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Conserved domains on  [gi|130490338|ref|NP_001076403|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.2 [Danio rerio]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 118-424 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467701  Cd Length: 309  Bit Score: 565.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 118 CATSLQNSSNPT--FKKKFIPNIQLFLQSDHLNMSEWNRLYHFNNPFGYMGLNYTAIKAAVETIHKPASSQLLQVHPGVK 195
Cdd:cd23973    1 CPTSVRSKAAKSdwFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLLALSPPGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 196 DGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKRGFKQIPTDKDI 275
Cdd:cd23973   81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKDI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 276 KYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQLKTKRWWVVRPTN 355
Cdd:cd23973  161 KYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTT 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 130490338 356 GAFTLLLAMHTCDIVRVYGFCTADYRKYPSYYYDTKHTKLVFYGNHDYRLEMKTWKKFHDDKLIWMYLG 424
Cdd:cd23973  241 GAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
 
Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 118-424 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 565.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 118 CATSLQNSSNPT--FKKKFIPNIQLFLQSDHLNMSEWNRLYHFNNPFGYMGLNYTAIKAAVETIHKPASSQLLQVHPGVK 195
Cdd:cd23973    1 CPTSVRSKAAKSdwFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLLALSPPGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 196 DGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKRGFKQIPTDKDI 275
Cdd:cd23973   81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKDI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 276 KYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQLKTKRWWVVRPTN 355
Cdd:cd23973  161 KYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTT 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 130490338 356 GAFTLLLAMHTCDIVRVYGFCTADYRKYPSYYYDTKHTKLVFYGNHDYRLEMKTWKKFHDDKLIWMYLG 424
Cdd:cd23973  241 GAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 141-418 4.38e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 273.33  E-value: 4.38e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338  141 FLQSDHLNMSEWNRLYHFNnpfgymgLNYTAIKAAVETihkpassqLLQVHPGVKDGCIRCAVVGASGILNGSKLGKEID 220
Cdd:pfam00777   1 FLTKENFPLGEWIRYSEWW-------LPFTVTEELLEL--------LPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEID 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338  221 SSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKrgfKQIPTDKDIKYVLIPEGPRDYNFLESLMKNRKIP 300
Cdd:pfam00777  66 SHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNLG---FSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVS 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338  301 SGAYRGRTPRKYYSGHfNESSYYILHPDFLRYVRNRFLRAKQLKTKrwwvvRPTNGAFTLLLAMHTCDIVRVYGFCTA-D 379
Cdd:pfam00777 143 RSLRVLYTLKEVKIPV-DPDKVLFLHPDFLRYVANFWLRSHGLKGR-----RPSTGLLMLSLALHLCDEVSLYGFGPFlD 216

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 130490338  380 YRKYPSYYYDT-KHTKLVFYGNHDYRLEMKTWKKFHDDKL 418
Cdd:pfam00777 217 SRGNSHHYYDNvLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 118-424 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 565.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 118 CATSLQNSSNPT--FKKKFIPNIQLFLQSDHLNMSEWNRLYHFNNPFGYMGLNYTAIKAAVETIHKPASSQLLQVHPGVK 195
Cdd:cd23973    1 CPTSVRSKAAKSdwFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLLALSPPGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 196 DGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKRGFKQIPTDKDI 275
Cdd:cd23973   81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKDI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 276 KYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQLKTKRWWVVRPTN 355
Cdd:cd23973  161 KYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTT 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 130490338 356 GAFTLLLAMHTCDIVRVYGFCTADYRKYPSYYYDTKHTKLVFYGNHDYRLEMKTWKKFHDDKLIWMYLG 424
Cdd:cd23973  241 GAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 118-422 3.66e-109

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 323.44  E-value: 3.66e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 118 CATSLQN--SSNPTFKKKFIPNIQLFLQSDHLNMSEWNRLYHFNNPFGYMGLNYTAIKAAVETIHKPaSSQLLQVHPGVK 195
Cdd:cd23964    1 CPSSLRKklQKSPWFRERFIPDIKVLLDSEDFNPEEYNRLSHYKLPFGWGGLNREVVERLLRNLNLT-SSRYMFVLRGGR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 196 DGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHkkrgfkqIPTDKDI 275
Cdd:cd23964   80 PRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKH-------VPQDKDT 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 276 KYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQlktkrwwVVRPTN 355
Cdd:cd23964  153 KYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSST-------SYRPTT 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 130490338 356 GAFTLLLAMHTCDIVRVYGFCTAdyRKYPSYYYDTK-HTKLVFYGNHDYRLEMKTWKKFHDDKLIWMY 422
Cdd:cd23964  226 GALMLLTALHTCDQVSVYGFGYD--PRFSLHYYDKTfVKFTVFYANHDFTNERKLWRKLHEEGIINLY 291
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 127-423 9.35e-93

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 282.03  E-value: 9.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 127 NPTFKKKFIPNIQLFLQSDHLNMSEWNRLYHFNNPFGYMGLNYTAIKAAVETIHKPASSQLLQ--VHPGVKDGCIRCAVV 204
Cdd:cd23974   11 NTEFSGKFLENIPVLQWAKHATLSEYQRLKRYAGAHGWQEVDWDVLKDALNLLNSSANGQMFDwwDRPNGRSPCIRCAVV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 205 GASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKRGFKQIPTDKDIKYVLIPEGP 284
Cdd:cd23974   91 GNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETRYIFLPDHD 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 285 RDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQLKTKRWWVVRPTNGAFTLLLAM 364
Cdd:cd23974  171 RDYLLVKAALTHTPIDRGRDKSKRPSKYFGKDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKQRDIYRPSTGAVMLLAAL 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 130490338 365 HTCDIVRVYGFCTADYRKYPSYYYDTKHTKLVFYGNHDYRLEMKTWKKFHDDKLIWMYL 423
Cdd:cd23974  251 HTCDQVSAYGFMTPDYGKYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIKLYM 309
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 118-422 2.59e-90

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 275.93  E-value: 2.59e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 118 CATSLQNS--SNPTFKKKFIPNIQLFLQSDHLNMSEWNRLYHFNNPFGYMGLNYTAIKAAVETIHKPASSQLLQVHPGvK 195
Cdd:cd23972    1 CPHSLHLRiqRDPHFRGLFNFDIPVLLWGQHFTPALWDRLSQRKVPYGWKGLSHQVVASTLSLLNDSANAKLFFPRDT-P 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 196 DGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKRGFKQIPTDKDI 275
Cdd:cd23972   80 GKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLGFTRTPQGQDL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 276 KYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQLKTKRWWVVRPTN 355
Cdd:cd23972  160 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHKYFGPEASAKKFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPST 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 130490338 356 GAFTLLLAMHTCDIVRVYGFCTADYRKYPSYYYDTKHTKLVFYGNHDYRLEMKTWKKFHDDKLIWMY 422
Cdd:cd23972  240 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQLY 306
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 141-418 4.38e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 273.33  E-value: 4.38e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338  141 FLQSDHLNMSEWNRLYHFNnpfgymgLNYTAIKAAVETihkpassqLLQVHPGVKDGCIRCAVVGASGILNGSKLGKEID 220
Cdd:pfam00777   1 FLTKENFPLGEWIRYSEWW-------LPFTVTEELLEL--------LPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEID 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338  221 SSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSLMIHKKrgfKQIPTDKDIKYVLIPEGPRDYNFLESLMKNRKIP 300
Cdd:pfam00777  66 SHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNLG---FSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVS 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338  301 SGAYRGRTPRKYYSGHfNESSYYILHPDFLRYVRNRFLRAKQLKTKrwwvvRPTNGAFTLLLAMHTCDIVRVYGFCTA-D 379
Cdd:pfam00777 143 RSLRVLYTLKEVKIPV-DPDKVLFLHPDFLRYVANFWLRSHGLKGR-----RPSTGLLMLSLALHLCDEVSLYGFGPFlD 216

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 130490338  380 YRKYPSYYYDT-KHTKLVFYGNHDYRLEMKTWKKFHDDKL 418
Cdd:pfam00777 217 SRGNSHHYYDNvLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 201-413 1.37e-34

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 127.09  E-value: 1.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 201 CAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVhTAHSIIQSLMIHKKRGFKQIPTDKDIKYVLI 280
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRV-LNSKWAGFYLRGPRCGCHPLPLEEEVVLILS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 281 PEGPRDYNFLeslmknrkipsgayrgrtprKYYSGHFNESSYYILH--PDFLRYVRNRFLRAKQLKTKRWwvVRPTNGAF 358
Cdd:cd19952   80 RAAAADFKRL--------------------KRRKKRHDNAVLLLTDpaPDLLSYVRKRLEKLGLKSFFGG--NAPSSGLL 137

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 130490338 359 TLLLAMHTCDIVRVYGF--CTADYRKYPSYYYDTKhTKLVFYGNHDYRLEMKTWKKF 413
Cdd:cd19952  138 AVLLALQLCDSVDLYGFgvDSGHAPKVPYHYYDLV-EAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 130-422 1.00e-31

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 122.00  E-value: 1.00e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 130 FKKKFIPNIQLFLQSDHLNMSE-----WNRLYHFNNPfgymglNYTAIKAavetihkpassQLLQVHPGVKD-------G 197
Cdd:cd23966   14 FDERFNPSIEPLLTRKNKELPPdvlkwWLSLQSSKNS------DLREVLE-----------KLFQVVPGENPyrtrdpnR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTS---VYVHTAHSIiqslmihkkrgfkqiptDKD 274
Cdd:cd23966   77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTThhfMYPESAVDL-----------------DPG 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 275 IKYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKyysghFNESSYYILHPDFLRYVRNRFLRakqlKTKRWwvvrPT 354
Cdd:cd23966  140 VHLVLVPFKVLDLQWLISALTTGEITRTYTPVKRFIK-----ADKDKVLVINPAFIKYVHDNWTE----HHGRY----PS 206

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 355 NGAFTLLLAMHTCDIVRVYGFcTADYRKYPSYYYDTKHTKLVFY--GNHDYRLEMKTWKKFHDDKLIWMY 422
Cdd:cd23966  207 TGFLALIFALHICDEVSVFGF-GADSKGNWHHYWEKNRSAGAFRktGVHDADFESDIIKKLAKEGKIRVY 275
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 197-412 5.10e-29

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 112.39  E-value: 5.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 197 GCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTS---VYVHTAHsiiqslmihkkrgFKQIPTDK 273
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTfrmFYPESAF-------------RDPEEYDS 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 274 DIKYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKyySGHFNESSYYILHPDFLRYVRNRFLR----AKQLKTkrww 349
Cdd:cd23967   68 DWLLVLVPFKSMDLLWLQAVIKGKKPNGKGGFWKKIAT--SVPKPPKKIRILNPYILQEAAFDLIGlpmnGKQGKN---- 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 130490338 350 vvRPTNGAFTLLLAMHTCDIVRVYGFCTADYR-KYPSYYYDTKHTKLV-FYGNHDYRLEMKTWKK 412
Cdd:cd23967  142 --VPTTGIIAIVMALHYCDEVDIAGFGYDPSDpNAPLHYYDSLTMKAIkRSWTHNVTKEKKYLKK 204
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 198-405 6.28e-27

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 107.33  E-value: 6.28e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVhTAHSIIQSLMIHKKRGFKQIPTDKdiky 277
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRV-VSHSSLPRLLRNAILLLAGTRAPT---- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 VLIPEGPrdynflESLMKNRKIPSGAYRGRTPRKYysghfNESSYYILHPDFLRYVRNRFLR---AKQLKTKRWWvvrpT 354
Cdd:cd23965   76 VVVFWGP------ETKMNKDGAGKYNLLRSLSKKY-----PDVEFYSLTPEKMDYADELFEKetgKSRIKSGTWL----S 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 130490338 355 NGAFTLLLAMHTCDIVRVYGFCTADY------RKYPSYYYDT-KHTKLVFYGNHDYRL 405
Cdd:cd23965  141 TGWFTMLLALDVCDEIKVYGMVPENYcrehpnSKVPYHYYEPgGLKECTYYNYHENAL 198
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 198-412 4.03e-26

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 104.75  E-value: 4.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSV---YVHTAHSIiqslmihkkrgfKQIPTDKD 274
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIrlfYPESAQFD------------PGIENDPD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 275 IKYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYysgHFNESSYYILHPDFLRYVRNRFLrakQLKTKRWWVVRPT 354
Cdd:cd23982   70 TLLVLVPFKPLDFYWLYEILSNEKRVRKGFWKQPPRIW---DANPKQIRILNPYYTYVAATKLL---QVPGQRKKKQKPT 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 355 NGAFTLLLAMHTCDIVRVYGFCTADYR--KYPSYYYDTKHTKLVFYGNHDYRLEMKTWKK 412
Cdd:cd23982  144 TGLLAITLALHLCDEVHIAGFGYPDNGnsNQPIHYYNQITLKSMANSGHNLNAEAQAIQR 203
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 167-419 4.16e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 103.50  E-value: 4.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 167 LNYTAIKAAVETIHKPASSQLLQVHPGVKDGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSv 246
Cdd:cd23963   32 LYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTN- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 247 yvhtaHSIIQSLMIHKKRGFKQIPTDKDikyvlipegprdyNFLESLMKNRK----IPSGAYRGRTPR-----KYYSGHF 317
Cdd:cd23963  111 -----LTTLNPSILKRRYNSLKKNRDRD-------------KFLNRLKEYNGsilwYPKFSFKSSTNLllkaaRALKKNG 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 318 NESSYYILHPDFlryvrnrFLRAKQLKTKRWWVVRPTNGAFTLLLAMHTCDIVRVYGF----CTADYRKYPSYYYDTKHT 393
Cdd:cd23963  173 LNLTVVYSNPEH-------FLAVQKFWKRRGLEKRPSTGLYLVSLALTFCDEIHLYGFwpfpTDPNGRPVPYHYYDDLSP 245

                        250       260
                 ....*....|....*....|....*.
gi 130490338 394 KLVFyGNHDYRLEMKTWKKFHDDKLI 419
Cdd:cd23963  246 STKN-KVHNMPEEFKLLRELHKKGVL 270
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 180-414 3.54e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.81  E-value: 3.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 180 HKPASSQLLQVHPGvkdgciRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVyvhtahSIIQSlm 259
Cdd:cd23968   33 PFPESSLENTKRYN------TCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTL------RLINS-- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 260 ihkkrgfkQIPTDkdikyvlipegpRDYNFLESLMKNRKI----PSGAYRGRTPRKYYSGHFN-------------ESSY 322
Cdd:cd23968   99 --------QILSK------------PEFNFLTDPLYRNVTllvwDPSSYNVNLEKWYKKPDFDffpnyikyrrrhpEEPF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 323 YILHPDFLRYVRNRFLRAKQLKTKRwwvVRPTNGAFTLLLAMHTCDIVRVYGFCTADYRKYPSYYYDTKHTKLVFYGN-H 401
Cdd:cd23968  159 YLIDPRFLWRLWDILQEYTPEKIKP---NPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAwH 235

                        250
                 ....*....|...
gi 130490338 402 DYRLEMKTWKKFH 414
Cdd:cd23968  236 PLAAEKLLVRHLN 248
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 198-400 5.91e-21

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 90.19  E-value: 5.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQSlmihkkrgfkQIPTDKDIKY 277
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSD----------PSHYDPNTTV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 VLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYsghFNESSYYILHPDFLRYVRNRFLRAKQLKTKRWWVVRPTNGA 357
Cdd:cd23984   72 VLIPFKPHDLRWLLDLLMGKKVSAKGFWKKPALNLI---YKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGI 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 130490338 358 FTLLLAMHTCDIVRVYGFctadyrkypSYYYDTKHTKLVFYGN 400
Cdd:cd23984  149 IAITLALHICNEVHIAGF---------KYDFSNLNSTLHYYGN 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 198-392 1.37e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 84.14  E-value: 1.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVhTAHSIIQSLMIHKKRGFKQiptDKDIKY 277
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV-VSHTSVPLLLRNQGYFFQQ---SRDTKY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 VLI-PE-------GPRDYNFLESLMknRKIPSGAYRGRTPRK--YYSGHF-NESSyyilhpdflryvRNRFLRAKQLKTk 346
Cdd:cd23977   77 VIWgPErnmdrdgGGKTYRALLTLA--KMYPHLQVYTLTEEKmaYCDGVFqNETG------------KNRMKSGSFLST- 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 130490338 347 rwwvvrptnGAFTLLLAMHTCDIVRVYGFCTADY---RKYPS---YYYDTKH 392
Cdd:cd23977  142 ---------GWFTMILALELCEEILVYGMVSDSYcrnKNHSSvpyHYYEKGR 184
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 197-400 1.53e-18

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 83.63  E-value: 1.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 197 GCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSV---YVHTAHSIIQSlmihkkrgfkqipTDK 273
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIrmtYPEGAPKSEQE-------------YDP 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 274 DIKYVLIPEGPRDYNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLR-AKQLKTKRWWVVR 352
Cdd:cd23983   68 TSLFVAVLFKSVDFAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQyPEPQSRLWGWDKN 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 130490338 353 -PTNGAFTLLLAMHTCDIVRVYGFctadyrkypSYYYDTKHTKLVFYGN 400
Cdd:cd23983  148 vPTLGVTAVVLATHLCDEVSLAGF---------GYDLSQPHAPLHYYDS 187
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 186-406 8.02e-18

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 83.01  E-value: 8.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 186 QLLQVHPGVKD--------GCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTsvyvhTAHSIIqs 257
Cdd:cd23980   61 ELFQVVPGNVDpllekrlvSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKT-----THHFVY-- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 258 lmihkKRGFKQIPtdKDIKYVLIPEGPRDYNFLESLMKNRKIpSGAYRgRTPRKYysgHFNESSYYILHPDFLRYVRNRF 337
Cdd:cd23980  134 -----PESFRELA--QNVSMILVPFKTLDLEWVISATTTGTI-SHTYV-PVPRKI---KVKKEKILIYHPAFIKYVFDRW 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 130490338 338 LrakqLKTKRWwvvrPTNGAFTLLLAMHTCDIVRVYGFcTADYRKYPSYYYDTKHTKLVF--YGNHDYRLE 406
Cdd:cd23980  202 L----QGHGRY----PSTGILSVIFSLHVCDEVDLYGF-GADSKGNWHHYWENNPSAGAFrkTGVHDGDFE 263
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 185-389 1.48e-17

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 82.23  E-value: 1.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 185 SQLLQVHPGV-------KDGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIiqs 257
Cdd:cd23979   60 SKLFQIIPGEnpyrswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA--- 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 258 lmihkkrgfKQIPTdkDIKYVLIPegprdYNFLESLMKNRKIPSGAYR-GRTPRKYYSgHFNESSYYILHPDFLRYVRNR 336
Cdd:cd23979  137 ---------KNLPA--NVSFVLVP-----FKTLDLLWITSALSTGQIRfTYAPVKQFL-RVDKDKVQIYNPAFFKYIHDR 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 130490338 337 FLRAKqlktKRWwvvrPTNGAFTLLLAMHTCDIVRVYGFcTADYRKYPSYYYD 389
Cdd:cd23979  200 WTEHH----GRY----PSTGMLVLFFALHVCDEVNVYGF-GADSRGNWHHYWE 243
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 201-414 2.32e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 81.67  E-value: 2.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 201 CAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAhSIIQslmihkkRGFKQIPTDKDIKyvli 280
Cdd:cd23970   71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-SILE-------KYYNNLLTIQDRN---- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 281 pegprdyNFLESLMKNRK----IPSGAYRG-----RTPRKYYSGHFNESSYYILHP-DFLRYVrNRFLRAKQLKTKRWwv 350
Cdd:cd23970  139 -------NFFLSLKKLDGailwIPAFFFHTsatvtRTLVDFFVEHRGQLKVQLAWPgNIMQHV-NRYWKTKHLSPKRL-- 208

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 130490338 351 vrpTNGAFTLLLAMHTCDIVRVYGF----CTADYRKYPSYYYDTKHTKlvFYgnhdyrlemKTWKKFH 414
Cdd:cd23970  209 ---STGILMYTLASAICEEIHLYGFwpfgFDPTGTPLPYHYYDKKGTK--FT---------TKWQESH 262
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 200-388 9.32e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 76.67  E-value: 9.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 200 RCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVyvhtahSIIQS-LMIHKKRGFKqiptdKDIKY- 277
Cdd:cd23985   47 RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTI------RLINSqLVTTEKHKFL-----KDSLYn 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 --VLIPEGPR-------------DYNFLESLMKnrkipsgaYRGRTPrkyysghfnESSYYILHPdflryvrnrflrakQ 342
Cdd:cd23985  116 egILIVWDPApyhsdipewyknpDYNFFENYKT--------YRRLNP---------NQPFYILHP--------------Q 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 130490338 343 LKTKRWWVVR-----------PTNGAFTLLLAMHTCDIVRVYGFCTADYRKYPSYYY 388
Cdd:cd23985  165 MQWELWDIIQenspeeiqpnpPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYY 221
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 198-391 2.10e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 75.28  E-value: 2.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVhTAHSIIQSLMihKKRGFKQiptDKDIKY 277
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV-VAHSSVYRVL--RRPQEFL---NRTPET 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 VLIPEGPrdYNfleslmKNRKiPSGAYRGRTPRKyYSGHFNESSYYILHPDFLRYVRNRFLR--AKQLKTKRWWVvrpTN 355
Cdd:cd23978   75 TLIFWGP--PN------KMQK-DGKSNLFRIIQR-ASMTFPNMSAFVVSPRRMRQFDDLFRGetGRDRKKSHSWL---ST 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 130490338 356 GAFTLLLAMHTCDIVRVYGFCTADY-------RKYPSYYYDTK 391
Cdd:cd23978  142 GWFTMVIAVELCDNVHVYGMVPPNYcskrptpKKMPYHYYEPK 184
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 198-414 2.18e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 74.97  E-value: 2.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVhTAHSIIQSLMIHKKRGFKQipTDKDIkY 277
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRV-VSHTSVPLLLKNPDYFFKE--TNETI-Y 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 VLIpeGP-----RD-----YNFLESLMKNRKIPSGAYRGRTPRKYYSGHFNESSYyilhpdflryvRNRFLRAKQLKTkr 347
Cdd:cd23975   77 VIW--GPfrnmrKDgkgivYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETG-----------KDRVQSGSYLST-- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 348 wwvvrptnGAFTLLLAMHTCDIVRVYG-----FC-TADYRKYPSYYYDTKHTKL--------VFYGNHDYRLEMKT---W 410
Cdd:cd23975  142 --------GWFTLILAMDACYGIHVYGmindtYCkTEGYRKVPYHYYEPGRDECdeyflhenAPYGGHRFITEKKVfakW 213


                 ....
gi 130490338 411 KKFH 414
Cdd:cd23975  214 AKKH 217
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 200-389 8.04e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 74.22  E-value: 8.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 200 RCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGhEEDVGKRTSVYvhTAH-SIiqslmIHKKRGFkqiptdkdikyv 278
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLND-SKDVGSKTNLV--TANpSI-----LREKFHN------------ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 279 liPEGPRDyNFLESlMKNRK-----IPSGAYRGRTP---RKYY--SGHFNESSYYILHPDFLRYVrNRFLRAKQLKTKrw 348
Cdd:cd23971  126 --LKKRRR-PFVER-MKVYGnalllLPAFSYTSNTEpslRALYtlEDFGSPQKVLFFNPEYLRNL-SRYWKSKGLKAR-- 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 130490338 349 wvvRPTNGAFTLLLAMHTCDIVRVYGF----CTADYRKYPSYYYD 389
Cdd:cd23971  199 ---RLSTGLMLVSAALELCENVHLYGFwpfsTDLDGNPISHHYYD 240
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 187-393 1.41e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 73.33  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 187 LLQVHPgvkDGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVyvhtahSIIQS-LMIHKKRG 265
Cdd:cd23986   41 LSKLHL---RGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTI------RIINSqILTNPNHH 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 266 FKQIPTDKDIkyVLIPEGPRDYNFleSLMKNRKIPSgaYRGRTPRKYYSGHFNESSYYILHPDFLRYVRNRFLRAKQLKT 345
Cdd:cd23986  112 FIDSSLYKDV--ILVAWDPAPYSA--NLHKWYKKPD--YNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKI 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 130490338 346 KRwwvVRPTNGAFTLLLAMHTCDIVRVYGFCTA----DYRKYPSYYYDTKHT 393
Cdd:cd23986  186 QP---NPPSSGFIGILIMMSMCREVHVYEYIPSvrqtDLCHYHERYYDAACT 234
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 198-390 1.67e-14

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 71.88  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 198 CIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVHTAHSIIQslmihKKRGFkqiptDKDIKY 277
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQ-----KPEQY-----EKDSLF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 278 VLIPEGPRDYNFLESLMKNRKIPS--GAYRG---RTPRKyysghfnESSYYILHPDFLRYVRNRFLrakQLKTKRWWVVR 352
Cdd:cd23981   72 VLAGFKWQDFKWLKYIVYKEKVSAsdGFWKSvatRVPRE-------PHEIRILNPYFIQEAAFSFI---GLPFNNGLMGR 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 130490338 353 ---PTNGAFTLLLAMHTCDIVRVYGF-CTADYRKYPSYYYDT 390
Cdd:cd23981  142 gniPTLGSVAITMALHNCDEVAVAGFgYDMNTPNAPLHYYET 183
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 201-415 1.23e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 67.67  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 201 CAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRtSVYVHTAHSIIQslmihkkRGFKQIPTDKD------ 274
Cdd:cd23988   67 CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTK-SDFITMNPSVVQ-------RAFGGFRNESDrekfvh 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 275 -----------IKYVLIPEGPRDYNFLESL-MKNRKIPSGAYrgrtprkyysghfneSSYYILHPdflryVRNRFLrakq 342
Cdd:cd23988  139 rlsmlndsvlwIPAFMVKGGEKHVEWVNALiLKNKLKVRTAY---------------PSLRLIHA-----VRGYWL---- 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 130490338 343 lkTKRWWVVRPTNGAFTLLLAMHTCDIVRVYGF------CTADYRKYpSYYYDTKHTKLVFYGNHDYRLEMKTWKKFHD 415
Cdd:cd23988  195 --TNKVNIKRPSTGLLMYTLATRFCDEIHLYGFwpfpkdANGNPVKY-HYYDDLKYRYFSNAGPHRMPLEFKTLNVLHN 270
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 201-415 1.38e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 67.82  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 201 CAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYvhtahSIIQSLMIHKKRGFKQiPTDKD------ 274
Cdd:cd23969   67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLT-----TMNPSVIPHAYGDLVN-ATDKEkfverl 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 275 ------IKYV--LIPEGPRDYNF-LESLMKNRKIPSgayrgRTprKYYSGHFNESsyyilhpdflryVRNRFLRAKqLKT 345
Cdd:cd23969  141 rqlgdsILWIpaFVSKGGEEHVQwTNEIILKHKLNV-----KT--AYPPLRLNHA------------IRGYWLTTK-FRI 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 130490338 346 KrwwvvRPTNGAFTLLLAMHTCDIVRVYGF--CTADYR----KYpsYYYDTKHTkLVFYGNHDYRLEMKTWKKFHD 415
Cdd:cd23969  201 K-----RPSTGLLMYTLATRFCDEIHLYGFypFSEDGNgravKY--HYYDNRKY-LTTARPHKMPEEFRALRSLHQ 268
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 191-389 5.32e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 65.27  E-value: 5.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 191 HPGVKDGCIRCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVYVhTAHSIIQSLMiHKKRGFKQIP 270
Cdd:cd23976    8 HKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRV-IAHSSIQRIL-RNRNELLNVS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 271 TDKdikyVLIPEGP-----RD-----YNFLESLmkNRKIPsgayrgrtprkyysghfNESSYYILHPDFLRYvRNRFLR- 339
Cdd:cd23976   86 QGT----VFIFWGPsnymrRDgkglvYNNLQLM--NQILP-----------------KLKVYTITRHKMLQF-DELFKRe 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 130490338 340 -AKQLKTKRWWVvrpTNGAFTLLLAMHTCDIVRVYG-----FCTA-DYRKYPSYYYD 389
Cdd:cd23976  142 tGKDRKISNTWL---STGWFTMIIALELCDRINVYGmvppdFCRDpNHPSVPYHYYE 195
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 200-423 2.37e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 64.08  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 200 RCAVVGASGILNGSKLGKEIDSSDYVFRMN-AAIIAGHEEDVGKRTSVyVHTAHSII----QSLMIHKKRgFKQIPTDKD 274
Cdd:cd23989   65 KCSVVGNGGILKNSGCGQQIDRADFVMRCNlPPLSREYTDDVGTKTQL-VTANPSIIdkrfQNLLWSRKS-FVESMKVYG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 275 IKYVLIPEGPrdynfleslMKNRKIPSgayrgrtPRKYYSGHFNESSYYIL--HPDFLRYVrNRFLRAKQLKTKRWwvvr 352
Cdd:cd23989  143 RSYIYMPAFS---------MKTGTDPS-------LRVYYTLADVGANQTVLfaNPNFLRNV-GKFWKSKGVHAKRL---- 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 130490338 353 pTNGAFTLLLAMHTCDIVRVYGF----CTADYRKYPSYYYDtkhTKLVFYGNHDYRLEMKTWKKFHDDKLIWMYL 423
Cdd:cd23989  202 -STGLFLVSAALGLCEEVTIYGFwpfsVDLDERTISHHYYD---NVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 200-394 4.77e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 62.85  E-value: 4.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 200 RCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHE-EDVGKRTSVYVHTAHSIIQSlmiHKKRGFKQIPtdkdikyv 278
Cdd:cd23991   66 QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKTNLVTANPSIISIK---YAKLNERRKP-------- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 279 lipegprdynFLESLMKNRK----IPSGAYRGRTP---RKYYSGHFNESSYYIL--HPDFLRYVrNRFLRAKQLKTKRWw 349
Cdd:cd23991  135 ----------FLETVSVYGDafllLPAFSYRSNTAlsfKVYYTLEDFKAKQKVIffHPIYLKHL-AQFWRSKGVQVYRL- 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 130490338 350 vvrpTNGAFTLLLAMHTCDIVRVYGFC----TADYRKYPSYYYDTKHTK 394
Cdd:cd23991  203 ----STGLMITSAALELCEEVKLYGFWpfskNTEGKPISHHYYDNQLPK 247
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 201-414 5.16e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 63.03  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 201 CAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAGHEEDVGKRTSVyVHTAHSIIQslmihkkRGFKQIPTDKDIKYVLi 280
Cdd:cd23987   67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSVVQ-------RAFEDLVNETWKEKFL- 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 281 pegPRDYNFLESLMknrKIPSGAYRGRTPRKYYSG------HFNESSYY----ILHPdflryVRNRFLrakqlkTKRWWV 350
Cdd:cd23987  138 ---QRLQSLNGSIL---WIPAFMAKGGEERVEWVNdlilkhHINVRTAYpslrLLHA-----VRGYWL------TNKVHI 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 130490338 351 VRPTNGAFTLLLAMHTCDIVRVYGFC--TADYRKYPS--YYYDT-KHTKLVFYGNHDYRLEMKTWKKFH 414
Cdd:cd23987  201 KRPTTGLLMYTLATRFCNRIHLYGFWpfPRDQNQNPVkyHYYDSlKYGYTSQASPHTMPLEFKALKNLH 269
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 200-375 1.08e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 59.08  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 200 RCAVVGASGILNGSKLGKEIDSSDYVFRMNAAIIAG-HEEDVGKRTSVyVHTAHSIIQSlMIHK----KRGFKQIPTDKD 274
Cdd:cd23990   66 KCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDV-VTINPSIITE-RFHKlekwRRPFYEVLQVYE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 130490338 275 IKYVLIPEGprdYNFLESLMKNRKipsgayrgrtprKYYSGHFNES-SYYILHPDFL----RYVRNRFLRAKqlktkrww 349
Cdd:cd23990  144 NASVVLPAF---YNTRNTDVSIRV------------KYVLDDFESQqAVYYFHPQYLlnvsRFWLRQGVRAK-------- 200

                        170       180
                 ....*....|....*....|....*.
gi 130490338 350 vvRPTNGAFTLLLAMHTCDIVRVYGF 375
Cdd:cd23990  201 --RISSGLMLVTAALELCEEVHLYGF 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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