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Conserved domains on  [gi|145332889|ref|NP_001078310|]
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2-aminoethanethiol dioxygenase, putative (DUF1637) [Arabidopsis thaliana]

Protein Classification

cysteine dioxygenase family protein( domain architecture ID 10545174)

cysteine dioxygenase family protein containing a cupin domain, similar to plant cysteine oxidases and mammalian 2-aminoethanethiol dioxygenase (also called cysteamine dioxygenase)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCO_ADO pfam07847
PCO_ADO; This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol ...
 33-240 1.16e-100

PCO_ADO; This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol dioxygenases (ADOs) from animals.


:

Pssm-ID: 462286  Cd Length: 201  Bit Score: 291.15  E-value: 1.16e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889   33 VLEKIKPSDVGLEQEAQLVRNwpgpgnERNGNHHSLPAIKYLQLHECDSFSIGIFCMPPGSIIPLHNHPGMTVLSKLVYG 112
Cdd:pfam07847   1 LLDKIRPADVGLEPSLQDFRS------TAARSSPGKPPVTYLHIYECDSFSMGVFCLPPGAVIPLHDHPGMTVFSKLLYG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889  113 SMHVKSYDWAEPDQSELDDPLQARPAKLVKDIDMTSPSPATTLYPTTGGNIHCFKAIT-HCAIFDILSPPYSSTHGRHCN 191
Cdd:pfam07847  75 SVHIKSYDWVDPPVDSPGQGRPLRLAKLVSDGEFTAPSDTSVLYPTEGGNLHEITAITgPCAFLDILAPPYSEDPGRDCT 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 145332889  192 YFRKSPMLDLPGeiEVMNGEVISNVTWLEEYQPPDNFVIWRVPYRGPVI 240
Cdd:pfam07847 155 YYRDSPLSSHSA--LKLAEEEKEEAAWLEEIPQPEDFWCRPEPYRGPEV 201
 
Name Accession Description Interval E-value
PCO_ADO pfam07847
PCO_ADO; This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol ...
 33-240 1.16e-100

PCO_ADO; This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol dioxygenases (ADOs) from animals.


Pssm-ID: 462286  Cd Length: 201  Bit Score: 291.15  E-value: 1.16e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889   33 VLEKIKPSDVGLEQEAQLVRNwpgpgnERNGNHHSLPAIKYLQLHECDSFSIGIFCMPPGSIIPLHNHPGMTVLSKLVYG 112
Cdd:pfam07847   1 LLDKIRPADVGLEPSLQDFRS------TAARSSPGKPPVTYLHIYECDSFSMGVFCLPPGAVIPLHDHPGMTVFSKLLYG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889  113 SMHVKSYDWAEPDQSELDDPLQARPAKLVKDIDMTSPSPATTLYPTTGGNIHCFKAIT-HCAIFDILSPPYSSTHGRHCN 191
Cdd:pfam07847  75 SVHIKSYDWVDPPVDSPGQGRPLRLAKLVSDGEFTAPSDTSVLYPTEGGNLHEITAITgPCAFLDILAPPYSEDPGRDCT 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 145332889  192 YFRKSPMLDLPGeiEVMNGEVISNVTWLEEYQPPDNFVIWRVPYRGPVI 240
Cdd:pfam07847 155 YYRDSPLSSHSA--LKLAEEEKEEAAWLEEIPQPEDFWCRPEPYRGPEV 201
cupin_ADO cd20289
2-aminoethanethiol dioxygenase, cupin domain; This family contains 2-aminoethanethiol ...
 80-183 4.23e-49

2-aminoethanethiol dioxygenase, cupin domain; This family contains 2-aminoethanethiol dioxygenase (also known as cysteamine dioxygenase, persulfurase or ADO; EC 1.13.11.19), which catalyzes the addition of two oxygen atoms to free cysteamine (2-aminoethanethiol) to form hypotaurine that subsequently oxidizes to taurine. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380423  Cd Length: 103  Bit Score: 156.56  E-value: 4.23e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889  80 DSFSIGIFCMPPGSIIPLHNHPGMTVLSKLVYGSMHVKSYDWAEPDQSElDDPLQARPAKLVKDIDMTSPSPATTLYPtT 159
Cdd:cd20289    1 EDFSMGIFVLPPGARIPLHDHPGMTGLSKVLYGSLRVKSYDWLDDPPED-LPPLKPRLARLVGDAVLTASSEPCVLTP-T 78

                         90       100
                 ....*....|....*....|....*
gi 145332889 160 GGNIHCFKAIT-HCAIFDILSPPYS 183
Cdd:cd20289   79 EGNIHEIVAVEgPAAFLDILSPPYD 103
COG5553 COG5553
Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General ...
 4-100 9.34e-04

Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only];


Pssm-ID: 444296  Cd Length: 179  Bit Score: 38.77  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889   4 FIQRLfntckSSLSPNGPVSEEALDKVRNVLEK-IKPSDVGLEQEAQlvrnwPGPGnerngnhhslpaiKYLQ--LHE-- 78
Cdd:COG5553   13 FIAAL-----RALVDRGPDEREILAAVRPLLRRlVASDDWLPAEFAE-----PDPD-------------RYARylLYAdp 69

                         90       100
                 ....*....|....*....|..
gi 145332889  79 CDSFSIGIFCMPPGSIIPLHNH 100
Cdd:COG5553   70 DGRFSVVAFVWGPGQKTPIHDH 91
 
Name Accession Description Interval E-value
PCO_ADO pfam07847
PCO_ADO; This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol ...
 33-240 1.16e-100

PCO_ADO; This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol dioxygenases (ADOs) from animals.


Pssm-ID: 462286  Cd Length: 201  Bit Score: 291.15  E-value: 1.16e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889   33 VLEKIKPSDVGLEQEAQLVRNwpgpgnERNGNHHSLPAIKYLQLHECDSFSIGIFCMPPGSIIPLHNHPGMTVLSKLVYG 112
Cdd:pfam07847   1 LLDKIRPADVGLEPSLQDFRS------TAARSSPGKPPVTYLHIYECDSFSMGVFCLPPGAVIPLHDHPGMTVFSKLLYG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889  113 SMHVKSYDWAEPDQSELDDPLQARPAKLVKDIDMTSPSPATTLYPTTGGNIHCFKAIT-HCAIFDILSPPYSSTHGRHCN 191
Cdd:pfam07847  75 SVHIKSYDWVDPPVDSPGQGRPLRLAKLVSDGEFTAPSDTSVLYPTEGGNLHEITAITgPCAFLDILAPPYSEDPGRDCT 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 145332889  192 YFRKSPMLDLPGeiEVMNGEVISNVTWLEEYQPPDNFVIWRVPYRGPVI 240
Cdd:pfam07847 155 YYRDSPLSSHSA--LKLAEEEKEEAAWLEEIPQPEDFWCRPEPYRGPEV 201
cupin_ADO cd20289
2-aminoethanethiol dioxygenase, cupin domain; This family contains 2-aminoethanethiol ...
 80-183 4.23e-49

2-aminoethanethiol dioxygenase, cupin domain; This family contains 2-aminoethanethiol dioxygenase (also known as cysteamine dioxygenase, persulfurase or ADO; EC 1.13.11.19), which catalyzes the addition of two oxygen atoms to free cysteamine (2-aminoethanethiol) to form hypotaurine that subsequently oxidizes to taurine. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380423  Cd Length: 103  Bit Score: 156.56  E-value: 4.23e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889  80 DSFSIGIFCMPPGSIIPLHNHPGMTVLSKLVYGSMHVKSYDWAEPDQSElDDPLQARPAKLVKDIDMTSPSPATTLYPtT 159
Cdd:cd20289    1 EDFSMGIFVLPPGARIPLHDHPGMTGLSKVLYGSLRVKSYDWLDDPPED-LPPLKPRLARLVGDAVLTASSEPCVLTP-T 78

                         90       100
                 ....*....|....*....|....*
gi 145332889 160 GGNIHCFKAIT-HCAIFDILSPPYS 183
Cdd:cd20289   79 EGNIHEIVAVEgPAAFLDILSPPYD 103
cupin_CDO cd10548
cysteine dioxygenase, cupin domain; This family contains cysteine dioxygenase (CDO; EC 1.13.11. ...
 76-137 3.09e-05

cysteine dioxygenase, cupin domain; This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380416 [Multi-domain]  Cd Length: 100  Bit Score: 41.90  E-value: 3.09e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145332889  76 LHECDSFSIGIFCMPPGSIIPLHNHPG----MTVLSklvyGSMHVKSYDWAEPDQSELDDPLQARP 137
Cdd:cd10548    6 LYRDPDFELLLLCWPPGQGSPIHDHGGswcvVKVLE----GELTETRYRRPDDGSLSGEETLEETP 67
COG5553 COG5553
Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General ...
 4-100 9.34e-04

Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only];


Pssm-ID: 444296  Cd Length: 179  Bit Score: 38.77  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332889   4 FIQRLfntckSSLSPNGPVSEEALDKVRNVLEK-IKPSDVGLEQEAQlvrnwPGPGnerngnhhslpaiKYLQ--LHE-- 78
Cdd:COG5553   13 FIAAL-----RALVDRGPDEREILAAVRPLLRRlVASDDWLPAEFAE-----PDPD-------------RYARylLYAdp 69

                         90       100
                 ....*....|....*....|..
gi 145332889  79 CDSFSIGIFCMPPGSIIPLHNH 100
Cdd:COG5553   70 DGRFSVVAFVWGPGQKTPIHDH 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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