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Conserved domains on  [gi|153792305|ref|NP_001093148|]
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leucine-rich repeat-containing protein 58 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-247 6.63e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 6.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  65 SGFPHLQLLDVSGNaltalgPELLALRGLRTLLAKNNRLggpSALPKGLAQsplCRSLQVLNLSGNCFQEVPASLLELRA 144
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQL---TDLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 145 LQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180
                 ....*....|....*....|...
gi 153792305 225 TYLPrEILNLIHLEELSLRGNPL 247
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-247 6.63e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 6.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  65 SGFPHLQLLDVSGNaltalgPELLALRGLRTLLAKNNRLggpSALPKGLAQsplCRSLQVLNLSGNCFQEVPASLLELRA 144
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQL---TDLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 145 LQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180
                 ....*....|....*....|...
gi 153792305 225 TYLPrEILNLIHLEELSLRGNPL 247
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-247 1.61e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.21  E-value: 1.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  66 GFPHLQLLDVSGNALTALGPE--LLALRGLRTLLAKNNRLGGPsaLPKG---------LAQSPLC----------RSLQV 124
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGS--IPRGsipnletldLSNNMLSgeipndigsfSSLKV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 125 LNLSGNCFQ-EVPASLLELRALQTLSLGGNQLQ-SIPAEIENLQSLECLYLG-GNFIKEIPPELGNLPSLNYLVLC-DNK 200
Cdd:PLN00113 169 LDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHLDLVyNNL 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 153792305 201 IQSIPPQLSQLHSLRSLSLHNNLLT-YLPREILNLIHLEELSLRGNPL 247
Cdd:PLN00113 249 TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 118-247 9.18e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 9.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 118 LCRSLQVLNLSGNCFQEVPaSLLELRALQTLSLGGNQLQSIPaEIENLQSLECLYLGGNFIKEI---------------- 181
Cdd:cd21340   22 LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVeglenltnleelhien 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 182 ---PPE----------LGNLPSLNYLVLCDNKIQSIPPqLSQLHSLRSLSLHNNLLTYLpREILNLI----HLEELSLRG 244
Cdd:cd21340  100 qrlPPGekltfdprslAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL-EELLDLLsswpSLRELDLTG 177


                 ...
gi 153792305 245 NPL 247
Cdd:cd21340  178 NPV 180
LRR_8 pfam13855
Leucine rich repeat;
166-224 7.18e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153792305  166 QSLECLYLGGNFIKEIPPE-LGNLPSLNYLVLCDNKIQSIPPQ-LSQLHSLRSLSLHNNLL 224
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-247 6.63e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 6.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  65 SGFPHLQLLDVSGNaltalgPELLALRGLRTLLAKNNRLggpSALPKGLAQsplCRSLQVLNLSGNCFQEVPASLLELRA 144
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQL---TDLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 145 LQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180
                 ....*....|....*....|...
gi 153792305 225 TYLPrEILNLIHLEELSLRGNPL 247
Cdd:COG4886  241 TDLP-ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-295 1.04e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 129.28  E-value: 1.04e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  53 HNRLVSLPRALGSgFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLggpSALPKGLAQsplCRSLQVLNLSGNCF 132
Cdd:COG4886  122 GNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQL---TDLPEELGN---LTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 133 QEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPpELGNLPSLNYLVLCDNKIQSIPPqLSQLH 212
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLT 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 213 SLRSLSLHNNLLTylpreILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGS 292
Cdd:COG4886  273 NLKTLDLSNNQLT-----DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347


                 ...
gi 153792305 293 ASN 295
Cdd:COG4886  348 ALL 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
125-247 1.02e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 125 LNLSGNCFQEVPASLLELRALQTLSLGGNQlqsipaEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSI 204
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 153792305 205 PPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-247 1.61e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.21  E-value: 1.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  66 GFPHLQLLDVSGNALTALGPE--LLALRGLRTLLAKNNRLGGPsaLPKG---------LAQSPLC----------RSLQV 124
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGS--IPRGsipnletldLSNNMLSgeipndigsfSSLKV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 125 LNLSGNCFQ-EVPASLLELRALQTLSLGGNQLQ-SIPAEIENLQSLECLYLG-GNFIKEIPPELGNLPSLNYLVLC-DNK 200
Cdd:PLN00113 169 LDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHLDLVyNNL 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 153792305 201 IQSIPPQLSQLHSLRSLSLHNNLLT-YLPREILNLIHLEELSLRGNPL 247
Cdd:PLN00113 249 TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 67-247 8.40e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.20  E-value: 8.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  67 FPHLQLLDVSGNALTA-LGPELLALRGLRTLLAKNNRLGGPsaLPKGLaqSPLCRSLQVLNLSGNCFQ-EVPASLLELra 144
Cdd:PLN00113  68 SSRVVSIDLSGKNISGkISSAIFRLPYIQTINLSNNQLSGP--IPDDI--FTTSSSLRYLNLSNNNFTgSIPRGSIPN-- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 145 LQTLSLGGNQLQ-SIPAEIENLQSLECLYLGGNFIK-EIPPELGNLPSLNYLVLCDNK-IQSIPPQLSQLHSLRSLSL-H 220
Cdd:PLN00113 142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLgY 221

                        170       180
                 ....*....|....*....|....*..
gi 153792305 221 NNLLTYLPREILNLIHLEELSLRGNPL 247
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNL 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
139-247 3.28e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 139 LLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNfikeipPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLS 218
Cdd:COG4886   69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELD 142

                         90       100
                 ....*....|....*....|....*....
gi 153792305 219 LHNNLLTYLPREILNLIHLEELSLRGNPL 247
Cdd:COG4886  143 LSNNQLTDLPEPLGNLTNLKSLDLSNNQL 171
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 118-247 9.18e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 9.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 118 LCRSLQVLNLSGNCFQEVPaSLLELRALQTLSLGGNQLQSIPaEIENLQSLECLYLGGNFIKEI---------------- 181
Cdd:cd21340   22 LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVeglenltnleelhien 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 182 ---PPE----------LGNLPSLNYLVLCDNKIQSIPPqLSQLHSLRSLSLHNNLLTYLpREILNLI----HLEELSLRG 244
Cdd:cd21340  100 qrlPPGekltfdprslAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL-EELLDLLsswpSLRELDLTG 177


                 ...
gi 153792305 245 NPL 247
Cdd:cd21340  178 NPV 180
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
52-259 2.41e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.18  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  52 PHNRLVSLPrALGsgfPHLQLLDVSGNALTALgPELLAlrGLRTLLAKNNRLGGPSALPKGLAQ-----------SPLCR 120
Cdd:PRK15387 230 PDNNLTSLP-ALP---PELRTLEVSGNQLTSL-PVLPP--GLLELSIFSNPLTHLPALPSGLCKlwifgnqltslPVLPP 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 121 SLQVLNLSGNCFQEVPASLLEL-----------------RALQTLSLGGNQLQSIP---AEIENL--------------Q 166
Cdd:PRK15387 303 GLQELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLASLPtlpSELYKLwaynnrltslpalpS 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 167 SLECLYLGGNFIKEIPPelgnLPS-LNYLVLCDNKIQSIPPQLSqlhSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN 245
Cdd:PRK15387 383 GLKELIVSGNRLTSLPV----LPSeLKELMVSGNRLTSLPMLPS---GLLSLSVYRNQLTRLPESLIHLSSETTVNLEGN 455

                        250
                 ....*....|....*..
gi 153792305 246 PL---VVRFVRDLTYDP 259
Cdd:PRK15387 456 PLserTLQALREITSAP 472
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-272 7.80e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 7.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  53 HNRLVSLPRALGsGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLggpSALPkGLAQSPlcrSLQVLNLSGNCF 132
Cdd:COG4886  191 NNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLP-ELGNLT---NLEELDLSNNQL 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 133 QEVPaSLLELRALQTLSLGGNQLQSIpaEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLH 212
Cdd:COG4886  263 TDLP-PLANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 213 SLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKI 272
Cdd:COG4886  340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-295 1.08e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.18  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  54 NRLVSLPRALGSgfpHLQLLDVSGNALTALgPELLALRGLRTLLAKNNRLGGPSALPKglaqsplcrSLQVLNLSGNCFQ 133
Cdd:PRK15370 209 NELKSLPENLQG---NIKTLYANSNQLTSI-PATLPDTIQEMELSINRITELPERLPS---------ALQSLDLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 134 EVPASLLElrALQTLSLGGNQLQSIPAEIENlqSLECLYLGGNFIKEIPPELGnlPSLNYLVLCDNKIQSIPPQLSQlhS 213
Cdd:PRK15370 276 CLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPP--E 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 214 LRSLSLHNNLLTYLPREIlnlihleelslrgnplvvrfvrdltydPPTLLELAARTIKIRNIsytPYDLPGnLLRYLGSA 293
Cdd:PRK15370 348 LQVLDVSKNQITVLPETL---------------------------PPTITTLDVSRNALTNL---PENLPA-ALQIMQAS 396


                 ..
gi 153792305 294 SN 295
Cdd:PRK15370 397 RN 398
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-213 1.30e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  53 HNRLVSLPRALGSGfphLQLLDVSGNALTALgPELLAlRGLRTLLAKNNRLGG-PSALPKGlaqsplcrsLQVLNLSGNC 131
Cdd:PRK15370 271 HNKISCLPENLPEE---LRYLSVYDNSIRTL-PAHLP-SGITHLNVQSNSLTAlPETLPPG---------LKTLEAGENA 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 132 FQEVPASLLElrALQTLSLGGNQLQSIPAEIEnlQSLECLYLGGNFIKEIPPelgNLP-SLNYLVLCDNKIQSIPPQLSQ 210
Cdd:PRK15370 337 LTSLPASLPP--ELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE---NLPaALQIMQASRNNLVRLPESLPH 409


                 ...
gi 153792305 211 LHS 213
Cdd:PRK15370 410 FRG 412
PLN03150 PLN03150
hypothetical protein; Provisional
 158-225 3.35e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.29  E-value: 3.35e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 158 IPAEIENLQSLECLYLGGNFIK-EIPPELGNLPSLNYLVLCDNKIQ-SIPPQLSQLHSLRSLSLHNNLLT 225
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-266 6.07e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 6.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  58 SLPRALGSgFPHLQLLDVSGNALTA-LGPELLALRGLRTLLAKNNRLGGpsALPKGLAQsplCRSLQVLNLSGNCFQ-EV 135
Cdd:PLN00113 251 PIPSSLGN-LKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSG--EIPELVIQ---LQNLEILHLFSNNFTgKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 136 PASLLELRALQTLSLGGNQLQ-SIPAEIENLQSLECLYLGGNFIK-EIPPELGNLPSLNYLVLCDNKIQS-IPPQLSQLH 212
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACR 404

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153792305 213 SLRSLSLHNNLLT-YLPREILNLIHLEELSLRGNPLVVRfVRDLTYDPPTL--LELA 266
Cdd:PLN00113 405 SLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQGR-INSRKWDMPSLqmLSLA 460
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-224 1.32e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  63 LGSGFPHLQL---LDVSGNALTA-LGPELLALRGLRTL-LAKNNRLGGpsalpkgLAQSPLCRSLQVLNLSGNCFQE-VP 136
Cdd:PLN00113 420 LPSEFTKLPLvyfLDISNNNLQGrINSRKWDMPSLQMLsLARNKFFGG-------LPDSFGSKRLENLDLSRNQFSGaVP 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 137 ASLLELRALQTLSLGGNQLQS-IPAEIENLQSLECLYLGGN-FIKEIPPELGNLPSLNYLVLCDNKIQ-SIPPQLSQLHS 213
Cdd:PLN00113 493 RKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNqLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVES 572

                        170
                 ....*....|.
gi 153792305 214 LRSLSLHNNLL 224
Cdd:PLN00113 573 LVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-247 1.70e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  59 LPRALGSGfPHLQLLDVSGNALTALGPELLALRG-LRTLLAKNNRLGGpsALPKGLAQsplCRSLQVLNLSGNCFQ-EVP 136
Cdd:PLN00113 348 IPKNLGKH-NNLTVLDLSTNNLTGEIPEGLCSSGnLFKLILFSNSLEG--EIPKSLGA---CRSLRRVRLQDNSFSgELP 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 137 ASLLELRALQTLSLGGNQLQ-SIPAEIENLQSLECLYLGGN------------------------FIKEIPPELGNLPSL 191
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNkffgglpdsfgskrlenldlsrnqFSGAVPRKLGSLSEL 501

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 153792305 192 NYLVLCDNKIQS-IPPQLSQLHSLRSLSL-HNNLLTYLPREILNLIHLEELSLRGNPL 247
Cdd:PLN00113 502 MQLKLSENKLSGeIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 52-242 1.79e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 56.42  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305   52 PHN-RLVSLP----RALGSGF--PHLQLLDVSGNALTALGPELLALRGLRTLlaknnRLGGPSALpKGLAQSPLCRSLQV 124
Cdd:PLN03210  588 PPKlRLLRWDkyplRCMPSNFrpENLVKLQMQGSKLEKLWDGVHSLTGLRNI-----DLRGSKNL-KEIPDLSMATNLET 661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  125 LNLSgNC--FQEVPASLLELRALQTLSLGG-NQLQSIPAEIeNLQSLECL---------------------YLGGNFIKE 180
Cdd:PLN03210  662 LKLS-DCssLVELPSSIQYLNKLEDLDMSRcENLEILPTGI-NLKSLYRLnlsgcsrlksfpdistniswlDLDETAIEE 739

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153792305  181 IPPELgNLPSLNYLVLCDNK-------IQSIPPQLSQL-HSLRSLSLHNN-LLTYLPREILNLIHLEELSL 242
Cdd:PLN03210  740 FPSNL-RLENLDELILCEMKseklwerVQPLTPLMTMLsPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEI 809
LRR_8 pfam13855
Leucine rich repeat;
166-224 7.18e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153792305  166 QSLECLYLGGNFIKEIPPE-LGNLPSLNYLVLCDNKIQSIPPQ-LSQLHSLRSLSLHNNLL 224
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
189-247 7.54e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153792305  189 PSLNYLVLCDNKIQSIPPQ-LSQLHSLRSLSLHNNLLTYL-PREILNLIHLEELSLRGNPL 247
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 120-189 2.47e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 2.47e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153792305 120 RSLQVLNLSGNCFQ-EVPASLLELRALQTLSLGGNQLQ-SIPAEIENLQSLECLYLGGNFIK-EIPPELGNLP 189
Cdd:PLN03150 442 RHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-276 4.04e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 142 LRALQTLSLGGNQLQSIPaEIENLQSLECLYLGGNFIKEIPPeLGNLPSLNYLVLCDNKIQSIPPqLSQLHSLRSLSLHN 221
Cdd:cd21340    1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGG 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153792305 222 NLLTYLprEIL-NLIHLEELSL------RGNPlvvrfvrdLTYDPPTLLELaARTIKIRNIS 276
Cdd:cd21340   78 NRISVV--EGLeNLTNLEELHIenqrlpPGEK--------LTFDPRSLAAL-SNSLRVLNIS 128
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-206 4.45e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 4.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  68 PHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGpsALPKGLAQSPlcrSLQVLNLSGNCFQ-EVPASLLELRALQ 146
Cdd:PLN00113 452 PSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSG--AVPRKLGSLS---ELMQLKLSENKLSgEIPDELSSCKKLV 526

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153792305 147 TLSLGGNQLQ-SIPAEIENLQSLECLYLGGNFIK-EIPPELGNLPSLNYLVLCDNKIQ-SIPP 206
Cdd:PLN00113 527 SLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPS 589
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-247 5.27e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 5.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305 136 PASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKiqsippQLSQLHSLR 215
Cdd:COG4886   43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLE 116

                         90       100       110
                 ....*....|....*....|....*....|..
gi 153792305 216 SLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQL 148
LRR_8 pfam13855
Leucine rich repeat;
143-201 2.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153792305  143 RALQTLSLGGNQLQSIPAEI-ENLQSLECLYLGGNFIKEIPPE-LGNLPSLNYLVLCDNKI 201
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-132 7.03e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 7.03e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153792305  60 PRALGSGFPHLQLLDVSGNALTALGPeLLALRGLRTLLAKNNRLGGPSALpKGLAQSplCRSLQVLNLSGNCF 132
Cdd:cd21340  112 PRSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEEL-LDLLSS--WPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
53-103 1.76e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 153792305   53 HNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLA-LRGLRTLLAKNNRL 103
Cdd:pfam13855  10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 83-162 4.61e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  83 LGPELLALRGLRTLLAKNNRLGGpsALPKGLAQSPlcrSLQVLNLSGNCFQ-EVPASLLELRALQTLSLGGNQLQS-IPA 160
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIPPSLGSIT---SLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPA 508


                 ..
gi 153792305 161 EI 162
Cdd:PLN03150 509 AL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 59-179 5.67e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 5.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  59 LPRALGSGFPHLQLLDVSGNALT-----ALGPELLALRGLRTLLAKNNRLGGP--SALPKGLAQSPlcrSLQVLNLSGNC 131
Cdd:cd00116  128 LAKGLKDLPPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIGDAgiRALAEGLKANC---NLEVLDLNNNG 204

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 153792305 132 FQEVPASLLE-----LRALQTLSLGGNQLQSI------PAEIENLQSLECLYLGGNFIK 179
Cdd:cd00116  205 LTDEGASALAetlasLKSLEVLNLGDNNLTDAgaaalaSALLSPNISLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
120-176 7.03e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 7.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 153792305  120 RSLQVLNLSGNCFQEVPASLLE-LRALQTLSLGGNQLQSI-PAEIENLQSLECLYLGGN 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 65-139 1.66e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 1.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153792305  65 SGFPHLQLLDVSGNALT-ALGPELLALRGLRTLLAKNNRLGGpsALPKGLAQsplCRSLQVLNLSGNCFQ-EVPASL 139
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNG--SIPESLGQ---LTSLRILNLNGNSLSgRVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
91-155 2.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 153792305   91 RGLRTLLAKNNRLggpSALPKGLAQSplCRSLQVLNLSGNCFQEV-PASLLELRALQTLSLGGNQL 155
Cdd:pfam13855   1 PNLRSLDLSNNRL---TSLDDGAFKG--LSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 189-222 3.14e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 153792305  189 PSLNYLVLCDNKIQSIPPqLSQLHSLRSLSLHNN 222
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-222 3.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792305  88 LALRGLRTLLAKNNRLG--GPSALPKGLAQSPLCRSLQvlnLSGNCFQEVPAS-----LLELRALQTLSLGGNQL--QSI 158
Cdd:COG5238  177 LQNNSVETVYLGCNQIGdeGIEELAEALTQNTTVTTLW---LKRNPIGDEGAEilaeaLKGNKSLTTLDLSNNQIgdEGV 253

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153792305 159 PAEIENLQ---SLECLYLGGNFIKE-----IPPELGNLPSLNYLVLCDNKI-----QSIPPQLSQLHSLRSLSLHNN 222
Cdd:COG5238  254 IALAEALKnntTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYN 330
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 166-206 6.65e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 6.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 153792305  166 QSLECLYLGGNFIKEIPPeLGNLPSLNYLVLCDN-KIQSIPP 206
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNnKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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