BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  14 VHSDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEF 93
Cdd:cd18212     1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMVAETFGALLEF 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2000185999  94 IYTGYLHASEKMTEQILATAQFLKVYDLVKAYTDFQN 130
Cdd:cd18212    81 IYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDYQN 117

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2000185999 295 CKDCDRVFKYSHFLAIHQR-RHtgerpFKCSECGKGFAQKHSLQVH 339
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  14 VHSDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEF 93
Cdd:cd18212     1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMVAETFGALLEF 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2000185999  94 IYTGYLHASEKMTEQILATAQFLKVYDLVKAYTDFQN 130
Cdd:cd18212    81 IYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDYQN 117

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999   38 DITLIVENVHFRAHKALLAASSEYFSMMFAEE-GEIGQSIYMLEGMVADTFGILLEFIYTGYLHASEKMTEQILATAQFL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 2000185999  117 KVYDLVKAYTDFQNSH 132
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 2000185999 420 LKKHLRTHTGEKPFTCEICGKSFT 443
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2000185999 295 CKDCDRVFKYSHFLAIHQR-RHtgerpFKCSECGKGFAQKHSLQVH 339
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 2000185999 477 RRHCVLHTGKKPFSCPECSLQFAR 500
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  14 VHSDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEF 93
Cdd:cd18212     1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMVAETFGALLEF 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2000185999  94 IYTGYLHASEKMTEQILATAQFLKVYDLVKAYTDFQN 130
Cdd:cd18212    81 IYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDYQN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEgeigQSIYMLEGMVADTFGILLEFIYTGY 98
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ----KDVVHLDISNAAGLGQVLEFMYTAK 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2000185999  99 LHASEKMTEQILATAQFLKVYDLVKAYTDFQN 130
Cdd:cd18206    81 LSLSPENVDDVLAVATFLQMQDIVTACHALKS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  36 LCDITLIVENVHFRAHKALLAASSEYFSMMF-AEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHASEKMTEQILATAQ 114
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFsSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                  ..
gi 2000185999 115 FL 116
Cdd:cd18186    81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  13 IVHSDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLE 92
Cdd:cd18278     8 VYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTARGFGPLLQ 87

                          90       100
                  ....*....|....*....|....*....
gi 2000185999  93 FIYTGYLHASEKMTEQILATAQFLKVYDL 121
Cdd:cd18278    88 FAYTAKLLLSRENIQEVIRCAEFLRMHNL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMV-ADTFGILLEFIYTG 97
Cdd:cd18194     6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVtAPAFGLLLDFMYEG 85

                          90       100
                  ....*....|....*....|....*.
gi 2000185999  98 YLHASEKMTEQILATAQFLKVYDLVK 123
Cdd:cd18194    86 RLALRDLPVEDVLAAASYLHMYDIVK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMV-ADTFGILLEFIYTG 97
Cdd:cd18324     6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVtAPAFALLLEFMYEG 85

                          90       100
                  ....*....|....*....|....*.
gi 2000185999  98 YLHASEKMTEQILATAQFLKVYDLVK 123
Cdd:cd18324    86 KLQFKDLPIEDVLAAASYLHMYDIVK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  18 THSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVadtFGILLEFIYTG 97
Cdd:cd18334     3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTV---FRQILDFIYTG 79

                          90       100
                  ....*....|....*....|....*...
gi 2000185999  98 YLHASEKMTEQ----ILATAQFLKVYDL 121
Cdd:cd18334    80 KLLTSDQPGEQnfnaLLTAASYLQLHDL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIG-QSIYMLEGMVADTFGILLEFIYTG 97
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDqQNVYEIDFVSAEALTALLDFAYTA 87

                          90       100
                  ....*....|....*....|.
gi 2000185999  98 YLHASEKMTEQILATAQFLKV 118
Cdd:cd18326    88 TLTVSTSNVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  16 SDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIY 95
Cdd:cd18277     7 SSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEPLIQFAY 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2000185999  96 TGYLHASEKMTEQILATAQFLKVYDLVKAYTDF 128
Cdd:cd18277    87 TAKLILSKDNVDEVCKCVEFLSVHNIEESCFQF 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEI-GQSIYMLEGMVADTFGILLEFIYTG 97
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGeSILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2000185999  98 YLHASEKMTEQILATAQFLKVYDLVKAYTDFQNSHNSPKppalNC 142
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ----NC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQS-IYMLEGMVADTFGILLEFIYTG 97
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISShVLELPDLKAEVFAEILNFIYSS 80

                          90
                  ....*....|....*.
gi 2000185999  98 YLHASEKMTEQILATA 113
Cdd:cd18223    81 KVVVKRQETVTDLVAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMV-ADTFGILLEFIYTG 97
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIePEGFRILLDFMYTS 81

                          90       100
                  ....*....|....*....|....*..
gi 2000185999  98 YLHASEKMTEQILATAQFLKVYDLVKA 124
Cdd:cd18215    82 RLNLREGNIMAVMATAMYLQMEHVVDT 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  11 HLIVHSDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEG-EIGQSIYMLEGMVADTFGI 89
Cdd:cd18264     3 YFLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTqESKARVIHLPVVSAAGLQR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2000185999  90 LLEFIYTGYLHASEKMTEQILATAQFLKVYDLVKAYTDFQNSHNSPKppalNC 142
Cdd:cd18264    83 VLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPE----NC 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFaeeGEIGQSIYMLEGMVADTFGILLEFIYTGY 98
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY---GDGTSGSVVLPESFAEVFGLLLDFFYTGE 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2000185999  99 LHASEKMTEQILATAQFLKVYDLVKAYTDFQ 129
Cdd:cd18232    78 LALTRENRDRVLLAAKELRVPEAVELCQRFQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  18 THSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVadtFGILLEFIYTG 97
Cdd:cd18216     2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLDQDMVSPTV---FQQILDFIYTG 78

                          90       100
                  ....*....|....*....|....*...
gi 2000185999  98 YLHAS---EKMTEQILATAQFLKVYDLV 122
Cdd:cd18216    79 KLLDSlfeEPNLSEVLAAANYLQLPDLA 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  36 LCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHASEKMTEQILATAQF 115
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ...
gi 2000185999 116 LKV 118
Cdd:cd18315    81 LQI 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  16 SDTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMF-AEEGEIGQSIYMLEGMVADTFGILLEFI 94
Cdd:cd18244    10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFtADMRERDQDKIHLKGLTATGFSHVLQFM 89

                          90       100
                  ....*....|....*....|....*....
gi 2000185999  95 YTGYLHASEKMTEQILATAQFLKVYDLVK 123
Cdd:cd18244    90 YYGTIELSMLTVHEILQAAMYVQLTEVVK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  21 DTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEgeiGQSIYMLEGMVADT-FGILLEFIYTGYL 99
Cdd:cd18289    14 NTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPATVPPAcFQQILSFCYTGKL 90

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2000185999 100 --HASEKMTeqILATAQFLKVYDLVKAYTDFQNSHNSP 135
Cdd:cd18289    91 tmAASEQLV--VMYTAGFLQIQHIVERGTDLMFKVSSP 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMF-AEEGEIGQSIYMLEGMVADTFGILLEFIYTG 97
Cdd:cd18235     4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFtGDLSESRANRVTLQDVDGKALLLLIDYVYTA 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2000185999  98 YLHASEKMTEQILATAQFLKVYDLVKAYTDFQNSHNSP 135
Cdd:cd18235    84 EIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  20 SDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMF-AEEGEIGQSIYMLEGMVADTFGILLEFIYTGY 98
Cdd:cd18240     1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFtNGWNETEKKVYKIPGVSPEMMELIIEYAYTRT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2000185999  99 LHASEKMTEQILATA-QFLkVYDLVKAYTDFQNSHNSPKppalNC 142
Cdd:cd18240    81 VPITAENVEELLPAAdQFN-IMGIVKACCDFLEDQLCPE----NC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQsiymLEGMVADTFGILLEFIYTGY 98
Cdd:cd18219     4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVE----LNFIRADIFAEILNYIYSSK 79

                          90       100
                  ....*....|....*....|.
gi 2000185999  99 L-HASEKMTEQILATAQFLKV 118
Cdd:cd18219    80 IvRVRSDLLEELIKSGQLLGV 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000185999  19 HSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEigQSIYMLEGMVADTFGILLEFIYTGY 98
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQ--EPLVEIEGVSNMAFRHLIEFTYTAK 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2000185999  99 LHA-SEKMTEQILATAQFLKVYDLVKAYtDFQNSHN 133
Cdd:cd18221    79 LMVqGEEEANDVWKAAEYLQMQEAIKAL-EFRNKES 113