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Conserved domains on  [gi|148227540|ref|NP_001082856|]
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uncharacterized protein LOC560569 [Danio rerio]

Protein Classification

acyl-CoA-binding domain-containing protein( domain architecture ID 10468367)

acyl-CoA-binding domain-containing protein binds acyl-CoA esters and may play a role in housekeeping and/or trafficking

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 365-493 9.06e-82

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


:

Pssm-ID: 464028  Cd Length: 133  Bit Score: 249.70  E-value: 9.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540  365 VGRGEVLTIRVPTHPDGSYLFWEFATDHYDIGFGLHFEWKDLTAPTSSNNGGESTTETKEGTAQAEEEKTEQGR----IP 440
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSESSDEEDEEEEEENPGDVEAGSvnanKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 148227540  441 LVNEVAPVSRRDSHEEVYAGSHQYPGEGVHLLKFDNSYSLWRPKVVYYRVYYT 493
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
59-140 6.59e-18

Acyl CoA binding protein;


:

Pssm-ID: 459982  Cd Length: 76  Bit Score: 78.02  E-value: 6.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540   59 EELFRLALKFFKemnGKAFNPTYEENLRLVALHKQITLGPYNpNSCPdiGFFDVLGNDRRKEWLSLGSMAKEDAMEDFVK 138
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCN-TPRP--GMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 148227540  139 LL 140
Cdd:pfam00887  75 LV 76
 
Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 365-493 9.06e-82

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 464028  Cd Length: 133  Bit Score: 249.70  E-value: 9.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540  365 VGRGEVLTIRVPTHPDGSYLFWEFATDHYDIGFGLHFEWKDLTAPTSSNNGGESTTETKEGTAQAEEEKTEQGR----IP 440
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSESSDEEDEEEEEENPGDVEAGSvnanKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 148227540  441 LVNEVAPVSRRDSHEEVYAGSHQYPGEGVHLLKFDNSYSLWRPKVVYYRVYYT 493
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
59-140 6.59e-18

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 78.02  E-value: 6.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540   59 EELFRLALKFFKemnGKAFNPTYEENLRLVALHKQITLGPYNpNSCPdiGFFDVLGNDRRKEWLSLGSMAKEDAMEDFVK 138
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCN-TPRP--GMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 148227540  139 LL 140
Cdd:pfam00887  75 LV 76
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 58-145 1.82e-09

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 54.25  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540  58 LEELFRLALKFFKEMngkAFNPTYEENLRLVALHKQITLGPYNpNSCPdiGFFDVLGNDRRKEWLSLGSMAKEDAMEDFV 137
Cdd:cd00435    1 LQEEFEAAAEKVKKL---KTKPSNEEKLQLYSLYKQATVGDCN-TERP--GMFDLKGRAKWDAWNSLKGMSKEDAMKAYI 74


                 ....*...
gi 148227540 138 KLLNSCCS 145
Cdd:cd00435   75 AKVEELIA 82
 
Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 365-493 9.06e-82

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 464028  Cd Length: 133  Bit Score: 249.70  E-value: 9.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540  365 VGRGEVLTIRVPTHPDGSYLFWEFATDHYDIGFGLHFEWKDLTAPTSSNNGGESTTETKEGTAQAEEEKTEQGR----IP 440
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSESSDEEDEEEEEENPGDVEAGSvnanKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 148227540  441 LVNEVAPVSRRDSHEEVYAGSHQYPGEGVHLLKFDNSYSLWRPKVVYYRVYYT 493
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
59-140 6.59e-18

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 78.02  E-value: 6.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540   59 EELFRLALKFFKemnGKAFNPTYEENLRLVALHKQITLGPYNpNSCPdiGFFDVLGNDRRKEWLSLGSMAKEDAMEDFVK 138
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCN-TPRP--GMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 148227540  139 LL 140
Cdd:pfam00887  75 LV 76
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 58-145 1.82e-09

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 54.25  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148227540  58 LEELFRLALKFFKEMngkAFNPTYEENLRLVALHKQITLGPYNpNSCPdiGFFDVLGNDRRKEWLSLGSMAKEDAMEDFV 137
Cdd:cd00435    1 LQEEFEAAAEKVKKL---KTKPSNEEKLQLYSLYKQATVGDCN-TERP--GMFDLKGRAKWDAWNSLKGMSKEDAMKAYI 74


                 ....*...
gi 148227540 138 KLLNSCCS 145
Cdd:cd00435   75 AKVEELIA 82
DRWD-C_FANCL cd23832
C-terminal double-RWD domain of Fanconi anemia group L protein (FANCL) and related proteins; ...
 78-147 5.34e-03

C-terminal double-RWD domain of Fanconi anemia group L protein (FANCL) and related proteins; FANCL, also called E3 ubiquitin-protein ligase FANCL, Fanconi anemia-associated polypeptide of 43 kDa (FAAP43), or RING-type E3 ubiquitin transferase FANCL, is an E3 ubiquitin-protein ligase component of the Fanconi anemia (FA) core complex which functions in the repair of interstrand crosslinks (ICLs), a toxic form of DNA damage. FANCL, works in conjunction with the E2 conjugating enzyme UBE2T (FANCT) to add a single ubiquitin to specific lysine residues on FANCD2 and FANCI. The mono-ubiquitinated FANCI-FANCD2 complex is thought to recruit downstream DNA-repair proteins for ICL processing. FANCL is composed of an N-terminal E2-like fold (ELF) domain, a novel double-RWD (DRWD) domain, and a C-terminal RING domain predicted to facilitate E2 binding. The DRWD domain is responsible for substrate binding. The model corresponds to the C-terminal DRWD domain (DRWD-C).


Pssm-ID: 467666  Cd Length: 89  Bit Score: 35.99  E-value: 5.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148227540  78 NPTYEENLRLVALHK----QITLGPYNPNSCPDIGFfdvLGNDRR-KEWlslgsmakEDAMEDFVKLLNSCCSLF 147
Cdd:cd23832   19 KPTRSDTYRRIALGNhcslQITIDPLHPRALPECRF---LGPESAvAPL--------RDKLNRNLSLWDPERSLL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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