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Conserved domains on  [gi|145328740|ref|NP_001077905|]
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ARM repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 10607647)

HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 72-126 2.56e-10

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 55.84  E-value: 2.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145328740   72 WKEREAAVFAFGAIAEGCNSFFYPHLAEIVAILRRLLDDQSPLVRRITCWTLYQF 126
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
58-184 1.31e-03

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145328740  58 PLIEAklskFDDETWKEREAAVFAFGAIAEgcnsffyphlAEIVAILRRLLDDQSPLVRRITCWTLYQFGtyvfeesNLE 137
Cdd:COG1413   20 ALIAA----LADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAAEALGRIG-------DPE 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 145328740 138 NSKLFTKVLHgfrfkllDSNIWVQEAACLALTTF-EEDAGDKLVPHLE 184
Cdd:COG1413   79 AVPALIAALK-------DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 72-126 2.56e-10

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 55.84  E-value: 2.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145328740   72 WKEREAAVFAFGAIAEGCNSFFYPHLAEIVAILRRLLDDQSPLVRRITCWTLYQF 126
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
28-130 4.35e-06

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 49.55  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145328740  28 DKEWNLRACSAKFIGILANVFGDEILLTLMPLIEAKLSkfdDETWKEREAAVFAFGAIAEG-CNSFFYPHLAEIVAILRR 106
Cdd:COG5215  339 GDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIR---SESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIEN 415

                         90       100
                 ....*....|....*....|....
gi 145328740 107 LLDDQSPLVRRITCWTLYQFGTYV 130
Cdd:COG5215  416 EMSDSCLWVKSTTAWCFGAIADHV 439
HEAT COG1413
HEAT repeat [General function prediction only];
58-184 1.31e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145328740  58 PLIEAklskFDDETWKEREAAVFAFGAIAEgcnsffyphlAEIVAILRRLLDDQSPLVRRITCWTLYQFGtyvfeesNLE 137
Cdd:COG1413   20 ALIAA----LADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAAEALGRIG-------DPE 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 145328740 138 NSKLFTKVLHgfrfkllDSNIWVQEAACLALTTF-EEDAGDKLVPHLE 184
Cdd:COG1413   79 AVPALIAALK-------DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 72-126 2.56e-10

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 55.84  E-value: 2.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145328740   72 WKEREAAVFAFGAIAEGCNSFFYPHLAEIVAILRRLLDDQSPLVRRITCWTLYQF 126
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
28-130 4.35e-06

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 49.55  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145328740  28 DKEWNLRACSAKFIGILANVFGDEILLTLMPLIEAKLSkfdDETWKEREAAVFAFGAIAEG-CNSFFYPHLAEIVAILRR 106
Cdd:COG5215  339 GDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIR---SESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIEN 415

                         90       100
                 ....*....|....*....|....
gi 145328740 107 LLDDQSPLVRRITCWTLYQFGTYV 130
Cdd:COG5215  416 EMSDSCLWVKSTTAWCFGAIADHV 439
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 68-128 9.11e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.47  E-value: 9.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145328740   68 DDETWKEREAAVFAFGAIAEgcnsffyphlAEIVAILRRLLDDQSPLVRRITCWTLYQFGT 128
Cdd:pfam13646  10 RDPDPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKIGD 60
HEAT COG1413
HEAT repeat [General function prediction only];
58-184 1.31e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145328740  58 PLIEAklskFDDETWKEREAAVFAFGAIAEgcnsffyphlAEIVAILRRLLDDQSPLVRRITCWTLYQFGtyvfeesNLE 137
Cdd:COG1413   20 ALIAA----LADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAAEALGRIG-------DPE 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 145328740 138 NSKLFTKVLHgfrfkllDSNIWVQEAACLALTTF-EEDAGDKLVPHLE 184
Cdd:COG1413   79 AVPALIAALK-------DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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