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Conserved domains on  [gi|145334125|ref|NP_001078443|]
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RAB geranylgeranyl transferase alpha subunit 1 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1905032)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BET4 super family cl44255
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 25-234 4.72e-44

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5536:

Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 160.81  E-value: 4.72e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  25 RSLQSQFMTNHHDKIYTNEAIELSTKLLEINPEAYTAWNYRklavEDRLARIEPDPNLVSAILDEELRVVESALRQNFKS 104
Cdd:COG5536   32 HPLMGRFRAKRRKKEYSVRALKLTQELIDKNPEFYTIWNYR----FSILKHVQMVSEDKEHLLDNELDFLDEALKDNPKN 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 105 YGAWHHRKWVLSK-GHSSVGNELRLLEKFQKLDSRNFHAWNYRRFVV----ELTNRSE-QDELQYTDDMINNNFSNYSAW 178
Cdd:COG5536  108 YQIWHHRQWMLELfPKPSWGRELFITKKLLDSDSRNYHVWSYRRWVLrtieDLFNFSDlKHELEYTTSLIETDIYNNSAW 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145334125 179 HNRSVLLSSLLaqNADGFMPNIKIPEEYDFVHSAIFTEPDDQSGWFYHLWLLDQTL 234
Cdd:COG5536  188 HHRYIWIERRF--NRGDVISQKYLEKELEYIFDKIFTDPDNQSVWGYLRGVSSEFA 241
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 511-596 4.79e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 511 NNLVCLRLNNLSLSRIASVEKLLF-----------VQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSAL-DSLRH 578
Cdd:cd21340   87 ENLTNLEELHIENQRLPPGEKLTFdprslaalsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSS 166

                         90
                 ....*....|....*...
gi 145334125 579 VKQLKVLDVSHNHIGKHS 596
Cdd:cd21340  167 WPSLRELDLTGNPVCKKP 184
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-670 4.30e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 535 VQMLDLSHNELHS------TEGLEAMQLLSCLNLSHNRIRSFSALDSLRHVK---QLKVLDVSHNHIGKHSVDTtryLCS 605
Cdd:COG5238  294 LTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQIGDEGAIA---LAK 370

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334125 606 SPLSNSELGQDDVGKQNPGLVTKYWDAYCVLTDlNLKQLDIAGNEIaGEEFSSFVLQVVPKLVWL 670
Cdd:COG5238  371 YLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLI-GAEAQQRLEQLLERIKSV 433
 
Name Accession Description Interval E-value
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 25-234 4.72e-44

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 160.81  E-value: 4.72e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  25 RSLQSQFMTNHHDKIYTNEAIELSTKLLEINPEAYTAWNYRklavEDRLARIEPDPNLVSAILDEELRVVESALRQNFKS 104
Cdd:COG5536   32 HPLMGRFRAKRRKKEYSVRALKLTQELIDKNPEFYTIWNYR----FSILKHVQMVSEDKEHLLDNELDFLDEALKDNPKN 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 105 YGAWHHRKWVLSK-GHSSVGNELRLLEKFQKLDSRNFHAWNYRRFVV----ELTNRSE-QDELQYTDDMINNNFSNYSAW 178
Cdd:COG5536  108 YQIWHHRQWMLELfPKPSWGRELFITKKLLDSDSRNYHVWSYRRWVLrtieDLFNFSDlKHELEYTTSLIETDIYNNSAW 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145334125 179 HNRSVLLSSLLaqNADGFMPNIKIPEEYDFVHSAIFTEPDDQSGWFYHLWLLDQTL 234
Cdd:COG5536  188 HHRYIWIERRF--NRGDVISQKYLEKELEYIFDKIFTDPDNQSVWGYLRGVSSEFA 241
PLN02789 PLN02789
farnesyltranstransferase
 44-225 2.88e-27

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 112.92  E-value: 2.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  44 AIELSTKLLEINPEAYTAWNYRKLAVEDrlariepdpnlVSAILDEELRVVESALRQNFKSYGAWHHRKWVLSK-GHSSV 122
Cdd:PLN02789  56 ALDLTADVIRLNPGNYTVWHFRRLCLEA-----------LDADLEEELDFAEDVAEDNPKNYQIWHHRRWLAEKlGPDAA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 123 GNELRLLEKFQKLDSRNFHAWNYRRFVVELTNRSEqDELQYTDDMINNNFSNYSAWHNR------SVLLSSLLAQNadgf 196
Cdd:PLN02789 125 NKELEFTRKILSLDAKNYHAWSHRQWVLRTLGGWE-DELEYCHQLLEEDVRNNSAWNQRyfvitrSPLLGGLEAMR---- 199

                        170       180
                 ....*....|....*....|....*....
gi 145334125 197 mpnikiPEEYDFVHSAIFTEPDDQSGWFY 225
Cdd:PLN02789 200 ------DSELKYTIDAILANPRNESPWRY 222
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 511-596 4.79e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 511 NNLVCLRLNNLSLSRIASVEKLLF-----------VQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSAL-DSLRH 578
Cdd:cd21340   87 ENLTNLEELHIENQRLPPGEKLTFdprslaalsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSS 166

                         90
                 ....*....|....*...
gi 145334125 579 VKQLKVLDVSHNHIGKHS 596
Cdd:cd21340  167 WPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
509-592 2.93e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 509 DMNNLVCLRLNNLSLSRI-ASVEKLLFVQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSALDSLrhvKQLKVLDV 587
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDL 279


                 ....*
gi 145334125 588 SHNHI 592
Cdd:COG4886  280 SNNQL 284
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 87-117 1.12e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 42.62  E-value: 1.12e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 145334125   87 LDEELRVVESALRQNFKSYGAWHHRKWVLSK 117
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLER 31
LRR_8 pfam13855
Leucine rich repeat;
535-592 2.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  535 VQMLDLSHNELHSTEG--LEAMQLLSCLNLSHNRIRSFSAlDSLRHVKQLKVLDVSHNHI 592
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-670 4.30e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 535 VQMLDLSHNELHS------TEGLEAMQLLSCLNLSHNRIRSFSALDSLRHVK---QLKVLDVSHNHIGKHSVDTtryLCS 605
Cdd:COG5238  294 LTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQIGDEGAIA---LAK 370

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334125 606 SPLSNSELGQDDVGKQNPGLVTKYWDAYCVLTDlNLKQLDIAGNEIaGEEFSSFVLQVVPKLVWL 670
Cdd:COG5238  371 YLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLI-GAEAQQRLEQLLERIKSV 433
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 505-592 9.19e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 9.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 505 LRYRDMNNLVCLRLNNLSLS-----RIASVEKLLfvqMLDLSHNEL--HSTEGLEAMQLLSCLNLSHNRIrSFSALDSLR 577
Cdd:PLN00113 493 RKLGSLSELMQLKLSENKLSgeipdELSSCKKLV---SLDLSHNQLsgQIPASFSEMPVLSQLDLSQNQL-SGEIPKNLG 568

                         90
                 ....*....|....*
gi 145334125 578 HVKQLKVLDVSHNHI 592
Cdd:PLN00113 569 NVESLVQVNISHNHL 583
 
Name Accession Description Interval E-value
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 25-234 4.72e-44

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 160.81  E-value: 4.72e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  25 RSLQSQFMTNHHDKIYTNEAIELSTKLLEINPEAYTAWNYRklavEDRLARIEPDPNLVSAILDEELRVVESALRQNFKS 104
Cdd:COG5536   32 HPLMGRFRAKRRKKEYSVRALKLTQELIDKNPEFYTIWNYR----FSILKHVQMVSEDKEHLLDNELDFLDEALKDNPKN 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 105 YGAWHHRKWVLSK-GHSSVGNELRLLEKFQKLDSRNFHAWNYRRFVV----ELTNRSE-QDELQYTDDMINNNFSNYSAW 178
Cdd:COG5536  108 YQIWHHRQWMLELfPKPSWGRELFITKKLLDSDSRNYHVWSYRRWVLrtieDLFNFSDlKHELEYTTSLIETDIYNNSAW 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145334125 179 HNRSVLLSSLLaqNADGFMPNIKIPEEYDFVHSAIFTEPDDQSGWFYHLWLLDQTL 234
Cdd:COG5536  188 HHRYIWIERRF--NRGDVISQKYLEKELEYIFDKIFTDPDNQSVWGYLRGVSSEFA 241
PLN02789 PLN02789
farnesyltranstransferase
 44-225 2.88e-27

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 112.92  E-value: 2.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  44 AIELSTKLLEINPEAYTAWNYRKLAVEDrlariepdpnlVSAILDEELRVVESALRQNFKSYGAWHHRKWVLSK-GHSSV 122
Cdd:PLN02789  56 ALDLTADVIRLNPGNYTVWHFRRLCLEA-----------LDADLEEELDFAEDVAEDNPKNYQIWHHRRWLAEKlGPDAA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 123 GNELRLLEKFQKLDSRNFHAWNYRRFVVELTNRSEqDELQYTDDMINNNFSNYSAWHNR------SVLLSSLLAQNadgf 196
Cdd:PLN02789 125 NKELEFTRKILSLDAKNYHAWSHRQWVLRTLGGWE-DELEYCHQLLEEDVRNNSAWNQRyfvitrSPLLGGLEAMR---- 199

                        170       180
                 ....*....|....*....|....*....
gi 145334125 197 mpnikiPEEYDFVHSAIFTEPDDQSGWFY 225
Cdd:PLN02789 200 ------DSELKYTIDAILANPRNESPWRY 222
PLN02789 PLN02789
farnesyltranstransferase
 42-178 1.52e-11

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 65.92  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  42 NEAIELSTKLLEINPEAYTAWNYRKLAVEdrlaRIEPDpnlvsaILDEELRVVESALRQNFKSYGAWHHRKWVLSKghss 121
Cdd:PLN02789  89 EEELDFAEDVAEDNPKNYQIWHHRRWLAE----KLGPD------AANKELEFTRKILSLDAKNYHAWSHRQWVLRT---- 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145334125 122 VGN---ELRLLEKFQKLDSRNFHAWNYRRFVV---------ELTNRSeqdELQYTDDMINNNFSNYSAW 178
Cdd:PLN02789 155 LGGwedELEYCHQLLEEDVRNNSAWNQRYFVItrspllgglEAMRDS---ELKYTIDAILANPRNESPW 220
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 511-596 4.79e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 511 NNLVCLRLNNLSLSRIASVEKLLF-----------VQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSAL-DSLRH 578
Cdd:cd21340   87 ENLTNLEELHIENQRLPPGEKLTFdprslaalsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSS 166

                         90
                 ....*....|....*...
gi 145334125 579 VKQLKVLDVSHNHIGKHS 596
Cdd:cd21340  167 WPSLRELDLTGNPVCKKP 184
PLN02789 PLN02789
farnesyltranstransferase
 126-235 6.47e-07

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 51.67  E-value: 6.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 126 LRLLEKFQKLDSRNFHAWNYRRFVVELTNRSEQDELQYTDDMINNNFSNYSAWHNRSVLLSSLLAQNADgfmpnikipEE 205
Cdd:PLN02789  57 LDLTADVIRLNPGNYTVWHFRRLCLEALDADLEEELDFAEDVAEDNPKNYQIWHHRRWLAEKLGPDAAN---------KE 127

                         90       100       110
                 ....*....|....*....|....*....|
gi 145334125 206 YDFVHSAIFTEPDDQSGWFYHLWLLdQTLN 235
Cdd:PLN02789 128 LEFTRKILSLDAKNYHAWSHRQWVL-RTLG 156
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
509-592 2.93e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 509 DMNNLVCLRLNNLSLSRI-ASVEKLLFVQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSALDSLrhvKQLKVLDV 587
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDL 279


                 ....*
gi 145334125 588 SHNHI 592
Cdd:COG4886  280 SNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
509-592 9.18e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 9.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 509 DMNNLVCLRLNNLSLSRI-ASVEKLLFVQMLDLSHNELHS-TEGLEAMQLLSCLNLSHNRIRSFSAldSLRHVKQLKVLD 586
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDlPEPLGNLTNLKSLDLSNNQLTDLPE--ELGNLTNLKELD 188


                 ....*.
gi 145334125 587 VSHNHI 592
Cdd:COG4886  189 LSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
509-592 9.93e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 9.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 509 DMNNLVCLRLNNLSLSRI-ASVEKLLFVQMLDLSHNELHS-TEGLEAMQLLSCLNLSHNRIRSFSalDSLRHVKQLKVLD 586
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlPEELGNLTNLKELDLSNNQITDLP--EPLGNLTNLEELD 211


                 ....*.
gi 145334125 587 VSHNHI 592
Cdd:COG4886  212 LSGNQL 217
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 87-117 1.12e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 42.62  E-value: 1.12e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 145334125   87 LDEELRVVESALRQNFKSYGAWHHRKWVLSK 117
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLER 31
LRR_8 pfam13855
Leucine rich repeat;
535-592 2.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125  535 VQMLDLSHNELHSTEG--LEAMQLLSCLNLSHNRIRSFSAlDSLRHVKQLKVLDVSHNHI 592
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-592 2.96e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 512 NLVCLRLNNLSLSRIASVEKLLFVQMLDLSHNELHSTEGLEAMQLLSCLNLSHNRIRSFSALDSLR-----HV-KQ---- 581
Cdd:cd21340   25 NLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTnleelHIeNQrlpp 104

                         90       100
                 ....*....|....*....|....*...
gi 145334125 582 -----------------LKVLDVSHNHI 592
Cdd:cd21340  105 gekltfdprslaalsnsLRVLNISGNNI 132
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 158-188 8.93e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 39.93  E-value: 8.93e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 145334125  158 QDELQYTDDMINNNFSNYSAWHNRSVLLSSL 188
Cdd:pfam01239   2 EEELALTDKLLELNPKNYSAWNHRRWLLERL 32
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 507-644 1.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 507 YRDMNNLVCLRLNNLSLS-----RIASVEKLLFVQMLDLSHNEL------HSTEGLEAMQL-LSCLNLSHNRIR---SFS 571
Cdd:cd00116   77 LTKGCGLQELDLSDNALGpdgcgVLESLLRSSSLQELKLNNNGLgdrglrLLAKGLKDLPPaLEKLVLGRNRLEgasCEA 156

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334125 572 ALDSLRHVKQLKVLDVSHNHIGkhsVDTTRYLCSSPLSNSELGQDDVgkqnpglvtkyWDayCVLTDLNLKQL 644
Cdd:cd00116  157 LAKALRANRDLKELNLANNGIG---DAGIRALAEGLKANCNLEVLDL-----------NN--NGLTDEGASAL 213
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
496-592 1.99e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 496 SSESLSRHLLRYRDMNNLVCLRLNNLSLSRIASVEKLLFVQMLDLSHNElhsteGLEAMQLLSCLNLSHNRIRSFSalDS 575
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLP--EE 131

                         90
                 ....*....|....*..
gi 145334125 576 LRHVKQLKVLDVSHNHI 592
Cdd:COG4886  132 LANLTNLKELDLSNNQL 148
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 124-151 3.53e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 3.53e-03
                          10        20
                  ....*....|....*....|....*...
gi 145334125  124 NELRLLEKFQKLDSRNFHAWNYRRFVVE 151
Cdd:pfam01239   3 EELALTDKLLELNPKNYSAWNHRRWLLE 30
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-670 4.30e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 535 VQMLDLSHNELHS------TEGLEAMQLLSCLNLSHNRIRSFSALDSLRHVK---QLKVLDVSHNHIGKHSVDTtryLCS 605
Cdd:COG5238  294 LTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQIGDEGAIA---LAK 370

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334125 606 SPLSNSELGQDDVGKQNPGLVTKYWDAYCVLTDlNLKQLDIAGNEIaGEEFSSFVLQVVPKLVWL 670
Cdd:COG5238  371 YLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLI-GAEAQQRLEQLLERIKSV 433
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 535-575 6.00e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 145334125  535 VQMLDLSHNELHSTEGLEAMQLLSCLNLSHN-RIRSFSALDS 575
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 505-592 9.19e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 9.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334125 505 LRYRDMNNLVCLRLNNLSLS-----RIASVEKLLfvqMLDLSHNEL--HSTEGLEAMQLLSCLNLSHNRIrSFSALDSLR 577
Cdd:PLN00113 493 RKLGSLSELMQLKLSENKLSgeipdELSSCKKLV---SLDLSHNQLsgQIPASFSEMPVLSQLDLSQNQL-SGEIPKNLG 568

                         90
                 ....*....|....*
gi 145334125 578 HVKQLKVLDVSHNHI 592
Cdd:PLN00113 569 NVESLVQVNISHNHL 583
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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