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Conserved domains on  [gi|145332819|ref|NP_001078275|]
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Pyruvate kinase family protein [Arabidopsis thaliana]

Protein Classification

PLN02765 family protein( domain architecture ID 11477128)

PLN02765 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02765 PLN02765
pyruvate kinase
 1-474 0e+00

pyruvate kinase


:

Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 1034.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPI 80
Cdd:PLN02765  54 MSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSKEASSEVLPI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVICLSRNAATLAGSLFTLHSSQVHIDLPTLTEKDKEVIS 160
Cdd:PLN02765 134 NFPGLAKAVKPGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVVCTVKNSATLAGSLFTLHVSQVRIDLPTLSEKDKEVIS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 161 TWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 240
Cdd:PLN02765 214 TWGVPNKIDFLSLSYTRHAEDVREAREFLSSLG-LSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 241 LFQKAALYKCNMAGKPAVLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEKV 320
Cdd:PLN02765 293 LFQKAALYKCNMAGKPAVVTRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKV 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 321 FNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRVKTNQLKWSFS 400
Cdd:PLN02765 373 FNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLKWSFT 452

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145332819 401 GAFEARQSLIVRGLFPMLADPRHPAESTSATNESVLKVALDHGKHAGVIKSHDRVVVCQKVGDASVVKIIELED 474
Cdd:PLN02765 453 GAFQARQCLIVRGLFPMLADPRHSAESTSATNESVLKVALDHGKAAGVIKSHDRVVVCQKVGDSSVVKIIELDD 526
 
Name Accession Description Interval E-value
PLN02765 PLN02765
pyruvate kinase
 1-474 0e+00

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 1034.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPI 80
Cdd:PLN02765  54 MSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSKEASSEVLPI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVICLSRNAATLAGSLFTLHSSQVHIDLPTLTEKDKEVIS 160
Cdd:PLN02765 134 NFPGLAKAVKPGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVVCTVKNSATLAGSLFTLHVSQVRIDLPTLSEKDKEVIS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 161 TWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 240
Cdd:PLN02765 214 TWGVPNKIDFLSLSYTRHAEDVREAREFLSSLG-LSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 241 LFQKAALYKCNMAGKPAVLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEKV 320
Cdd:PLN02765 293 LFQKAALYKCNMAGKPAVVTRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKV 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 321 FNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRVKTNQLKWSFS 400
Cdd:PLN02765 373 FNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLKWSFT 452

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145332819 401 GAFEARQSLIVRGLFPMLADPRHPAESTSATNESVLKVALDHGKHAGVIKSHDRVVVCQKVGDASVVKIIELED 474
Cdd:PLN02765 453 GAFQARQCLIVRGLFPMLADPRHSAESTSATNESVLKVALDHGKAAGVIKSHDRVVVCQKVGDSSVVKIIELDD 526
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-470 3.20e-128

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 380.51  E-value: 3.20e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVIN-KSEKAITLKADGLVTLTPNQDQEAS-SEVL 78
Cdd:cd00288   28 MNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLfKGGKDISLKAGDKFLVTTDPAAKKGtKEKI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  79 PINFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGDD-VICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKE 157
Cdd:cd00288  108 YVDYKNLTKDVSPGNTILVDDGLLS--------LKVLSKDDDKtLVCEVLNGGVL-GSRKGVNLPGTDVDLPALSEKDKA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 158 VIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPE 237
Cdd:cd00288  179 DLR-FGVEQGVDMIFASFVRKASDVLEIREVLGEKG--KDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAE 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 238 KVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAE 316
Cdd:cd00288  256 EVFLAQKMLIAKCNLAGKPVITaTQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLE 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 317 AEKVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRvKTnqlk 396
Cdd:cd00288  336 AEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNE-QT---- 410

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332819 397 wsfsgafeARQSLIVRGLFPMLADprHPAESTSATNESVLKVALDHGKHAGVIKSHDRVVVCQKV----GDASVVKII 470
Cdd:cd00288  411 --------ARQLHLYRGVYPVLFE--EPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWpvgsGSTNTMRIL 478
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-457 5.40e-125

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 372.06  E-value: 5.40e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNqDQEASSEVLPI 80
Cdd:COG0469   29 MDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGPVELKKGDTFTLTTD-DVEGDAERVSV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFV--GqylftgsettSVWLEVDEVKGDDVICLSRNAATLagslftlhSSQ-------VHIDLPTL 151
Cdd:COG0469  108 TYPELPEDVKPGDRILLddG----------KIELRVEEVEGDEVVCEVVNGGVL--------SSRkgvnlpgVGLSLPAL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 152 TEKDKEVIsTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLG 231
Cdd:COG0469  170 TEKDREDL-KFALELGVDFIALSFVRSAEDVLEARELLEEAG--GRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 232 IDLPPEKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTV 310
Cdd:COG0469  247 VEIPLEEVPLIQKRIIRKARRAGKPVITaTQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETM 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 311 GRICAEAEKVFNQDLYFKKTVKYVGEPMThlESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRV 390
Cdd:COG0469  327 ARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT-PNE 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145332819 391 KTnqlkwsfsgafeARQSLIVRGLFPMLADprhPAESTSATNESVLKVALDHgkhaGVIKSHDRVVV 457
Cdd:COG0469  404 RT------------ARRLALVWGVYPVLVD---DVESTDEMIEEAVEALLEE----GLVKPGDLVVI 451
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 1-459 3.32e-115

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 346.96  E-value: 3.32e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819    1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTP-NQDQEASSEVLP 79
Cdd:TIGR01064  27 MNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGEVKLKKGDKVIITTdDIKGEGDEEKVY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   80 INFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGDDVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKEVI 159
Cdd:TIGR01064 107 VDYKGLTKDVVEGDKILVDDGKIS--------LVVVSVEGDKVICEVLNGGTL-KSKKGVNLPGADVDLPALSEKDKKDL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  160 sTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKV 239
Cdd:TIGR01064 178 -KFGVEQGVDMVAASFVRTAEDVLEVREVLGEKG-AKDVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEV 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  240 FLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAE 318
Cdd:TIGR01064 256 PIAQKKMIRKCNRAGKPVITaTQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAE 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  319 KVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRVKTnqlkws 398
Cdd:TIGR01064 336 KALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVT-PNERV------ 408

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145332819  399 fsgafeARQSLIVRGLFPMLADprhpaESTSATNESVLKvALDHGKHAGVIKSHDRVVVCQ 459
Cdd:TIGR01064 409 ------ARQLALYWGVFPFLVD-----EEPSDTDARVNK-ALELLKEKGIVKKGDLVVVIQ 457
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-319 4.48e-93

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 285.80  E-value: 4.48e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819    1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQV--INKSEKAITLKADG--LVTLTPNQDQEASSE 76
Cdd:pfam00224  28 ANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTgnTKDGKKDIELKAGDemIVSTDAKYKGACDDE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   77 VLPINFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGD-DVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKD 155
Cdd:pfam00224 108 MIYVDYKNIVKDVSVGGTILVDDGLLS--------LKVLSKDDDkTLVVEVLNGGVI-GSRKGVNLPGTDVDLPALSEKD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  156 KEVIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLP 235
Cdd:pfam00224 179 KADLR-FGVKNGVDMIFASFVRKASDVLEIREVLGEAG--KNIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIP 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  236 PEKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRIC 314
Cdd:pfam00224 256 AEEVFLAQKMLIAKCNLAGKPVITaTQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEIC 335


                  ....*
gi 145332819  315 AEAEK 319
Cdd:pfam00224 336 LEAEK 340
 
Name Accession Description Interval E-value
PLN02765 PLN02765
pyruvate kinase
 1-474 0e+00

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 1034.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPI 80
Cdd:PLN02765  54 MSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSKEASSEVLPI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVICLSRNAATLAGSLFTLHSSQVHIDLPTLTEKDKEVIS 160
Cdd:PLN02765 134 NFPGLAKAVKPGDTIFVGQYLFTGSETTSVWLEVDEVKGDDVVCTVKNSATLAGSLFTLHVSQVRIDLPTLSEKDKEVIS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 161 TWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 240
Cdd:PLN02765 214 TWGVPNKIDFLSLSYTRHAEDVREAREFLSSLG-LSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 241 LFQKAALYKCNMAGKPAVLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEKV 320
Cdd:PLN02765 293 LFQKAALYKCNMAGKPAVVTRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKV 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 321 FNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRVKTNQLKWSFS 400
Cdd:PLN02765 373 FNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLKWSFT 452

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145332819 401 GAFEARQSLIVRGLFPMLADPRHPAESTSATNESVLKVALDHGKHAGVIKSHDRVVVCQKVGDASVVKIIELED 474
Cdd:PLN02765 453 GAFQARQCLIVRGLFPMLADPRHSAESTSATNESVLKVALDHGKAAGVIKSHDRVVVCQKVGDSSVVKIIELDD 526
PLN02461 PLN02461
Probable pyruvate kinase
 1-473 2.62e-165

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 476.39  E-value: 2.62e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQV-INKSEKAITLKADGLVTLTPNQDQEASSEVLP 79
Cdd:PLN02461  47 MNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTgFLKDGKPVQLKQGQEITITTDYSIKGDENMIA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  80 INFNGLAKAVKKGDTIFVGQylftGSETTSVwLEVDEVKGDdVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKEVI 159
Cdd:PLN02461 127 MSYKKLAVDVKPGSVILCAD----GTITLTV-LSCDVEAGT-VRCRCENSAML-GERKNVNLPGVVVDLPTLTEKDKEDI 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 160 STWGVQNKIDFLSLSYCRHAEDVRQTREMLkklGDLSQT-QIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEK 238
Cdd:PLN02461 200 LQWGVPNKIDFIALSFVRKGSDLVEVRKVL---GEHAKSiLLISKVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEK 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 239 VFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEA 317
Cdd:PLN02461 277 IFLAQKMMIYKCNLAGKPVVTaTQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVKTMARICREA 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 318 EKVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRVKTNQLKW 397
Cdd:PLN02461 357 EASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPAVPILSVVVPEITTDSFDW 436

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145332819 398 SFSGAFEARQSLIVRGLFPMLADPRHPAESTSATNEsVLKVALDHGKHAGVIKSHDRVVVCQKVGDASVVKIIELE 473
Cdd:PLN02461 437 SCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEE-ILEAAIEHAKKKGLCKPGDSVVALHRIGGASVIKILTVK 511
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-470 3.20e-128

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 380.51  E-value: 3.20e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVIN-KSEKAITLKADGLVTLTPNQDQEAS-SEVL 78
Cdd:cd00288   28 MNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLfKGGKDISLKAGDKFLVTTDPAAKKGtKEKI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  79 PINFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGDD-VICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKE 157
Cdd:cd00288  108 YVDYKNLTKDVSPGNTILVDDGLLS--------LKVLSKDDDKtLVCEVLNGGVL-GSRKGVNLPGTDVDLPALSEKDKA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 158 VIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPE 237
Cdd:cd00288  179 DLR-FGVEQGVDMIFASFVRKASDVLEIREVLGEKG--KDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAE 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 238 KVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAE 316
Cdd:cd00288  256 EVFLAQKMLIAKCNLAGKPVITaTQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLE 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 317 AEKVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRvKTnqlk 396
Cdd:cd00288  336 AEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNE-QT---- 410

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332819 397 wsfsgafeARQSLIVRGLFPMLADprHPAESTSATNESVLKVALDHGKHAGVIKSHDRVVVCQKV----GDASVVKII 470
Cdd:cd00288  411 --------ARQLHLYRGVYPVLFE--EPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWpvgsGSTNTMRIL 478
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-457 5.40e-125

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 372.06  E-value: 5.40e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNqDQEASSEVLPI 80
Cdd:COG0469   29 MDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGPVELKKGDTFTLTTD-DVEGDAERVSV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFV--GqylftgsettSVWLEVDEVKGDDVICLSRNAATLagslftlhSSQ-------VHIDLPTL 151
Cdd:COG0469  108 TYPELPEDVKPGDRILLddG----------KIELRVEEVEGDEVVCEVVNGGVL--------SSRkgvnlpgVGLSLPAL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 152 TEKDKEVIsTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLG 231
Cdd:COG0469  170 TEKDREDL-KFALELGVDFIALSFVRSAEDVLEARELLEEAG--GRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 232 IDLPPEKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTV 310
Cdd:COG0469  247 VEIPLEEVPLIQKRIIRKARRAGKPVITaTQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETM 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 311 GRICAEAEKVFNQDLYFKKTVKYVGEPMThlESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRV 390
Cdd:COG0469  327 ARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT-PNE 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145332819 391 KTnqlkwsfsgafeARQSLIVRGLFPMLADprhPAESTSATNESVLKVALDHgkhaGVIKSHDRVVV 457
Cdd:COG0469  404 RT------------ARRLALVWGVYPVLVD---DVESTDEMIEEAVEALLEE----GLVKPGDLVVI 451
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 1-459 3.32e-115

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 346.96  E-value: 3.32e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819    1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTP-NQDQEASSEVLP 79
Cdd:TIGR01064  27 MNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGEVKLKKGDKVIITTdDIKGEGDEEKVY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   80 INFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGDDVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKEVI 159
Cdd:TIGR01064 107 VDYKGLTKDVVEGDKILVDDGKIS--------LVVVSVEGDKVICEVLNGGTL-KSKKGVNLPGADVDLPALSEKDKKDL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  160 sTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKV 239
Cdd:TIGR01064 178 -KFGVEQGVDMVAASFVRTAEDVLEVREVLGEKG-AKDVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEV 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  240 FLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAE 318
Cdd:TIGR01064 256 PIAQKKMIRKCNRAGKPVITaTQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAE 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  319 KVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRVKTnqlkws 398
Cdd:TIGR01064 336 KALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVT-PNERV------ 408

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145332819  399 fsgafeARQSLIVRGLFPMLADprhpaESTSATNESVLKvALDHGKHAGVIKSHDRVVVCQ 459
Cdd:TIGR01064 409 ------ARQLALYWGVFPFLVD-----EEPSDTDARVNK-ALELLKEKGIVKKGDLVVVIQ 457
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-457 2.59e-109

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 331.73  E-value: 2.59e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPI 80
Cdd:PRK05826  30 VNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGKITLKTGDKFTLDTDQKEEGDKERVGV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFV--GqylftgsettSVWLEVDEVKGDDVICLSRNAATLagslftlhSSQ-------VHIDLPTL 151
Cdd:PRK05826 110 DYKGLPKDVKPGDILLLddG----------KLQLKVVEVDGDEVETEVKNGGPL--------SNNkginipgGGLSLPAL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 152 TEKDKEVIsTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLG 231
Cdd:PRK05826 172 TEKDKADI-KFAAEQGVDYIAVSFVRSAEDVEEARRLLREAG-CPHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLG 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 232 IDLPPEKVFLFQKAALYKCNMAGKPA-VLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTV 310
Cdd:PRK05826 250 VEIPDEEVPGLQKKIIRKAREAGKPViTATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAM 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 311 GRICAEAEKVFNQDLY---FKKTVKYVGepmthlESIASSAVRAAIK---VKAsvIICFTSSGRAARLIAKYRPTMPVIS 384
Cdd:PRK05826 330 ARICKGAEKEFSINLSkhrLDRQFDRID------EAIAMSAMYAANHlkgVKA--IVALTESGRTARLISRFRPGAPIFA 401

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145332819 385 VViPRVKTnqlkwsfsgafeARQSLIVRGLFPMLADprhpaesTSATNESVLKVALDHGKHAGVIKSHDRVVV 457
Cdd:PRK05826 402 VT-RDEKT------------QRRLALYRGVYPVLFD-------SAADTDDAAEEALRLLLEKGLVESGDLVVV 454
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 1-463 7.74e-107

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 326.72  E-value: 7.74e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRST-KKLCAVMLDTVGPELQV-INKSEKAITLKADGLVTLTPNQDQEASSEVL 78
Cdd:PTZ00066  64 MNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTgFLKNHKPITLKEGQTLKITTDYTFLGDETCI 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  79 PINFNGLAKAVKKGDTIFVGQylftGSETTsvwlEVDEVKGDDVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKEV 158
Cdd:PTZ00066 144 SCSYKKLPQSVKVGNIILIAD----GSLSC----KVLEVHDDYIITKVLNNATI-GERKNMNLPGVKVELPVIGEKDKND 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 159 ISTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDlsQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEK 238
Cdd:PTZ00066 215 ILNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGR--HIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEK 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 239 VFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEA 317
Cdd:PTZ00066 293 VFLAQKMMISKCNVAGKPVITaTQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEA 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 318 EKVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVIsvviprvktnqlkw 397
Cdd:PTZ00066 373 ETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTIL-------------- 438

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145332819 398 SFSGAFEARQSL-IVRGLFPMLADprhpaeSTSATnESVLKVALDHGKHAGVIKSHDRVVVCQKVGD 463
Cdd:PTZ00066 439 ALSASPSVVKSLsVARGVTTYVVN------SFQGT-DVVIRNAIALAKERGLVESGDSAIAVHGVKE 498
PRK09206 PRK09206
pyruvate kinase PykF;
1-420 3.33e-95

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 295.42  E-value: 3.33e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVIN-KSEKAITLKADGLVTLTPNQDQEASSEVLP 79
Cdd:PRK09206  28 MNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKlEGGNDVSLKAGQTFTFTTDKSVVGNKERVA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  80 INFNGLAKAVKKGDTIFVGQYLftgsettsVWLEVDEVKGDDVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKDKEVI 159
Cdd:PRK09206 108 VTYEGFTADLSVGNTVLVDDGL--------IGMEVTAITGNEVICKVLNNGDL-GENKGVNLPGVSIALPALAEKDKQDL 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 160 sTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKV 239
Cdd:PRK09206 179 -IFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGG-ENIQIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEV 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 240 FLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAE 318
Cdd:PRK09206 257 IFAQKMMIEKCNRARKVVITaTQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTD 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 319 KVFNQDLYFKKtvkyVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViprvkTNQLKws 398
Cdd:PRK09206 337 RVMNSRLESNN----DNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILALT-----TNEKT-- 405

                        410       420
                 ....*....|....*....|..
gi 145332819 399 fsgafeARQSLIVRGLFPMLAD 420
Cdd:PRK09206 406 ------ARQLVLSKGVVPQLVK 421
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-319 4.48e-93

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 285.80  E-value: 4.48e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819    1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQV--INKSEKAITLKADG--LVTLTPNQDQEASSE 76
Cdd:pfam00224  28 ANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTgnTKDGKKDIELKAGDemIVSTDAKYKGACDDE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   77 VLPINFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGD-DVICLSRNAATLaGSLFTLHSSQVHIDLPTLTEKD 155
Cdd:pfam00224 108 MIYVDYKNIVKDVSVGGTILVDDGLLS--------LKVLSKDDDkTLVVEVLNGGVI-GSRKGVNLPGTDVDLPALSEKD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  156 KEVIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLP 235
Cdd:pfam00224 179 KADLR-FGVKNGVDMIFASFVRKASDVLEIREVLGEAG--KNIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIP 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  236 PEKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRIC 314
Cdd:pfam00224 256 AEEVFLAQKMLIAKCNLAGKPVITaTQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEIC 335


                  ....*
gi 145332819  315 AEAEK 319
Cdd:pfam00224 336 LEAEK 340
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 1-470 1.04e-86

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 273.08  E-value: 1.04e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQ--VINKSEKAITLKADGLVTLTPNQDQEASSEVL 78
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRtgLFVGGEAVMERGATCYVTTDPAFADKGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  79 PINFNGLAKAVKKGDTIfvgqYLFTGSETTSVWLEVDEvkgDDVICLSRNAATLAGSLfTLHSSQVHIDLPTLTEKDKEV 158
Cdd:PTZ00300  81 YIDYQNLSKVVRPGGYI----YIDDGILILHVQSHEDE---QTLKCTVTNAHTISDRR-GVNLPGCDVDLPAVSAKDCAD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 159 IStWGVQNKIDFLSLSYCRHAEDVRQTREML-KKLGDLsqtQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPE 237
Cdd:PTZ00300 153 LQ-FGVEQGVDMIFASFIRSAEQVGEVRKALgAKGGDI---MIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 238 KVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAE 316
Cdd:PTZ00300 229 KVVVAQKILISKCNVAGKPVICaTQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLE 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 317 AEKVFNQDLYFKKTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIpRVKTnqlk 396
Cdd:PTZ00300 309 AQSAVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTT-RLQT---- 383

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332819 397 wsfsgafeARQSLIVRGLFPMLADPRHPAESTSatNESVLKVALDHGKHAGVIKSHDRVVVC---QKV-GDASVVKII 470
Cdd:PTZ00300 384 --------CRQLNITQGVESVFFDAERLGHDEG--KEQRVAMGVGFAKSKGYVQSGDLMVVVhadHKVkGYANQTRII 451
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-457 2.12e-81

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 263.32  E-value: 2.12e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTpNQDQEASSEVLPI 80
Cdd:PRK06354  34 ATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDGPIELKTGDEFILT-SREVLGTQEKFSV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFVGQYLftgsettsVWLEVDEVKGDD--VICLSRNAATLA---GSLFtlhsSQVHIDLPTLTEKD 155
Cdd:PRK06354 113 TYDGLADEVPVGSRILLDDGL--------IELEVEEVDKADgeLHCKVLVGGVLSnkkGVNF----PGVSLSLPAITEKD 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 156 KEVIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDLSqTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLP 235
Cdd:PRK06354 181 REDLI-FGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKH-IPIIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIP 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 236 PEKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRIC 314
Cdd:PRK06354 259 AEEVPLLQKRLIKKANRLGKPVITaTQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 315 AEAEKVFNQDLYFKKTVKyvgEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRVKTnq 394
Cdd:PRK06354 339 VRIEKDLPYRDILSKRPE---FTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAVT-PNESV-- 412

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145332819 395 lkwsfsgafeARQSLIVRGLFPMLADprhPAESTSATNESVLKVALDHgkhaGVIKSHDRVVV 457
Cdd:PRK06354 413 ----------ARRLQLVWGVTPLLVL---DAPSTDETFDAAINVAQES----GLLKQGDLVVI 458
PRK06247 PRK06247
pyruvate kinase; Provisional
 1-457 9.27e-68

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 224.42  E-value: 9.27e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQVINKSEKAITLKADGLVTLTpNQDQEASSEVLPI 80
Cdd:PRK06247  31 ADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGKVQLANGQTFRLD-VDDAPGDHDRVSL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFVgqylftgsETTSVWLEVDEVKGDDVICLSRNAATLAG----SLftlhsSQVHIDLPTLTEKDK 156
Cdd:PRK06247 110 PHPEIAAALKPGDRLLV--------DDGKVRLVVEACDGDDVVCRVVEGGPVSDrkgvSL-----PGTVLSVSALTEKDR 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 157 EVIsTWGVQNKIDFLSLSYCRHAEDVRQTREMLKklgdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPP 236
Cdd:PRK06247 177 ADL-EFALELGVDWVALSFVQRPEDVEEVRKIIG-----GRVPVMAKIEKPQAIDRLEAIVEASDAIMVARGDLGVEVPL 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 237 EKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICA 315
Cdd:PRK06247 251 EQVPLIQKRIIRAARRAGKPVVVaTQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEAVRTMARIIR 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 316 EAEkvfnQDLYFkKTVKYVGEPM---THLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRVKT 392
Cdd:PRK06247 331 QVE----RDPTY-PPLIHAQRPQpeaTKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALT-PNPET 404

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332819 393 nqlkwsfsgafeARQSLIVRGLFPMLAdprHPAESTSATNESVLKVALDHGKHagviKSHDRVVV 457
Cdd:PRK06247 405 ------------ARRLALTWGVHCVVV---DDARDTDDMVRRADRIALAEGFY----KRGDRVVI 450
PRK06739 PRK06739
pyruvate kinase; Validated
 1-331 2.01e-47

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 167.04  E-value: 2.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKklcaVMLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVlPI 80
Cdd:PRK06739  27 MKIVRLNLSHGTHESHKDIIRLVKSLDDSIK----ILGDVQGPKIRLGEIKGEQITLQAGDSFILHTQPVTGSSTEA-SV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  81 NFNGLAKAVKKGDTIFVGQylftgsetTSVWLEVDEVKGDDVICLSRNAATLAgSLFTLHSSQVHIDLPTLTEKDKEVIS 160
Cdd:PRK06739 102 DYEGIANDVKVGSRILMND--------GEVELIVEKVSTDKIETKVKTGGNIS-SHKGVNLPGAIVRLPAITEKDKKDIQ 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 161 tWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDLSQTQIfAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVF 240
Cdd:PRK06739 173 -FLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLI-AKIETMEAIENFQDICKEADGIMIARGDLGVELPYQFIP 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 241 LFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEK 319
Cdd:PRK06739 251 LLQKMMIQECNRTNTYVITaTQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTLRLVSEFAEH 330

                        330
                 ....*....|..
gi 145332819 320 VFNQDLYFKKTV 331
Cdd:PRK06739 331 VKKDGPFVMKDV 342
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 1-471 1.25e-43

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 160.68  E-value: 1.25e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKvAVRSTKKLC-AVMLDTVGPELQVINKSeKAITLKA-DGLVTLTPNQDQEAS--SE 76
Cdd:PLN02762  51 MNVARLNMCHGTREWHRDVIRRVR-RLNEEKGFAvAVMMDTEGSEIHMGDLG-GASSAKAeDGEEWTFTVRKFDGSrpEF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  77 VLPINFNGLAKAVKKGDTIFV--GQYLFtgsettsvwlEVDEVKGDDVIC--------LSRNAATL--AGSLFtlhsSQV 144
Cdd:PLN02762 129 TIQVNYDGFAEDVKVGDELVVdgGMVRF----------EVIEKIGPDVKCkctdpgllLPRANLTFwrDGSLV----RER 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 145 HIDLPTLTEKDKEVIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDLSQTQIFAKIENVEGLTHFDEILQEADGII 224
Cdd:PLN02762 195 NAMLPTISSKDWLDID-FGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDSDIGVIAKIESLDSLKNLEEIIRASDGAM 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 225 LSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPA-VLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYP 303
Cdd:PLN02762 274 VARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPViVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMGLYP 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 304 VETISTVGRICAEAEKVFNQDLYFKKT-VKYVGEPMTHL--ESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTM 380
Cdd:PLN02762 354 EKALSVLRSVSLRMELWSREEKRHEALeLPQLSSSLSDRisEEICNSAAKMANNLGVDAIFVYTKHGHMASLLSRNRPDC 433

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 381 PVisvviprvktnqlkWSFSGAFEARQSLIVR-GLFPMLADPRHPAESTSATNESVLKValdhgkhAGVIKSHDRVVVCQ 459
Cdd:PLN02762 434 PI--------------FAFTDTTSVRRRLNLQwGLIPFRLDFSDDMESNLNKTFSLLKA-------RGMIKSGDLVIAVS 492

                        490
                 ....*....|..
gi 145332819 460 KVGDASVVKIIE 471
Cdd:PLN02762 493 DLTPSSMLQSIQ 504
PLN02623 PLN02623
pyruvate kinase
 1-379 1.47e-43

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 161.63  E-value: 1.47e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLK-VAVRSTKKLCAVMLDTVGPELQVINKSEkAITLKADGLVTLTPNQDQEASSEVlP 79
Cdd:PLN02623 136 MNVARLNMSHGDHASHQKVIDLVKeYNAQSKDNVIAIMLDTKGPEVRSGDLPQ-PIMLEEGQEFTFTIKRGVSTEDCV-S 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  80 INFNGLAKAVKKGDTIFVGQYLFTgsettsvwLEVDEVKGDDVICLSRNAATLagslftlhSSQVHID-------LPTLT 152
Cdd:PLN02623 214 VNYDDFVNDVEVGDMLLVDGGMMS--------LAVKSKTSDSVKCEVVDGGEL--------KSRRHLNvrgksatLPSIT 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 153 EKDKEVIStWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGdlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGI 232
Cdd:PLN02623 278 EKDWEDIK-FGVENKVDFYAVSFVKDAQVVHELKDYLKSCN--ADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGA 354

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 233 DLPPEKVFLFQKAALYKCNMAGKPA-VLTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVG 311
Cdd:PLN02623 355 ELPIEEVPLLQEEIIRRCRSMGKPViVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMH 434

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 312 RICAEAEKVfnqdLYFKKTVKYVGEPM-THL-ESIASSAVRAAIKVKASVIIcFTSSGRAARLIAKYRPT 379
Cdd:PLN02623 435 TVALRTEAT----LPEGTTPPNLGQAFkNHMsEMFAFHATMMANTLGTSIIV-FTRTGFMAILLSHYRPS 499
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 342-470 9.28e-26

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 101.02  E-value: 9.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  342 ESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVViPRVKTnqlkwsfsgafeARQSLIVRGLFPMLADP 421
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVT-PNELT------------ARQLALYWGVYPVLFDE 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 145332819  422 rhpaestSATNESVLKVALDHGKHAGVIKSHDRVVVCQ-----KVGDASVVKII 470
Cdd:pfam02887  68 -------AETTDEMLRRAVKVAKEAGLVKKGDLVVITAgvpfgVSGTTNTLKVI 114
PRK14725 PRK14725
pyruvate kinase; Provisional
 145-284 1.17e-14

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 76.14  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 145 HIDLPTLTEKDKEVISTwgVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDlSQTQIFAKIENVEGLTHFDEILQEA---- 220
Cdd:PRK14725 424 HLPLPALTDKDLEDLAF--VAKHADIVALSFVRSPEDVRLLLDALEKLGA-DDLGVVLKIETRRAFENLPRILLEAmrhp 500

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145332819 221 -DGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAV 284
Cdd:PRK14725 501 rFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWaTQVLESLAKKGLPSRAEITDAAMAL 566
PRK08187 PRK08187
pyruvate kinase; Validated
 1-283 2.36e-13

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 71.97  E-value: 2.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819   1 MSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAVMLDTVGPELQ---VINKSEKAITLKADGLVtLTPNQDQEASSEV 77
Cdd:PRK08187 160 MDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRtgaVAGPLGKTRLYTGDRLA-LVAQGPPRRIDEE 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819  78 LP---INFNGLAKAVKKGDTIFV--GQylfTGSETTSV--W---LEVDEVKGDDVICLSRNAATLAGSlftlhssqvHID 147
Cdd:PRK08187 239 HFqvtCTLPEILARLAVGARVWIddGK---LGARVERVgpGgalLEVTHARPKGLKLKPEKGLNFPDT---------ALD 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332819 148 LPTLTEKDKEVISTwgVQNKIDFLSLSYCRHAEDVRQTREML--KKLGDLSQTQIFAKIENVEGLTHFDEILQEADG--- 222
Cdd:PRK08187 307 LPALTEKDRADLDF--VARHADLVGYSFVQSPGDVEALQAALaaRRPDDWRKLGLVLKIETPRAVANLPELIVQAAGrqp 384

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145332819 223 --IILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-LTRVVDSMTDNLRPTRAEATDVANA 283
Cdd:PRK08187 385 fgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIwATQVLEGLVKKGLPSRAEMTDAAMA 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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