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Conserved domains on  [gi|145334565|ref|NP_001078628|]
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cysteine synthase D2 [Arabidopsis thaliana]

Protein Classification

PALP domain-containing protein; threonine synthase( domain architecture ID 10791233)

PALP domain-containing protein belonging to the tryptophan synthase beta superfamily (fold type II) that consists of pyridoxal phosphate (PLP)-dependent enzymes that catalyze beta-replacement and beta-elimination reactions| threonine synthase catalyzes the final step of threonine biosynthesis, the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00011 PLN00011
cysteine synthase
 1-323 0e+00

cysteine synthase


:

Pssm-ID: 177651  Cd Length: 323  Bit Score: 610.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   1 MEDRCLIKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNT 80
Cdd:PLN00011   1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  81 GIGLACMGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHY 160
Cdd:PLN00011  81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLT 240
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 241 IVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAENL 320
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320


                 ...
gi 145334565 321 PIE 323
Cdd:PLN00011 321 PIE 323
 
Name Accession Description Interval E-value
PLN00011 PLN00011
cysteine synthase
 1-323 0e+00

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 610.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   1 MEDRCLIKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNT 80
Cdd:PLN00011   1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  81 GIGLACMGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHY 160
Cdd:PLN00011  81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLT 240
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 241 IVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAENL 320
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320


                 ...
gi 145334565 321 PIE 323
Cdd:PLN00011 321 PIE 323
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 7-307 1.90e-151

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 426.77  E-value: 1.90e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   7 IKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLAC 86
Cdd:COG0031    3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  87 MGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPE 166
Cdd:COG0031   82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 167 IWRDSAGKVDILvagvgtggtatgvgKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEII 246
Cdd:COG0031  162 IWEQTDGKVDAFvagvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334565 247 QVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRpENAGKLIVVVFPSGGERYLST 307
Cdd:COG0031  242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 11-310 1.70e-150

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 424.47  E-value: 1.70e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   11 ITELIGNTPMVYLNNVvDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKsTLIEPTAGNTGIGLACMGAA 90
Cdd:TIGR01139   1 ISELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGY-IPQQFENPANPEIHYRTTGPEIWR 169
Cdd:TIGR01139  79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  170 DSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVA 249
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334565  250 GEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPEnAGKLIVVVFPSGGERYLSTKLF 310
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 16-306 3.02e-137

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 390.34  E-value: 3.02e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  16 GNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLACMGAARGYKV 95
Cdd:cd01561    1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  96 ILVMPSTMSLERRIILRALGAELHLSD--QRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPEIWRDSAG 173
Cdd:cd01561   80 IIVMPETMSEEKRKLLRALGAEVILTPeaEADGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 174 KVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAGEEA 253
Cdd:cd01561  160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145334565 254 IETAKLLALKEGLLVGISSGAAAAAALKVAKRPEnAGKLIVVVFPSGGERYLS 306
Cdd:cd01561  240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 11-298 9.62e-61

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 195.61  E-value: 9.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   11 ITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGlitpGKSTLIEPTAGNTGIGLACMGAA 90
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQriGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIhYRTTGPEIWRD 170
Cdd:pfam00291  77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  171 SAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGG---------QPGPHLIQGIGSGIVPFNLDLTI 241
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334565  242 ----VDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFP 298
Cdd:pfam00291 234 ldeyVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGGDRVVVVLT 294
 
Name Accession Description Interval E-value
PLN00011 PLN00011
cysteine synthase
 1-323 0e+00

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 610.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   1 MEDRCLIKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNT 80
Cdd:PLN00011   1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  81 GIGLACMGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHY 160
Cdd:PLN00011  81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLT 240
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 241 IVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAENL 320
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320


                 ...
gi 145334565 321 PIE 323
Cdd:PLN00011 321 PIE 323
PLN02565 PLN02565
cysteine synthase
 3-323 1.04e-175

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 489.05  E-value: 1.04e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   3 DRCLIKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNTGI 82
Cdd:PLN02565   1 EKSSIAKDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  83 GLACMGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRT 162
Cdd:PLN02565  81 GLAFMAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 163 TGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIV 242
Cdd:PLN02565 161 TGPEIWKGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 243 DEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAENLPI 322
Cdd:PLN02565 241 DEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAENMVF 320


                 .
gi 145334565 323 E 323
Cdd:PLN02565 321 E 321
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 7-307 1.90e-151

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 426.77  E-value: 1.90e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   7 IKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLAC 86
Cdd:COG0031    3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  87 MGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPE 166
Cdd:COG0031   82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 167 IWRDSAGKVDILvagvgtggtatgvgKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEII 246
Cdd:COG0031  162 IWEQTDGKVDAFvagvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334565 247 QVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRpENAGKLIVVVFPSGGERYLST 307
Cdd:COG0031  242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 11-310 1.70e-150

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 424.47  E-value: 1.70e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   11 ITELIGNTPMVYLNNVvDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKsTLIEPTAGNTGIGLACMGAA 90
Cdd:TIGR01139   1 ISELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGY-IPQQFENPANPEIHYRTTGPEIWR 169
Cdd:TIGR01139  79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  170 DSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVA 249
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334565  250 GEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPEnAGKLIVVVFPSGGERYLSTKLF 310
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 11-310 5.01e-148

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 418.22  E-value: 5.01e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   11 ITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKsTLIEPTAGNTGIGLACMGAA 90
Cdd:TIGR01136   1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGD-TIIEATSGNTGIALAMVAAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPEIWRD 170
Cdd:TIGR01136  80 RGYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  171 SAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAG 250
Cdd:TIGR01136 160 TDGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSD 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  251 EEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLF 310
Cdd:TIGR01136 240 EDAIETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
PLN03013 PLN03013
cysteine synthase
 7-323 6.88e-142

cysteine synthase


Pssm-ID: 178587 [Multi-domain]  Cd Length: 429  Bit Score: 407.63  E-value: 6.88e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   7 IKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNTGIGLAC 86
Cdd:PLN03013 113 IADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  87 MGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPE 166
Cdd:PLN03013 193 IAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPE 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 167 IWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEII 246
Cdd:PLN03013 273 IWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVI 352

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145334565 247 QVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGeRYLSTKLFDSIRYEAENLPIE 323
Cdd:PLN03013 353 AISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKRWRKCSL 428
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 16-306 3.02e-137

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 390.34  E-value: 3.02e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  16 GNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLACMGAARGYKV 95
Cdd:cd01561    1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  96 ILVMPSTMSLERRIILRALGAELHLSD--QRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPEIWRDSAG 173
Cdd:cd01561   80 IIVMPETMSEEKRKLLRALGAEVILTPeaEADGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 174 KVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAGEEA 253
Cdd:cd01561  160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145334565 254 IETAKLLALKEGLLVGISSGAAAAAALKVAKRPEnAGKLIVVVFPSGGERYLS 306
Cdd:cd01561  240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 7-320 2.61e-132

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 380.84  E-value: 2.61e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   7 IKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNTGIGLAC 86
Cdd:PLN02556  49 IKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  87 MGAARGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPE 166
Cdd:PLN02556 129 MAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 167 IWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEII 246
Cdd:PLN02556 209 IWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVL 288

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145334565 247 QVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAENL 320
Cdd:PLN02556 289 EVSSEDAVNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENM 362
PRK10717 PRK10717
cysteine synthase A; Provisional
 7-322 2.99e-98

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 292.92  E-value: 2.99e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   7 IKNDITELIGNTPMVYLNNVVD--GCvaRIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKsTLIEPTAGNTGIGL 84
Cdd:PRK10717   3 IFEDVSDTIGNTPLIRLNRASEatGC--EILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGG-TIVEGTAGNTGIGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  85 ACMGAARGYKVILVMPSTMSLERRIILRALGAELHL------SDQRIGLKGMLEKTEAILSKTPGGYI-PQQFENPANPE 157
Cdd:PRK10717  80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLvpaapyANPNNYVKGAGRLAEELVASEPNGAIwANQFDNPANRE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 158 IHYRTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLS---GGQ---PGPHLIQGIGSG 231
Cdd:PRK10717 160 AHYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyykTGElkaEGSSITEGIGQG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 232 IVPFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRpENAGKLIVVVFPSGGERYLStKLFD 311
Cdd:PRK10717 240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARE-LGPGHTIVTILCDSGERYQS-KLFN 317

                        330
                 ....*....|.
gi 145334565 312 SIRYEAENLPI 322
Cdd:PRK10717 318 PDFLREKGLPV 328
cysta_beta TIGR01137
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ...
 7-311 5.37e-83

cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273464 [Multi-domain]  Cd Length: 455  Bit Score: 258.19  E-value: 5.37e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565    7 IKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLAC 86
Cdd:TIGR01137   1 ILDNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPG-DTIIEPTSGNTGIGLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   87 MGAARGYKVILVMPSTMSLERRIILRALGAEL---------HLSDQRIGLKGMLEKteailsKTPGGYIPQQFENPANPE 157
Cdd:TIGR01137  80 VAAIKGYKCIIVLPEKMSSEKVDVLRALGAEIvrtptaaafDSPESHIGVAKRLVR------EIPGAHILDQYRNPSNPL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  158 IHYRTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPvESPVLSGGQP------GPHLIQGIGSG 231
Cdd:TIGR01137 154 AHYDTTGPEILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADP-EGSILAQPEElnqtgrTPYKVEGIGYD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  232 IVPFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLsTKLFD 311
Cdd:TIGR01137 233 FIPTVLDRKVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDELQEGQRCVVLLPDSIRNYM-TKFLN 311
cysM PRK11761
cysteine synthase CysM;
11-312 5.89e-82

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 250.18  E-value: 5.89e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  11 ITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLACMGAA 90
Cdd:PRK11761   6 LEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMIAAI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAiLSKTPGGYIPQQFENPANPEIHYRTTGPEIWRD 170
Cdd:PRK11761  85 KGYRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQ-MQAEGEGKVLDQFANPDNPLAHYETTGPEIWRQ 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 171 SAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVEspvlsGGQpgphlIQGI---GSGIVPFNLDLTIVDEIIQ 247
Cdd:PRK11761 164 TEGRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEE-----GSS-----IPGIrrwPEEYLPKIFDASRVDRVLD 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334565 248 VAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAgkLIVVVFPSGGERYLSTKLFDS 312
Cdd:PRK11761 234 VSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIARENPNA--VIVAIICDRGDRYLSTGVFPA 296
cysM TIGR01138
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ...
 11-310 8.97e-76

cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]


Pssm-ID: 130208 [Multi-domain]  Cd Length: 290  Bit Score: 234.42  E-value: 8.97e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   11 ITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKsTLIEPTAGNTGIGLACMGAA 90
Cdd:TIGR01138   2 IEQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGD-VLIEATSGNTGIALAMIAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLEKTEAILSKTPGGYIpQQFENPANPEIHYRTTGPEIWRD 170
Cdd:TIGR01138  81 KGYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGKLL-DQFNNPDNPYAHYTSTGPEIWQQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  171 SAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGgqpgphlIQGIGSGIVPFNLDLTIVDEIIQVAG 250
Cdd:TIGR01138 160 TGGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEEGSSIPG-------IRRWPTEYLPGIFDASLVDRVLDIHQ 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  251 EEAIETAKLLALKEGLLVGISSGAAAAAALKVAKrpENAGKLIVVVFPSGGERYLSTKLF 310
Cdd:TIGR01138 233 RDAENTMRELAVREGIFCGVSSGGAVAAALRLAR--ELPDAVVVAIICDRGDRYLSTGVF 290
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 11-298 9.62e-61

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 195.61  E-value: 9.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   11 ITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGlitpGKSTLIEPTAGNTGIGLACMGAA 90
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQriGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIhYRTTGPEIWRD 170
Cdd:pfam00291  77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  171 SAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPVLSGG---------QPGPHLIQGIGSGIVPFNLDLTI 241
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334565  242 ----VDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVFP 298
Cdd:pfam00291 234 ldeyVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGGDRVVVVLT 294
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 18-300 4.45e-59

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 189.65  E-value: 4.45e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  18 TPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLItpGKSTLIEPTAGNTGIGLACMGAARGYKVIL 97
Cdd:cd00640    1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  98 VMPSTMSLERRIILRALGAELHLSDQriGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYrTTGPEIWRDsagkvdi 177
Cdd:cd00640   79 VMPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQG-TIGLEILEQ------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 178 lvagvgtggtatgvgkfLKEQNKDIKVCvvepvesPVLSGGqpgphLIQGIGSGIVPFNLDLTIV---DEIIQVAGEEAI 254
Cdd:cd00640  149 -----------------LGGQKPDAVVV-------PVGGGG-----NIAGIARALKELLPNVKVIgvePEVVTVSDEEAL 199

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 145334565 255 ETAKLLALKEGLLVGISSGAAAAAALKVAKRPeNAGKLIVVVFPSG 300
Cdd:cd00640  200 EAIRLLAREEGILVEPSSAAALAAALKLAKKL-GKGKTVVVILTGG 244
PLN02356 PLN02356
phosphateglycerate kinase
 8-312 4.27e-35

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 132.04  E-value: 4.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   8 KNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEPTAGNTGIGLACM 87
Cdd:PLN02356  44 RNGLIDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPG-GVVTEGSAGSTAISLATV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  88 GAARGYKVILVMPSTMSLERRIILRALGAELH---------------------------LSDQRIGLK---GMLEKTEAI 137
Cdd:PLN02356 123 APAYGCKCHVVIPDDVAIEKSQILEALGATVErvrpvsithkdhyvniarrraleanelASKRRKGSEtdgIHLEKTNGC 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 138 LS---KTP--------GGYIPQQFENPANPEIHYRTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCV 206
Cdd:PLN02356 203 ISeeeKENslfsssctGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFL 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 207 VEPVESPVLSG-----------------GQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVG 269
Cdd:PLN02356 283 IDPPGSGLFNKvtrgvmytreeaegrrlKNPFDTITEGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLKNDGLFVG 362

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 145334565 270 ISSGAAAAAALKVAKRPeNAGKLIVVVFPSGGERYLStKLFDS 312
Cdd:PLN02356 363 SSSAMNCVGAVRVAQSL-GPGHTIVTILCDSGMRHLS-KFHDP 403
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 18-301 8.01e-08

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 52.87  E-value: 8.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  18 TPMVY---LNNVVDgcvARIAAKLEMMEPCSSVKDRIAYSMI----KDAEDKGLITPgkstliepTAGNTGIGLACMGAA 90
Cdd:cd01562   18 TPLLTsptLSELLG---AEVYLKCENLQKTGSFKIRGAYNKLlslsEEERAKGVVAA--------SAGNHAQGVAYAAKL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  91 RGYKVILVMPSTMSLERRIILRALGAELHLSDQRIGLKgmLEKTEAILSKTPGGYIPqqfenPANpeiHYR------TTG 164
Cdd:cd01562   87 LGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEA--EAKARELAEEEGLTFIH-----PFD---DPDviagqgTIG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 165 PEIWRDsAGKVDILvagvgtggtatgvgkF---------------LKEQNKDIKVCVVEPVESPVLS----GGQP----- 220
Cdd:cd01562  157 LEILEQ-VPDLDAV---------------FvpvggggliagiataVKALSPNTKVIGVEPEGAPAMAqslaAGKPvtlpe 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 221 GPHLIQGIGSGIV---PFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPEnaGKLIVVVF 297
Cdd:cd01562  221 VDTIADGLAVKRPgelTFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLDLK--GKKVVVVL 298


                 ....
gi 145334565 298 pSGG 301
Cdd:cd01562  299 -SGG 301
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 18-269 5.29e-07

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 50.42  E-value: 5.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  18 TPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMI----KDAEDKGLITPgkstliepTAGNTGIGLACMGAARGY 93
Cdd:COG1171   25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALaslsEEERARGVVAA--------SAGNHAQGVAYAARLLGI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  94 KVILVMPSTMSLERRIILRALGAELHLSDqriglkGMLEKTEAI---LSKTPGG-YIPqqfenPANPE--IH-YRTTGPE 166
Cdd:COG1171   97 PATIVMPETAPAVKVAATRAYGAEVVLHG------DTYDDAEAAaaeLAEEEGAtFVH-----PFDDPdvIAgQGTIALE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 167 IWRDsAGKVDILvagvgtggtatgvgkF---------------LKEQNKDIKVCVVEPVESPV----LSGGQP----GPH 223
Cdd:COG1171  166 ILEQ-LPDLDAV---------------FvpvggggliagvaaaLKALSPDIRVIGVEPEGAAAmyrsLAAGEPvtlpGVD 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 145334565 224 LI-QGIGSGIV---PFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVG 269
Cdd:COG1171  230 TIaDGLAVGRPgelTFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVE 279
PRK08329 PRK08329
threonine synthase; Validated
 37-122 3.14e-06

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 48.28  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  37 KLEMMEPCSSVKDRIAYSMIKDAEDKGLitpgkSTLIEPTAGNTGIGLACMGAARGYKVILVMPSTMSLERRIILRALGA 116
Cdd:PRK08329  77 KLDYLQPTGSFKDRGTYVTVAKLKEEGI-----NEVVIDSSGNAALSLALYSLSEGIKVHVFVSYNASKEKISLLSRLGA 151


                 ....*.
gi 145334565 117 ELHLSD 122
Cdd:PRK08329 152 ELHFVE 157
PRK06450 PRK06450
threonine synthase; Validated
 7-118 3.57e-06

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 47.81  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   7 IKNDITELIGNTPMVYLNNVvdgcvariAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLitpgkSTLIEPTAGNTGIGLAC 86
Cdd:PRK06450  48 IKHFISLGEGRTPLIKKGNI--------WFKLDFLNPTGSYKDRGSVTLISYLAEKGI-----KQISEDSSGNAGASIAA 114

                         90       100       110
                 ....*....|....*....|....*....|..
gi 145334565  87 MGAARGYKVILVMPSTMSLERRIILRALGAEL 118
Cdd:PRK06450 115 YGAAAGIEVKIFVPETASGGKLKQIESYGAEV 146
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 16-119 4.41e-06

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 47.59  E-value: 4.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  16 GNTPMVYLNNVVD-GCVARIAAKLEMMEPCSSVKDRIAYSMIKDAedKGLitpGKSTLIEPTAGNTGIGLACMGAARGYK 94
Cdd:cd01563   21 GNTPLVRAPRLGErLGGKNLYVKDEGLNPTGSFKDRGMTVAVSKA--KEL---GVKAVACASTGNTSASLAAYAARAGIK 95

                         90       100
                 ....*....|....*....|....*
gi 145334565  95 VILVMPSTMSLERRIILRALGAELH 119
Cdd:cd01563   96 CVVFLPAGKALGKLAQALAYGATVL 120
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 18-315 8.50e-06

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 47.05  E-value: 8.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   18 TPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGlitpGKSTLIEPTAGNTGIGLACMGAARGYKVIL 97
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANLSEDQ----RQRGVVAASAGNHAQGVAYAAKKFGIKAVI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   98 VMPSTMSLERRIILRALGAELHLS----DQRIGLKGMLEKTEailsktpgGYIpqqFENPAN-PEI--HYRTTGPEIWRD 170
Cdd:TIGR01127  77 VMPESAPPSKVKATKSYGAEVILHgddyDEAYAFATSLAEEE--------GRV---FVHPFDdEFVmaGQGTIGLEIMED 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  171 sAGKVDILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEPVESPV----LSGGQP-----GPHLIQGIG---SGIVPFNLD 238
Cdd:TIGR01127 146 -IPDVDTVIVPVGGGGLISGVASAAKQINPNVKVIGVEAEGAPSmyesLREGKIkavesVRTIADGIAvkkPGDLTFNII 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  239 LTIVDEIIQVAgEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVVfpSGG-------ERYLSTKLFD 311
Cdd:TIGR01127 225 KEYVDDVVTVD-EEEIANAIYLLLERHKILAEGAGAAGVAALLEQKVDVKGKKIAVVL--SGGnidlnllNKIIEKGLVK 301


                  ....
gi 145334565  312 SIRY 315
Cdd:TIGR01127 302 SGRK 305
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 16-120 1.48e-05

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 46.35  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  16 GNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDR---IAYSMIKDAedkglitpGKSTLIEPTAGNTGIGLACMGAARG 92
Cdd:COG0498   65 GGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRamqVAVSLALER--------GAKTIVCASSGNGSAALAAYAARAG 136

                         90       100
                 ....*....|....*....|....*....
gi 145334565  93 YKVILVMPST-MSLERRIILRALGAELHL 120
Cdd:COG0498  137 IEVFVFVPEGkVSPGQLAQMLTYGAHVIA 165
PRK08197 PRK08197
threonine synthase; Validated
 31-126 5.20e-04

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 41.52  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  31 VARIAAKLEMMEPCSSVKDR---IAYSMIKDAedkglitpGKSTLIEPTAGNTGIGLACMGAARGYKVILVMPSTMSLER 107
Cdd:PRK08197  94 IGRLWVKDEGLNPTGSFKARglaVGVSRAKEL--------GVKHLAMPTNGNAGAAWAAYAARAGIRATIFMPADAPEIT 165

                         90
                 ....*....|....*....
gi 145334565 108 RIILRALGAELHLSDQRIG 126
Cdd:PRK08197 166 RLECALAGAELYLVDGLIS 184
PRK06815 PRK06815
threonine/serine dehydratase;
32-296 6.01e-04

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 40.83  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  32 ARIAAKLEMMEPCSSVKDRIAYSMIK----DAEDKGLITPgkstliepTAGNTGIGLACMGAARGYKVILVMPSTMSLER 107
Cdd:PRK06815  35 CEVYLKCEHLQHTGSFKFRGASNKLRllneAQRQQGVITA--------SSGNHGQGVALAAKLAGIPVTVYAPEQASAIK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 108 RIILRALGAELHLsdqrIGLKGMLEKTEAILSKTPGG--YIPqqfenPAN-PEI--HYRTTGPEIWRdSAGKVDILVAGV 182
Cdd:PRK06815 107 LDAIRALGAEVRL----YGGDALNAELAARRAAEQQGkvYIS-----PYNdPQViaGQGTIGMELVE-QQPDLDAVFVAV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565 183 GTGGTATGVGKFLKEQNKDIKV--C----------------VVEPVESPVLSGGQPGphliqGIGSGIVPFNLDLTIVDE 244
Cdd:PRK06815 177 GGGGLISGIATYLKTLSPKTEIigCwpanspslytsleageIVEVAEQPTLSDGTAG-----GVEPGAITFPLCQQLIDQ 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145334565 245 IIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPEnaGKLIVVV 296
Cdd:PRK06815 252 KVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPRYQ--GKKVAVV 301
PRK06381 PRK06381
threonine synthase; Validated
 33-118 8.78e-04

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 40.46  E-value: 8.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565  33 RIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLitpgkSTLIEPTAGNTGIGLACMGAARGYKVILVMPSTMSLERRIILR 112
Cdd:PRK06381  32 KIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY-----SGITVGTCGNYGASIAYFARLYGLKAVIFIPRSYSNSRVKEME 106


                 ....*.
gi 145334565 113 ALGAEL 118
Cdd:PRK06381 107 KYGAEI 112
PRK06110 PRK06110
threonine dehydratase;
67-118 1.83e-03

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 39.59  E-value: 1.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145334565  67 PGKSTLIEPTAGNTGIGLACMGAARGYKVILVMPSTMSLERRIILRALGAEL 118
Cdd:PRK06110  68 PRVRGVISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAEL 119
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
8-120 4.33e-03

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 38.56  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334565   8 KNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAY---SMIKDAE-DKGLITPgkstliepTAGNTGIG 83
Cdd:PRK08638  18 KQRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFnklSSLTDAEkRKGVVAC--------SAGNHAQG 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 145334565  84 LACMGAARGYKVILVMPSTMSLERRIILRALGAELHL 120
Cdd:PRK08638  90 VALSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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