|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
28-452 |
0e+00 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 620.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 28 HVFIFVHTFMSYAMLHATRKTLSTVKPSLIHTWISNTSTP----------DGPVFPSQQAAAEFLGVLDTGFLVAYAIGL 97
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTsielheetwnANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 98 YICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVM 177
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 178 GAWSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssdilpeqmeeeetddepterpppi 257
Cdd:cd17342 161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 258 gflkawllPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVF 337
Cdd:cd17342 213 --------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 338 IMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGKCDQLRGNAEALSTVTGIIDGTGSIGAAIG 417
Cdd:cd17342 285 VMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIG 364
|
410 420 430
....*....|....*....|....*....|....*
gi 133901856 418 QWFIPSVQHWFGWDAVFYGFIVMILCTALCLVPVL 452
Cdd:cd17342 365 QVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
30-455 |
1.75e-95 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 294.61 E-value: 1.75e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 30 FIFVHTFMSYAMLHATRKTLSTVKpSLIHTWISNTSTPDGPVFPSQQA----------AAEFLGVLDTGFLVAYAIGLYI 99
Cdd:cd17344 3 FILVLTFLAYACYHLSRKPISIVK-SVLHPNCSALIPPPNIVLNNTTWcgwapfdgknGTELLGALDSAFLFAYAIGMFF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 100 CGILGDNYNPRRLLTAGMMLSSIIVFCFGyLTETFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGA 179
Cdd:cd17344 82 SGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 180 WSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssdilpeqmeeeetddepterpppigf 259
Cdd:cd17344 161 WNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 260 lkawllPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIM 339
Cdd:cd17344 211 ------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAM 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 340 LLMATVSLYIY-AHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGKCDQLRGNAEALSTVTGIIDGTGSIGAAIGq 418
Cdd:cd17344 285 LILAAPMLFIYnYFGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALG- 363
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 133901856 419 wfiPSVQHWF---GWDAVFYGFIVMILCTALCLVPVLWKE 455
Cdd:cd17344 364 ---PLLAGLIssrGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
28-452 |
1.58e-78 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 249.50 E-value: 1.58e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 28 HVFIFVHTFMSYAMLHATRKTLSTVKPSLIHtwisntstpDGPVFPSQqaaaefLGVLDTGFLVAYAIGLYICGILGDNY 107
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE---------EIGLSKDD------LGIIGSAFLIAYAVGKFISGFLSDRS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 108 NPRRLLTAGMMLSSIIVFCFGYLTETFhfyspmVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVG 187
Cdd:cd17312 66 NIRRFMSAGLLLSALANIFMGFSTSLW------FFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 188 NIIGTLIA-SYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssdilpeqmeeeetddepterpppigflkawllP 266
Cdd:cd17312 140 GILAPILAaSLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------------------P 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 267 GVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHM--RSRTPVVFIMLLMAT 344
Cdd:cd17312 184 YVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 345 VSLYIYAHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIPSV 424
Cdd:cd17312 264 LSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGR-------KEAAGTATGFVGLFGYLGASLAGLPLGYI 336
|
410 420
....*....|....*....|....*...
gi 133901856 425 QHWFGWDAVFYGFIVMILCTALCLVPVL 452
Cdd:cd17312 337 IDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-457 |
3.63e-42 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 153.87 E-value: 3.63e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 22 QKWSKHHVFIFVHTFMSYAMLHATRKTLSTVKPSLIHTW-ISNTStpdgpvfpsqqaaaefLGVLDTGFLVAYAIGLYIC 100
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLgLSAAQ----------------LGLLASAFFLGYALGQIPA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 101 GILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAW 180
Cdd:COG2271 66 GLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLL------LLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIF 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 181 SSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIysflvffqlpsapwevssdilpeqmeeeetddepterpppigf 259
Cdd:COG2271 140 NAGGPLGGALAPPLLGWlLAAFGWRAAFLILGLPGLL------------------------------------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 260 lkaWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHM-RSRTPVVFI 338
Cdd:COG2271 177 ---LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 339 MLLMATVSLYIYAHSPeSYNWNAFLLLVAGFFIGGPaNMISSSITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQ 418
Cdd:COG2271 254 GLLLAALALLLLALLP-SPALAIALLFLAGFGLGGA-FGLLWALAAELFP-------KKARGTASGLVNTFGFLGGALGP 324
|
410 420 430
....*....|....*....|....*....|....*....
gi 133901856 419 WFIPSVQHWFGWDAVFYGFIVMILCTALCLVPVLWKEHK 457
Cdd:COG2271 325 LLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
31-452 |
4.87e-35 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 135.45 E-value: 4.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 31 IFVHTFMSYAMLHATRKTLSTVKPSLIHTwisntstpdgpvfpsQQAAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPR 110
Cdd:cd17345 4 VFLGIFIGYAGYYLVRNNFSLAQPYLIEQ---------------YGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 111 RLLTAGMMLSSIIVFCFGYLTetFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGN-I 189
Cdd:cd17345 69 RFLAIGLILSAIINILIGFVP--SATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGgL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 190 IGTLIASYTLFLG---YQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSDILPEQMEEEETDDEPTERPPPigfLKAWLL- 265
Cdd:cd17345 147 VGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQE---LSAWEIf 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 266 -------PGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMR--SRTPVV 336
Cdd:cd17345 224 vkyvlknKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFkgRRAPTG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 337 FIMLLMATVSLYIYAHSPeSYNWNAFLLLVAGFFIGGPANMISSSITADLGKcdqlrgnaEALSTVTGIidgTGS----I 412
Cdd:cd17345 304 IIFMILVIVALIVYWLAP-NVLVDLIALIALGFLIYGPVMLIGLQALELVPK--------KAAGTAAGL---TGLfgylG 371
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 133901856 413 GAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTALCLVPVL 452
Cdd:cd17345 372 GSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-434 |
3.42e-32 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 126.72 E-value: 3.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 36 FMSYAMLHATRKTLSTVKPSLIHTWISNTSTpdgpvfpsqqaaaefLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTA 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTD---------------LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 116 GMMLSSIIVFCFGYLTetfhfySPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLI- 194
Cdd:TIGR00881 66 GLILCAIVNLFFGFST------SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLv 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 195 -ASYTLFLGYQYSFLIACSLLFIYSFLVFFQL---PSAPWEVSSDILPEQMEEEETDDEPTERPPPIGFLKAWLLPGVIA 270
Cdd:TIGR00881 140 lFGIAELYSWHWVFIVPGIIAIIVSLICFLLLrdsPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLW 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 271 Y-SLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHM--RSRTPVVFIMLLMATVSL 347
Cdd:TIGR00881 220 YiSLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 348 YIYAHSPE-SYNWNAFLLLVAGFFIGGPANMIsSSITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIPSVQH 426
Cdd:TIGR00881 300 LVYWLNPAaNPLMDLICLFALGFLVYGPQMLI-GVIASELAP-------KKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
....*...
gi 133901856 427 WFGWDAVF 434
Cdd:TIGR00881 372 GFGWAGAF 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
82-417 |
3.73e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.04 E-value: 3.73e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWPVEV 161
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL------VLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssdilpeq 240
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLlASLFGWRAAFLILAILSLLAAVLLLLPRPPPE----------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 meEEETDDEPTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYlHAGLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:pfam07690 177 --SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 321 LAGAFSDHMRSRTPVVFIMLLMATVSL-YIYAHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGKcdqlrgnaEAL 399
Cdd:pfam07690 254 LLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK--------EER 325
|
330
....*....|....*...
gi 133901856 400 STVTGIIDGTGSIGAAIG 417
Cdd:pfam07690 326 GTASGLYNTAGSLGGALG 343
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-377 |
5.70e-25 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 106.65 E-value: 5.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 31 IFVHTFMSYAMLHATRKTLSTVKPSLIHtwisntstpDGPVFPSQqaaaefLGVLDTGFLVAYAIGLYICGILGDNYNPR 110
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMN---------ELGLDKSD------LGLITSSQSLAYAISKFIGGVLSDQISAR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 111 RLLTAGMMLSSIIVFCFGyltetfHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNII 190
Cdd:cd17343 69 WLFSSGLVLSGLTTVAFS------GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 191 GTLIASYTLF-LGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSdilpEQMEEEETDDEPTERPPPIGFLKAWLL-PGV 268
Cdd:cd17343 143 GPILATLLALsYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGL----NNIEEEESKGKKKKSPRGESTLKELLLsPFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 269 IAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRS----------RTPVVFI 338
Cdd:cd17343 219 WLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAkhgsssrgnpRMPLALV 298
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 133901856 339 MLLMATVSLYIYAHSPESYNWNAFLLLVaGFFIG----GPANM 377
Cdd:cd17343 299 FMAGLTVSLHLFRVHITSDSSELFILLL-GFLIGfslyGPIAI 340
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
31-452 |
6.55e-25 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 105.95 E-value: 6.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 31 IFVHTFMSYAMLHATRKTLSTVKPSLIhtwiSNTSTpdgpvfpsqqaAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPR 110
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPAML----ADLGL-----------DKSDIGILGSLFYITYGVSKFVSGLMSDRSNPR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 111 RLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGN-I 189
Cdd:cd17488 69 YFMGIGLIATGIINILFGFSSSLWAFA------VLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGaL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 190 IGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSapwevssdilpeqmeeeetddepteRPPPIgflkaWLLpgVI 269
Cdd:cd17488 143 IPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRD-------------------------RPPYI-----WLL--AF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 270 AYSLAYACLKLVNYgfffWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHM----RSRTPVVFIMLLMATV 345
Cdd:cd17488 191 CYVLVYVVRTAIND----WGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfkgnRGPMNLIFALGLLVSV 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 346 SLYIYAHSpESYNWNAFLLLVAGFFIGGPANMISSSiTADLgkcdqlrGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQ 425
Cdd:cd17488 267 GALWLVPV-HSYWLLATCFFTIGFFVFGPQMLIGMA-AAEC-------SHKDAAGSATGFVGLFAYLGAALAGYPLAKVI 337
|
410 420
....*....|....*....|....*..
gi 133901856 426 HWFGWDAVFYGFIVMILCTALCLVPVL 452
Cdd:cd17488 338 ESWGWSGFFIVISIAAAISGLLLLPLL 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
77-384 |
6.59e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.74 E-value: 6.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 77 AAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfhfySPMVYSFLWILNGFIQSVG 156
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP------SLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 157 WPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssd 235
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLlADLFGWRWVFLVNAVLALLALLLLLRLLPESR------ 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 236 ilpeqmeeeetddEPTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGG 315
Cdd:COG2814 190 -------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 133901856 316 IVAAVLAGAFSDHMrSRTPVVFIMLLMATVSLYIYAHSPesynwNAFLLLVAGFFIGGPANMISSSITA 384
Cdd:COG2814 257 VLGALLAGRLADRF-GRRRLLLIGLLLLALGLLLLALAG-----SLWLLLLALFLLGFGFGLLFPLLQA 319
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
89-451 |
3.49e-23 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 100.72 E-value: 3.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 89 FLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWPVEVSIMGNWF 168
Cdd:cd17319 47 FFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY------VLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 169 GHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFqlpsapwevssdilpeqmeeeetd 247
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWlLLLFGWRWAFIIEGLLGLLLAVLWWF------------------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 248 depterpppigflkawLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSD 327
Cdd:cd17319 177 ----------------YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 328 HM--RSRTPVVFIMLLMATVSLYIYAHSPESYnWNAFLLLVAGFFIGGPANMIsSSITADLGKcdqlrgnAEALSTVTGI 405
Cdd:cd17319 241 RLlrGARRLVIIIGLLLAAVGLLLAYLTTSPV-VAVILLSLAGFGIGAASPVF-WSLPADLLP-------GEAAATAGGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 133901856 406 IDGTGSIGAAIGQWFIPS-VQHWFGWDAVFYGFIVMILCTALCLVPV 451
Cdd:cd17319 312 INSGGNLGGFVAPLLIGYlVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
24-452 |
1.00e-22 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 100.55 E-value: 1.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 24 WSKHhvfIFVHTFMSYAMLHATRKTLSTVKPSLIHTWISNTSTpdgpvfpsqqaaaefLGVLDTGFLVAYAIGLYICGIL 103
Cdd:PRK11663 20 WRRH---ILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSD---------------IGLLATLFYITYGVSKFVSGIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 104 GDNYNPRRLLTAGMMLSSIIVFCFGYLTetfhfySPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSC 183
Cdd:PRK11663 82 SDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 184 ASVGN-IIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAP----------WEVSSDILPEQMEEEETDDEPTE 252
Cdd:PRK11663 156 HNVGGaLIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPqamglpsvgeWRHDALELAQQQEGAGLSRKEIL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 253 RPPPIGFLKAWLLpgviaySLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRS- 331
Cdd:PRK11663 236 TKYVLLNPYIWLL------SFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNg 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 332 -RTPVVFIM---LLMATVSLYIYAHspESYNWNAFLLLVAGFFIGGPANMISSSItadlGKCdqlrGNAEALSTVTGIID 407
Cdd:PRK11663 310 nRGPMNLIFaagILLSVGSLWLMPF--ASYVMQAACFFTIGFFVFGPQMLIGMAA----AEC----SHKEAAGAATGFVG 379
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 133901856 408 GTGSIGAAIGQWFIPSVQHWFGWDavfyGFIVMILCTA----LCLVPVL 452
Cdd:PRK11663 380 LFAYLGAALSGYPLAKVLEIWHWT----GFFVVISIAAgisaLLLLPFL 424
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
22-470 |
2.88e-22 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 99.35 E-value: 2.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 22 QKWSKHHVFIFVHTFMSYAMLHATRKTLSTVKPSLIHTWisNTSTPDgpvfpsqqaaaefLGVLDTGFLVAYAIGLYICG 101
Cdd:PRK09556 21 KMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTY--GLSTTE-------------LGMIGLGFSITYGVGKTLVG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 102 ILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHF-YSPMVysFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAW 180
Cdd:PRK09556 86 YYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVsLGLMI--ALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 181 SSCASVGNIIGTLIA---SYTLFLGYQYSFLIACSLL-FIYSFLVFFQLPSAP----WEVSSDILPE------------Q 240
Cdd:PRK09556 164 NISHNLGGAGAGGVAlwgANYFFDGHVIGMFIFPSIIaLIIGFIGLRYGSDSPeelgWGKAEEIFGEpiseedketestD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 MEEEETDDEPTERPPPIgflkaWLLpgVIAYSLAYaclkLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:PRK09556 244 MTKWQIFVEYVLKNPVI-----WLL--CFANIFLY----IVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 321 LAGAFSDHMRSR---TPVVFIMLLMATVSLYIYAHSPESYNWNAFLLlvaGFFIGGPANMISSSITADLGKcdqlrgnaE 397
Cdd:PRK09556 313 LWGWLSDLANGRralVACIALALIIFTLGVYQHATSEYMYLASLFAL---GFLVFGPQLLIGVAAVGFVPK--------K 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 398 ALSTVTGIidgTGSIGAAIGQWF---------------IPSVQHWF-GWDAVFYGFIVMILCTALCLVPVLWKEhkERRI 461
Cdd:PRK09556 382 AIGVANGI---KGTFAYLFGDSFakvglgmiadptkngTPIFGYTLtGWAGTFAALDIAAIGCICLMAIVAVME--ERKI 456
|
....*....
gi 133901856 462 HRSEEVDSL 470
Cdd:PRK09556 457 RREKKIQQL 465
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
82-459 |
5.19e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 94.95 E-value: 5.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFyspMVYSFLWilnGFIQSVGWPVEV 161
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL---LLLGLLL---GIGGGGSFAVGI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSDilpeq 240
Cdd:COG2223 116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA----- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 meeeetddeptERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:COG2223 191 -----------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRP 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 321 LAGAFSDHMrSRTPVVFIMLLMATVSLYIYAHSPESYnWNAFLLLVAGFFIGGPANMISSSITADLGKcdqlrgnAEALS 400
Cdd:COG2223 260 LGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSL-WLFLVLFLLLGLALGGGNGAVFALVPDIFP-------TKNAG 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 401 TVTGIIDGTGSIGAAIGQWFIPSVQHWFG-WDAVFYGFIVMILCTALCLVPVLWKEHKER 459
Cdd:COG2223 331 AVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
79-449 |
1.26e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 93.65 E-value: 1.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 79 AEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWP 158
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL------LGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 159 VEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYT---LFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSD 235
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILassLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 236 ILPEqmeeeetddepTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGG 315
Cdd:cd06174 184 NEEA-----------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 316 IVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPeSYNWNAFLLLVAGFFIGGPANMISSSItadlgkcdQLRGN 395
Cdd:cd06174 253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP-SLLLLLLLLLLLGFGLGGLLPLSFALI--------AELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 133901856 396 AEALSTVTGIIDGTGSIGAAIGQWFIPSVQ-HWFGWDAVFYGFIVMILCTALCLV 449
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
31-460 |
1.17e-19 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 91.31 E-value: 1.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 31 IFVHTFMSYAMLHATRKTLSTVKPSLIHTWISNTStpdgpvfpsqqaaaefLGVLDTGFLVAYAIGLYICGILGDNYNPR 110
Cdd:PRK11273 30 IFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGD----------------LGFALSGISIAYGFSKFIMGSVSDRSNPR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 111 RLLTAGMMLSSIIVFCFGYLteTFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASV-GNI 189
Cdd:PRK11273 94 VFLPAGLILAAAVMLFMGFV--PWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVgGGL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 190 IGTL-IASYTLFLGYQYSFLI---ACSLLFIYSFLVFFQLPSA----PWEVSSDILPEQMEEEETDDEPTERPppigFLK 261
Cdd:PRK11273 172 PPLLfLLGMAWFNDWHAALYMpafAAILVALFAFAMMRDTPQScglpPIEEYKNDYPDDYNEKHEQELTAKQI----FMQ 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 262 aWLLPGVIAYSLAYA--CLKLVNYGFFFWLPYYLHAGLHwpesYADSLSTW----YDVGGIVAAVLAGAFSDHM----RS 331
Cdd:PRK11273 248 -YVLPNKLLWYIAIAnvFVYLLRYGILDWSPTYLKEVKH----FALDKSSWayflYEYAGIPGTLLCGWMSDKVfrgnRG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 332 RTPVVFIMLLMATVSLYiYAHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGKcdQLRGNAEALSTVTGIIDGTGS 411
Cdd:PRK11273 323 ATGVFFMTLVTIATIVY-WLNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPK--KAAGTAAGFTGLFGYLGGSVA 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 133901856 412 IGAAIGQwfipSVQHwFGWDAvfyGFIVMI---LCTALCLVPVLWKEHKERR 460
Cdd:PRK11273 400 ASAIVGY----TVDF-FGWDG---GFMVMIggsILAVILLIVVMIGEKRHHE 443
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
83-447 |
2.26e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 2.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 83 GVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfHFYSPMVYSFlwiLNGFIQSVGWPVEVS 162
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP---SFALLLLARA---LAGLAHGGFWAIAAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 163 IMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSdilpeqm 241
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLlGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 242 eeeetddeptERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVL 321
Cdd:cd17324 184 ----------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 322 AGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGPANmisSSITADLGKcdqlRGNAEALST 401
Cdd:cd17324 254 AGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL---QTRVLRLAP----EARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 133901856 402 VTGIIDGTGSIGAAIGQWFIpsvqHWFGWDAVFYGFIVMILCTALC 447
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVL----DHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
70-449 |
2.19e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 80.70 E-value: 2.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 70 PVFP----SQQAAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFL 145
Cdd:cd17325 17 PILPlyaeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL------LA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 146 WILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLIACSLLFIYSFLVFFQ 224
Cdd:cd17325 91 RFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALALLALVLALLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 225 LPsapwevssdilPEQMEEEETDDEPTERPPPIGFLKAWllPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYA 304
Cdd:cd17325 171 LP-----------EPRPPPNKRAVSAARLRSGLRLLLRD--RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 305 DSLSTWYDVGGIVAAVLAGAFSDHMrSRTPVVFIMLLMATVSLYIYAHSPesynwNAFLLLVAGFFIGGPANMISSSITA 384
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133901856 385 DLGKcdqlRGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFY-GFIVMILCTALCLV 449
Cdd:cd17325 312 LLAD----IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLaAAALLLLAAVLFLL 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
82-453 |
1.26e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 78.76 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWPVEV 161
Cdd:COG2807 55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL------AGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNaRGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssdilpeq 240
Cdd:COG2807 129 GLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAVWALLALLALLLWLPLLRRRP----------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 meeeetdDEPTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAgLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:COG2807 197 -------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 321 LAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWnaFLLLVAGFFIGGPANMISSSITadlgkcdqLR-GNAEAL 399
Cdd:COG2807 269 LVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW--LWAVLLGLGQGGLFPLALTLIG--------LRaRTPAEA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 133901856 400 STVTGIIDGTGSIGAAIGQWFIPSVQHWFG-WDAVfygFIVMILCTALCLVPVLW 453
Cdd:COG2807 339 AALSGMAQSVGYLLAALGPLLVGALHDATGsWTAA---LLLLAALAVLMLVAGLL 390
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
69-449 |
1.50e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.95 E-value: 1.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 69 GPVFPSQQAAAEFLGVLDTGFLVaYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfhfySPMVYSFLWIL 148
Cdd:cd17316 26 AAEFSLGLSLLQTGLLFAAGFLG-RPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP------TPILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 149 NGFiqSVG--WPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIAS-----YTLFLGYQYSFLIACsllfiysflv 221
Cdd:cd17316 99 QGI--GIGgeYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASlliplLSGDWGWRILFLIGA---------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 222 ffqlpsapwevssdilpeqmeeeetddepterppPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPE 301
Cdd:cd17316 167 ----------------------------------LPALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 302 SYADSLSTWYDVGGIVAAVLAGAFSDhMRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGPANMISSS 381
Cdd:cd17316 213 ATSSLYLLLISLGALVGALIAGLLSD-RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 133901856 382 ITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIPS-VQHWFGWDAVFYGFIVMILCTALCLV 449
Cdd:cd17316 292 YLAELFP-------TEVRATGVGLSYNLGRLGGGGAPPLIALlLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
76-446 |
4.67e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 70.72 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 76 QAAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYSPMVYSFLwILNGFIQSV 155
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 156 GWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSD 235
Cdd:cd06173 109 FGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 236 ILPEQMEEEETDDEPTERPPPigflkawLLPGVIAYSLAYaclkLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGG 315
Cdd:cd06173 189 SSSLLLRDLREGLRYLRRSPL-------LRLLLLALALFA----LLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 316 IVAAVLAGAFSDHMRSRTpVVFIMLLMATVSLYIYAHSPesynwnAFLLLVAGFFIGGPANMISSSITADLgkcDQLRGN 395
Cdd:cd06173 258 LLGALLLGRLSKRRRRGR-LLLIGALLLGLALLVLGLSP------SLWLLLAALFLLGLAGGLFNVPLNTL---LQLRVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 133901856 396 AEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTAL 446
Cdd:cd06173 328 DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
82-449 |
6.23e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 6.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGyLTETFhfysPMVYSFLWIL---NGFIQSVGWP 158
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA-LAPSY----PLLLLALFLLglgLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 159 vevsiMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLG----YQYSFLIACSLLFIYSFLVFFQ-LPSAPWEVS 233
Cdd:COG0738 120 -----YVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLRSkLPEIEEEEE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 234 SDilpeqmeeeetddepteRPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDV 313
Cdd:COG0738 195 EA-----------------AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 314 GGIVAAVLAGAFSDHMRSRTpVVFIMLLMATVSLYIYAHSPeSYNWNAFLLLVAGFFIGGPANMISSSITADLGKcdqlr 393
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPVR-LLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLSLMFPTIFSLALDGLGK----- 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 133901856 394 gnaeALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGwdaVFYGFIVMILCTALCLV 449
Cdd:COG0738 331 ----RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVPLVCYLLILL 379
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
87-417 |
7.40e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.89 E-value: 7.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 87 TGFLVAYAIGLYICGILGDNYNPRRLLTAGmmlssIIVFCFGYLTETFhfySPmvySFLWILNG-FIQSVG----WPVEV 161
Cdd:cd17321 38 NAYLLAFAALLLLAGRLGDRFGRKRVFLIG-----LALFGLASLLCAL---AP---SLAFLIAArALQGIGaaaiMPASL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIacsllfiysflvffqlpsapwevssdilpeq 240
Cdd:cd17321 107 ALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLlLELFGWRWIFLI------------------------------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 meeeetddepterPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:cd17321 156 -------------NVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 321 LAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLV-----AGFFIGGPANMISSSITADlgkcdqLRGN 395
Cdd:cd17321 223 LAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVllglgLGLFATPLTNAALSSVPKE------KAGA 296
|
330 340
....*....|....*....|..
gi 133901856 396 AealstvTGIIDGTGSIGAAIG 417
Cdd:cd17321 297 A------SGILNTARQLGGALG 312
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
173-432 |
2.72e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 2.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 173 RGAVMGAWSSCASVGNIIGTLIA-------SYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevssdilpeqmeeee 245
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPpplvaafGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP---------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 246 tddepTERPPPIGFLKAWLL----PGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVL 321
Cdd:COG2211 209 -----VPEEEKVSLKESLKAllknRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 322 AGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGpANMISSSITADLGKCDQLRGNAEALST 401
Cdd:COG2211 284 WPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGA-ILVLPWAMLADVVDYDEWKTGRRREGL 362
|
250 260 270
....*....|....*....|....*....|.
gi 133901856 402 VTGIIDGTGSIGAAIGQWFIPSVQHWFGWDA 432
Cdd:COG2211 363 YFGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
82-325 |
6.53e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.13 E-value: 6.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfhfySPMVYSFLWILNGFIQSVGWPVEV 161
Cdd:COG0477 51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP------SPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSDILPEQ 240
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLlVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 MEEEETDDEPTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:COG0477 205 ALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
....*
gi 133901856 321 LAGAF 325
Cdd:COG0477 285 LLLLL 289
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
87-449 |
5.47e-08 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 54.95 E-value: 5.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 87 TGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfHFYSPMVYSFLwilNGFIQSVGWPVEVSIMGN 166
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVK---NFGGLIALRFF---LGLFESGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 167 WFGHNARGAVMGAWSSCASVGNIIGTLIASYTL-------FLGYQYSFLIACSLLFIYSFLVFFQLPSAP---W------ 230
Cdd:cd17327 122 WYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvggLAGWRWLFIIEGLITIIIGLVIFFWLPDNPskaWflteee 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 231 -EVSSDILPEQMEEEETDDEPTErpppiGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGlhwpeSYADSLST 309
Cdd:cd17327 202 kELAVERLRANQTGKGDQKFKWK-----QIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSL-----GFYSLQTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 310 WYDVG----GIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESyNWNAFLLLVAGFFIGGPANMISSSITAD 385
Cdd:cd17327 272 LLSVPigalGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNP-PGAYFAAYILGGGSYAGFPILLSWISSN 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133901856 386 LGKcDQLRGnaealsTVTGIIDGTGSIGAAIGQwfipsvQHWFGWDAVFY--GFIVMILCTALCLV 449
Cdd:cd17327 351 CAG-YTKRA------TVLAIMLIFYNVGNIVAP------QIFRAGDAPRYipGNIALLVCACVSIV 403
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
272-466 |
5.55e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.73 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 272 SLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIYA 351
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 352 HSpesynwNAFLLLVAGFFIG---GPANMISSSITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWF 428
Cdd:pfam07690 82 AS------SLWLLLVLRVLQGlgaGALFPAALALIADWFP-------PEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
170 180 190
....*....|....*....|....*....|....*...
gi 133901856 429 GWDAVFYGFIVMILCTALCLvpVLWKEHKERRIHRSEE 466
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLL--LLPRPPPESKRPKPAE 184
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
101-452 |
5.98e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.48 E-value: 5.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 101 GILGDNYNPRRLLTAGMMLSSIIVFCFGYltetFHFYSPMVysFLWILNGFIQSVGWPvEVSIMGNWFGHNARGAVMGAW 180
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGF----APNYWLLL--LLVALAGIGSAAFHP-EGARLASQAAGGRRGLAMSIF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 181 SSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSapweVSSDILPEQMEEEETDDEPTERPPPIG-- 258
Cdd:cd17478 125 SVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----LKKPEAKKAAAKSSARSTLKGVWRALLll 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 259 ----FLKAWLLPGVIAYslayaclklvnygfffwLPYYLHAgLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMrSRTP 334
Cdd:cd17478 201 liivFLRSWVLSSLTTF-----------------LPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF-GRRR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 335 VVFIMLLMATVSLYIYAHSPesYNWNAFLLLVAGFFIGGPanmISSSITADLgkcDQLRGNAEALSTVT-GIIDGTGSIG 413
Cdd:cd17478 262 VIIASLLLAAPFLLLFLLTP--GIWSYILLVLAGFLLFAS---FPVTVVLAQ---ELLPGNVGLASGLMmGLSFGLGGIG 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 133901856 414 AAIgqwfipsvqhwFGWDAVFYGF-IVMILCTALCLVPVL 452
Cdd:cd17478 334 APV-----------LGALADAFGLeSVLLILALLPLLGAL 362
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
82-452 |
6.23e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.55 E-value: 6.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVGWPVEV 161
Cdd:cd17328 36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLL------LFRALVGIGEASYSPIAP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY--TLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPwevSSDILPE 239
Cdd:cd17328 110 TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLvaQATGGWRWAFRVTGVLGVLLAILLLLFVREPP---RGAAEGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 240 QMEEEETddepterpppIGFLKAWLL----PGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYD--- 312
Cdd:cd17328 187 VMAKSTA----------TSFLADLKAlaknPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGait 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 313 -VGGIVAAVLAGAFSDHMRSRTP-----VVFIMLLMATVSLYIYAHSPESynwNAFLLLVAGFFIGGPANMISSSITADL 386
Cdd:cd17328 257 cIAGVLGVLLGGILADRLRRKTPradplVCAVGLLAAAPFLFLALVLALS---NLLLAWVLLFLGEFLLSLNWAPVFAIL 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 133901856 387 GKC--DQLRGNAEALSTVTgiidgTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTAL---CLVPVL 452
Cdd:cd17328 334 LYVviPTRRSTASAIQILL-----SHLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYALllcSFVLVL 399
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
36-452 |
6.53e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.63 E-value: 6.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 36 FMSYAMLHATrktLSTVKPSLIHTWISNTSTpdgpvfpsqqaaaefLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTA 115
Cdd:cd17333 5 FFSNGLTDAL---LGILGPSLEEAFNLNVAD---------------VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 116 GMMLssIIVFCFGYLTeTFHFYspmVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNaRGAVMGAWSSCASVGNIIGTLIA 195
Cdd:cd17333 67 GLLL--ISLALALIFA-TPSIY---LFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 196 SYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSDILPEQmeeeetddepTERPPPIGFLKAWLlPGVIAYSLAY 275
Cdd:cd17333 140 TSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQS----------VGAFSASASRLLRN-PSIILGALAL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 276 ACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTpVVFIMLLMATVSLYIYAHSPe 355
Cdd:cd17333 209 FLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT-LLVLSGSGALLGLLILLLAP- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 356 SYNWNAFLLLVAGFFIGGPANMISSSITADLGKcdqlrgnaeALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGwdaVFY 435
Cdd:cd17333 287 TLVVGLVATALLGLFMAALFPTILSLGISNLPY---------AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVG---IQT 354
|
410
....*....|....*..
gi 133901856 436 GFIVMILCTALCLVPVL 452
Cdd:cd17333 355 AMLLITILYAIIFVLAL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
280-471 |
3.39e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 280 LVNYGFFFWLPY--YLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHmRSRTPVVFIMLLMATVSLYIYAHSPeSY 357
Cdd:COG2814 21 LSGLGIGIVLPAlpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCALAP-SL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 358 NWNAFLLLVAGFFIGGpANMISSSITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGF 437
Cdd:COG2814 99 WLLLAARFLQGLGAGA-LFPAALALIADLVP-------PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190
....*....|....*....|....*....|....
gi 133901856 438 IVMILCTALCLVPVLWKEHKERRIHRSEEVDSLL 471
Cdd:COG2814 171 AVLALLALLLLLRLLPESRPAARARLRGSLRELL 204
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
99-453 |
4.67e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.87 E-value: 4.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 99 ICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspMVYSFLWILNGFIQSVGwpveVSIMGNWF-GHNARGAVM 177
Cdd:cd17341 53 PYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGL--LVLGFLLGFAGANFASG----QPWASFWFpKEKIGGAAG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 178 GAwsscASVGNI-----------IGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFF---QLPSAPWevSSDILPEQMEe 243
Cdd:cd17341 127 GI----AGAGNMgvavsqllaplIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLfgdDLPTGKA--SALEFLKVQL- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 244 eetddepterpPPIGFLKAWLLpgviaySLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAG 323
Cdd:cd17341 200 -----------AVLKNYRTWIL------SLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 324 AFSDH--MRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGPAN-----MISSSITADLGkcdqlrgna 396
Cdd:cd17341 263 WLSDRfgGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNgsvfrMVPFIFRRELG--------- 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 133901856 397 ealsTVTGIIDGTGSIGAAIGQWFIPSVQHWFGwdAVFYGFIVMILCTALCLVPVLW 453
Cdd:cd17341 334 ----AVTGLVGAIGGLGGFFLPLLFGSSALMTG--SGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
89-451 |
6.25e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.50 E-value: 6.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 89 FLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYspmvysFLWILNGFIQSVG--WPVEVSIMGN 166
Cdd:cd17355 47 GLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY------LLWGLLGGGGAGTlaAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 167 WFGHNaRGAVMGAWSSCASVGNIIGT-LIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSdilpeqmeeeE 245
Cdd:cd17355 121 WFERR-RGLALGILTAGGGLGSLVFLpLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLAL----------R 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 246 TDDEPTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYL-HAGLHwPESYADSLSTwYDVGGIVAAVLAGA 324
Cdd:cd17355 190 AYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLaDRGIS-PAAAAVALAL-IGLFNIVGRLLSGW 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 325 FSDHMrSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGpaNMISSSITAdlgkcdQLRGNAEALSTVTG 404
Cdd:cd17355 268 LGDRY-SPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGA--TVPLTAALA------ARYFGARSYGTLFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 133901856 405 IIDGTGSIGAAIGQWFIPSVQHWFG-WDAVFYGFIVMILCTALCLVPV 451
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
83-417 |
6.92e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.53 E-value: 6.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 83 GVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAgmmlsSIIVFCFGYLTETFhfysPMVYSFLWILNgFIQSVG----WP 158
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVI-----TILLFAVFTLLCGF----AQNYWQLLILR-ALAGLGfggeWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 159 VEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLiASYTLF------LGYQYSFLIACSLLFIYSFLVFFQLPSAPWEV 232
Cdd:cd17371 107 AGAALMAEYVPARHRGKALGYVQSGWAVGWLLATL-LAALLFpllppeIAWRVLFLLGALPALLVLFIRRFVKEPPQWQA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 233 SSDILPEqmeeeetddePTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHwpesYADSLSTWYD 312
Cdd:cd17371 186 ARAARRH----------FADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERG----LSFEGSAGYL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 313 V----GGIVAAVLAGAFSDHM-RSRTPVVFIMLLMATVSLYIYAHSPESynwnafLLLVAGFFIGGPANMISSSITADL- 386
Cdd:cd17371 252 VvtilGGFLGYLAGGFLADRIgRRNNFALFALGSAISILLYFFLPLSPT------LILILGFPLGFFASGPFSGMGAYLt 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 133901856 387 ------------GKCDQL-RGNAEALSTVTGIIDGTGSIGAAIG 417
Cdd:cd17371 326 elfptavrataqGFCYNVgRIIGALFPFLVGFLATSGSLGTAIA 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
83-446 |
9.50e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 9.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 83 GVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfhfySPMVYSFLWILNGFIQSVGWPVEVS 162
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD------SPWVWFLLRFVMGIGLAGLFVVSES 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 163 IMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLGYQysFLIACSLLFIYSFLVFFQLPSAPWEVSSdilpeqme 242
Cdd:cd17477 108 WLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLLALVPLLLTRRAAPEIEE-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 243 eeetddepterPPPIGFLKAW-LLPGVIAYSLAYACLKLVNYGFffwLPYYLHAgLHWPESYADSLSTWYDVGGIVAAVL 321
Cdd:cd17477 178 -----------AESISLRRLLrIAPLALLGAFVAGFLEGAFYSL---LPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 322 AGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYnwnafLLLVAGFFIGGPANMISSSITADLGkcDQLRGNaeALST 401
Cdd:cd17477 243 LGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPL-----ALLVLLFLWGGAAGPLYTLALALAG--DRLPGD--ELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 133901856 402 VTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTAL 446
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
93-373 |
1.92e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.93 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 93 YAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFcFGYLTETFhfysPMVYSFLW---ILNGFIQSVGwpvEVSIMGnWFG 169
Cdd:cd17475 44 VAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL-LMALVGSY----PVLLVLLFlvgAGYGSVQPGG---GRAIMR-WFP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 170 HNARGAVMGAWSSCASVGNIIGTLIASYT-LFLGYQYSFLIACSLLFI--YSFLVFFQLPSAPWEVSSDILPEQMeeeet 246
Cdd:cd17475 115 PRERGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILaaVLFWLFYREPPAASAATESASTLLR----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 247 ddeptERPPPIGFLKAWLLpgviaySLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFS 326
Cdd:cd17475 190 -----SLKEVLRNRDVWLI------AIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 133901856 327 DHM---RSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLL-VAGFFIGG 373
Cdd:cd17475 259 DRVfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIG 309
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
87-452 |
3.30e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.11 E-value: 3.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 87 TGFLVAYAIGLYICGILGDNYNPRRLltagmMLSSIIVFCFGYLTETFhfySPMVYSFLW--ILNGFIQSVGWPVEVSIM 164
Cdd:cd17503 38 TSYLLALAIMIPLSGWLADRFGTRRL-----FLTALALFTLGSLLCGL---APNLASLIIfrILQGFGGGVLIPLAQTIL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 165 GNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACsllfiysflvffqlpsapwevssdilpeqmee 243
Cdd:cd17503 110 LRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWlTDNLSWRWIFYINL-------------------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 244 eetddepterppPIGFLKAWLLP--------------GVIAYSLAYACLklvnYGFFFWLPYYLHAGLHWPESYADSLST 309
Cdd:cd17503 158 ------------PIGILALLLAPlldlrlfkdrnftlGLLLSFLLGLGL----FGAMFLLPLYLQNVLGYSAFESGLVLA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 310 WYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPES-YNWNAFLLLVAGFFIGgpanMISSSIT----A 384
Cdd:cd17503 222 PGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTsLWLIILPLFIRGLGMG----LVFMPLNtlalN 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 385 DLGKcdQLRGNAEALSTVTGIIdgTGSIGAAIGQWFIPSVQHWFGW----------------DAVFYGFIVMILCTALCL 448
Cdd:cd17503 298 SLPP--EQIGDATALFNTIRQL--GGSIGTALLATLLTNRTQFHHSrlsellaqqvqkqaliIAFNDAFLVSAILLLVGL 373
|
....
gi 133901856 449 VPVL 452
Cdd:cd17503 374 LLAL 377
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
87-449 |
6.31e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.34 E-value: 6.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 87 TGFLVAYAIGLYICGILGDNYNPRRLLTAGM---MLSSIIVFcfgyLTETFHfyspmVYSFLWILNGFIQSVGWPVEVSI 163
Cdd:cd17320 41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLllfILASLLCA----LASSIE-----QLLIARFLQGLGAAAGSVVARAI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 164 MGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFQLPSapwevssdILPEQme 242
Cdd:cd17320 112 VRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLlLLFFGWRAIFVFLALLGLLLLLLVLLFLPE--------TLPEE-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 243 eeetddepTERPPPIGFLKAWLL----PGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVA 318
Cdd:cd17320 182 --------KRKPLLSSLLRAYKRvlknRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 319 AVLAGAFSDHMRSRTPVVFIM-LLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGgpANMISSSITA-DLGKCDQLRGNA 396
Cdd:cd17320 254 SLLNGRLVRRFGPRRLLRLGLlLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFG--FGLIFPNATSlALEPFPHVAGTA 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 133901856 397 EALstVTGIIDGTGSIGAAIGQWFIPSVQHWFGWdavfygfiVMILCTALCLV 449
Cdd:cd17320 332 SAL--LGFLQFLIGALAGALVGLLPNGTALPMGL--------LILVLGLLALL 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
101-226 |
1.02e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.61 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 101 GILGDNYNPRRlltagMMLSSIIVFCFGYLTETFHFySPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAW 180
Cdd:cd17329 56 GRLADRFGRKP-----VMLAGLLLRALGFALLGFAH-SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 133901856 181 SSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLP 226
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
311-469 |
1.05e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 311 YDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVS-LYIYAHSPEsynwnafLLLVAGFFIG---GPANMISSSITADL 386
Cdd:cd17325 40 YALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTlLFAFATSYW-------QLLLARFLQGlasAAVWPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 387 GKcDQLRGnaEALSTVTGIIDGTGSIGAAIGQWFIpsvqHWFGWDAVFYgfiVMILCTALCLVPVLWKEHKERRIHRSEE 466
Cdd:cd17325 113 AP-PEERG--RAMGIFSSAIGLGFLIGPLLGGLLA----DALGYRAPFL---VCAALALLALVLALLLLPEPRPPPNKRA 182
|
...
gi 133901856 467 VDS 469
Cdd:cd17325 183 VSA 185
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
89-347 |
1.56e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 89 FLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFcfgyLTETFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWF 168
Cdd:cd17380 43 FFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATL----LTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 169 GHNARGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLIACSLLFIYSFLVFfqlpsapwevssdilpeqmeeeetd 247
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLeYYGWPSVFYFFGLLGLLWALVWL------------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 248 depterpppigflkaWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLhWPESYADSLSTWYDVGGIVAAVLAGAFSD 327
Cdd:cd17380 174 ---------------IYLPPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLAD 237
|
250 260
....*....|....*....|.
gi 133901856 328 HMRSR-TPVVFIMLLMATVSL 347
Cdd:cd17380 238 HLISRgWTVTSVRKLMQSIGF 258
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
82-374 |
2.77e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.20 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 82 LGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFyspMVYSFlwiLNGFIQSVGWPVEV 161
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL---LILRF---LAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 162 SIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLIACSLLFIYSFLVFFQLP-SAPWEVS------ 233
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLPeSIDFLVSkrpetv 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 234 ----SDILPEQMEEEETDDEPTERPPPIG------FLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPyYLHAGLHWPESY 303
Cdd:TIGR00895 208 rrivNAIAPQMQAEAQSALPEQKSTQGTKrsvfkaLFQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSL 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 133901856 304 ADSLSTWYDVGGIVAAVLAGAFSDHMRSRtpVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGP 374
Cdd:TIGR00895 287 AATGGALFNFGGVIGSIIFGWLADRLGPR--VTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGG 355
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
78-222 |
7.34e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 78 AAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFgylteTFHFYSPMVYSFLWILNGFIQSVGW 157
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL-----LLLAPSLLLLLLLLLLLGFGLGGLL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 133901856 158 PVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTL--FLGYQYSFLIACSLLFIYSFLVF 222
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
70-448 |
8.75e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 8.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 70 PVFPsqqAAAEFLGV-------LDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLssIIVFCFGyltetfhfySPMVY 142
Cdd:cd17474 20 PILP---AIAEALGAspaqvglLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLL--FGIGGLL---------CGLSD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 143 SFLWILNG-FIQSVG----WPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIY 217
Cdd:cd17474 86 SFALLLAGrALQGIGaaglGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 218 SFLVFFqlpsapwevssdILPEQMEEEETDDEPTERPPPIGFLKAWLLPGVIAYSLAYACLklvnYGFFFWLPYYLHAGL 297
Cdd:cd17474 166 FLAILF------------LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY----FAFLTYLPFLLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 298 HWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPeSYNWNAFLLLVAGFFIGGPANM 377
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 133901856 378 ISSSITAdlgkcdqlRGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFY-GFIVMILCTALCL 448
Cdd:cd17474 309 LTTLVTE--------LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLvGAAIALAAAVLLA 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
268-473 |
8.90e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 8.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 268 VIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRS----RTPVVFIMLLMA 343
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 344 TVSLYIYAHSPESYNWNAFLLLVAGFFIGGPA----NMISSSITADLGKCDQLRgnaealSTVTGIIDGTGSIGAAIGQW 419
Cdd:COG2211 92 ALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAytlvNIPYSALGAELTPDYEER------TRLSSWRFAFAGLGGLLASV 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 133901856 420 FIPSVQHWFGWDAVFYGFIVMILCTALCLVPVLW-----KEhkerRIHRSEEVDSLLQS 473
Cdd:COG2211 166 LPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLtffgtKE----RPVPEEEKVSLKES 220
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
297-452 |
2.48e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 297 LHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMrSRTPVVFIMLLMATVSLYIYAHSPesynwNAFLLLVAGFFIGGPAN 376
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRI-ERRRLLLVLLLLFILGNLLAALAP-----SFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133901856 377 MISSSITADLGKcdqlRGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTALCLVPVL 452
Cdd:cd17324 103 GFWAIAAAYAAD----LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
76-223 |
2.96e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 76 QAAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETfhfySPMVYSFLWILNGFIQSV 155
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG----NLWLLLVLAALAGIGLGA 335
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133901856 156 GWPVEVSIM------GNW-FGHNARGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLIACSLLFIYSFLVFF 223
Cdd:COG2211 336 ILVLPWAMLadvvdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLaLFGYVAGAAQSPSALTGIRLLFFL 411
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
264-449 |
3.05e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 264 LLPGVIAYSLAYACLKLVNYGFFFWLPYYL-HAGLhwPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLM 342
Cdd:cd17365 169 LLRGTLLLWVTFFMGLLLVYLLNSWLPKLMvEAGY--SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALG 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 343 AtVSLYIYAHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGkcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIP 422
Cdd:cd17365 247 A-VSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYP--------TEVRATGVGWALGVGRLGAILGPLLGG 317
|
170 180
....*....|....*....|....*...
gi 133901856 423 SVQHW-FGWDAVFYGFIVMILCTALCLV 449
Cdd:cd17365 318 LLLAAgLGPESVFLALAIPAALGALAVL 345
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
60-225 |
3.14e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.98 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 60 WISNTSTPDG--PVFPSQQAAAEF-LGVLDTGFLVAYAIGLYICGIL-GDNYNPRRLLTAGMMLSSIIVFCFGYLTETFH 135
Cdd:cd17490 207 QMITFSTTFGftPLIAKQLGASSFqLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 136 FYspmvysFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLL 214
Cdd:cd17490 287 LY------LLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIiSEAFGLQTGFFVIGVIA 360
|
170
....*....|.
gi 133901856 215 FIYSFLVFFQL 225
Cdd:cd17490 361 LLAAILSLAYY 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
271-465 |
3.46e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 271 YSLAYACLKLVNYGFFFWLPYYLHAgLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIY 350
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 351 ahSPESYNWNAFLLLVAGFFiGGPANMISSSITADLGKcdqlrgnAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGW 430
Cdd:cd06174 80 --FAPSFWLLLLGRFLLGLG-SGLIDPAVLALIADLFP-------ERERGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
|
170 180 190
....*....|....*....|....*....|....*
gi 133901856 431 DaVFYGFIVMILCTALCLVPVLWKEHKERRIHRSE 465
Cdd:cd06174 150 G-WRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
89-451 |
4.88e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 4.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 89 FLVAYAIGLYICGILGDNYNPRRLLTAGMmlssiIVFCFGYLTETFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWF 168
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGG-----ILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 169 GHNaRGAVMGAWSSCASVGNIIGTLIASYTL-FLGYQYSFLI--ACSLLFIYSFLVFFQLPSAPWEVSSDILPEQMEEEE 245
Cdd:cd17353 122 PDK-RGLATGIVIAGFGLGSLIFSPLIAYLInTVGVPTTFLIlgIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 246 TDDEPTE---RPPPIGFLKAWLLPGVIAYSLAYACLKlvnygfffwlpYYLHAGLHWPESYADSLSTWYDVGGIVAAVLA 322
Cdd:cd17353 201 PRDYTPRemlRTPTFWLLWLMFFLNATAGLMLIGQAK-----------PIGQEFAGLDAGIAALAVSILSIFNGGGRPFW 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 323 GAFSDHMrSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGPANMIsSSITADlgkcdqLRGNAEAlSTV 402
Cdd:cd17353 270 GWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALF-PALTAD------FFGTKNA-GTN 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 133901856 403 TGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTALCLVPV 451
Cdd:cd17353 341 YGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
87-442 |
1.44e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 87 TGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSsiIVFCFGYLTetfhfySPMVYSFLW--ILNGFIQSVGWPVEVSIM 164
Cdd:cd17323 41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF--VIFQIGCAL------APNIAMLIIlrFLQGFFGSSPLAIGAGTI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 165 GNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSF---LIACSLLFIYSFLVFfqlpsapwevssdilpeq 240
Cdd:cd17323 113 ADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFiTQSLGWRWIFwflAIISGFCLILIFLFL------------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 241 meeeetddepterpPPIGFLkawllpgVIAYSLAYACLklvnYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAV 320
Cdd:cd17323 175 --------------PIVLLL-------GLYVGLVYAIL----YLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 321 LAGAFSDHMRS--------------RTPVVFIMLLMATVSLYIYAHSpESYNWNAFLLLVAGFFIGGPANMISSSITADL 386
Cdd:cd17323 230 IGGRLSDYYYRrlkkknggkpepeaRLPPAFIGAFLFPIGLFIFGWT-IYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 133901856 387 GKCDQLRGnAEALSTVTGIIdgtgSIGAAIGQWFIPSVQH--WFGWDAVFYGFIVMIL 442
Cdd:cd17323 309 VDSYPKYA-ASALAANTLVR----SIFAAIFPLFAQPMFNnlGVGWAFTLLAFISLAM 361
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
94-372 |
1.93e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 94 AIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTEtfhFYSPMVYSF-LWILNGFIQSVGwpveVSIMGNWFGHNA 172
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS---LYALLASRAlLGIGVAGIMTLA----TALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 173 RGAVMGAWSSCASVGNIIGTLIASYTLFLGYQYSFLI-ACSLLFIysFLVFFQLPSAPWEVSSDILPEQMEeeetddept 251
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVyLLALPVL--ILVLLFLPEPARKSKSAASPGAAT--------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 252 erpppigfLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYL-HAGLHWPE--SYADSLSTwydVGGIVAAVLAGAFSDH 328
Cdd:cd17473 191 --------AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLqERGGGSAAliGLALAIAS---LAGAIGALLFGRLKRR 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 133901856 329 MRSRTPVVFIMLLMAtVSLYIYAHSPeSYNWNAFLLLVAGFFIG 372
Cdd:cd17473 260 LGKRRLLAIGFALMA-LGFLLLALAS-GLWVVLLGAILAGLGFG 301
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
74-223 |
2.85e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 74 SQQAAAEFLGVldtgFLVAYAIGLYICGILGDNYNPRRLLtAGMMLSSIIVFCFGYLTETFhfySPMVYSFLWILNGFIQ 153
Cdd:cd17477 221 SVAQAALLLAA----FVLGGLLLQWPLGWLADRFDRRRVL-LGCALLGALAALLLPLVPGL---PLALLVLLFLWGGAAG 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 154 SVgWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIySFLVFF 223
Cdd:cd17477 293 PL-YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL-LFLLFL 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
89-192 |
3.84e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 89 FLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWF 168
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS---LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
90 100
....*....|....*....|....
gi 133901856 169 GHNARGAVMGAWSSCASVGNIIGT 192
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
313-460 |
4.83e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 313 VGGIVAAVLAGAFSDHMRSRTpVVFIMLLMATVSLYIYAHSPESYNWNAFLLLV-AGFFIGGPAnmISSSITADLgkcdq 391
Cdd:COG2807 64 LAFGLFAPLAPRLARRFGLER-TLLLALLLLAAGLLLRSLAPSVALLLAGTALIgAGIAVGNVL--LPGLIKRWF----- 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 133901856 392 lrgnAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTALCLVPVLWKEHKERR 460
Cdd:COG2807 136 ----PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA 200
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
90-371 |
5.92e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 5.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 90 LVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETF-HFYspMVYSFLWILNG-FIQSVGWPVE---VSIM 164
Cdd:TIGR00886 47 VLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYsVLL--LIRLFIGIAGGsFASCMPWISFffpKKIQ 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 165 GNWFGHNARGAVMGAWSSCASVGNIIGTLI--ASYTLFLGYQYSFLIACS-LLFIYSFLVFFqlpSAPWEVSSDILPEQM 241
Cdd:TIGR00886 125 GTALGLAAGWGNMGGGVAQFVMPPIIGSLIfgGGQPAHLAWGWAFVIVPAgILLLPALLIFF---VGADTPPGKPATGKL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 242 EEEETDDEpterpppIGFLKAWLLpgviaySLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVL 321
Cdd:TIGR00886 202 SFKEALKV-------FGNRHTWIL------ALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPA 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 133901856 322 AGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFI 371
Cdd:TIGR00886 269 GGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFF 318
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
72-230 |
7.09e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 7.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 72 FPSQQAAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTetfhfySPMVYSFLWILNGF 151
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR------NLWLLFLARFLDGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 152 IqSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASY-TLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPW 230
Cdd:cd17330 100 T-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFlSTPYGYALPFLVAAALALLNLVLVLFFLPPLRR 178
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
280-452 |
7.20e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 280 LVNYGFFFWLPyyLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMAtVSLYIYAHSPESYNW 359
Cdd:cd17355 18 IRYYFGVFIIP--IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA-AGLVLLALATSLWQL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 360 NAFLLLVAGFFIGGPANMISSSITAdlgkcdqlRGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIV 439
Cdd:cd17355 95 YLLWGLLGGGGAGTLAAVAFATVAA--------WWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAL 166
|
170
....*....|...
gi 133901856 440 MILctaLCLVPVL 452
Cdd:cd17355 167 LAL---LVLVPVL 176
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
173-432 |
7.69e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 173 RGAVMGAWSSCASVGNIIGTLIAS--YTLF------LGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSDILPEQMeeE 244
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPplVAYFgggnasRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL--L 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 245 ETDDEPTERPPPIGFLKAWLLpgviaYSLAYAclkLVNYGFFFWLPYYLhaglhWPESYADSLSTWYDVGGIVAAVLAGA 324
Cdd:cd17332 212 KSLKALLKNRPFLILLLAYLL-----YFLAFN---IVNTVLVYYFKYVL-----GGRAELVLLLLLILSGALLALLPWPP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 325 FSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWnAFLLLVAGFFIGGPANMISSSITADLGKCDQLRGNAEALSTVTG 404
Cdd:cd17332 279 LKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVL-ILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYS 357
|
250 260
....*....|....*....|....*...
gi 133901856 405 IIDGTGSIGAAIGQWFIPSVQHWFGWDA 432
Cdd:cd17332 358 VMTFFRKLGLALAGALVGLILSLAGYVA 385
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
253-373 |
8.81e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.40 E-value: 8.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901856 253 RPPPIGFLKAWLLPG----VIAYSLAYACLKLVNYGFFFWLPYYLHA-GLHWPEsyADSLSTWYDVGGIVAAVLAGAFSD 327
Cdd:PRK11551 203 GKQRAPVLRALFGEGrataTLLLWISYFFTLIVLYFLLNWLPSLLVGqGLSRSQ--AGLVQIAFNIGGALGSLLIGALMD 280
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 133901856 328 HMRSRtPVVFIMLLMATVSLYIYAHSPeSYNWNAFLLLVAGFFIGG 373
Cdd:PRK11551 281 RLRPR-RVVLLIYAGILASLAALAAAP-SFAGMLLAGFAAGLFVVG 324
|
|
| |
