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Conserved domains on  [gi|1983575952|ref|NP_001094125|]
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NAC-alpha domain-containing protein 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAC_NACA cd22054
nascent polypeptide-associated complex (NAC), alpha subunit; The nascent ...
 1280-1327 1.34e-23

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.


:

Pssm-ID: 409233  Cd Length: 48  Bit Score: 94.55  E-value: 1.34e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1983575952 1280 GLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDL 1327
Cdd:cd22054      1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDTYIVFGEAKIEDL 48
UBA_NACAD cd14416
UBA-like domain found in nascent polypeptide-associated complex subunit alpha ...
 1375-1416 6.49e-21

UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD); The subfamily includes a group of uncharacterized proteins mainly found in vertebrates. Their biological function remains unknown, but they show high sequence similarity to the nascent polypeptide-associated complex (NAC) subunit alpha (NACA) that exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. Like NACA, NACAD contains an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


:

Pssm-ID: 270599  Cd Length: 44  Bit Score: 87.05  E-value: 6.49e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1983575952 1375 AGLEPRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELTM 1416
Cdd:cd14416      3 TGLEVRDIELVMAQANVSRAKAVRALRHNNNDIVNAIMELTM 44
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
630-758 6.77e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07994:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 647  Bit Score: 47.55  E-value: 6.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  630 PVVSLPSPQSTDPTPGPEAGAMATFEFQQAKEGVPELQDTPVASSPALQASDPTSEPEPEAVLTLRSQ--QDEEIVTVPQ 707
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQlqRAQGATKAKK 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575952  708 ESPTAS--------------SVPLQSSDPTSEPEPEVAATPEPQQPEEGVTIPQVAPVALPSPLQ 758
Cdd:PRK07994   441 SEPAAAsrarpvnsalerlaSVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALE 505
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 594-1105 8.61e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 8.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  594 PPLLQNTDPTSGPESVAVVMLEPQQDEGCVTVLQDVPvvSLPSPQSTDPTPGPEAGAMAtfefQQAKEGVPELQDTPVAS 673
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRP--DAPPQSARPRAPVDDRGDPR----GPAPPSPLPPDTHAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  674 SPALQASDPTSEPEPEAVLTLRSQQDEEIVTVPQESP----TASSVPLQSSDPTSEPEPEVAATP---------EPQQPE 740
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprraRRLGRAAQASSPPQRPRRRAARPTvgsltsladPPPPPP 2706

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  741 EGVTIPQVAPVALPSPLQGLDSTSDLESVVAGTMESWQDEGIATATQDMPVVAPPPLGGIESTSDPELSAQDTPQALQRE 820
Cdd:PHA03247  2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  821 AGYTPG----TKPSVSEAHQELGVALGPRPVPKEQDA-----KPPHSELPASDQAQQNGSEPVVKNDNLGVPG------- 884
Cdd:PHA03247  2787 AVASLSesreSLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrp 2866

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  885 --EGSGPTLSTKTSEPLSCMGEKVTENLAAPKPGACLEAHDGAKTHSPQRQASRAKNKCGRGPKPPGQGKGSKSTASQGT 962
Cdd:PHA03247  2867 psRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  963 TETFKAhsaarsetSQPQLMNSAGEGTSLSVKDSSGPRLPVAVSVQSKLGSCPGSPARATCTLSRVYSEETARCAPPFQH 1042
Cdd:PHA03247  2947 TDPAGA--------GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETD 3018

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575952 1043 PEPVLGLGSGEQPKVTLGTLNLSS--------ENSAGDLLTTPQNRLLDPDPDPSAPSALNRAFQSSP-GPP 1105
Cdd:PHA03247  3019 PPPVSLKQTLWPPDDTEDSDADSLfdsdsersDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQfGPP 3090
 
Name Accession Description Interval E-value
NAC_NACA cd22054
nascent polypeptide-associated complex (NAC), alpha subunit; The nascent ...
 1280-1327 1.34e-23

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 409233  Cd Length: 48  Bit Score: 94.55  E-value: 1.34e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1983575952 1280 GLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDL 1327
Cdd:cd22054      1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDTYIVFGEAKIEDL 48
NAC pfam01849
NAC domain;
1271-1324 5.13e-21

NAC domain;


Pssm-ID: 426474  Cd Length: 54  Bit Score: 87.52  E-value: 5.13e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1983575952 1271 KARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKI 1324
Cdd:pfam01849    1 KLQKALKKLGLKPIPGVEEVNIFKSDGKVLVFNNPKVQKSPGSNTYVVFGEAEE 54
UBA_NACAD cd14416
UBA-like domain found in nascent polypeptide-associated complex subunit alpha ...
 1375-1416 6.49e-21

UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD); The subfamily includes a group of uncharacterized proteins mainly found in vertebrates. Their biological function remains unknown, but they show high sequence similarity to the nascent polypeptide-associated complex (NAC) subunit alpha (NACA) that exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. Like NACA, NACAD contains an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 270599  Cd Length: 44  Bit Score: 87.05  E-value: 6.49e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1983575952 1375 AGLEPRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELTM 1416
Cdd:cd14416      3 TGLEVRDIELVMAQANVSRAKAVRALRHNNNDIVNAIMELTM 44
EGD2 COG1308
Transcription factor homologous to NACalpha-BTF3 [Transcription];
1270-1415 3.57e-10

Transcription factor homologous to NACalpha-BTF3 [Transcription];


Pssm-ID: 440919 [Multi-domain]  Cd Length: 116  Bit Score: 58.70  E-value: 3.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952 1270 KKARKAMSKLGLRQIQ-GVTRITIQ-KSKNIlfVIAKPDV--FKSPASDTYVVFGEAKIEDLsqqvhKAAAEKFKVPSEs 1345
Cdd:COG1308      8 RKMKQMMKQMGIKVEEiDAEEVIIRtKDKEI--VFENPQVtvMKAQGQETYQIVGEPEEVEK-----GAEEAEVEIPEE- 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952 1346 salvpelapgprvrpeceeqeeeeeeveeagleprDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:COG1308     80 -----------------------------------DVELVAEQTGVSEEEAREALEEANGDLAEAILKLE 114
nac PRK06369
nascent polypeptide-associated complex protein; Reviewed
 1270-1415 2.59e-09

nascent polypeptide-associated complex protein; Reviewed


Pssm-ID: 235786 [Multi-domain]  Cd Length: 115  Bit Score: 56.41  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952 1270 KKARKAMSKLGL--RQIqGVTRITIQ-KSKNIlfVIAKPDV--FKSPASDTYVVFGEAKiedlsqQVHKAAAEKFKVPSE 1344
Cdd:PRK06369     8 RKMKQMMKQMGIdvEEL-DVEEVIIRlKDKEI--VFENPQVtvMDAQGQKTYQIVGEPE------EVEKEAEKEVEIPEE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575952 1345 ssalvpelapgprvrpeceeqeeeeeeveeagleprDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:PRK06369    79 ------------------------------------DIELVAEQTGVSEEEARKALEEANGDLAEAILKLS 113
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 1376-1415 7.74e-08

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


Pssm-ID: 436907  Cd Length: 41  Bit Score: 49.86  E-value: 7.74e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1983575952 1376 GLEPRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:pfam19026    2 KVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 630-758 6.77e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.55  E-value: 6.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  630 PVVSLPSPQSTDPTPGPEAGAMATFEFQQAKEGVPELQDTPVASSPALQASDPTSEPEPEAVLTLRSQ--QDEEIVTVPQ 707
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQlqRAQGATKAKK 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575952  708 ESPTAS--------------SVPLQSSDPTSEPEPEVAATPEPQQPEEGVTIPQVAPVALPSPLQ 758
Cdd:PRK07994   441 SEPAAAsrarpvnsalerlaSVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALE 505
TIGR00264 TIGR00264
alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its ...
 1381-1414 8.63e-05

alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator. [Unknown function, General]


Pssm-ID: 272988 [Multi-domain]  Cd Length: 116  Bit Score: 43.40  E-value: 8.63e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1983575952 1381 DIELVMAQANVSRAKAVRALKDNHSDIVNAIMEL 1414
Cdd:TIGR00264   81 DIELVMKQCNVSKEEARRALEECGGDLAEAIMKL 114
PHA03247 PHA03247
large tegument protein UL36; Provisional
 594-1105 8.61e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 8.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  594 PPLLQNTDPTSGPESVAVVMLEPQQDEGCVTVLQDVPvvSLPSPQSTDPTPGPEAGAMAtfefQQAKEGVPELQDTPVAS 673
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRP--DAPPQSARPRAPVDDRGDPR----GPAPPSPLPPDTHAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  674 SPALQASDPTSEPEPEAVLTLRSQQDEEIVTVPQESP----TASSVPLQSSDPTSEPEPEVAATP---------EPQQPE 740
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprraRRLGRAAQASSPPQRPRRRAARPTvgsltsladPPPPPP 2706

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  741 EGVTIPQVAPVALPSPLQGLDSTSDLESVVAGTMESWQDEGIATATQDMPVVAPPPLGGIESTSDPELSAQDTPQALQRE 820
Cdd:PHA03247  2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  821 AGYTPG----TKPSVSEAHQELGVALGPRPVPKEQDA-----KPPHSELPASDQAQQNGSEPVVKNDNLGVPG------- 884
Cdd:PHA03247  2787 AVASLSesreSLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrp 2866

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  885 --EGSGPTLSTKTSEPLSCMGEKVTENLAAPKPGACLEAHDGAKTHSPQRQASRAKNKCGRGPKPPGQGKGSKSTASQGT 962
Cdd:PHA03247  2867 psRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  963 TETFKAhsaarsetSQPQLMNSAGEGTSLSVKDSSGPRLPVAVSVQSKLGSCPGSPARATCTLSRVYSEETARCAPPFQH 1042
Cdd:PHA03247  2947 TDPAGA--------GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETD 3018

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575952 1043 PEPVLGLGSGEQPKVTLGTLNLSS--------ENSAGDLLTTPQNRLLDPDPDPSAPSALNRAFQSSP-GPP 1105
Cdd:PHA03247  3019 PPPVSLKQTLWPPDDTEDSDADSLfdsdsersDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQfGPP 3090
 
Name Accession Description Interval E-value
NAC_NACA cd22054
nascent polypeptide-associated complex (NAC), alpha subunit; The nascent ...
 1280-1327 1.34e-23

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 409233  Cd Length: 48  Bit Score: 94.55  E-value: 1.34e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1983575952 1280 GLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDL 1327
Cdd:cd22054      1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDTYIVFGEAKIEDL 48
NAC pfam01849
NAC domain;
1271-1324 5.13e-21

NAC domain;


Pssm-ID: 426474  Cd Length: 54  Bit Score: 87.52  E-value: 5.13e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1983575952 1271 KARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKI 1324
Cdd:pfam01849    1 KLQKALKKLGLKPIPGVEEVNIFKSDGKVLVFNNPKVQKSPGSNTYVVFGEAEE 54
UBA_NACAD cd14416
UBA-like domain found in nascent polypeptide-associated complex subunit alpha ...
 1375-1416 6.49e-21

UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD); The subfamily includes a group of uncharacterized proteins mainly found in vertebrates. Their biological function remains unknown, but they show high sequence similarity to the nascent polypeptide-associated complex (NAC) subunit alpha (NACA) that exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. Like NACA, NACAD contains an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 270599  Cd Length: 44  Bit Score: 87.05  E-value: 6.49e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1983575952 1375 AGLEPRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELTM 1416
Cdd:cd14416      3 TGLEVRDIELVMAQANVSRAKAVRALRHNNNDIVNAIMELTM 44
UBA_NAC_euk cd14358
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its ...
 1379-1415 3.34e-19

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes; The subfamily contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. All family members contain an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 270541 [Multi-domain]  Cd Length: 37  Bit Score: 81.90  E-value: 3.34e-19
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1983575952 1379 PRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:cd14358      1 PKDIELVMQQANVSRAKAVKALKENDNDIVNAIMELT 37
UBA_NACA_NACP1 cd14415
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and ...
 1375-1415 1.26e-18

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1); NACA, also called NAC-alpha or alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. Both NACA and BTF3 harbor an NAC domain that mediates the dimerization of the two subunits. By contrast, NACA has an extra ubiquitin-associated (UBA) domain in the C-terminus. In addition to NACA, the family includes NACP1, also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1. The biological function of NACP1 remains unclear.


Pssm-ID: 270598  Cd Length: 46  Bit Score: 80.38  E-value: 1.26e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1983575952 1375 AGLEPRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:cd14415      6 TGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELT 46
UBA_NAC_like cd14278
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and ...
 1379-1415 1.35e-13

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins; The family contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins found in archaea and bacteria. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. The family also includes huntingtin-interacting protein K (HYPK), also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K. It is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It may be involved in regulating cell growth, cell cycle, unfolded protein response and cell death. All members in this family contain an ubiquitin-associated (UBA) domain.


Pssm-ID: 270464 [Multi-domain]  Cd Length: 37  Bit Score: 65.97  E-value: 1.35e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1983575952 1379 PRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:cd14278      1 EEDIELVMSQTGVSREEAIKALRENKGDVVDAILELT 37
EGD2 COG1308
Transcription factor homologous to NACalpha-BTF3 [Transcription];
1270-1415 3.57e-10

Transcription factor homologous to NACalpha-BTF3 [Transcription];


Pssm-ID: 440919 [Multi-domain]  Cd Length: 116  Bit Score: 58.70  E-value: 3.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952 1270 KKARKAMSKLGLRQIQ-GVTRITIQ-KSKNIlfVIAKPDV--FKSPASDTYVVFGEAKIEDLsqqvhKAAAEKFKVPSEs 1345
Cdd:COG1308      8 RKMKQMMKQMGIKVEEiDAEEVIIRtKDKEI--VFENPQVtvMKAQGQETYQIVGEPEEVEK-----GAEEAEVEIPEE- 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952 1346 salvpelapgprvrpeceeqeeeeeeveeagleprDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:COG1308     80 -----------------------------------DVELVAEQTGVSEEEAREALEEANGDLAEAILKLE 114
NAC cd21114
NAC domain; This family contains the NAC domain, named after the nascent ...
 1284-1326 1.45e-09

NAC domain; This family contains the NAC domain, named after the nascent polypeptide-associated complex (NAC) whose subunits contain NAC domains. In eukaryotes, the NAC complex, which plays an important role in co-translational targeting of nascent polypeptides to endoplasmic reticulum (ER), consists of 2 subunits: NAC alpha and a shortened splice variant of the basal transcription factor 3 (BTF3; also called BTF3b or NAC beta). The full length BTF3a protein excites transcription.


Pssm-ID: 409232  Cd Length: 43  Bit Score: 54.62  E-value: 1.45e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1983575952 1284 IQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIED 1326
Cdd:cd21114      1 IPGIEEVTMVMEDGSVIVFTMPKVQASLASNVFVVTGEATREQ 43
nac PRK06369
nascent polypeptide-associated complex protein; Reviewed
 1270-1415 2.59e-09

nascent polypeptide-associated complex protein; Reviewed


Pssm-ID: 235786 [Multi-domain]  Cd Length: 115  Bit Score: 56.41  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952 1270 KKARKAMSKLGL--RQIqGVTRITIQ-KSKNIlfVIAKPDV--FKSPASDTYVVFGEAKiedlsqQVHKAAAEKFKVPSE 1344
Cdd:PRK06369     8 RKMKQMMKQMGIdvEEL-DVEEVIIRlKDKEI--VFENPQVtvMDAQGQKTYQIVGEPE------EVEKEAEKEVEIPEE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575952 1345 ssalvpelapgprvrpeceeqeeeeeeveeagleprDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:PRK06369    79 ------------------------------------DIELVAEQTGVSEEEARKALEEANGDLAEAILKLS 113
UBA_AeNAC cd14359
UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from ...
 1381-1415 1.47e-08

UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from Methanothermobacter marburgensis (AeNAC) and similar proteins; AeNAC is a functional archaeal homolog of eukaryotic nascent polypeptide-associated complex (NAC). Both AeNAC and eukaryotic NAC function as the cytosolic chaperone that can bind to ribosomal RNA, interact with the nascent polypeptide chains as they emerge from the ribosome, and assist in post-translational processes. They all contain a NAC domain and an ubiquitin-associated (UBA) domain in the C-terminus. However, unlike eukaryotic NAC, AeNAC forms a ribosome associated homodimer, but not heterodimer. The NAC domain of AeNAC is responsible for the homodimer formation.


Pssm-ID: 270542 [Multi-domain]  Cd Length: 40  Bit Score: 51.84  E-value: 1.47e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1983575952 1381 DIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:cd14359      6 DIELVMEQTGVSREEARKALEESGGDLAEAILKLT 40
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 1376-1415 7.74e-08

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


Pssm-ID: 436907  Cd Length: 41  Bit Score: 49.86  E-value: 7.74e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1983575952 1376 GLEPRDIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:pfam19026    2 KVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 630-758 6.77e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.55  E-value: 6.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  630 PVVSLPSPQSTDPTPGPEAGAMATFEFQQAKEGVPELQDTPVASSPALQASDPTSEPEPEAVLTLRSQ--QDEEIVTVPQ 707
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQlqRAQGATKAKK 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575952  708 ESPTAS--------------SVPLQSSDPTSEPEPEVAATPEPQQPEEGVTIPQVAPVALPSPLQ 758
Cdd:PRK07994   441 SEPAAAsrarpvnsalerlaSVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALE 505
TIGR00264 TIGR00264
alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its ...
 1381-1414 8.63e-05

alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator. [Unknown function, General]


Pssm-ID: 272988 [Multi-domain]  Cd Length: 116  Bit Score: 43.40  E-value: 8.63e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1983575952 1381 DIELVMAQANVSRAKAVRALKDNHSDIVNAIMEL 1414
Cdd:TIGR00264   81 DIELVMKQCNVSKEEARRALEECGGDLAEAIMKL 114
rne PRK10811
ribonuclease E; Reviewed
 569-743 5.47e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 44.65  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  569 VAVASvgPWKAEGGVAI------PQDPFMTlpPLLQNTDPTSGPESVAVVMLEPQQDEGCVTVLQDVPVVSLPSPQSTDP 642
Cdd:PRK10811   829 VACAS--PEMASGKVWIrypvvrPQDVQVE--EQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEP 904

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  643 TPgPEAGAMATFEFQQAKEGVPEL------QDTPVASSPAlQASDPTSEPEPEAVLTLRSQQDEEIVTVPQESPTASSVP 716
Cdd:PRK10811   905 QP-EEVVVVETTHPEVIAAPVTEQpqviteSDVAVAQEVA-EHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAP 982

                          170       180
                   ....*....|....*....|....*...
gi 1983575952  717 LQSSDPTSEPEPEVAAT-PEPQQPEEGV 743
Cdd:PRK10811   983 VVAEVAAEVETVTAVEPeVAPAQVPEAT 1010
PHA03247 PHA03247
large tegument protein UL36; Provisional
 594-1105 8.61e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 8.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  594 PPLLQNTDPTSGPESVAVVMLEPQQDEGCVTVLQDVPvvSLPSPQSTDPTPGPEAGAMAtfefQQAKEGVPELQDTPVAS 673
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRP--DAPPQSARPRAPVDDRGDPR----GPAPPSPLPPDTHAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  674 SPALQASDPTSEPEPEAVLTLRSQQDEEIVTVPQESP----TASSVPLQSSDPTSEPEPEVAATP---------EPQQPE 740
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprraRRLGRAAQASSPPQRPRRRAARPTvgsltsladPPPPPP 2706

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  741 EGVTIPQVAPVALPSPLQGLDSTSDLESVVAGTMESWQDEGIATATQDMPVVAPPPLGGIESTSDPELSAQDTPQALQRE 820
Cdd:PHA03247  2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  821 AGYTPG----TKPSVSEAHQELGVALGPRPVPKEQDA-----KPPHSELPASDQAQQNGSEPVVKNDNLGVPG------- 884
Cdd:PHA03247  2787 AVASLSesreSLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrp 2866

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  885 --EGSGPTLSTKTSEPLSCMGEKVTENLAAPKPGACLEAHDGAKTHSPQRQASRAKNKCGRGPKPPGQGKGSKSTASQGT 962
Cdd:PHA03247  2867 psRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  963 TETFKAhsaarsetSQPQLMNSAGEGTSLSVKDSSGPRLPVAVSVQSKLGSCPGSPARATCTLSRVYSEETARCAPPFQH 1042
Cdd:PHA03247  2947 TDPAGA--------GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETD 3018

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575952 1043 PEPVLGLGSGEQPKVTLGTLNLSS--------ENSAGDLLTTPQNRLLDPDPDPSAPSALNRAFQSSP-GPP 1105
Cdd:PHA03247  3019 PPPVSLKQTLWPPDDTEDSDADSLfdsdsersDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQfGPP 3090
UBA_HYPK cd14361
UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, ...
 1381-1415 1.27e-03

UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K, is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It is involved in regulating cell growth, cell cycle, unfolded protein response, and cell death. All members in this subfamily contain an N-terminal ubiquitin-associated (UBA) that shows high sequence similarity with that of eukaryotic nascent polypeptide-associated complex proteins (NAC) which is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes.


Pssm-ID: 270544  Cd Length: 41  Bit Score: 37.87  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1983575952 1381 DIELVMAQANVSRAKAVRALKDNHSDIVNAIMELT 1415
Cdd:cd14361      7 DVELIVNELEVSKAQAERALREHNGDVVKALRALI 41
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
684-814 2.18e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 42.34  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  684 SEPEPEAVLTLRSQQDEEIVTVPQESPTASSVPLQSSDPTSEPEPEVAATPEPQQPEEGVTIPQVAPVALPSPLQGL--- 760
Cdd:PRK14960   372 VQQNGQAEVGLNSQAQTAQEITPVSAVQPVEVISQPAMVEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPQPNQDLmvf 451

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1983575952  761 DSTSD----LESVVAGTMESWQDEGI----------------ATATQDMPVVAPPPLGGIESTSDPELSAQDTP 814
Cdd:PRK14960   452 DPNHHeligLESAVVQETVSVLEEDFipvpeqklvqvqaetqVKQIEPEPASTAEPIGLFEASSAEFSLAQDTS 525
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 564-850 3.92e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 3.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  564 STMEYVAVASVGPWKAEGGVAiPQDPFMTLPPLLQNTDPTSGPESVAVVMLEPQQDEgcvtvlqdvPVVSlPSPQSTDPT 643
Cdd:PRK10263   315 PITEPVAVAAAATTATQSWAA-PVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGE---------PVIA-PAPEGYPQQ 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  644 PgpeagamatfEFQQAKEGVPELQDTPVASSPALQASDPTSEPEPEAVLTLRSQQDEEIVTVPQESPTASSVPLQSSDPT 723
Cdd:PRK10263   384 S----------QYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQ 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575952  724 SEPEPEVAATPEPQQPEEGVTIPQ-VAPVALPSPlqgldSTSDLESVVAGTMES---------------WQDEGIATATQ 787
Cdd:PRK10263   454 STFAPQSTYQTEQTYQQPAAQEPLyQQPQPVEQQ-----PVVEPEPVVEETKPArpplyyfeeveekraREREQLAAWYQ 528

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575952  788 DMPVVAPPPLGGIESTSDPELSAQDTPQALQREAGYTPGTKPSVSEAHQELGVAL---------GPRPVPKE 850
Cdd:PRK10263   529 PIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAApvfslansgGPRPQVKE 600
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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