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Conserved domains on  [gi|307611943|ref|NP_001091984|]
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UPF0764 protein C16orf89 isoform 2 precursor [Homo sapiens]

Protein Classification

DUF4735 domain-containing protein( domain architecture ID 11239535)

DUF4735 domain-containing protein similar to Homo sapiens UPF0764 protein C16orf89

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4735 pfam15882
Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. ...
60-340 1.62e-134

Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.


:

Pssm-ID: 464922  Cd Length: 283  Bit Score: 384.78  E-value: 1.62e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943   60 DGMVGVRVLEEQLKSVREKWAQE-PLLQPLSLRVGMLGEKLEAAIQRSLHYLKLSDPKYLREFQLTLQPGfWKLPHAWIH 138
Cdd:pfam15882   1 DGVFGLRVLEGQLRAILEEWEALsPLSQQQLDRIKQLSKRLSALIDKALPYLAKSDPKYYREFGPLLQPP-WKLPHQWRK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943  139 TDASLVYPTFGPQDSFSEERSDVCLVQLLGTGTDSSEPCGLSDLCRSLMTKPGCSGYCLSHQLLFFLWARMRGCT---QG 215
Cdd:pfam15882  80 TDPSLVYSYPEPVDSFSEEISDKCLAELLGTGNDGGPPCTISDECWDLMTQPGTSGYSLTHQLLYFLLGRMLGCTeklDK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943  216 PLQQS-----QDYINLFCANMMDLNRRAEAIGYAYPTRDIFMENIMFCGMGGFSDFYKLRWLEAILSWQKQQEGCFGEPD 290
Cdd:pfam15882 160 YLLASklggvQDLQEIFCSNIYKEMELLEKNGFPIQTQDLFLEQIVVCGMAGFSDFYKPDWLQMILSWQDPESGCFGKPA 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 307611943  291 aedeelSKAIQYQQHFSRRVKRREKQFPDGCSSHNTATAVAALGGFLYIL 340
Cdd:pfam15882 240 ------ETEGESRSSPLSRVKRREKTLTDGCSSHKTAVAVAALAGFLRWL 283
 
Name Accession Description Interval E-value
DUF4735 pfam15882
Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. ...
60-340 1.62e-134

Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.


Pssm-ID: 464922  Cd Length: 283  Bit Score: 384.78  E-value: 1.62e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943   60 DGMVGVRVLEEQLKSVREKWAQE-PLLQPLSLRVGMLGEKLEAAIQRSLHYLKLSDPKYLREFQLTLQPGfWKLPHAWIH 138
Cdd:pfam15882   1 DGVFGLRVLEGQLRAILEEWEALsPLSQQQLDRIKQLSKRLSALIDKALPYLAKSDPKYYREFGPLLQPP-WKLPHQWRK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943  139 TDASLVYPTFGPQDSFSEERSDVCLVQLLGTGTDSSEPCGLSDLCRSLMTKPGCSGYCLSHQLLFFLWARMRGCT---QG 215
Cdd:pfam15882  80 TDPSLVYSYPEPVDSFSEEISDKCLAELLGTGNDGGPPCTISDECWDLMTQPGTSGYSLTHQLLYFLLGRMLGCTeklDK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943  216 PLQQS-----QDYINLFCANMMDLNRRAEAIGYAYPTRDIFMENIMFCGMGGFSDFYKLRWLEAILSWQKQQEGCFGEPD 290
Cdd:pfam15882 160 YLLASklggvQDLQEIFCSNIYKEMELLEKNGFPIQTQDLFLEQIVVCGMAGFSDFYKPDWLQMILSWQDPESGCFGKPA 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 307611943  291 aedeelSKAIQYQQHFSRRVKRREKQFPDGCSSHNTATAVAALGGFLYIL 340
Cdd:pfam15882 240 ------ETEGESRSSPLSRVKRREKTLTDGCSSHKTAVAVAALAGFLRWL 283
 
Name Accession Description Interval E-value
DUF4735 pfam15882
Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. ...
60-340 1.62e-134

Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.


Pssm-ID: 464922  Cd Length: 283  Bit Score: 384.78  E-value: 1.62e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943   60 DGMVGVRVLEEQLKSVREKWAQE-PLLQPLSLRVGMLGEKLEAAIQRSLHYLKLSDPKYLREFQLTLQPGfWKLPHAWIH 138
Cdd:pfam15882   1 DGVFGLRVLEGQLRAILEEWEALsPLSQQQLDRIKQLSKRLSALIDKALPYLAKSDPKYYREFGPLLQPP-WKLPHQWRK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943  139 TDASLVYPTFGPQDSFSEERSDVCLVQLLGTGTDSSEPCGLSDLCRSLMTKPGCSGYCLSHQLLFFLWARMRGCT---QG 215
Cdd:pfam15882  80 TDPSLVYSYPEPVDSFSEEISDKCLAELLGTGNDGGPPCTISDECWDLMTQPGTSGYSLTHQLLYFLLGRMLGCTeklDK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307611943  216 PLQQS-----QDYINLFCANMMDLNRRAEAIGYAYPTRDIFMENIMFCGMGGFSDFYKLRWLEAILSWQKQQEGCFGEPD 290
Cdd:pfam15882 160 YLLASklggvQDLQEIFCSNIYKEMELLEKNGFPIQTQDLFLEQIVVCGMAGFSDFYKPDWLQMILSWQDPESGCFGKPA 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 307611943  291 aedeelSKAIQYQQHFSRRVKRREKQFPDGCSSHNTATAVAALGGFLYIL 340
Cdd:pfam15882 240 ------ETEGESRSSPLSRVKRREKTLTDGCSSHKTAVAVAALAGFLRWL 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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