|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NaGLT1_MFSD4B |
cd17454 |
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily ... |
82-489 |
0e+00 |
|
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily domain-containing protein 4B; Sodium-dependent glucose transporter 1 (NaGLT1) is also called major facilitator superfamily domain-containing protein 4B (MFSD4B). NaGLT1 is a primary fructose transporter in rat renal brush-border membranes. It also facilitates sodium-independent urea uptake in assays performed on Xenopus oocytes. NaGLT1/MFSD4B belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341012 Cd Length: 369 Bit Score: 609.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 82 ALCASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTP 161
Cdd:cd17454 1 ALCASFLGLGMSIAVLGPTFQDLATNVNKNISNISYIFVGRSLGYLGGSVLGGILFDCMNHHLLLGFSMLITAAGLFAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 162 FCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFAAGAFASPIIAKLLfghhnsstntslmsgha 241
Cdd:cd17454 81 WCKKALLLTALMSLIGVSMGVLDTGGNVLILNTWGDQAGPHMQALHFSFALGAFVAPILAKLA----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 242 sktidavlpfshpkgtstidlpWMWAYIVIGAFVLLVSLLFFSLYFCISTNSNRTKTASGKQQFSKHHNTLIILLSMFFF 321
Cdd:cd17454 144 ----------------------FLWAYIVIGTYVLLVSLFFFILYSKSSSNREKSKASAQKTRFAKYHNALIILLFLFFF 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 322 FYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLCLFSQNY 401
Cdd:cd17454 202 FYVGAEVTYGSYIFTYAKTYVHMEESEAAGLNSLFWGTFAACRGLAIFFAACLYPGTMILLSLIGSTVSSLFLVLFSKNP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 402 PMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAAIFVVGAALGEMVLPALLGFLLGHVQNYPLLMYLTLCTATFTSI 481
Cdd:cd17454 282 ISLWVGTAVYGASMATTFPSGISWIEQYTTITGKSAALFVVGAALGEMVIPAVVGYLQGHVPDYPVLMYTALGTSTMTAI 361
|
....*...
gi 147901269 482 LFPVLYKL 489
Cdd:cd17454 362 LFPVMYKL 369
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
85-489 |
7.14e-100 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 307.91 E-value: 7.14e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 85 ASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTPFCK 164
Cdd:cd17395 4 SVFFSFGLSIAFLGPTLLDLACNTNSSLPQISWVFFSRQLGYLLGSALGGVFKRTLNSLWALFTSSLLIALVLAVIPFCK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 165 KAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFAAGAFASPIIAKLLFghhnsstntslmsghaskt 244
Cdd:cd17395 84 DVKVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPFL------------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 245 idavlpfshpkgtstidlpwMWAYIVIGAFVLLVSLLFFSLYFC-ISTNSNRTKTASGKQQFSKHHNTLIILLSMFFFFY 323
Cdd:cd17395 145 --------------------SYAYWIMALINLPVPMAVLMLLSKeRLLTCCSQRRRKNLRRAPYSFFAIHITGALFLFMY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 324 VGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLCLFSQNYPM 403
Cdd:cd17395 205 VGLEGAYGAFVYSYAVEKPGVGHKVAAYLPSLFWGTFTLGRLLSIPISSRMKPATMVVLNVVGVVVTSLVLLLFSKSVVF 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 404 LWACTALYGISMSTTFPSGISWVEQYTTVTGRSAAIFVVGAALGEMVLPALLGFLLghvQNYPLLMYLTLCTATFTSILF 483
Cdd:cd17395 285 LWIGTASLGLFLASTFPSMLSYTEDSLQYTGCSTTVLVTGAGLGEMVLPMLVGSIQ---PFQAQGSYSFLVCGVLFGCLA 361
|
....*.
gi 147901269 484 PVLYKL 489
Cdd:cd17395 362 FTFYIL 367
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
76-493 |
1.30e-40 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 151.93 E-value: 1.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 76 RWLVSLALCASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAF 155
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 156 GMSGTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFAAGAFASPIIAKLLFGHHnsstnts 235
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLG------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 236 lmsghasktidavlpfshpkgtstIDLPWMWAYIVIGAFVLLVSLLFFSLYFCISTNSNRTKTASGKQQFSKHHNTLIIL 315
Cdd:COG0738 159 ------------------------LSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 316 LSMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLc 395
Cdd:COG0738 215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 396 LFSQNYPMLWACTALYGISMSTTFPSGISWV-EQYTTVTGRSAAIFVVGAALGEMVLPALLGFLLGHVqNYPLLMYLTLC 474
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLAlDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLV 372
|
410
....*....|....*....
gi 147901269 475 TATFTSILFPVLYKLASPE 493
Cdd:COG0738 373 CYLLILLLALALKRKRRKK 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
83-483 |
2.32e-38 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 145.16 E-value: 2.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 83 LCASFLGLGMAI---SVLGPTFEDLAinvNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSG 159
Cdd:cd17333 1 LYISFFSNGLTDallGILGPSLEEAF---NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 160 TPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFAAGAFASPIIAKLLFghhnsstntslmsg 239
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLL-------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 240 hasktidavlpfshpkgtsTIDLPWMWAYIVIGAFVLLVSLLFFSLYFCISTNSNRTKTASGKQQ---FSKHHNTLIILL 316
Cdd:cd17333 144 -------------------TSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSasaSRLLRNPSIILG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 317 SMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLCL 396
Cdd:cd17333 205 ALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 397 FSQNYPMLWACtALYGISMSTTFPSGISWVEQYTTV-TGRSAAIFVVGAALGEMVLPALLGFLLGHVQ-NYPLLMYLTLC 474
Cdd:cd17333 285 APTLVVGLVAT-ALLGLFMAALFPTILSLGISNLPYaKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGiQTAMLLITILY 363
|
....*....
gi 147901269 475 TATFTSILF 483
Cdd:cd17333 364 AIIFVLALL 372
|
|
| MFS_MFSD4A |
cd17453 |
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily ... |
87-483 |
9.79e-28 |
|
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4A (MFSD4A) belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341011 Cd Length: 415 Bit Score: 115.67 E-value: 9.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 87 FLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLllgFALLTTAFGMSGT----PF 162
Cdd:cd17453 8 FFSFGLCIAFLGPTLLDLRCQTQSSLQQITWVFFSQQFCLLLGSTLGGVFKRTLAQSL---FALFVSSLAISVVfaiiPF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 163 CKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFAAGAFASPIIAKLLFGHHNS-STNTSLMSGHA 241
Cdd:cd17453 85 CRNVGVLAFVMAVAGLAMGCIDTISNMQLVKIYQKDSAVFLQALHFFVGFGALLSPLIADPFLSDTNCvSYAFWIMAIIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 242 SKTIDAVLPFSHPKGTSTI-----------DLPWMWAYIV----IGAFVLLVSLLFFSLYFCISTNSNRTKTASgkqQFS 306
Cdd:cd17453 165 LPVPIAVFVLLYKERMVPCcsdpsrpllsaDELAMEARPEekldESTGKAHTSNGHADLFSCCQSKNFRGAPFS---FFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 307 KHhntliILLSMFFFFYVGSEVAYGSFIFTYG-KDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLV 385
Cdd:cd17453 242 IH-----VTGALVLFMTDGIVGEYSGFVYSYAvEPPLNLPHKVAGYLPSLFWGFITLGRLISIPISYRMKPATMVFINLV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 386 GTTVSSLLLCLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAAIFVVGAALGEMVLPALLGFLLGHVQNY 465
Cdd:cd17453 317 GVIVTFLLLLIFSNSTVFLFVGTASLGLFLSSTFPSMLAYTEDILQYKGCATTVLVTGAGMGEMVLQMLVGSIMHSQGSY 396
|
410
....*....|....*...
gi 147901269 466 PLLmyltLCTATFTSILF 483
Cdd:cd17453 397 SFL----VCGMIFGCLAF 410
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
83-483 |
1.54e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.62 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 83 LCASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTPF 162
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 163 CKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSF-AAGAFASPIIAKLLFGHHNSStntslmsgha 241
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFgSVGGILGPLLGGILASSLGFG---------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 242 sktidavlpfshpkgtstidlpWMWAYIVIGAFVLLVSLLFFSLYF-----CISTNSNRTKTASGKQQFSKHHNTLIILL 316
Cdd:cd06174 151 ----------------------WRAVFLIAAALALLAAILLLLVVPdppesARAKNEEASSKSVLKLLKRVLKNPGLWLL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 317 SMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLCL 396
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 397 FSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAA--IFVVGAALGEMVLPALLGFLLGHVQNYPLLMYLTLC 474
Cdd:cd06174 289 LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAfgLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAV 368
|
....*....
gi 147901269 475 TATFTSILF 483
Cdd:cd06174 369 LLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
75-446 |
2.10e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 2.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 75 WRWLVSLALCASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTA 154
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 155 FGMSGTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFS-FAAGAFASPIIAKLLFGHhnsstn 233
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAgLGLGPALGPLLGGLLADL------ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 234 tslmsghasktidavlpfshpkgtstidLPWMWAYIVIGAFVLLVSLLFfslYFCISTNSNRTKTASGKQQFSKHHNTLI 313
Cdd:COG2814 161 ----------------------------FGWRWVFLVNAVLALLALLLL---LRLLPESRPAARARLRGSLRELLRRPRL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 314 ILLSMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLL 393
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 147901269 394 LcLFSQNYPMLWACTALYGISMSTTFPSGISWV------EQYTTVTGRSAAIFVVGAAL 446
Cdd:COG2814 290 L-ALAGSLWLLLLALFLLGFGFGLLFPLLQALVaelappEARGRASGLYNSAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
69-488 |
1.12e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.51 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 69 SKTGTCWRWLVSLALCASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGF 148
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 149 ALLTTAFGMSGTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFA-AGAFASPIIAKLLFGH 227
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGpLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 228 HNsstntslmsghasktidavlpfshpkgtstidlpWMWAYIVIGAFVLLVSLLFfslyfcistnsnrtktasgkqqfsk 307
Cdd:COG2271 161 FG----------------------------------WRAAFLILGLPGLLLALLR------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 308 hhntlIILLSMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACL--HPGTLILLSLV 385
Cdd:COG2271 182 -----FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 386 GTTVsSLLLCLFSQNYPMLWACTALYGISMSTTFPSGISWVEQY--TTVTGRSAAIFVVGAALGEMVLPALLGFLLGHVq 463
Cdd:COG2271 257 LAAL-ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELfpKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT- 334
|
410 420
....*....|....*....|....*
gi 147901269 464 NYPLLMYLTLCTATFTSILFPVLYK 488
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
321-458 |
6.93e-12 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 67.63 E-value: 6.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 321 FFYVGSEVAYGSFIFTYGKDYVH-MEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLcLFSQ 399
Cdd:cd17394 237 FFYVGAEVAIWSFLINYLMEYIAgLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGA-IFTG 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147901269 400 NYPMLWaCTALYGISMS----TTFPSGISWVEQYttvTGRSAAIFVVgAALGEMVLPALLGFL 458
Cdd:cd17394 316 GMVALY-ALVLVGFFNSimfpTIFSLALKGLGKH---TKTGSGLLVM-AIVGGAVVPLIQGAV 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
315-488 |
1.69e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.98 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 315 LLSMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLL 394
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 395 CLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAAIFVVGAA--LGEMVLPALLGFLLGHVQNYPLLMYLT 472
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAggLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
170
....*....|....*.
gi 147901269 473 LCTATFTSILFPVLYK 488
Cdd:COG2223 369 AVLALVALVLTLLLYR 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
79-447 |
7.04e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.81 E-value: 7.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 79 VSLALCASFLGLGMAISVLGPTfedLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMS 158
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLL---LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 159 GTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQAL-HFSFAAGAFASPIIAKLLFGHHNsstntslm 237
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLvSAGFGLGAALGPLLGGLLASLFG-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 238 sghasktidavlpfshpkgtstidlpWMWAYIV------IGAFVLLVSLLFFSLYFCISTNSNRTKTASGKQQFSKHHNT 311
Cdd:pfam07690 150 --------------------------WRAAFLIlailslLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 312 LIILLSMFFFFYVgseVAYGSFIFTYGKDYvHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSS 391
Cdd:pfam07690 204 WLLLALLLFGFAF---FGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147901269 392 LLLCLFS--QNYPMLWACTALYGISMSTTFPSGISWV------EQYTTVTGRSAAIFVVGAALG 447
Cdd:pfam07690 280 LGLLLLSltLSSLWLLLALLLLGFGFGLVFPALNALVsdlapkEERGTASGLYNTAGSLGGALG 343
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
94-363 |
4.47e-07 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 52.24 E-value: 4.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 94 ISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTPFCKKAWVLTVLM 173
Cdd:PRK03699 23 VIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 174 SSVGVSMGVLDTGGNVLILNTW-GEQAGPHMQALHFSFAAGAFASPIIAKLLFGHHnsstntslmsghasktidavlpfs 252
Cdd:PRK03699 103 FVLGVVSGITMSIGTFLITHVYeGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARS------------------------ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 253 hpkgtstidLPWMWAYIVIGAFVLLVSLLFFSLYFCIstnSNRTKTASGKQQFSKHHNTLIILLSMFFFFYVGSEVAYGS 332
Cdd:PRK03699 159 ---------IEWYWVYACIGLVYVAIFILTLFSEFPA---LGKHAPKADKPVAKEKWGIGVLFLAIAALLYILAQLTFIS 226
|
250 260 270
....*....|....*....|....*....|.
gi 147901269 333 FIFTYGKDYVHMEETEAAGLNSLFWGAFAAG 363
Cdd:PRK03699 227 WVPEYAQKKFGMSLEDAGNLVSNFWMAYMVG 257
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
79-483 |
4.56e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 4.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 79 VSLALCASFLGLGMAISVLGPTFEDLAINVnkniSNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMS 158
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASV----AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 159 GTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWG-EQAGPHMQALHFSFAAGAFASPIIAKLLFGHhnsstntslM 237
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADA---------L 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 238 SGHASKTIDAVLPFshpkgtstIDLPWMWAYIVIGAFVllvsllffslyfcISTNSNRTKTASGKQQFSKHHNTLIILLS 317
Cdd:cd17325 148 GYRAPFLVCAALAL--------LALVLALLLLPEPRPP-------------PNKRAVSAARLRSGLRLLLRDRRLLALFL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 318 MFFFFYVGSeVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSsLLLCLF 397
Cdd:cd17325 207 AIFVLAFAF-GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA-LLLLPL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 398 SQNYPMLWACTALYGISMSTTFPSGISWV------EQYTTVTGRSAAIFVVGAALGemvlPALLGFLLGHVqNYPLLMYL 471
Cdd:cd17325 285 ATSFWLLLLLLALLGLGLGLVFPATLALLadivppEGRGTAMGLFNTAFSLGMVLG----PLLGGFLYDAF-GFATPFLA 359
|
410
....*....|..
gi 147901269 472 TLCTATFTSILF 483
Cdd:cd17325 360 AAALLLLAAVLF 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
311-462 |
1.12e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.44 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 311 TLIILLSMFFFFYVGSEVAYGSFIFtYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVS 390
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLY-YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 391 SLLLCLFS-QNYPMLWACTALYGISMSTTFPSGISWV------EQYTT---VTGRSAAIFVVGAALGEMVLPALLGFLLG 460
Cdd:COG2211 308 LLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDEWKTgrrREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
..
gi 147901269 461 HV 462
Cdd:COG2211 388 LF 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
315-483 |
2.83e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 315 LLSMFFFFYVGSEVAYGSFIFTYGKDYvHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSsLLL 394
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG-LLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 395 CLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAA--IFVVGAALGEMVLPALLGFLLGHVqNYPLLMYLT 472
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRAlgLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLIL 157
|
170
....*....|.
gi 147901269 473 LCTATFTSILF 483
Cdd:pfam07690 158 AILSLLAAVLL 168
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
312-462 |
4.48e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.20 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 312 LIILLSMFFFFYVGSEVAYGSFIFTYGKDYvHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSS 391
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147901269 392 LLlCLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAA--IFVVGAALGEMVLPALLGFLLGHV 462
Cdd:COG2814 90 LL-CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRAlgLLGAGLGLGPALGPLLGGLLADLF 161
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
379-482 |
4.90e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 4.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 379 LILLSLVGTTVSSLLLCLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAA--IFVVGAALGEMVLPALLG 456
Cdd:cd17477 255 VLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAAnaALLLLYGLGSVIGPLLAG 334
|
90 100
....*....|....*....|....*.
gi 147901269 457 FLLGHVQNYPLLMYLTLCTATFTSIL 482
Cdd:cd17477 335 ALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
343-472 |
9.52e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 343 HMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLCLFSQNYPMLWACTALYGISMSTTFPSG 422
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 147901269 423 ISWV------EQYTTVTGRSAAIFVVGAALGemvlPALLGFLLGHVQNYPLLMYLT 472
Cdd:cd17355 321 AALAaryfgaRSYGTLFGLVFAPHQLGSALG----PWLGGLLYDRTGSYTAAWALA 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
306-504 |
1.20e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.38 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 306 SKHHNTLIILLSMFFFFYVGSEVAYGSFIfTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLV 385
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLI-PALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 386 GTTVSSLLLcLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSA-----AIFVVGAALGEMVLPALLGFLLG 460
Cdd:COG0738 82 LMALGLLLF-ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRlnllhAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 147901269 461 HVQNYPLLMYLTLCTATFTSILFPVLYKLASPEGNVTLRKSSGK 504
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK 204
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
113-461 |
1.21e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.52 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 113 SNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLIL 192
Cdd:cd06180 34 AQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 193 NTWGEQAGPHMQALHFS-FAAGAFASPIIAKLLFGHHNSSTNTSLMSGHASKTIDAVLpfshpkgtstidlpWMWAYIVI 271
Cdd:cd06180 114 HHATAAGRGHLIGLLFAgVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLS--------------FLLLRRGP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 272 GAfvllvsllffslyfcistnsNRTKTASGKQQFSKHHNTLIILLsmFFFFYVGSeVAYGSFIFTYGKDyvhmeeteaAG 351
Cdd:cd06180 180 SA--------------------PTEASAAESAPGLNRPLWRLALA--YGLFGFGY-IITATFLPLIARE---------TG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 352 LNSLFWGAFAAGRGLAIFFAACL-------HPGTLILLSLVGTTVSSLLLCLFSQNYPMLWACTALYGIS-MSTTFPSGI 423
Cdd:cd06180 228 AGSLLAGLLWSLFGLAAVPSCFLwgalsdrWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTfMAITALVMA 307
|
330 340 350
....*....|....*....|....*....|....*...
gi 147901269 424 SWVEQYTTVTGRSAAIFVVGAALGEMVLPALLGFLLGH 461
Cdd:cd06180 308 LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADA 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
107-478 |
1.27e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 107 NVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTPFCKKAWVLTVLMSSVGVSMGVLDTG 186
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 187 GNVLILNTWGEQAGPHMQAL-HFSFAAGAFASPIIAKLLFGHHNSSTNTslmsghasktIDAVLPFshpkgtstidLPWM 265
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLlYWAINLGVAIGPLLGGLLLLYSFRLLFL----------AAAVLFL----------LAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 266 WAYIVIGAFVLlvsllffslyfcISTNSNRTKTASGKQQFSKHHNTLIILLSMFFFFYvgsevAYGSFIFTYGkdyVHME 345
Cdd:cd17329 169 VLLFLLPETRP------------KRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISL-----IYFQLESTLP---VYVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 346 ETEAAGLN--SLFWGAFA----AGRGLAIFFAACLHPGTLILLSLVGTTVSsLLLCLFSQNYPMLWACTALYGISMSTTF 419
Cdd:cd17329 229 EILGLGESllGLLLALNAllivLLQFPVARLVERFRLRKILMIGILLFAIG-FAVLAFANTLAVLILAMIVLTLGEMLVF 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 147901269 420 PSGISWVEQY--TTVTGRSAAIFVVGAALGEMVLPALLGFLLGHVQ-NYPLLMYLTLCTATF 478
Cdd:cd17329 308 PAVQTLVAALapPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGpGLPWLILAALGLIAA 369
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
309-458 |
2.23e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.63 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 309 HNTLIILLSMFFFFYVGSEVAYGSFIFTYGKDYvHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTT 388
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147901269 389 VSSLLLcLFSQNYPMLWACTALYGISMSTTFPSGISWV------EQYTTVTGRSAAIFVVGAALGEMVLPALLGFL 458
Cdd:COG2223 82 IGLLLL-ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVskwfppDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
309-483 |
2.63e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 309 HNTLIILLSMFFFFYVGSEVAYGSFIFTYGKDYvHMEETEAAGLNSLFWGAFAAGRGLAIFFAA-CLHPGTLILLSLVGT 387
Cdd:COG2807 213 RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGLLG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 388 TVSSLLLCLFSQNYPMLWActALYGISMSTTFPSGISWV-------EQYTTVTGRSAAIFVVGAALGemvlPALLGFLLG 460
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWA--VLLGLGQGGLFPLALTLIglrartpAEAAALSGMAQSVGYLLAALG----PLLVGALHD 365
|
170 180
....*....|....*....|....*
gi 147901269 461 HVQNY--PLLMYLTLCTATFTSILF 483
Cdd:COG2807 366 ATGSWtaALLLLAALAVLMLVAGLL 390
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
294-458 |
3.71e-03 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 39.88 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 294 NRTKTASGKQQFSKHHNTLIILLSMFFFFYVGSEVAYGSFIFTYGKDY--VHMEETEAAGLNSLFWGAFAAGRGLAIFFA 371
Cdd:TIGR01272 123 ARVSSGDTTQKTSAFQFTHLVLGALGIFVYVGAEVSAGSFLVNFLSDPhaLGLPEDQAAHFTAYTWGGAMVGRFIGSAVM 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 372 ACLHPGTLILLSLVgTTVSSLLLCLFSQNYPMLWACTALyGISMSTTFPSGISW-VEQYTTVTGRSAAIFVVGAALGEMV 450
Cdd:TIGR01272 203 PMISQGRYLAFNAF-LAVLLSIGAALTHGYVAMWFVLAL-GLFNSIMFPTIFSLaLNALGRHTSQGSGILCLAIVGGAIV 280
|
....*...
gi 147901269 451 lPALLGFL 458
Cdd:TIGR01272 281 -PLLQGSL 287
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
290-483 |
5.06e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 5.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 290 STNSNRTKTASGKQQFSKHHNTLIILLSMFFFFYVGsevaYGSFIfTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIF 369
Cdd:cd17474 178 EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFL----YFAFL-TYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147901269 370 FAACLHPG-----TLILLSLVGTTVSSLLLcLFSQNYPMLWACTALYGISMSTTFPS-------GISWVEQYTTVTGRSA 437
Cdd:cd17474 253 FVGRLLKKrfgarRILVIGLLLYALSLLLL-GFVPSLALLLIAIVLFGLGLGLNLPLlttlvteLAPEEERGTASSLYNF 331
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 147901269 438 AIFvVGAALGEMVLPALLGFLLGHVqnypllMYLTLCTATFTSILF 483
Cdd:cd17474 332 VRF-LGQAVGPLLFGLLLEIFGLSA------PFLVGAAIALAAAVL 370
|
|
| |
