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Conserved domains on  [gi|133901802|ref|NP_001076676|]
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SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein [Caenorhabditis elegans]

Protein Classification

ANIS5 family metal-binding protein( domain architecture ID 10494995)

ANIS5 (Ani s 5) family metal-binding protein is a DUF148 domain-containing protein; similar to Anisakis simplex SXP/RAL-2 family protein Ani s 5, an excretory-secretory and highly heat-resistant allergen useful for the diagnosis of Anisakis larvae sensitization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANIS5_cation-bd pfam02520
SXP/RAL-2 family protein Ani s 5-like, metal-binding domain; This domain is found in proteins ...
 85-191 3.67e-39

SXP/RAL-2 family protein Ani s 5-like, metal-binding domain; This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.


:

Pssm-ID: 396877 [Multi-domain]  Cd Length: 107  Bit Score: 130.78  E-value: 3.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901802   85 ARREYMAIVTNSTLTISEIEEQSTTWAETNGVSEQYSEFTANVTAKLEELKQNVTSVLTNLSSVLNSLETILENEDQTVA 164
Cdd:pfam02520   1 ARKEFFAILKNETLTIAEKEEQLAAWAEKYGVTDQYKEFQANVTALKEEVKKNVTAVISNLSSVLNQLSAILDNKNQTRA 80

                          90       100
                  ....*....|....*....|....*..
gi 133901802  165 AQKQAIEELRQENPEEVDALFFIAQEV 191
Cdd:pfam02520  81 QQHEAIDALKQQYPREVDTLFFIRKQL 107
 
Name Accession Description Interval E-value
ANIS5_cation-bd pfam02520
SXP/RAL-2 family protein Ani s 5-like, metal-binding domain; This domain is found in proteins ...
 85-191 3.67e-39

SXP/RAL-2 family protein Ani s 5-like, metal-binding domain; This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.


Pssm-ID: 396877 [Multi-domain]  Cd Length: 107  Bit Score: 130.78  E-value: 3.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901802   85 ARREYMAIVTNSTLTISEIEEQSTTWAETNGVSEQYSEFTANVTAKLEELKQNVTSVLTNLSSVLNSLETILENEDQTVA 164
Cdd:pfam02520   1 ARKEFFAILKNETLTIAEKEEQLAAWAEKYGVTDQYKEFQANVTALKEEVKKNVTAVISNLSSVLNQLSAILDNKNQTRA 80

                          90       100
                  ....*....|....*....|....*..
gi 133901802  165 AQKQAIEELRQENPEEVDALFFIAQEV 191
Cdd:pfam02520  81 QQHEAIDALKQQYPREVDTLFFIRKQL 107
 
Name Accession Description Interval E-value
ANIS5_cation-bd pfam02520
SXP/RAL-2 family protein Ani s 5-like, metal-binding domain; This domain is found in proteins ...
 85-191 3.67e-39

SXP/RAL-2 family protein Ani s 5-like, metal-binding domain; This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.


Pssm-ID: 396877 [Multi-domain]  Cd Length: 107  Bit Score: 130.78  E-value: 3.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901802   85 ARREYMAIVTNSTLTISEIEEQSTTWAETNGVSEQYSEFTANVTAKLEELKQNVTSVLTNLSSVLNSLETILENEDQTVA 164
Cdd:pfam02520   1 ARKEFFAILKNETLTIAEKEEQLAAWAEKYGVTDQYKEFQANVTALKEEVKKNVTAVISNLSSVLNQLSAILDNKNQTRA 80

                          90       100
                  ....*....|....*....|....*..
gi 133901802  165 AQKQAIEELRQENPEEVDALFFIAQEV 191
Cdd:pfam02520  81 QQHEAIDALKQQYPREVDTLFFIRKQL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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