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Conserved domains on  [gi|133901684|ref|NP_001076615|]
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eLRR (extracellular Leucine-Rich Repeat) ONly [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-491 3.41e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 3.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 123 LKVGDDSFKGLEQTLRNLTIHACNLQTIPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFITSIEEKAF 202
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 203 EPLTSLETLVigehnFINETVVEEIGRLKALKTLDLSRaDGIFQPPETLfKEIPQIEVLKLSGCSIPTLePGQFATLKKL 282
Cdd:COG4886   90 TDLGDLTNLT-----ELDLSGNEELSNLTNLESLDLSG-NQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 283 KELDLRVNLIENITAyAFDGLESLTRLSLAGNFISKLePDVFFGLSSLEELDLGWNEIKTIPTDvFKPLTdKLKTISLRN 362
Cdd:COG4886  162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLT-NLETLDLSN 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 363 NPISELPS-TGLGMLEKLSLAECGFTSISAdqLKDYPKLEELDLSKCNIS--NIVENTFENQKDSLKKLNLQKNKLKSLP 439
Cdd:COG4886  238 NQLTDLPElGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 133901684 440 NLIKNLPAIESLDVSSNPYRCDGELVNFVFGVEDRVKKAEENGNSFFVANTN 491
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-491 3.41e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 3.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 123 LKVGDDSFKGLEQTLRNLTIHACNLQTIPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFITSIEEKAF 202
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 203 EPLTSLETLVigehnFINETVVEEIGRLKALKTLDLSRaDGIFQPPETLfKEIPQIEVLKLSGCSIPTLePGQFATLKKL 282
Cdd:COG4886   90 TDLGDLTNLT-----ELDLSGNEELSNLTNLESLDLSG-NQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 283 KELDLRVNLIENITAyAFDGLESLTRLSLAGNFISKLePDVFFGLSSLEELDLGWNEIKTIPTDvFKPLTdKLKTISLRN 362
Cdd:COG4886  162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLT-NLETLDLSN 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 363 NPISELPS-TGLGMLEKLSLAECGFTSISAdqLKDYPKLEELDLSKCNIS--NIVENTFENQKDSLKKLNLQKNKLKSLP 439
Cdd:COG4886  238 NQLTDLPElGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 133901684 440 NLIKNLPAIESLDVSSNPYRCDGELVNFVFGVEDRVKKAEENGNSFFVANTN 491
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-318 2.95e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 140 LTIHACNLQTIPpSVDSLENLETVVFSNNKLDSLgvDQFKNKKQLSYLDVSGNFITSIEEkaFEPLTSLETLVIGeHNFI 219
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG-GNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 220 neTVVEEIGRLKALKTLDLSR---ADG---IFQPpETLFKEIPQIEVLKLSGCSIPTLEPgqFATLKKLKELDLRVNLIE 293
Cdd:cd21340   81 --SVVEGLENLTNLEELHIENqrlPPGeklTFDP-RSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....*..
gi 133901684 294 NIT--AYAFDGLESLTRLSLAGNFISK 318
Cdd:cd21340  156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
281-340 2.90e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.90e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  281 KLKELDLRVNLIENITAYAFDGLESLTRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEI 340
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-476 8.93e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 8.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 150 IPPSVDSLENLETVVFSNNKL-DSLGVDQFKNKKQLSyLDVSGNFITSIEEKAFEPLTSLETLVIGEHNFINE--TVVEE 226
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLsGPIPPSIFSLQKLIS-LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKipVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 227 IGRLKALKTLDLSRADGIfqpPETLFKEiPQIEVLKLSGCSIPTLEPGQFATLKKLKELDLRVNLIENITAYAFDGLESL 306
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGEI---PKNLGKH-NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 307 TRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEIkTIPTDVFKPLTDKLKTISL-RNNPISELP-STGLGMLEKLSLAEC 384
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL-QGRINSRKWDMPSLQMLSLaRNKFFGGLPdSFGSKRLENLDLSRN 485

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 385 GFTSISADQLKDYPKLEELDLSKCNISNIVENTFENQKDsLKKLNLQKNKLK-SLPNLIKNLPAIESLDVSSNpyRCDGE 463
Cdd:PLN00113 486 QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKK-LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQN--QLSGE 562

                        330
                 ....*....|...
gi 133901684 464 LVNFVFGVEDRVK 476
Cdd:PLN00113 563 IPKNLGNVESLVQ 575
LRR smart00370
Leucine-rich repeats, outliers;
327-348 8.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.97e-03
                           10        20
                   ....*....|....*....|..
gi 133901684   327 LSSLEELDLGWNEIKTIPTDVF 348
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-491 3.41e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 3.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 123 LKVGDDSFKGLEQTLRNLTIHACNLQTIPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFITSIEEKAF 202
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 203 EPLTSLETLVigehnFINETVVEEIGRLKALKTLDLSRaDGIFQPPETLfKEIPQIEVLKLSGCSIPTLePGQFATLKKL 282
Cdd:COG4886   90 TDLGDLTNLT-----ELDLSGNEELSNLTNLESLDLSG-NQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 283 KELDLRVNLIENITAyAFDGLESLTRLSLAGNFISKLePDVFFGLSSLEELDLGWNEIKTIPTDvFKPLTdKLKTISLRN 362
Cdd:COG4886  162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLT-NLETLDLSN 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 363 NPISELPS-TGLGMLEKLSLAECGFTSISAdqLKDYPKLEELDLSKCNIS--NIVENTFENQKDSLKKLNLQKNKLKSLP 439
Cdd:COG4886  238 NQLTDLPElGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 133901684 440 NLIKNLPAIESLDVSSNPYRCDGELVNFVFGVEDRVKKAEENGNSFFVANTN 491
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-452 1.67e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 1.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  81 SLITSSISIQHMEFPDGGLPEFGKLAPDLKSLEIKECSGQDELKVGDDSFKGLEQTLRNLTIHACNLQTIPPSVDSLENL 160
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 161 ETVVFSNNKLDSLGvDQFKNKKQLSYLDVSGNFITSIEekafepltsletlvigehnfinetvvEEIGRLKALKTLDLSR 240
Cdd:COG4886  139 KELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP--------------------------EELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 241 AdgifqppetlfkeipQIEVLklsgcsiptlePGQFATLKKLKELDLRVNLIENITAyAFDGLESLTRLSLAGNFISKLE 320
Cdd:COG4886  192 N---------------QITDL-----------PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 321 pdVFFGLSSLEELDLGWNEIKTIPTDVFKPltdKLKTISLRNNPISELPSTGLGMLEKL-SLAECGFTSISADQLKDYPK 399
Cdd:COG4886  245 --ELGNLTNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNNQLTDLKLKELELLLGLnSLLLLLLLLNLLELLILLLL 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 133901684 400 LEELDLSKCNISNIVENTFENQKDSLKKLNLQKNKLKSLPNLIKNLPAIESLD 452
Cdd:COG4886  320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
137-421 6.20e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 6.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 137 LRNLTIHACNLQTIPPSVDSLENLETVVFSNNKLDSLGvDQFKNKKQLSYLDVSGNFITSIEEkAFEPLTSLETLVIGeH 216
Cdd:COG4886  138 LKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLS-G 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 217 NFINEtVVEEIGRLKALKTLDLSRaDGIFQPPEtlFKEIPQIEVLKLSGCSIPTLEPgqFATLKKLKELDLRVNLIENIT 296
Cdd:COG4886  215 NQLTD-LPEPLANLTNLETLDLSN-NQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLK 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 297 AYAFDGLESLTRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEIKTIPTDVFKPLTDKLKTISLRNNPISELPSTGLGML 376
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 133901684 377 EKLSLAECGFTSISADQLKDYPKLEELDLSKCNISNIVENTFENQ 421
Cdd:COG4886  369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-318 2.95e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 140 LTIHACNLQTIPpSVDSLENLETVVFSNNKLDSLgvDQFKNKKQLSYLDVSGNFITSIEEkaFEPLTSLETLVIGeHNFI 219
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG-GNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 220 neTVVEEIGRLKALKTLDLSR---ADG---IFQPpETLFKEIPQIEVLKLSGCSIPTLEPgqFATLKKLKELDLRVNLIE 293
Cdd:cd21340   81 --SVVEGLENLTNLEELHIENqrlPPGeklTFDP-RSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....*..
gi 133901684 294 NIT--AYAFDGLESLTRLSLAGNFISK 318
Cdd:cd21340  156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
281-340 2.90e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.90e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  281 KLKELDLRVNLIENITAYAFDGLESLTRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEI 340
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 261-457 2.69e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 2.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 261 LKLSGCSIPTLEPgqFATLKKLKELDLRVNLIENITAyaFDGLESLTRLSLAGNFISKLEPdvFFGLSSLEELDLGWNEI 340
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 341 KTIptdvfKPLT--DKLKTISLRNNpisELPSTglgmlEKLSLAECGFTSISadqlkdyPKLEELDLSKCNISNIveNTF 418
Cdd:cd21340   81 SVV-----EGLEnlTNLEELHIENQ---RLPPG-----EKLTFDPRSLAALS-------NSLRVLNISGNNIDSL--EPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 133901684 419 ENQKdSLKKLNLQKNKLKSLP---NLIKNLPAIESLDVSSNP 457
Cdd:cd21340  139 APLR-NLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
305-365 2.82e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.82e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 133901684  305 SLTRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEIKTIPTDVFKPLTdKLKTISLRNNPI 365
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 234-456 6.33e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.91  E-value: 6.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 234 KTLDLSRADgifqppeTLFKEIPQIEVLKLSGCSIPTLEPGQFATLKK----LKELDLRVN---LIENITAYAFDGLES- 305
Cdd:cd00116    8 ELLKTERAT-------ELLPKLLCLQVLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNetgRIPRGLQSLLQGLTKg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 306 --LTRLSLAGNFISKLEPDVFFGL---SSLEELDLGWNEIKTIPTD-VFKPLTD-------------------------- 353
Cdd:cd00116   81 cgLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRlLAKGLKDlppaleklvlgrnrlegascealaka 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 354 -----KLKTISLRNNPISE--LPSTGLGM-----LEKLSLAECGFTSISADQL----KDYPKLEELDLSKCNISNIVENT 417
Cdd:cd00116  161 lranrDLKELNLANNGIGDagIRALAEGLkancnLEVLDLNNNGLTDEGASALaetlASLKSLEVLNLGDNNLTDAGAAA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 133901684 418 FENQ----KDSLKKLNLQKNKL-----KSLPNLIKNLPAIESLDVSSN 456
Cdd:cd00116  241 LASAllspNISLLTLSLSCNDItddgaKDLAEVLAEKESLLELDLRGN 288
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-476 8.93e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 8.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 150 IPPSVDSLENLETVVFSNNKL-DSLGVDQFKNKKQLSyLDVSGNFITSIEEKAFEPLTSLETLVIGEHNFINE--TVVEE 226
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLsGPIPPSIFSLQKLIS-LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKipVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 227 IGRLKALKTLDLSRADGIfqpPETLFKEiPQIEVLKLSGCSIPTLEPGQFATLKKLKELDLRVNLIENITAYAFDGLESL 306
Cdd:PLN00113 331 LPRLQVLQLWSNKFSGEI---PKNLGKH-NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 307 TRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEIkTIPTDVFKPLTDKLKTISL-RNNPISELP-STGLGMLEKLSLAEC 384
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL-QGRINSRKWDMPSLQMLSLaRNKFFGGLPdSFGSKRLENLDLSRN 485

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 385 GFTSISADQLKDYPKLEELDLSKCNISNIVENTFENQKDsLKKLNLQKNKLK-SLPNLIKNLPAIESLDVSSNpyRCDGE 463
Cdd:PLN00113 486 QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKK-LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQN--QLSGE 562

                        330
                 ....*....|...
gi 133901684 464 LVNFVFGVEDRVK 476
Cdd:PLN00113 563 IPKNLGNVESLVQ 575
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 124-456 7.17e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 7.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 124 KVGDDSFKgLEQTLRNLTIHACNLqTIPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFITSIEEKAFE 203
Cdd:PLN00113 108 PIPDDIFT-TSSSLRYLNLSNNNF-TGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 204 PLTSLETLVIGEHNFINEtVVEEIGRLKALKTLDLSRADgifqppetlfkeipqievlkLSGcSIPTlepgQFATLKKLK 283
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQ-IPRELGQMKSLKWIYLGYNN--------------------LSG-EIPY----EIGGLTSLN 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 284 ELDLRVNLIENITAYAFDGLESLTRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEIK-TIPTdvfkpLTDKLKTISL-- 360
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE-----LVIQLQNLEIlh 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 361 --RNNPISELPS--TGLGMLEKLSLAECGFTSISADQLKDYPKLEELDLSKCNISNIVENT------------FENQKD- 423
Cdd:PLN00113 315 lfSNNFTGKIPValTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssgnlfklilFSNSLEg 394

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 133901684 424 ----------SLKKLNLQKNKLK-SLPNLIKNLPAIESLDVSSN 456
Cdd:PLN00113 395 eipkslgacrSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNN 438
LRR_8 pfam13855
Leucine rich repeat;
256-314 1.16e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 133901684  256 PQIEVLKLSGCSIPTLEPGQFATLKKLKELDLRVNLIENITAYAFDGLESLTRLSLAGN 314
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 267-452 5.26e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 5.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 267 SIPTLEpgqfaTLKKLKELDLRVNLIENITAyaFDGLESLTRLSLAGNFISKLEpdvffGL---SSLEELDLgwnEIKTI 343
Cdd:cd21340   38 KIENLE-----FLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLenlTNLEELHI---ENQRL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 344 PTDV---FKPLTdkLKTISlrnnpiselPStglgmLEKLSLAECGFTSISadQLKDYPKLEELDLSKCNISNI--VENTF 418
Cdd:cd21340  103 PPGEkltFDPRS--LAALS---------NS-----LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLeeLLDLL 164

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 133901684 419 ENQKdSLKKLNLQKNKLKSLP----NLIKNLPAIESLD 452
Cdd:cd21340  165 SSWP-SLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
159-217 3.05e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 133901684  159 NLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFITSIEEKAFEPLTSLETLVIgEHN 217
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL-SGN 59
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 221-453 8.17e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 55.65  E-value: 8.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  221 ETVVEEIGRLKALKTLDLSRADGIfqppetlfKEIP------QIEVLKLSGCSIPTLEPGQFATLKKLKELDL-RVNLIE 293
Cdd:PLN03210  624 EKLWDGVHSLTGLRNIDLRGSKNL--------KEIPdlsmatNLETLKLSDCSSLVELPSSIQYLNKLEDLDMsRCENLE 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  294 NITAYAfdGLESLTRLSLAGNFISKLEPDVffgLSSLEELDLGWNEIKTIPTDV---------------------FKPLT 352
Cdd:PLN03210  696 ILPTGI--NLKSLYRLNLSGCSRLKSFPDI---STNISWLDLDETAIEEFPSNLrlenldelilcemkseklwerVQPLT 770

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  353 DKLKTIS-------LRNNP-ISELPST--GLGMLEKLSLAECgftsISADQLK---DYPKLEELDLSKCniSNIveNTFE 419
Cdd:PLN03210  771 PLMTMLSpsltrlfLSDIPsLVELPSSiqNLHKLEHLEIENC----INLETLPtgiNLESLESLDLSGC--SRL--RTFP 842

                         250       260       270
                  ....*....|....*....|....*....|....
gi 133901684  420 NQKDSLKKLNLQKNKLKSLPNLIKNLPAIESLDV 453
Cdd:PLN03210  843 DISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDM 876
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 303-456 2.52e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 303 LESLTRLSLAGNFISKLepDVFFGLSSLEELDLGWNEIKTIPTdvFKPLTdKLKTISLRNNPISELPS-TGLGMLEKLSL 381
Cdd:cd21340    1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLT-NLTHLYLQNNQIEKIENlENLVNLKKLYL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 382 aecGFTSISA-DQLKDYPKLEELDLSKCNISNIVENTFENQ-----KDSLKKLNLQKNKLKSLPNLiKNLPAIESLDVSS 455
Cdd:cd21340   76 ---GGNRISVvEGLENLTNLEELHIENQRLPPGEKLTFDPRslaalSNSLRVLNISGNNIDSLEPL-APLRNLEQLDASN 151


                 .
gi 133901684 456 N 456
Cdd:cd21340  152 N 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-372 3.84e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 3.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 150 IPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFIT-SIEEKAFEpLTSLETLVIGEHNFINEtvVEEIG 228
Cdd:PLN00113 396 IPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARNKFFGG--LPDSF 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 229 RLKALKTLDLSRAdgifqppetlfkeipqievlKLSGCSiptlePGQFATLKKLKELDLRVNLIENITAYAFDGLESLTR 308
Cdd:PLN00113 473 GSKRLENLDLSRN--------------------QFSGAV-----PRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVS 527

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133901684 309 LSLAGNFISKLEPDVFFGLSSLEELDLGWNEIK-TIPTDVFKplTDKLKTISLRNNPI-SELPSTG 372
Cdd:PLN00113 528 LDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGN--VESLVQVNISHNHLhGSLPSTG 591
LRR_8 pfam13855
Leucine rich repeat;
398-457 1.33e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.33e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 133901684  398 PKLEELDLSKCNISNIVENTFENQKdSLKKLNLQKNKLKSL-PNLIKNLPAIESLDVSSNP 457
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
135-192 2.47e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 133901684  135 QTLRNLTIHACNLQTIPPSV-DSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGN 192
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
332-459 5.82e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 5.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 332 ELDLGWNEIKTIPTDVfkplTDKLKTISLRNNPISELPSTGLGMLEKLSLAECGFTSISAdQLKDypKLEELDLSKCNIS 411
Cdd:PRK15370 182 ELRLKILGLTTIPACI----PEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRIT 254

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 133901684 412 NIVENTfenqKDSLKKLNLQKNKLKSLPNlikNLP-AIESLDVSSNPYR 459
Cdd:PRK15370 255 ELPERL----PSALQSLDLFHNKISCLPE---NLPeELRYLSVYDNSIR 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 118-451 2.45e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 118 SGQDELKVGDDSFKGLEQTLRNLTIHAcnlQTIPPSVDSLENLETVVFSNNKLDSLGVDQFKNKKQLSYLDVSGNFI--T 195
Cdd:COG5238  119 LRRIMAKTLEDSLILYLALPRRINLIQ---VLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIgdE 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 196 SIEE--KAFEPLTSLETLVIGEhNFINETVVEEIG----RLKALKTLDLSR----ADGIFQPPETLfKEIPQIEVLKLSG 265
Cdd:COG5238  196 GIEElaEALTQNTTVTTLWLKR-NPIGDEGAEILAealkGNKSLTTLDLSNnqigDEGVIALAEAL-KNNTTVETLYLSG 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 266 CSIPtlEPG------QFATLKKLKELDLRVNLIENITAYAF-DGLE---SLTRLSLAGNFISklepdvffglssleelDL 335
Cdd:COG5238  274 NQIG--AEGaialakALQGNTTLTSLDLSVNRIGDEGAIALaEGLQgnkTLHTLNLAYNGIG----------------AQ 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 336 GWNEI-KTIPTDVfkpltdKLKTISLRNNPISELPSTGLgmleklslaecgftsisADQLKDYPKLEELDLSKCNISN-- 412
Cdd:COG5238  336 GAIALaKALQENT------TLHSLDLSDNQIGDEGAIAL-----------------AKYLEGNTTLRELNLGKNNIGKqg 392

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 133901684 413 IVENTFENQKDSLKKLNLQKNKLKSLPN--LIKNLPAIESL 451
Cdd:COG5238  393 AEALIDALQTNRLHTLILDGNLIGAEAQqrLEQLLERIKSV 433
LRR_8 pfam13855
Leucine rich repeat;
376-435 2.64e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  376 LEKLSLAECGFTSISADQLKDYPKLEELDLSKCNISNIVENTFENQKdSLKKLNLQKNKL 435
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-197 2.80e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 2.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 133901684 121 DELKVGDDSFKGLEQTLRNLTIHACNLQTIPPSVdSLENLETVVFSNNKLDSLG--VDQFKNKKQLSYLDVSGNFITSI 197
Cdd:cd21340  106 EKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLA-PLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKK 183
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 282-456 3.54e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 282 LKELDLRVNLIENITAYAF----DGLESLTRLSLAGNFISKLEPDVFFGL----SSLEELDLGWNEI-----KTIPTDVF 348
Cdd:COG5238  210 VTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIgaegaIALAKALQ 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684 349 KPLTdkLKTISLRNNPISELPSTGLgmleklslaecgftsisADQLKDYPKLEELDLSKCNISN-----IVENTFENQKd 423
Cdd:COG5238  290 GNTT--LTSLDLSVNRIGDEGAIAL-----------------AEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTT- 349

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 133901684 424 sLKKLNLQKNKL-----KSLPNLIKNLPAIESLDVSSN 456
Cdd:COG5238  350 -LHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKN 386
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 424-461 5.83e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 5.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 133901684  424 SLKKLNLQKNKLKSLPNLiKNLPAIESLDVSSNPYRCD 461
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPL-AKLPNLETLDLSGNNKITD 38
LRR_8 pfam13855
Leucine rich repeat;
328-410 7.66e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901684  328 SSLEELDLGWNEIKTIPTDVFKPLTdKLKTISLRNNPIselpstglgmleklslaecgfTSISADQLKDYPKLEELDLSK 407
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLL---------------------TTLSPGAFSGLPSLRYLDLSG 58


                  ...
gi 133901684  408 CNI 410
Cdd:pfam13855  59 NRL 61
LRR smart00370
Leucine-rich repeats, outliers;
327-348 8.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.97e-03
                           10        20
                   ....*....|....*....|..
gi 133901684   327 LSSLEELDLGWNEIKTIPTDVF 348
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
327-348 8.97e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.97e-03
                           10        20
                   ....*....|....*....|..
gi 133901684   327 LSSLEELDLGWNEIKTIPTDVF 348
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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