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Conserved domains on  [gi|145334797|ref|NP_001078744|]
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Uncharacterized protein family (UPF0172) [Arabidopsis thaliana]

Protein Classification

MPN domain-containing protein( domain architecture ID 46114)

MPN domain-containing protein contains the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, which is involved in zinc ion coordination; similar to components of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin conjugation pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0172 super family cl47834
Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 ...
 1-50 2.98e-19

Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.


The actual alignment was detected with superfamily member pfam03665:

Pssm-ID: 461011  Cd Length: 189  Bit Score: 75.35  E-value: 2.98e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 145334797    1 MIEEHYVAQGLSIVGYFHANERFDDVELCGVAKNIGDHISRYFPQAPILL 50
Cdd:pfam03665  62 QIDAYAKSKGLVIVGYYQANERLDDTSLSPVAEKIADKIAENFSDAVLLV 111
 
Name Accession Description Interval E-value
UPF0172 pfam03665
Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 ...
 1-50 2.98e-19

Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.


Pssm-ID: 461011  Cd Length: 189  Bit Score: 75.35  E-value: 2.98e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 145334797    1 MIEEHYVAQGLSIVGYFHANERFDDVELCGVAKNIGDHISRYFPQAPILL 50
Cdd:pfam03665  62 QIDAYAKSKGLVIVGYYQANERLDDTSLSPVAEKIADKIAENFSDAVLLV 111
MPN_UPF0172 cd08060
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); ...
 1-50 1.41e-17

Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); This family includes Noc4p (neighbor of COX4; neighbor of Cytochrome c Oxidase 4; nucleolar complex associated 4 homolog) which belongs to the family of unknown function, UPF0172, with MPN/JAMM-like domains. Proteins in this family are homologs of the NOC4 gene which is conserved in eukaryotic members including human, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice. NOC4 highly expressed in the pancreas and moderately in liver, heart, lung, kidney, brain, skeletal muscle, and placenta. This nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.


Pssm-ID: 163691  Cd Length: 182  Bit Score: 70.79  E-value: 1.41e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 145334797   1 MIEEHYVAQGLSIVGYFHANERFDDVELCGVAKNIGDHISRYFPQAPILL 50
Cdd:cd08060   60 LVDAYCKSSGLVIVGYYQANERLDDSSPSPVAKKIADKIAENFSNACLLM 109
 
Name Accession Description Interval E-value
UPF0172 pfam03665
Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 ...
 1-50 2.98e-19

Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.


Pssm-ID: 461011  Cd Length: 189  Bit Score: 75.35  E-value: 2.98e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 145334797    1 MIEEHYVAQGLSIVGYFHANERFDDVELCGVAKNIGDHISRYFPQAPILL 50
Cdd:pfam03665  62 QIDAYAKSKGLVIVGYYQANERLDDTSLSPVAEKIADKIAENFSDAVLLV 111
MPN_UPF0172 cd08060
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); ...
 1-50 1.41e-17

Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); This family includes Noc4p (neighbor of COX4; neighbor of Cytochrome c Oxidase 4; nucleolar complex associated 4 homolog) which belongs to the family of unknown function, UPF0172, with MPN/JAMM-like domains. Proteins in this family are homologs of the NOC4 gene which is conserved in eukaryotic members including human, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice. NOC4 highly expressed in the pancreas and moderately in liver, heart, lung, kidney, brain, skeletal muscle, and placenta. This nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.


Pssm-ID: 163691  Cd Length: 182  Bit Score: 70.79  E-value: 1.41e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 145334797   1 MIEEHYVAQGLSIVGYFHANERFDDVELCGVAKNIGDHISRYFPQAPILL 50
Cdd:cd08060   60 LVDAYCKSSGLVIVGYYQANERLDDSSPSPVAKKIADKIAENFSNACLLM 109
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 5-48 4.42e-03

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 32.77  E-value: 4.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 145334797   5 HYVAQGLSIVGYFHANERFDDVELCGVAKNIGDhISRYFPQAPI 48
Cdd:cd01916  208 HNVAPGAEIMDYLEENGLEDKVEVGGICCTAID-LTRYNEKAKV 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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