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Conserved domains on  [gi|145331998|ref|NP_001078121|]
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Transcription factor jumonji (jmjC) domain-containing protein [Arabidopsis thaliana]

Protein Classification

lysine-specific demethylase; cupin domain-containing protein( domain architecture ID 10382028)

lysine-specific demethylase is a jumonji C domain-containing (JMJD) family histone demethylase demethylates specific residues of histone, similar to human lysine-specific demethylases 3A and 3B that specifically demethylate 'Lys-9' of histone H3, thereby playing a central role in the histone code| cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-4CXXC_R1 super family cl20401
Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor ...
149-211 1.76e-05

Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.


The actual alignment was detected with superfamily member pfam10497:

Pssm-ID: 463117  Cd Length: 99  Bit Score: 44.18  E-value: 1.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145331998  149 YRPDNM--CHQC-QKSDRIVERC--QTCNSKR--YCHPCLDTWYPLIAKEDVAKK---CMFCSSTCNCRACLR 211
Cdd:pfam10497   1 YDSVNGktCHQCrQKTLDTKTSCrnSQCKGVRgqFCGDCLRNRYGENVEEALANPdwiCPKCRGICNCSFCRK 73
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
621-689 4.29e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 4.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145331998   621 EEFLCSLPLKhythpvngpLNLAVKLPQNCLKPDMGPktYVASGFAqelgrgDSVTKLHCDMSDAVSTH 689
Cdd:smart00558   2 LWNLAKLPFK---------LNLLSDLPEDIPGPDVGP--YLYMGMA------GSTTPWHIDDYDLVNYL 53
 
Name Accession Description Interval E-value
zf-4CXXC_R1 pfam10497
Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor ...
149-211 1.76e-05

Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.


Pssm-ID: 463117  Cd Length: 99  Bit Score: 44.18  E-value: 1.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145331998  149 YRPDNM--CHQC-QKSDRIVERC--QTCNSKR--YCHPCLDTWYPLIAKEDVAKK---CMFCSSTCNCRACLR 211
Cdd:pfam10497   1 YDSVNGktCHQCrQKTLDTKTSCrnSQCKGVRgqFCGDCLRNRYGENVEEALANPdwiCPKCRGICNCSFCRK 73
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
621-689 4.29e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 4.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145331998   621 EEFLCSLPLKhythpvngpLNLAVKLPQNCLKPDMGPktYVASGFAqelgrgDSVTKLHCDMSDAVSTH 689
Cdd:smart00558   2 LWNLAKLPFK---------LNLLSDLPEDIPGPDVGP--YLYMGMA------GSTTPWHIDDYDLVNYL 53
 
Name Accession Description Interval E-value
zf-4CXXC_R1 pfam10497
Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor ...
149-211 1.76e-05

Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.


Pssm-ID: 463117  Cd Length: 99  Bit Score: 44.18  E-value: 1.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145331998  149 YRPDNM--CHQC-QKSDRIVERC--QTCNSKR--YCHPCLDTWYPLIAKEDVAKK---CMFCSSTCNCRACLR 211
Cdd:pfam10497   1 YDSVNGktCHQCrQKTLDTKTSCrnSQCKGVRgqFCGDCLRNRYGENVEEALANPdwiCPKCRGICNCSFCRK 73
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
621-689 4.29e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 4.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145331998   621 EEFLCSLPLKhythpvngpLNLAVKLPQNCLKPDMGPktYVASGFAqelgrgDSVTKLHCDMSDAVSTH 689
Cdd:smart00558   2 LWNLAKLPFK---------LNLLSDLPEDIPGPDVGP--YLYMGMA------GSTTPWHIDDYDLVNYL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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