NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148231494|ref|NP_001091652|]
View 

coiled-coil domain-containing protein 125 [Danio rerio]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
56-227 1.09e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494  56 EELEAE-RVARWEKRQSESST--------EDTSEELQRRLQEVTEEVELLRTELEVTHRHLEGKHEALRILQGQAI-LDK 125
Cdd:COG1196  223 KELEAElLLLKLRELEAELEEleaeleelEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELArLEQ 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494 126 AtchtkmlLQKSEERTKALEKEVNALQWEITfnqvQFKNVENSWSLKYERVLAENEALKKGLEEKMKEHQKQRTENASLS 205
Cdd:COG1196  303 D-------IARLEERRRELEERLEELEEELA----ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371
                        170       180
                 ....*....|....*....|..
gi 148231494 206 QKCLELLSMLSAKERRDFQRTQ 227
Cdd:COG1196  372 AELAEAEEELEELAEELLEALR 393
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
56-227 1.09e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494  56 EELEAE-RVARWEKRQSESST--------EDTSEELQRRLQEVTEEVELLRTELEVTHRHLEGKHEALRILQGQAI-LDK 125
Cdd:COG1196  223 KELEAElLLLKLRELEAELEEleaeleelEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELArLEQ 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494 126 AtchtkmlLQKSEERTKALEKEVNALQWEITfnqvQFKNVENSWSLKYERVLAENEALKKGLEEKMKEHQKQRTENASLS 205
Cdd:COG1196  303 D-------IARLEERRRELEERLEELEEELA----ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371
                        170       180
                 ....*....|....*....|..
gi 148231494 206 QKCLELLSMLSAKERRDFQRTQ 227
Cdd:COG1196  372 AELAEAEEELEELAEELLEALR 393
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
55-221 1.53e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494    55 REELEAERVARWEKRQSESS----TEDTSEELQRRLQEVTEEVELLRTELevthRHLEGKHEALRILQGQAILDKATCHT 130
Cdd:TIGR02168  756 LTELEAEIEELEERLEEAEEelaeAEAEIEELEAQIEQLKEELKALREAL----DELRAELTLLNEEAANLRERLESLER 831
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494   131 KM-----LLQKSEERTKALEKEVNALQWEITFNQVQFKNVE---NSWSLKYERVLAENEALKKGLEEKMKEHQKQRTENA 202
Cdd:TIGR02168  832 RIaaterRLEDLEEQIEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRS 911
                          170
                   ....*....|....*....
gi 148231494   203 SLSQKCLELLSMLSAKERR 221
Cdd:TIGR02168  912 ELRRELEELREKLAQLELR 930
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
55-220 8.48e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494   55 REELEA--ERVARWEKRQSESSTEdtSEELQRRLQEVTEEVELLRTELEvTHRHLegkhealrilqgqaildkatchtKM 132
Cdd:pfam13851  32 KEEIAElkKKEERNEKLMSEIQQE--NKRLTEPLQKAQEEVEELRKQLE-NYEKD-----------------------KQ 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494  133 LLQKSEERTKALEKEVNALQWEitfNQVQFKnvenswslKYERVLAENEALKKGLEEKMKEHQkQRTE--NASLSQKCLE 210
Cdd:pfam13851  86 SLKNLKARLKVLEKELKDLKWE---HEVLEQ--------RFEKVERERDELYDKFEAAIQDVQ-QKTGlkNLLLEKKLQA 153
                         170
                  ....*....|
gi 148231494  211 LLSMLSAKER 220
Cdd:pfam13851 154 LGETLEKKEA 163
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
56-227 1.09e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494  56 EELEAE-RVARWEKRQSESST--------EDTSEELQRRLQEVTEEVELLRTELEVTHRHLEGKHEALRILQGQAI-LDK 125
Cdd:COG1196  223 KELEAElLLLKLRELEAELEEleaeleelEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELArLEQ 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494 126 AtchtkmlLQKSEERTKALEKEVNALQWEITfnqvQFKNVENSWSLKYERVLAENEALKKGLEEKMKEHQKQRTENASLS 205
Cdd:COG1196  303 D-------IARLEERRRELEERLEELEEELA----ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371
                        170       180
                 ....*....|....*....|..
gi 148231494 206 QKCLELLSMLSAKERRDFQRTQ 227
Cdd:COG1196  372 AELAEAEEELEELAEELLEALR 393
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
55-221 1.53e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494    55 REELEAERVARWEKRQSESS----TEDTSEELQRRLQEVTEEVELLRTELevthRHLEGKHEALRILQGQAILDKATCHT 130
Cdd:TIGR02168  756 LTELEAEIEELEERLEEAEEelaeAEAEIEELEAQIEQLKEELKALREAL----DELRAELTLLNEEAANLRERLESLER 831
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494   131 KM-----LLQKSEERTKALEKEVNALQWEITFNQVQFKNVE---NSWSLKYERVLAENEALKKGLEEKMKEHQKQRTENA 202
Cdd:TIGR02168  832 RIaaterRLEDLEEQIEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRS 911
                          170
                   ....*....|....*....
gi 148231494   203 SLSQKCLELLSMLSAKERR 221
Cdd:TIGR02168  912 ELRRELEELREKLAQLELR 930
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
56-196 5.52e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.07  E-value: 5.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494  56 EELEAERVARWEKR--QSESSTEDTSEELQRRLQEVTEEVELLRTELEVTHRHLEGKHEALRILQgqAILDKAtchtkml 133
Cdd:COG2433  383 EELIEKELPEEEPEaeREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLE--RELSEA------- 453
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148231494 134 lqKSEERTKAL-EKEVNALQWEItfnqvqfKNVENswslKYERVLAENEALKKGLEEkMKEHQK 196
Cdd:COG2433  454 --RSEERREIRkDREISRLDREI-------ERLER----ELEEERERIEELKRKLER-LKELWK 503
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
55-220 8.48e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494   55 REELEA--ERVARWEKRQSESSTEdtSEELQRRLQEVTEEVELLRTELEvTHRHLegkhealrilqgqaildkatchtKM 132
Cdd:pfam13851  32 KEEIAElkKKEERNEKLMSEIQQE--NKRLTEPLQKAQEEVEELRKQLE-NYEKD-----------------------KQ 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494  133 LLQKSEERTKALEKEVNALQWEitfNQVQFKnvenswslKYERVLAENEALKKGLEEKMKEHQkQRTE--NASLSQKCLE 210
Cdd:pfam13851  86 SLKNLKARLKVLEKELKDLKWE---HEVLEQ--------RFEKVERERDELYDKFEAAIQDVQ-QKTGlkNLLLEKKLQA 153
                         170
                  ....*....|
gi 148231494  211 LLSMLSAKER 220
Cdd:pfam13851 154 LGETLEKKEA 163
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
70-243 8.68e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 8.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494    70 QSESSTEDTSEELQRRLQEVTEEVELLRTELEVTHRHLEGKHEALRILQgqailDKATCHTKMLLQKSEERTKaLEKEVN 149
Cdd:TIGR02168  691 EKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE-----AEVEQLEERIAQLSKELTE-LEAEIE 764
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231494   150 ALQWEITFNQVQFKNVENSW---SLKYERVLAENEALKKGLEEKMKEHQKQRTENASLSQKCLELLSMLSAKERRDFQRT 226
Cdd:TIGR02168  765 ELEERLEEAEEELAEAEAEIeelEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLE 844
                          170
                   ....*....|....*..
gi 148231494   227 QPSCSLRTDGSALELAV 243
Cdd:TIGR02168  845 EQIEELSEDIESLAAEI 861
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH