|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
42-482 |
7.26e-158 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 453.61 E-value: 7.26e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 42 ALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSevlpvdsfgglskAPKSLPAKAPVYDWSPQIQGIIFGAVGY 121
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 122 GGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSR 201
Cdd:cd17318 68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 202 LCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIyddpvsypwistsekeyiisslkqqvgss 281
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 282 kqplpikamlrsLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKK 361
Cdd:cd17318 199 ------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 362 -FRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIA 440
Cdd:cd17318 267 iLSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 148743791 441 PVIVPTVSGFLLSQD-PEFGWRNVFFLLFAVNLLGLLFYLIFG 482
Cdd:cd17318 347 GIISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
23-497 |
4.22e-139 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 408.75 E-value: 4.22e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 23 DETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPqSQLNDSSEVLPVDSfgglskapkslpAKA 102
Cdd:TIGR00894 2 ENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENS-TDLACLSAENELDN------------IKN 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 103 PVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVTRIVQGLSQSSI 182
Cdd:TIGR00894 69 PNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 183 LGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISET-LGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPW 261
Cdd:TIGR00894 149 SPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 262 ISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFI 341
Cdd:TIGR00894 229 ISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 342 VAWVIGMVGGYLADFLLTKK-FRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLD 420
Cdd:TIGR00894 309 FAWLCSIFAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLD 388
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148743791 421 IAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTR 497
Cdd:TIGR00894 389 LAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
41-482 |
3.44e-86 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 270.50 E-value: 3.44e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 41 IALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQlNDSSEVLPVDSFGGLSKAPKSlpakAPVYDWSPQIQGIIFGAVG 120
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPS-NNSSNACPEHSSSPSVEHNET----GKKYDWDAETQGWILGSFF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 121 YGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERS 200
Cdd:cd17381 76 YGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 201 RLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIyddpvsypwistsekeyiisslkqqvgs 280
Cdd:cd17381 156 RLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV---------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 281 skqplpikamlrsLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTK 360
Cdd:cd17381 208 -------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREK 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 361 K-FRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSI 439
Cdd:cd17381 275 QnFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATI 354
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 148743791 440 APVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFG 482
Cdd:cd17381 355 PGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
105-482 |
7.51e-67 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 219.35 E-value: 7.51e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 105 YDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILG 184
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 185 GQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIyddpvsypwist 264
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 265 sekeyiisslkqqvgsskqplpikamlrsLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYhVNIRDNGLLSALPFIVAW 344
Cdd:cd17380 177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 345 VIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSgYITATALLTLSCGLSTLCQSGIYINVLDIAPR 424
Cdd:cd17380 227 PSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDS-FSLALLCMSVALGLSAFSSSGVLVNHQDIAPN 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 425 YSSFLMGASRGFSSIAPVIVPTVSGFLLSQdpeFG-WRNVFFLLFAVNLLGLLFYLIFG 482
Cdd:cd17380 306 YAGIVFGISNTAGTIPGIVGVYLTGYILEA---TGsWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
103-482 |
2.57e-62 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 207.96 E-value: 2.57e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 103 PVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVTRIVQGLSQSSI 182
Cdd:cd17382 42 AEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVT 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 183 LGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWfvviyddpvsypwi 262
Cdd:cd17382 122 YPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW-------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 263 stsekeyiisslkqqvgsskqplpikaMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIV 342
Cdd:cd17382 188 ---------------------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 343 AWVIGMVGGYLADFLLTKKFRLIT-VRKIATILGSLPSSALIVSLPYLNSgYITATALLTLSCGLSTLCQSGIYINVLDI 421
Cdd:cd17382 241 MTIIVPIGGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFSHS-PTVAISFLVLAVGFSGFAISGFNVNHLDI 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148743791 422 APRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFG 482
Cdd:cd17382 320 APRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
105-482 |
4.50e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 128.83 E-value: 4.50e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 105 YDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSSILG 184
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFW--QLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 185 GQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGcvccLLWFVviyddpvsypwist 264
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG----LLLAL-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 265 sekeyiisslkqqvgsskqplpikamlrsLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAW 344
Cdd:COG2271 180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 345 VIGMVGGYLADflltkkfRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLcQSGIYINVLDIAP- 423
Cdd:COG2271 231 VGSLLGGWLSD-------RLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA-FGLLWALAAELFPk 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 424 RYSSFLMGASRGFSSIAPVIVPTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLFYLIFG 482
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
107-480 |
4.87e-31 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 123.06 E-value: 4.87e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 107 WSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFgiVLLIVTRIVQGLSQSSILGGQ 186
Cdd:cd17319 35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL--TSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 187 FAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDdpvsypwistse 266
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 267 keyiisslkqqvgsskqplpikamlrslpIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVI 346
Cdd:cd17319 181 -----------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 347 GMVGGYLADFLLTKKfrlitvRKIATILGSLPSSALIVSLPYLNSGYITAtALLTLSCGLSTLCQSGIYINVLDIAPR-Y 425
Cdd:cd17319 232 MILGGRLSDRLLRGA------RRLVIIIGLLLAAVGLLLAYLTTSPVVAV-ILLSLAGFGIGAASPVFWSLPADLLPGeA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 148743791 426 SSFLMGASRGFSSIAPVIVPTVSGFLLsqDPEFGWRNVFFLLFAVNLLGLLFYLI 480
Cdd:cd17319 305 AATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
113-481 |
3.80e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.59 E-value: 3.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFgiVLLIVTRIVQGLSQSSILGGQFAIWEK 192
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--WQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 193 WGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIyddpvsypwistseKEYIIS 272
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL--------------PEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 273 SLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGY 352
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 353 LADflltkkfrliTVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYS-SFLMG 431
Cdd:cd17325 258 LSD----------RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMG 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 148743791 432 ASRGFSSIAPVIVPTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:cd17325 328 LFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
105-445 |
1.35e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.50 E-value: 1.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 105 YDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATdfGIVLLIVTRIVQGLSQSSILG 184
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 185 GQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVViydDPVSYPWIST 264
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP---RPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 265 SEKEYIISSLkqqvgsskqpLPIKAMLRSLPIWSIcLGCFSHQWLVSTMVVYIPTYIsSVYHVNIRDNGLLSALPFIVAW 344
Cdd:pfam07690 182 PAEEARLSLI----------VAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 345 VIGMVGGYLADFLLTKKfrlitvRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPR 424
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRR------RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
330 340
....*....|....*....|.
gi 148743791 425 YSSFLMGASRGFSSIAPVIVP 445
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
104-479 |
7.50e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.89 E-value: 7.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSSIL 183
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW--LLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 184 GGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISE--TLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSypw 261
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPES--- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 262 istsekeyiISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSalpfI 341
Cdd:cd06174 180 ---------ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL----S 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 342 VAWVIGMVGGYLADFLLTKKFRlitvRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDI 421
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRLIG----RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 148743791 422 APRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDpeFGWRNVFFLLFAVNLLGLLFYL 479
Cdd:cd06174 323 PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
98-440 |
4.71e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.27 E-value: 4.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 98 LPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGL 177
Cdd:COG2814 33 LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW--LLLAARFLQGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 178 SQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIyddPV 257
Cdd:COG2814 111 GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 258 SYPWISTSEKEyiisslkqqvgsskqplPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSA 337
Cdd:COG2814 188 SRPAARARLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 338 LPFIVAWVIGMVGGYLADFLLTKKfrlitvrkiaTILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYIN 417
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRR----------LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|....*...
gi 148743791 418 VLDIAP-----RYSSFLMGASRGFSSIA 440
Cdd:COG2814 321 VAELAPpeargRASGLYNSAFFLGGPLA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
105-481 |
2.15e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.02 E-value: 2.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 105 YDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSqssiLG 184
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYW--LLLLLGLLLGIG----GG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 185 GQFAIW----EKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYP 260
Cdd:COG2223 109 GSFAVGialvSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 261 wistsekeyiisslkqqVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPF 340
Cdd:COG2223 189 -----------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 341 IVAWVIGMVGGYLADFLLTKKFRLITVrkIATILGSLPSSALIVSLPylnsGYITATALLTLSCGLSTlcqSGIYINVLD 420
Cdd:COG2223 252 LLGALGRPLGGWLSDRIGGRRVLLIVF--ALMALGLLLLALALGSLW----LFLVLFLLLGLALGGGN---GAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148743791 421 IAP-RYSSFLMGASRGFSSIAPVIVPTVSGFLLsqDPEFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:COG2223 323 IFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
113-479 |
4.37e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 4.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSSILGGQFAIWEK 192
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--LLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 193 WGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVC-CLLWFVViyddPvsypwistsekeyii 271
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAaLLLWRLL----P--------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 272 SSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGG 351
Cdd:cd17324 176 SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 352 YLADFLLTKkfrlitvrkiATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMG 431
Cdd:cd17324 256 RLADRGGRR----------ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 148743791 432 ASRGFSSIAPVIVPTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLFYL 479
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
113-477 |
3.24e-18 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 86.14 E-value: 3.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSIL-GGQFAIWE 191
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL--FLVGAGYGSVQpGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 192 kWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFyIFGGVGCVCCLLWFVVIYDDPVsypwistsekeyiI 271
Cdd:cd17475 112 -WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF-VVAGLVSILAAVLFWLFYREPP-------------A 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 272 SSLKQQVGSSKQPLpIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGG 351
Cdd:cd17475 177 ASAATESASTLLRS-LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 352 YLADFLLTKKFRLITVrkIATILGSLPSsaLIVSLPYLNSGYITATALLTLScGLSTLCQSGIYIN-VLDIAP-RYSSFL 429
Cdd:cd17475 256 RVSDRVFGGRRRPVLV--ITAAIAAAAL--LVLSLLSPGTPLWLLVLLLILL-GLFAIGWNGLYLTlVAESAGpEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 148743791 430 MGASRGFSSIAPVIVPTVSGFLLsqDPEFGWRNVFFLLFAVNLLGLLF 477
Cdd:cd17475 331 LGLANTINFIGIAIGPPLFGLLV--DATHSYAPAWLALALLLVLAALL 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
98-359 |
4.69e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.76 E-value: 4.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 98 LPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATdfGIVLLIVTRIVQGL 177
Cdd:COG0477 37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP--SPELLIAARALQGI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 178 SQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVcCLLWFVVIYDDPV 257
Cdd:COG0477 115 GAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL-ALVLRLRLPESRG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 258 SYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSA 337
Cdd:COG0477 194 LLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLA 273
|
250 260
....*....|....*....|..
gi 148743791 338 LPFIVAWVIGMVGGYLADFLLT 359
Cdd:COG0477 274 LLLALLLLLLLLLLLLLLALLL 295
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
113-481 |
6.27e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.10 E-value: 6.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSILGGQFAIWEK 192
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL--FLLGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 193 WGPPQERSRLcSIALSGMLLGCFTAILIGGFI---SETLGWPFVFYIFGGVgcvcCLLWFVVIYddPVSYPWISTSEKEy 269
Cdd:COG0738 124 LGPETAASRL-NLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVL----LLLLALLFL--RSKLPEIEEEEEE- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 270 iisslkqqvgSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRdnglLSALPFIVAWVIGMV 349
Cdd:COG0738 196 ----------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA----TAALGLSLFWGGMTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 350 GGYLADFLLtKKFRLITVRKIATILGSLpssaLIVSLPYLNSGYITATALLTLSCGLStLCQSGIYINVLDIAPRYSSFL 429
Cdd:COG0738 262 GRFLGGFLL-KRFGPVRLLRLSALLAAV----GLLLALLAPGPWLALIGLALVGLGLS-LMFPTIFSLALDGLGKRTAAA 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 148743791 430 MGASRGFSSIAPVIVPTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:COG0738 336 VSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
104-253 |
9.97e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.36 E-value: 9.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSIL 183
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL--ALLGLGLGLVF 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 184 GGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVgCVCCLLWFVVIY 253
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
129-465 |
1.53e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.78 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 129 PSGYLAGRVGTKRVVGISLFATSFLTLCIPLATdfGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALS 208
Cdd:TIGR00881 49 VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNC 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 209 GMLL-GCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPwISTSEKEYI----ISSLKQQVGSSKQ 283
Cdd:TIGR00881 127 SHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCG-LPPAEEMPNeepdGDAEKKEEELTKK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 284 PLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFR 363
Cdd:TIGR00881 206 QIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 364 LITVRKIATILGSLPSSALIVSLpylnSGYITATALLTLSCgLSTLCQSGIYINVLDIAPRYSSFLMGASRGF-SSIAPV 442
Cdd:TIGR00881 286 PLAVFFMALIIVSLLVYWLNPAA----NPLMDLICLFALGF-LVYGPQMLIGVIASELAPKKAAGTAAGFVGFfAYLGGI 360
|
330 340
....*....|....*....|...
gi 148743791 443 IVPTVSGFLLSQdpeFGWrNVFF 465
Cdd:TIGR00881 361 LAGLPLGYLADG---FGW-AGAF 379
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
119-406 |
9.99e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 60.34 E-value: 9.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 119 VGYggILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQE 198
Cdd:cd17327 52 VGY--IIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFG--GLIALRFFLGLFESGVFPGFILYLGMWYKREE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 199 RS-RLCSIALSGMLLGCFTAILIGGFISETL-----GWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIIS 272
Cdd:cd17327 128 QAkRIAFFYAAAGLGSIFGGLLAYGVFKILGvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 273 SLKQ-QVGSSKQPLPIKAMLRSLP---IWSICLGCFShQWLVSTM-VVYIPTYISSVYHVNIRDNgLLSALPFIVAWVIG 347
Cdd:cd17327 208 RLRAnQTGKGDQKFKWKQIKEAFKdprTWLLFLFFFC-SQITNNGiSNFLPLILKSLGFYSLQTN-LLSVPIGALGAVSL 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 348 MVGGYLADFLltkKFRLITVrkIATILGSLPSSALIVSLPYLNSGYitaTALLTLSCGL 406
Cdd:cd17327 286 LIAALLSDRF---KKRGLFA--IFACVLALVGSIILLAAPNPPGAY---FAAYILGGGS 336
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
105-482 |
1.74e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.42 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 105 YDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATdfGIVLLIVTRIVQGLSqssILG 184
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAG---IAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 185 GQFAI--WEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPwi 262
Cdd:COG2807 123 GNVLLpgLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 263 stsekeyiisslkqqvgSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSvYHVNIRDNGLLSALPFIV 342
Cdd:COG2807 201 -----------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 343 AWVIGMVGGYLADflltkkfRLITVRKIATILGSLPSSALIvslpylnsGYITA-TALLTLSCGLSTLCQSGIYINVLDI 421
Cdd:COG2807 263 GIPGSLLVPLLAD-------RLGDRRPLLLLLGLLGLAGLL--------GLLLApGSLPWLWAVLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148743791 422 APRYS------SFLMGASRGFSSIAPVIVPTVSGFLLSQDPefGWRNVFFLLFAVNLLGLLFYLIFG 482
Cdd:COG2807 328 IGLRArtpaeaAALSGMAQSVGYLLAALGPLLVGALHDATG--SWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
129-415 |
2.29e-08 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 56.26 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 129 PSGYLAGRVGTKRVVGISLFATSFLTL--CIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIA 206
Cdd:cd17334 58 AFCWLLDKVGLRIGVLIGAALNALGSVlkCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 207 LSGMLLGCFTAILIGGFI-----SETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSS 281
Cdd:cd17334 138 SLANFLGCAIGFLLPPVVvpppkGTKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSI 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 282 KQPLPIKAMLRSLPIWSICLGCFshqWLVSTMVVYIPTyissVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFllTKK 361
Cdd:cd17334 218 SELLRNEPFVLLAVAFSIMMGVF---AGFSSVLAQILL----PFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDR--TRM 288
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 148743791 362 FRLITvrKIATILGSLPSS-ALIVSLPYLNSGYitaTALLTLSCGLSTLCQSGIY 415
Cdd:cd17334 289 FKLIG--LIILALGTVVCTfFMLLVDRYGLPYV---TLAFYLLCGLLGFFQNSMV 338
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
104-252 |
2.63e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.65 E-value: 2.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVG--TKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSS 181
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFGLGG 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148743791 182 ILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVI 252
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
124-247 |
3.88e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 3.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 124 ILTMAPSGYLAGRVGTKRVVGISLFA-TSFLTLCIpLATDFGIvlLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRL 202
Cdd:cd17503 45 AIMIPLSGWLADRFGTRRLFLTALALfTLGSLLCG-LAPNLAS--LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAA 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 148743791 203 CSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLL 247
Cdd:cd17503 122 MGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
113-252 |
4.23e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.27 E-value: 4.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTlcIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEK 192
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLST--AMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 193 WGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVI 252
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
113-481 |
5.84e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 5.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIvtRIVQGLSQSSILGGQFAIWEK 192
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG--RALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 193 WGPPQERSRLcsIALSGMLLGCFTAI--LIGGFISeTLGWPFVFYIFGgvgcVCCLLWFVVIYddpvsypWISTSEKEyi 270
Cdd:cd17474 115 LFEGGERAKA--MGLYEAALGLGIAVgpLLGGLLA-AISWRYPFFLLA----ALIPVAFLAIL-------FLLPEPKE-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 271 isslKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFivawVIGMVG 350
Cdd:cd17474 179 ----KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWS----VLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 351 GYLADFLLTKKFRLITVRKIATILgslpSSALIVSLPYLNSGY--ITATALLTLSCGLSTLCQSGIYINVLDIAPRysSF 428
Cdd:cd17474 251 SLFVGRLLKKRFGARRILVIGLLL----YALSLLLLGFVPSLAllLIAIVLFGLGLGLNLPLLTTLVTELAPEEER--GT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 148743791 429 LMGASRGFSSIAPVIVPTVSGFLLSqdpEFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLE---IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
104-250 |
2.74e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSIL 183
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL--FLLGLAGGLFN 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 184 GGQFAIWEKWGPPQERSRLcsIALSGMLLGCFTAI--LIGGFISETLGWPFVFYIFGGVGCVCCLLWFV 250
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRV--FSVYNALNSGAMPLgaLLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
108-479 |
3.25e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.21 E-value: 3.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 108 SPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATdfGIVLLIVTRIVQGLSQSSILGGQF 187
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 188 AIWEKWGPPQERSRlcSIALSGMLLGCFTAI--LIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVsypwists 265
Cdd:cd17489 107 TLVADIIPPSRRGE--GIGYYGLATTLAMALgpALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 266 ekeyiisslkqQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIrdnGLLSALPFIVAWV 345
Cdd:cd17489 177 -----------AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 346 IGMVGGYLADflltkKFRLITVRKIATILGSLpSSALIVSLPYLNSGYITAtALLTLSCGLStlcQSGIYINVLDIAPRY 425
Cdd:cd17489 243 SRPFSGKLSD-----RKGPKTVIIPGLLLLAL-GLLLLSFAGSPWMLLLAA-VLYGLGFGLL---FPALQALAVDLVPPH 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 148743791 426 S-SFLMGASRGFSSIAPVIVPTVSGFLLSqdpEFGWRNVFFLLFAVNLLGLLFYL 479
Cdd:cd17489 313 RrGAANGTFFIFFDLGIGLGGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
107-476 |
4.28e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 4.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 107 WSPQIQGIIFGAVGY-----GGILtmapSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFgiVLLIVTRIVQGLSQSS 181
Cdd:cd17316 32 GLSLLQTGLLFAAGFlgrpiGALL----FGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 182 ILGGQFAIWEKWGPPQERSRLCSIALS----GMLLGCFTAILIGGFISETLGWpFVFYIFGGVGCVCCLLWFvviyddpv 257
Cdd:cd17316 106 EYPGASTYVAEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGW-RILFLIGALPALLALLLR-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 258 sypwistsekeyiisslkqqvgsskqplpiKAMLRSLPIWSICLGCFshqwlvSTMVVYIPTYISSVYHVNIRDNGLLSA 337
Cdd:cd17316 177 ------------------------------RRTLLLILLWFFISFGY------YGLTTFLPTYLQTVLGLSPATSSLYLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 338 LPFIVAWVIGMVGGYLADFLLTKKFRLitvrkIATILgslpssALIVSLPYLNSGYITATALLTLSC---GLSTLCQSGI 414
Cdd:cd17316 221 LISLGALVGALIAGLLSDRIGRKKTLV-----IGLIL------SGILALPLFYLLSGSPTLLLLLLFilsFFVGGVWGAL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148743791 415 YINVLDIAP-RYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDpeFGWRNVFFLLFAVNLLGLL 476
Cdd:cd17316 290 YAYLAELFPtEVRATGVGLSYNLGRLGGGGAPPLIALLLAST--GGTGVPALILALLAIVALI 350
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
130-256 |
5.58e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 52.00 E-value: 5.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 130 SGYLAGRVGTKRVVGISLFATSFLTLCIPLATDfgIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSG 209
Cdd:TIGR00711 57 TGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN--LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLT 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 148743791 210 MLLGCFTAILIGGFISETLGWPFVFYIFGGVGC-VCCLLWFVVIYDDP 256
Cdd:TIGR00711 135 VLVAPALGPTLGGWIIENYHWRWIFLINVPIGIiVVVVAFFILPRDKP 182
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
106-250 |
5.66e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.59 E-value: 5.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 106 DWSpqIQGIIFGAVGYGGILTMAP----SGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFgiVLLIVTRIVQGLSQSS 181
Cdd:TIGR00895 46 EWG--LDPVQLGFLFSAGLIGMAFgalfFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--TQLLILRFLAGLGLGG 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 182 ILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVccLLWFV 250
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLL 188
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
299-498 |
8.46e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 299 ICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFrlitvrkiatILGSLP 378
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV----------LLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 379 SSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPR-YSSFLMGASRGFSSIAPVIVPTVSGFLLSQdpe 457
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASL--- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 148743791 458 FGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL 498
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
111-240 |
3.36e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.19 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 111 IQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDfgIVLLIVTRIVQGLSQSSILGGQFAIW 190
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQT--PWQLGILRFLLGLATGGLLPAINSLL 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 148743791 191 EKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGV 240
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
131-407 |
3.41e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.10 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 131 GYLAGRVGTKRVVGISLFAtsFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGM 210
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIVI--FELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 211 LLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCllwfvviyddpvsypwistsekeyiisslkqqvgsskqplpikAM 290
Cdd:cd17502 129 GIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLAL-------------------------------------------AL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 291 LRSlpIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSaLPFIVAWVIG-MVGGYladfLLTKKFRLITVRK 369
Cdd:cd17502 166 LRT--ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRL-LPLIIGLVIGsIISGA----LISKTGRYKPLIV 238
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 148743791 370 IATILGSLpSSALIVSLPY--LNSGYITATALLTLSCGLS 407
Cdd:cd17502 239 IGTILMSV-GAGLLTTLTLdtSKWLLIGYLILLGLGLGIG 277
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
99-241 |
4.91e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 48.81 E-value: 4.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 99 PAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLS 178
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFP--SLLVARLLTGVG 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148743791 179 QSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIfGGVG 241
Cdd:PRK11551 117 LGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV-GGVG 178
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
129-405 |
7.00e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.39 E-value: 7.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 129 PSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSS-------ILGGQFaiwekwgPPQERSR 201
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--QLLLFRALVGIGEASyspiaptIIADLF-------PKEKRTR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 202 LCSIALSGMLLGCFTAILIGGFI-SETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQqvgs 280
Cdd:cd17328 124 ALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 281 skqplpIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFlLTK 360
Cdd:cd17328 200 ------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGI-LAD 272
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 148743791 361 KFRLITVRKIATILG-SLPSSALIVSLPYLNSGYITATALLTLSCG 405
Cdd:cd17328 273 RLRRKTPRADPLVCAvGLLAAAPFLFLALVLALSNLLLAWVLLFLG 318
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
127-247 |
8.58e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.94 E-value: 8.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 127 MAPSGYLAGRVGTKRV--VGISLFATSflTLCIPLATDFGivLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLcs 204
Cdd:cd17321 48 LLLAGRLGDRFGRKRVflIGLALFGLA--SLLCALAPSLA--FLIAARALQGIGAAAIMPASLALIAATFPGERRGRA-- 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 148743791 205 IALSGMLLGCFTAI--LIGGFISETLGWPFVFYIFGGVGCVCCLL 247
Cdd:cd17321 122 LGLWGAVVGIGAALgpLLGGLLLELFGWRWIFLINVPIGLVALLL 166
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
292-481 |
9.00e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.93 E-value: 9.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 292 RSLPIWSICLGCFSHQWLVSTMVVYIPtYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKfrlitvrkiA 371
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKR---------G 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 372 TILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLcQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFL 451
Cdd:COG0738 76 LLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL-DVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLL 154
|
170 180 190
....*....|....*....|....*....|
gi 148743791 452 LSQDPEFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:COG0738 155 ILLGLSLSWHLPYLILAVLLLLLALLFLRS 184
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
106-252 |
1.02e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 106 DW--SPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSSIL 183
Cdd:cd17365 28 DWglSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL--QLALLRFLTGLGLGAAM 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 184 GGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVI 252
Cdd:cd17365 106 PNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
119-249 |
1.34e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 119 VGYG-GILTMAPSGYLAGRvgtKRVVGISLFAtsFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILG-GQFAIWEKWgPP 196
Cdd:cd17323 45 LGFGlGPLIWAPLSELYGR---RPVYLVSLFI--FVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAiGAGTIADLF-TP 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 148743791 197 QERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFY---IFGGVGCVCCLLWF 249
Cdd:cd17323 119 EERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWflaIISGFCLILIFLFL 174
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
123-365 |
2.03e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 123 GILTMAP-SGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSR 201
Cdd:cd17473 47 FIALFAPlAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--ALLASRALLGIGVAGIMTLATALIGDYFEGEERAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 202 LCSIALSGMLLGCFTAILIGGFISEtLGWPFVFYIFGgvgcVCCLLWFVViyddpvsypWISTSEKEyiisslKQQVGSS 281
Cdd:cd17473 125 MLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL----LALPVLILV---------LLFLPEPA------RKSKSAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 282 KQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKK 361
Cdd:cd17473 185 SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
....
gi 148743791 362 FRLI 365
Cdd:cd17473 265 LLAI 268
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
108-477 |
5.51e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 5.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 108 SPQIQGIIfGAVGYGGILTMAP-SGYLAGRVGTKRVVGISLFATSFLTLCIPLATDfgIVLLIVTRIVQGLSqssiLGGQ 186
Cdd:cd17477 29 STALIGLV-ASAYYLGILLGSPlVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--PWVWFLLRFVMGIG----LAGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 187 FAIWEKW----GPPQERSRLcsIALSGMLLGCFTAI--LIGGFISETLGWPFVfyifggVGCVCCLLWFVVIYddpvsyp 260
Cdd:cd17477 102 FVVSESWlnalATNENRGRV--LGLYSTVLGLGFALgpLLLALVGTAGALPFL------IAAVLLLLALVPLL------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 261 wistsekeyiISSLKQQVGSSKQPLPIKAMLRSLPiwSICLGCFSHQWLVSTMVVYIPTYISSVyHVNIRDNGLLSALpF 340
Cdd:cd17477 167 ----------LTRRAAPEIEEAESISLRRLLRIAP--LALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAA-F 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 341 IVAWVIGMVG-GYLADFLLtkkfrlitvRKIATILGSLPSSALIVSLPYLNSGYITATALLTL----SCGLSTLC--QSG 413
Cdd:cd17477 233 VLGGLLLQWPlGWLADRFD---------RRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLwggaAGPLYTLAlaLAG 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148743791 414 IYINVLDIAPRYSSFLMgasrgFSSIAPVIVPTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLF 477
Cdd:cd17477 304 DRLPGDELVAANAALLL-----LYGLGSVIGPLLAGALMDA---FGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
107-251 |
6.23e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 6.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 107 WSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSILGGQ 186
Cdd:cd17335 230 GSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIE--LLHGLTFALVWAAA 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148743791 187 FAIWEKWGPPQERSRLCSIaLSGMLLGCFTAI--LIGGFISETLGWPFVFYIFGGVGCVCCLLWFVV 251
Cdd:cd17335 308 VSYASAAAPPGLRATAQGL-LQGLYFGLGGGLgsLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
113-456 |
7.73e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 7.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILGGQF--AIW 190
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFvgALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 191 EKWGPpqerSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFvviyddPVSYPWIStsekeyi 270
Cdd:cd17333 114 EESSA----TRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILIL------LTLFPELP------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 271 iSSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALpfivAWVIGMVG 350
Cdd:cd17333 177 -SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSG----FWVGITIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 351 GYLADFLLTkkfRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCglstlcqSGIYINVL----DIAPRYS 426
Cdd:cd17333 252 RLLGGPISR---RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM-------AALFPTILslgiSNLPYAK 321
|
330 340 350
....*....|....*....|....*....|
gi 148743791 427 SFLMGASRGFSSIAPVIVPTVSGFLLSQDP 456
Cdd:cd17333 322 GKGTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
97-481 |
9.65e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 9.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 97 SLPAKAPVYDWSPQIQGI------IFGAVGygGILtmapSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIv 170
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLlgtvtlAGGAIG--GIL----GGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 171 tRIVQGLSqssiLGGQFA-----IWEKWGPPQERSRLCSIALS---GMLLGCFTAILIGGFISETLGWPFVFYiFGGVGC 242
Cdd:cd17371 94 -RALAGLG----FGGEWAagaalMAEYVPARHRGKALGYVQSGwavGWLLATLLAALLFPLLPPEIAWRVLFL-LGALPA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 243 VCCLlwfvviyddpvsypWISTSEKEYIISSLKQQVGSSKQPLPI------KAMLRSLPIWSI-CLGCFSHQWLVSTmvv 315
Cdd:cd17371 168 LLVL--------------FIRRFVKEPPQWQAARAARRHFADRPSlrelfsPPLLRTTLLASLlATGALGGYYGITT--- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 316 YIPTYISSVYHVNIrdnglLSALPFIVAWVIGMVGGYLADFLLTKKFRlitvRKIATILGSLPSSALIVSLPYLNSGYiT 395
Cdd:cd17371 231 WLPSYLTGERGLSF-----EGSAGYLVVTILGGFLGYLAGGFLADRIG----RRNNFALFALGSAISILLYFFLPLSP-T 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 396 ATALLTLSCGLSTlcqSGIYINVLDIAPR-YSSFLMGASRGFSSIAPVIV----PTVSGFLLSQdpeFGWRNVFFLLFAV 470
Cdd:cd17371 301 LILILGFPLGFFA---SGPFSGMGAYLTElFPTAVRATAQGFCYNVGRIIgalfPFLVGFLATS---GSLGTAIAVFAAV 374
|
410
....*....|.
gi 148743791 471 NLLGLLFYLIF 481
Cdd:cd17371 375 YYIAGLVLALL 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
113-480 |
1.01e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAVGYGGILTMAPSGYLAGRVGTKR-------VVGISLFATSFLTLCI--PLATDFGIVLLIVTRIVQGLSQSSIL 183
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiLIGAIPLALSFVLLFTapDLSPTGKLIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 184 GGQFAiwekWGP-----PQERSRLCSIALSGMLLGCFTAILIGGFI------SETLGWPFVFYIFGGVGCVCCLLWFVVI 252
Cdd:COG2211 129 IPYSA----LGAeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 253 yddpvsypwistseKEYIIsslkqqvgSSKQPLPIKAMLRSL----PIWSICLGCFShQWL-VSTMVVYIPTYISSVYHV 327
Cdd:COG2211 205 --------------KERPV--------PEEEKVSLKESLKALlknrPFLLLLLAYLL-FFLaLALVAALLLYYFKYVLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 328 NIRDNGLLSALPFIVAWVIGMVGGYLAdflltKKFRlitvRKIATILGSLPSSALIVSLPYLNSGyitATALLTLSCGLS 407
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLA-----KRFG----KKKAFIIGLLLAALGLLLLFFLGPG---NLWLLLVLAALA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 408 TLCQSGIYINVL----DIAP--------RYSSFLMGASRGFSSIAPVIVPTVSGFLLS---------QDPE--FGWRNVF 464
Cdd:COG2211 330 GIGLGAILVLPWamlaDVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLAlfgyvagaaQSPSalTGIRLLF 409
|
410 420
....*....|....*....|
gi 148743791 465 FL----LFAVNLLGLLFYLI 480
Cdd:COG2211 410 FLlpavLLLLAALLLLFYPL 429
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
131-409 |
1.26e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 44.21 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 131 GYLAGRVGTKR--VVGISLFA-TSFLTLCIPLATDFGI---VLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCS 204
Cdd:cd17367 61 GRLADRIGRRAalTLSVSLMAaGSLVIAVTPTYATIGIwapIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 205 I----ALSGMLLGCFTAILIGGFISE----TLGWPFVFyIFGGVGCVcCLLWFVVIYDDPVSYPWISTSEKeyiisslkq 276
Cdd:cd17367 141 FqyvtLIGGQLLALGVLLVLQHTLGEdqmaAWGWRIPF-LLGGVLAV-VVLWLRRGLEETESFEAIAESNE--------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 277 qvgssKQPLPIKAMLR----SLPIWSICLGcfsHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGY 352
Cdd:cd17367 210 -----ASAGTLRELRRhpreLLLVVGLTAG---GTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGR 281
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 148743791 353 LADFLLTKKFRLITvrkiaTILGSLPSSALIVSLPYLNSGYitaTALLTLSCGLSTL 409
Cdd:cd17367 282 LSDRIGRRPLLLFF-----GIGGTLATVPLLSALDHTDSPY---TAFALVLVGLVFL 330
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
130-481 |
2.08e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 130 SGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSILGGQFAIWEKWGPPQERSRL-----CS 204
Cdd:cd17312 58 SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW--GLNGLFQSMGWPPCVKLLGNWFSKKERGTVygiwsTS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 205 IALSGMLLGCFTAILIGGFisetlGWPFVFYIFGGVGCVCCLLWFVVIYDDPvsypwistsekeyiisslkqqvgsskqP 284
Cdd:cd17312 136 HNFGGILAPILAASLASYY-----GWRAAFLVPGIVGLVVAIILFFFLRDSP---------------------------P 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 285 LpikamlrslpIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSalpfIVAWVIGMVGGYLADFLLTKKFRL 364
Cdd:cd17312 184 Y----------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFS----SLYEVGGIAGTILAGLLSDKLFGG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 365 iTVRKIATILGSLPSSALIVSLPYLNSGYITATALLT-------LSCGLSTLCQSgiyinvlDIAPRYSSflmGASRGFS 437
Cdd:cd17312 250 -RRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLigffvggPINLIGGAAAQ-------DIGRKEAA---GTATGFV 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 148743791 438 SIAPVIVPTVSGFLLSQ-DPEFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:cd17312 319 GLFGYLGASLAGLPLGYiIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
118-267 |
2.60e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.06 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 118 AVGY--GGILTMApsgyLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIvtRIVQGLSQSS--ILGGQFAIweKW 193
Cdd:cd06180 44 YAGYlvGALLASF----LRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLAL--RFLAGAASAFvfVFGSNLVL--HH 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148743791 194 GPPQERSRLCSIALSGMLLGCF-TAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEK 267
Cdd:cd06180 116 ATAAGRGHLIGLLFAGVGLGIAlSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAES 190
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
105-480 |
4.38e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.61 E-value: 4.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 105 YDWSPQIQGIIFGAVG--YGgiLTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIP--LATDFGIVLLIVTRIVQGLSQS 180
Cdd:cd17345 33 YGLSKTEIGLIGSALSiaYG--LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfvPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 181 SILGGQFAIWEKWGPPQERSRLCSI-----ALSGMLLGcfTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDD 255
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIwnishNVGGGLVG--PLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 256 PVSYPWISTSE------KEYIISSLKQQVgSSKQPLpIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNI 329
Cdd:cd17345 189 PESEGLPPIEEykgdypEEADGEEEEQEL-SAWEIF-VKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSK 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 330 RDNGLLSALPFIVAWVIGMVGGYLADfLLTKKFRLITvrkiATILGSLPSSALIV--SLPYLNSGYITATALLTLSCGLS 407
Cdd:cd17345 267 AQAMWAFSLFEWAAIPGTLLAGWLSD-KLFKGRRAPT----GIIFMILVIVALIVywLAPNVLVDLIALIALGFLIYGPV 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 408 TLcqsgIYINVLDIAPRyssFLMGASRGF---------SSIAPVIVPTVSGFllsqdpeFGWRNVFFLLFAVNLLGLLFY 478
Cdd:cd17345 342 ML----IGLQALELVPK---KAAGTAAGLtglfgylggSVLATALIGIIVDH-------FGWNGGFIVLLASCILAIIFL 407
|
..
gi 148743791 479 LI 480
Cdd:cd17345 408 AL 409
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
131-477 |
5.28e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 5.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 131 GYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIvlLIVTRIVQGLSqSSILGGQFAIWEKWGPPqERSRLCSIALSGM 210
Cdd:cd17504 52 GRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--LIAGRALQGIG-GAVFPLAFALVREEFPP-ERVPVAQGILSAT 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 211 L-LGCFTAILIGGFISETLGWPFVFYifggVGCVCCLLWFVVIyddpvsyPWISTSekeyiisslkqqvgsskqplpika 289
Cdd:cd17504 128 FgIGAGIGLPLGGWIVQHLGWRWIFW----TAAPVAVLLAALV-------PLIDLR------------------------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 290 MLRSLPIWSICLG----CFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLAdflltkkfRLI 365
Cdd:cd17504 173 LLRRRNVLLANITallaGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLI--------ARV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 366 TVRKIAtILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIyINVLDIA--PRYSSFLMGASRGF----SSI 439
Cdd:cd17504 245 GPRRVL-LIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASL-PNIVVESvpPDRTGIATGMNTVLrtigSAI 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 148743791 440 APVIVP------TVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLF 477
Cdd:cd17504 323 GPAIAGailttyTVSITSGGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
104-249 |
5.57e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.17 E-value: 5.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILTMAPSGY-LAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVT--RIVQGLSQS 180
Cdd:cd17474 228 LYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVlfGLGLGLNLP 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148743791 181 SIlggQFAIWEKwGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWF 249
Cdd:cd17474 308 LL---TTLVTEL-APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
131-252 |
7.34e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.99 E-value: 7.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 131 GYLAGRVGTKRVVGISLFAtsFLTLCIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGM 210
Cdd:TIGR00710 61 GPLSDRYGRRPVLLLGLFI--FALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVL 138
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 148743791 211 LLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVI 252
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFIL 180
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
131-481 |
7.55e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.79 E-value: 7.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 131 GYLAGRVGTKRV--VGISLFATSFLtLCIpLATDFGivLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALS 208
Cdd:cd17320 55 GPLSDRFGRRPVllAGLLLFILASL-LCA-LASSIE--QLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMM 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 209 GMLLGCFTAILIGGFISETLGWPFVFYIFGGVGcvcCLLWFVVIYDDPvsypwiSTSEKEYIISSLKQQVGSskqplpIK 288
Cdd:cd17320 131 ILAIAPALAPLLGGLLLLFFGWRAIFVFLALLG---LLLLLLVLLFLP------ETLPEEKRKPLLSSLLRA------YK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 289 AMLRSLPIWS--ICLGCFShqwlvSTMVVYI---PTYISSVYHVNIRDNGLLSALPFIVAwvigMVGGYLADFLLTKkfr 363
Cdd:cd17320 196 RVLKNRRFLGyaLALGLSF-----AGLFAYLaaaPFIYIEQLGLSPAQFGLLFALNAIAL----ILGSLLNGRLVRR--- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 364 lITVRKIaTILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVI 443
Cdd:cd17320 264 -FGPRRL-LRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFL 341
|
330 340 350
....*....|....*....|....*....|....*...
gi 148743791 444 VPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:cd17320 342 IGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
189-360 |
1.02e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.55 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 189 IWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDP--VSYPWISTSE 266
Cdd:cd17343 115 ILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPsdVGLNNIEEEE 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 267 KEyiisslKQQVGSSKQPLPIKAMLRSLPIWSICLGcfshqWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVI 346
Cdd:cd17343 195 SK------GKKKKSPRGESTLKELLLSPFLWLLSLG-----YLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEV 263
|
170
....*....|....*....
gi 148743791 347 G-----MVGGYLADFLLTK 360
Cdd:cd17343 264 GgfvgsIAAGYLSDWAVAK 282
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
286-481 |
1.21e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 286 PIKAMLRSLPIWSICLGCFShQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLI 365
Cdd:COG2814 2 PATPRRRWLALLALALGAFL-SGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 366 TVrkIATILGSLpSSALIVSLPYLnsgyITATALLTLSCGLSTlcqSGIYINVLDIAP-RYSSFLMGASRGFSSIAPVIV 444
Cdd:COG2814 81 GL--LLFALGSL-LCALAPSLWLL----LAARFLQGLGAGALF---PAALALIADLVPpERRGRALGLLGAGLGLGPALG 150
|
170 180 190
....*....|....*....|....*....|....*..
gi 148743791 445 PTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:COG2814 151 PLLGGLLADL---FGWRWVFLVNAVLALLALLLLLRL 184
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
104-252 |
1.64e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.63 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDfGIVLLIVTRIVQGLSQSSIL 183
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGN 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 184 GGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLG-WPFVFYIFGGVGCVCCLLWFVVI 252
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
98-444 |
1.87e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 98 LPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGL 177
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--ALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 178 S------QSSILGGQFAiwekwgpPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVV 251
Cdd:cd17478 97 GsaafhpEGARLASQAA-------GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 252 iyddpvsypwistseKEYIISSLKQQVGSSKQPLPIKAMLRSLpiWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRD 331
Cdd:cd17478 170 ---------------RPLKKPEAKKAAAKSSARSTLKGVWRAL--LLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 332 NGLLSAlpFIVAWVIG-MVGGYLADFLLTKkfRLItvrkIATILGSLPSSALIvslpyLNSGYITATALLTLSCGLSTLC 410
Cdd:cd17478 233 GLLLSL--FLFAGAIGtLIGGPLSDRFGRR--RVI----IASLLLAAPFLLLF-----LLTPGIWSYILLVLAGFLLFAS 299
|
330 340 350
....*....|....*....|....*....|....*...
gi 148743791 411 QSGIYINVLDIAPRY----SSFLMGASRGFSSIAPVIV 444
Cdd:cd17478 300 FPVTVVLAQELLPGNvglaSGLMMGLSFGLGGIGAPVL 337
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
104-253 |
2.37e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.25 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 104 VYDWSPQIQGIIFGAVGYGGILT-MAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDFGIVLLIVtrIVQGLSQSSI 182
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAA--AILAFGTGIV 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148743791 183 LGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIfggvGCVCCLLWFVVIY 253
Cdd:cd17330 282 FPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL----AAGLLLIALFLLS 348
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
122-387 |
2.64e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.05 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 122 GGILTmapsGYLAGRVGTKRVVGISLFATSFLTLCIPLATDF------GIVLLIVTRIVQGLSQSSILGGQFAIWEKWGP 195
Cdd:cd17368 56 GAIVL----GAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiaAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 196 PQERSRLCSIALSGMLLGCFTAILIGGFISETL--------GWPFVFYIfgGVGCVCCLLWFVVIYDDPVSYP-WISTSE 266
Cdd:cd17368 132 PGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLtaealaewGWRIPFFI--GLLIIPLGLWLRRSLEETEAFLeRKARPT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 267 KEYIISSLKQqvgsskqplPIKAMLRSLPIWSIClgcfshqwLVSTMV--VYIPTYISSVYHVNIRDNGLLSALPFIVAW 344
Cdd:cd17368 210 RRELFALLAN---------NRRIILLGMLLVAGS--------TVTFYFttVYTPTYAKTVLGLSARDSFLVTLLAGVANF 272
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 148743791 345 VIGMVGGYLADFLLTKkfRLITVRKIATILGSLPSSALIVSLP 387
Cdd:cd17368 273 IWAPLGGALSDRIGRR--PVLLVITLAALVTLYPVFAWLTAAP 313
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
282-483 |
3.09e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 282 KQPLPIKAMLRSLPIWSICLGCFSHqWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKK 361
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLE-GLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 362 FRLITVrkIATILGSLpSSALIVSLPYLnsgyITATALLTLSCGLSTLCQSGIyinVLDIAP-RYSSFLMGASRGFSSIA 440
Cdd:COG0477 81 VLLIGL--LLFGLASL-LCGLAPSPELL----IAARALQGIGAGGLMPGALAL---IAELFPaRERGRALGLWGAAIGLG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 148743791 441 PVIVPTVSGFLLSQdpeFGWRNVFFLLFAVNLLGLLFYLIFGE 483
Cdd:COG0477 151 LALGPLLGGLLVAA---LGWRWIFLINAPLGLLALVLRLRLPE 190
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
108-275 |
3.10e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.89 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 108 SPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVV--GISLFATSFLtLCIpLATDfgIVLLIVTRIVQGLsqSSILGG 185
Cdd:cd17472 30 TPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVIlfGLLLFIAGSL-LAA-YATS--IYGLILGRALQGS--GAISSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 186 QFAIWEKWGPPQERSRlcSIALSGMLLGCFTAI--LIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVsYPWIS 263
Cdd:cd17472 104 VMALLADLTREENRTK--AMALIGASIGIAFAIsmVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK-IVQIS 180
|
170
....*....|..
gi 148743791 264 TSEKEYIISSLK 275
Cdd:cd17472 181 EKEKKKLKKLLK 192
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
108-481 |
3.37e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 108 SPQIQGIIFGAVGYGGILTMAPSGYLAGRVGT-KRVVGISLFATSFLTLCIPLATDFGivLLIVTRIVQGLSQSS--ILG 184
Cdd:cd17490 29 SLSMIGIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPSPW--GLLIARFLSGIAAATwvSFT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 185 GQFAiweKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPwiST 264
Cdd:cd17490 107 VLYA---SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP--VL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 265 SEKEYIISSLKQqvgsskqplpikamlRSLPIWSIcLGCFSHQWLVSTMVVYIPTYISSVYHVNIrDNGLLSalpfIVAW 344
Cdd:cd17490 182 TELKELLSVLKD---------------KKLLFFSL-LAILQQMITFSTTFGFTPLIAKQLGASSF-QLGLLS----IIYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 345 VIGMVGGYLADFLLTKKFRLITVRKIATILGSLpSSALIVSLPYLNSGYITaTALLTLSCGL-STLCQSgiyINVLDIAP 423
Cdd:cd17490 241 LPNALASLLSGTLFYKKLGERNTIIIGFLLLGA-YCFLIPFAPNLTLLYLL-QALNGFGTGIlFPLLMS---LSIEGVPA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 148743791 424 RYSSFLMGASRGFSSIAPVIVPTVSGFLLSqdpEFGWRNVFFLLFAVNLLGLLFYLIF 481
Cdd:cd17490 316 EQRSTAMGFFQAIYALGMFLGPVLVGIISE---AFGLQTGFFVIGVIALLAAILSLAY 370
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
167-399 |
4.68e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 39.14 E-value: 4.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 167 LLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGC-----FTAILIGGFISETL---GWPFVFYIFG 238
Cdd:cd17398 97 VAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGValgfvLPPLLVPNSENKDEigkGLSILFYGVA 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 239 GVGCVCCLLWFVVIYDDPVSYPWISTSEkeyiisslKQQVGSSKQplpikamlrslPIWSICLGCFSHQWLVSTMVVY-- 316
Cdd:cd17398 177 GICTALFILVIIFFKEKPPIPPSRAQAA--------AQELRSEDQ-----------SYLGSLKRLFKNKGFLLLLITYgi 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 317 -------IPTYISSV---YHVNIRDNGLLSALPFIVAwviGMVGGYLADFLL--TKKFRLITVRKIATILGSLPSSALIV 384
Cdd:cd17398 238 ntgvyyaISTLLNQMvleYFPNEEVNAGWIGLTLVIA---GLVGSVVAGIWLdkTKKYKETTIIVYILSFIGMVAFTFTL 314
|
250
....*....|....*
gi 148743791 385 SLPYLNSGYITATAL 399
Cdd:cd17398 315 DLGSIWVVFLTAGAL 329
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
113-250 |
9.38e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.33 E-value: 9.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 113 GIIFGAvgYGGILTMAPS--GYLAGRV-GTKRVV--GISLFATSFLTLCIPLATDFGIVLLIVTRIV-QGLSQ---SSIL 183
Cdd:cd17346 43 ASIYGA--YTALVYLTPIigGWLADKVlGARRTVfiGGILMALGYLLLALSPFSVSMLYLGLALIIVgNGLFKpniSSLV 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148743791 184 GGQFAiwekwGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIfGGVGCVCCLLWFV 250
Cdd:cd17346 121 GKLYD-----ENDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYGYHYGFGL-AAVGMLLGLLIFL 181
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
131-361 |
9.49e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 38.37 E-value: 9.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 131 GYLAGRVGTKRVVGISLFATSFLTLCIPLATdfGIVLLIVTRIVQGLSQSS--ILGGQFAIwEKWgPPQERSRLCSIALS 208
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLAS--GVIMLTLSRFIVGMGMAGeyACASTYAV-ESW-PKHLKSKASAFLVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 209 GMLLGCFTAILIGGFISETLGWPFVFYIfggvGCVCCLLWFVVIYDDPVSYPWIstsEKEYIISSLKQQVGSSKQPLPIK 288
Cdd:PRK12307 150 GFGIGNIIAAYFMPSFAEAYGWRAAFFV----GLLPVLLVIYIRARAPESKEWE---EAKLSGKGKHSQSAWSVFSLSMK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148743791 289 AMLR------SLPIWSICLGCFSHQWLVSTMvvyIPTYISSvyhvNIRDNGLLSALPFIVAW--VIG-MVGGYLADFLLT 359
Cdd:PRK12307 223 GLFNraqfplTLCVFIVLFSIFGANWPIFGL---LPTYLAG----EGFDTGVVSNLMTAAAFgtVLGnIVWGLCADRIGL 295
|
..
gi 148743791 360 KK 361
Cdd:PRK12307 296 KK 297
|
|
| |
