNIPLI 1402

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1555 RALITSHFVNLNQFDGMLRDCMDNGNNYVaISFGIALLERLIMDDRVINIVSDneFMATVELLGrltqhrhrypecivna 1634
Cdd:COG5103  1403 GSLIEHNLINVVEYDQALSRKIPLADGNV-TDFAIALLASLVTAEVPICTVYD--FICTLEMLA---------------- 1463

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1635 idtlwsgnfnSSSDYSPFNGNDRYLSGASHYIHSGMHHVRScdtddppglqEKTEFLLKDWVALYtqQNQQSTRDARNfg 1714
Cdd:COG5103  1464 ----------GSSDPKVKDFFQKISNTMMHIVAKGNKQQLN----------DQIIIVFSEWVELL--RNCRFNDTVPE-- 1519

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1715 AFVQKMNTYGILKTDDLITRFFRqathICTDVVYRMFAEpSLPINQaknkIFQWIDAFVHLIAMLVRHSGEAGNptTKIN 1794
Cdd:COG5103  1520 MFLPQLMERGDYSASLDIRSFFK----VSLEHFIRAFHE-RIPTAY----CYLKIDALPSLIKNRLYEEGSTEG--TVSV 1588

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1795 LLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLEL 1874
Cdd:COG5103  1589 LFRKIIKDILFVFAEAHRKRAEFVHNYLFFRLFSRILIETLDVIDEDTSCFVNNRSVVYSIFEALQPSRFPGFTFAWLEL 1668

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1875 ISHRvFLGRILVQIPGQKGWPLYAQLLQDLFKYLApfLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTI 1954
Cdd:COG5103  1669 LSHK-FLLPKVLLVNNDKINDLFSEGLMSFLKFLD--LSEEGVVLVMEALYCGFLRTILVYLHDFPGFLITQIYQLFRRN 1745

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1955 PPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPvTFLSELRGHL 2034
Cdd:COG5103  1746 PLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQFRDRIVPLEGQNSFFDLEACLRSALQ-NRTSVKVTDL 1824

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 2035 QVTSEPGTRYNMA---LMNALVMYVGTQAIAlirNKNFVPNTSniahSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYP 2111
Cdd:COG5103  1825 YIGKNTPLWVYLIdnlNEMDAVSHTVVESIK---FMIERFMHK----SEILTMLWIRMRAGGPPKRYFLLTAILAQLRYP 1897

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 2112 NSHTHYFSCAVLHLF--AEANSEA--IQEQITRVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLF 2187
Cdd:COG5103  1898 EIHTYDFSRVFLKSFksHGYNPQKllIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLF 1977

                        1610
                  ....*....|....*...
gi 161076464 2188 ESVARSCLAKSNVTQQLN 2205
Cdd:COG5103  1978 DSLHEHVMAPSSANNVST 1995
CNOT1_CAF1_bind pfam16415
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ...
 864-1082 9.52e-110

CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465111  Cd Length: 225  Bit Score: 348.72  E-value: 9.52e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   864 VPPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKET 943
Cdd:pfam16415    4 EPPEEVQDKILFIVNNLSEDNLESKLKELKELLEEEYYPWFAQYLVVKRASIEPNFHKLYLKLLDKLNSPLLYEEVLNET 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   944 LRNIKVLLRSDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQqeLLFVVPFVAKILESSAKS 1023
Cdd:pfam16415   84 YRNIKVLLNSEKTLTSSSERSLLKNLGSWLGSITLARNKPILHKNIAFKELLLEAYDKGR--LIVVIPFVCKVLEQAKKS 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 161076464  1024 RIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPNR 1082
Cdd:pfam16415  162 KVFKPPNPWTMGILKLLVELYHLADLKLNLKFEIEVLCKNLNLDIKDIEPSTLLRDRDR 220
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 291-446 1.26e-47

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


Pssm-ID: 465113  Cd Length: 146  Bit Score: 167.39  E-value: 1.26e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   291 QDLFNQLIPTFLGNHPNSNVILASAWSSNnfqlRSNIMNAMSEWYLRgnefDQVKLSRILDLAQDLKALSALLNARSFLF 370
Cdd:pfam16418    1 QELIDELFPLFLQGHPNSDLVLHSLWEVD----PQLLLKRLVDYYAR----DPLNLSRILDVAQELKILDELLNLLPFNF 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161076464   371 IIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAKVPEDqlPPKQAQLLPETVTTMINCLQ 446
Cdd:pfam16418   73 ALDLAALASRRGYLDLEKWLQDKLKEHGEPFAQALLDFLEIKAKLELEVQANQP--EPSSVPLSVETVHTLLKVLQ 146
NOT1_connector cd20710
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
 1438-1638 3.87e-23

Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.


Pssm-ID: 411008 [Multi-domain]  Cd Length: 202  Bit Score: 99.26  E-value: 3.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1438 YGELASKMEAFMNTAIGVPTLQI-QASKMHMLLNALIATRRLRDQ--ESAFNLLTRAVEGLTEGLvnmhenmeQMKMYQN 1514
Cdd:cd20710    11 FDKLLAELERLLAEAPEEHISDLpPDHEIRSLLRQILQLIISSEQrdELALALAQKIVQLLYESS--------ESQLARE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1515 IHLRILGLLNNSFgaPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNYVAISFGIALLER 1594
Cdd:cd20710    83 VLVALLEKLCDLS--PKVAKEVTSWLIYSDDERKFNVPVTVALIRSGLLNLAEYDAQLAKLIENGRNPAALEFAAQLLRE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 161076464 1595 LIMDDRVINIVSDneFMATVELLGRLTQHRhRYPECIVNAIDTL 1638
Cdd:cd20710   161 LLLDDRPVALRAD--FANTLEALAKLAQES-PSPEGLQQLLEKL 201
 
Name Accession Description Interval E-value
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1831-2187 0e+00

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 427680  Cd Length: 365  Bit Score: 575.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1831 FMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILvQIPGQKGWPLYAQLLQDLFKYLAP 1910
Cdd:pfam04054    1 LCELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLL-RLPDQKGWPLYTKLLIDLLKFLGE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1911 FLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSD 1990
Cdd:pfam04054   80 YLKKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1991 SSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELRGHLQVTS-------EPGTRYNMALMNALVMYVGTQAIAL 2063
Cdd:pfam04054  160 IRQAPKILYDPVADLQEAGLKKPVDNYLRSIPSESLLATILHALYLSEyketgfgFVPISVNVKLINALVLYVGIHAVAE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  2064 IRNKNFVPNTSniAHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEA----IQEQIT 2139
Cdd:pfam04054  240 AQKKGSSAVFN--PKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPeeteIQEQIT 317

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 161076464  2140 RVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLF 2187
Cdd:pfam04054  318 RVLLERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 624-2205 2.08e-171

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 578.50  E-value: 2.08e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  624 SKEVEDEVNSYFQRIYNHQpnptLSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLFGGI 703
Cdd:COG5103   598 EIDIEEEASSYIQQIYNSQ----RGIESSINQLKEFLRSENPRDKELFSCIFHALLEEYGFFYDYPLSALALTAVLFGSL 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  704 IDRNLVPtFVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYVEygmhgq 783
Cdd:COG5103   674 IKFRLLP-KPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEKLPSYPSYCSEVLEIPTLNNRILIYKSIVE------ 746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  784 epppqkliglsntipsaissgpgtepiyrnssmlgnmpAATPGSGPKSNAAVSHAtrMKSIANATNIDTLLVANQEEKvt 863
Cdd:COG5103   747 --------------------------------------MDSNENTEVEKANPTHP--MLPLEDFVRLIVKCDANNEGR-- 784

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  864 vpPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKET 943
Cdd:COG5103   785 --ATEVVKSILFAINNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSKDLYLRFSRKT 862

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  944 LRNIKVLLrsDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQqeLLFVVPFVAKILESSAKS 1023
Cdd:COG5103   863 LEFLKMLL--DYRCESPSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRR--ILFVVPFVSKFLRQASCS 938

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1024 RIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPnrthriEEQMSQPKPKQLEPVAS 1103
Cdd:COG5103   939 IIFKPPNPWVMGILKLLSELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNH------LVLKSRLEKELPEDVLN 1012

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1104 ApalpreqqspaqpppppqqqqppqqqvpPPPSSADVDAQNAAAMmmaagganstpgsvSSPNLPTDssQVALPPPEPRy 1183
Cdd:COG5103  1013 A----------------------------KFPDGTDYLAQYIIED--------------SSQITVTD--LVARHVGSPK- 1047

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1184 syvdvnvsnfqligqqlvlppntpflhanPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRM 1263
Cdd:COG5103  1048 -----------------------------PAIKNLTQLALDLSVREICGAVVEKSCGIAIQTTMALFKKDFAMEVEKSML 1098

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1264 RTAAHQMVRNLAAGMAMITGKDEIARAISQNLHKALLSGLNGMPSMAEiqaAAMQLASENVELVCAFIQKTSAEKAAAEI 1343
Cdd:COG5103  1099 YVAARNMVVNLAKFLALVTAQEPLKACISGNVRSYAMKLCSVLDFSAE---KVDKIAMENQDVACRLIERAGVSKVSESI 1175

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1344 DRRLSTDFETRKIAREE--GNRFVDAQILTYQQErLPEAVRIKVGAAPATLYAVYSEFAR----SIPGFQQMSDRDIALF 1417
Cdd:COG5103  1176 SAEIEHMIVERVRHRKTtpNLPFVDPAAANLSLN-LPSSLELSIGKATPQQFSLYEDFDRlslsTIMGHIEKIAINAIDT 1254

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1418 VPKPTDLSQPNVFANDDSMVYGELASKMEAFMNTAIGvPTLQIQASKMHMLLNALIAtrrlrDQESafNLLTRAVEGLTE 1497
Cdd:COG5103  1255 DSADSTDALNNNLNNTVENEANQTALEYQENLLIIKA-QLVQLSKKIPYSSKKNVIA-----DEEH--GLLKEGKNQFET 1326

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1498 GLVNMHENMEQ-----MKMYQNIhLRILGLLNNSfgaPNTERAVTKCF-------FDIREEV-----------RYNVEAA 1554
Cdd:COG5103  1327 VFRRILESIASsddkdLECIQLC-RYILGHLSKS---PSKEEVLSRCLekickisFKTQKEVlgwliysndprKFNIPLI 1402

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1555 RALITSHFVNLNQFDGMLRDCMDNGNNYVaISFGIALLERLIMDDRVINIVSDneFMATVELLGrltqhrhrypecivna 1634
Cdd:COG5103  1403 GSLIEHNLINVVEYDQALSRKIPLADGNV-TDFAIALLASLVTAEVPICTVYD--FICTLEMLA---------------- 1463

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1635 idtlwsgnfnSSSDYSPFNGNDRYLSGASHYIHSGMHHVRScdtddppglqEKTEFLLKDWVALYtqQNQQSTRDARNfg 1714
Cdd:COG5103  1464 ----------GSSDPKVKDFFQKISNTMMHIVAKGNKQQLN----------DQIIIVFSEWVELL--RNCRFNDTVPE-- 1519

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1715 AFVQKMNTYGILKTDDLITRFFRqathICTDVVYRMFAEpSLPINQaknkIFQWIDAFVHLIAMLVRHSGEAGNptTKIN 1794
Cdd:COG5103  1520 MFLPQLMERGDYSASLDIRSFFK----VSLEHFIRAFHE-RIPTAY----CYLKIDALPSLIKNRLYEEGSTEG--TVSV 1588

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1795 LLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCTADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLEL 1874
Cdd:COG5103  1589 LFRKIIKDILFVFAEAHRKRAEFVHNYLFFRLFSRILIETLDVIDEDTSCFVNNRSVVYSIFEALQPSRFPGFTFAWLEL 1668

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1875 ISHRvFLGRILVQIPGQKGWPLYAQLLQDLFKYLApfLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTI 1954
Cdd:COG5103  1669 LSHK-FLLPKVLLVNNDKINDLFSEGLMSFLKFLD--LSEEGVVLVMEALYCGFLRTILVYLHDFPGFLITQIYQLFRRN 1745

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1955 PPNCVQMRNIILSAFPRNMRLPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPvTFLSELRGHL 2034
Cdd:COG5103  1746 PLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQFRDRIVPLEGQNSFFDLEACLRSALQ-NRTSVKVTDL 1824

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 2035 QVTSEPGTRYNMA---LMNALVMYVGTQAIAlirNKNFVPNTSniahSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYP 2111
Cdd:COG5103  1825 YIGKNTPLWVYLIdnlNEMDAVSHTVVESIK---FMIERFMHK----SEILTMLWIRMRAGGPPKRYFLLTAILAQLRYP 1897

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 2112 NSHTHYFSCAVLHLF--AEANSEA--IQEQITRVLLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLF 2187
Cdd:COG5103  1898 EIHTYDFSRVFLKSFksHGYNPQKllIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLF 1977

                        1610
                  ....*....|....*...
gi 161076464 2188 ESVARSCLAKSNVTQQLN 2205
Cdd:COG5103  1978 DSLHEHVMAPSSANNVST 1995
CNOT1_CAF1_bind pfam16415
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ...
 864-1082 9.52e-110

CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465111  Cd Length: 225  Bit Score: 348.72  E-value: 9.52e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   864 VPPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKET 943
Cdd:pfam16415    4 EPPEEVQDKILFIVNNLSEDNLESKLKELKELLEEEYYPWFAQYLVVKRASIEPNFHKLYLKLLDKLNSPLLYEEVLNET 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   944 LRNIKVLLRSDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQqeLLFVVPFVAKILESSAKS 1023
Cdd:pfam16415   84 YRNIKVLLNSEKTLTSSSERSLLKNLGSWLGSITLARNKPILHKNIAFKELLLEAYDKGR--LIVVIPFVCKVLEQAKKS 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 161076464  1024 RIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPNR 1082
Cdd:pfam16415  162 KVFKPPNPWTMGILKLLVELYHLADLKLNLKFEIEVLCKNLNLDIKDIEPSTLLRDRDR 220
CNOT1_TTP_bind pfam16417
CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of ...
 615-788 1.39e-86

CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of CCR4-NOT transcription complex subunit 1. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465112  Cd Length: 183  Bit Score: 280.64  E-value: 1.39e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   615 VMADLQIPVSKEVEDEVNSYFQRIYNhqpnPTLSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQ 694
Cdd:pfam16417   15 LDSSTDQQFSQEVEKEANSYFQRLYN----GEISIEEFIEMLKQFKSSKNKREQEVFACMITNLFDEYKFFPQYPDKELL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   695 ITAQLFGGIIDRNLVpTFVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQ 774
Cdd:pfam16417   91 ITGQLFGSIIEHGLV-SYKALGIALRYVLEALRKPPGSKMFEFGIKALEQFKSRLKEWPQYCQHLDSIPHLREFPPDLVE 169

                          170
                   ....*....|....
gi 161076464   775 YVEYGMHGQEPPPQ 788
Cdd:pfam16417  170 YIEYGLKQQESPPQ 183
DUF3819 pfam12842
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized ...
 1213-1357 4.26e-58

CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 463726  Cd Length: 143  Bit Score: 197.36  E-value: 4.26e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464  1213 PGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRMRTAAHQMVRNLAAGMAMITGKDEIARAIS 1292
Cdd:pfam12842    1 PDLKRLVQAAIERAIREIISPVVERSVTIAVITTEELVLKDFATEPDENKMRKAAHLMVRNLAGSLALVTCKEPLRESIS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161076464  1293 QNLHKALLSGLNGMPSMAEiqAAAMQLASENVELVCAFIQKTSAEKAAAEIDRRLSTDFETRKIA 1357
Cdd:pfam12842   81 NNLRSLLSNLLPNVNEQPE--QAIQLAANDNLDLACAFIEKAAMEKAIPEIDERLAPAYELRRRH 143
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 291-446 1.26e-47

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


Pssm-ID: 465113  Cd Length: 146  Bit Score: 167.39  E-value: 1.26e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464   291 QDLFNQLIPTFLGNHPNSNVILASAWSSNnfqlRSNIMNAMSEWYLRgnefDQVKLSRILDLAQDLKALSALLNARSFLF 370
Cdd:pfam16418    1 QELIDELFPLFLQGHPNSDLVLHSLWEVD----PQLLLKRLVDYYAR----DPLNLSRILDVAQELKILDELLNLLPFNF 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161076464   371 IIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAKVPEDqlPPKQAQLLPETVTTMINCLQ 446
Cdd:pfam16418   73 ALDLAALASRRGYLDLEKWLQDKLKEHGEPFAQALLDFLEIKAKLELEVQANQP--EPSSVPLSVETVHTLLKVLQ 146
NOT1_connector cd20710
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
 1438-1638 3.87e-23

Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.


Pssm-ID: 411008 [Multi-domain]  Cd Length: 202  Bit Score: 99.26  E-value: 3.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1438 YGELASKMEAFMNTAIGVPTLQI-QASKMHMLLNALIATRRLRDQ--ESAFNLLTRAVEGLTEGLvnmhenmeQMKMYQN 1514
Cdd:cd20710    11 FDKLLAELERLLAEAPEEHISDLpPDHEIRSLLRQILQLIISSEQrdELALALAQKIVQLLYESS--------ESQLARE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076464 1515 IHLRILGLLNNSFgaPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNYVAISFGIALLER 1594
Cdd:cd20710    83 VLVALLEKLCDLS--PKVAKEVTSWLIYSDDERKFNVPVTVALIRSGLLNLAEYDAQLAKLIENGRNPAALEFAAQLLRE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 161076464 1595 LIMDDRVINIVSDneFMATVELLGRLTQHRhRYPECIVNAIDTL 1638
Cdd:cd20710   161 LLLDDRPVALRAD--FANTLEALAKLAQES-PSPEGLQQLLEKL 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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