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Conserved domains on  [gi|124486757|ref|NP_001074794|]
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sulfotransferase 2A6 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 9.79e-98

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 287.32  E-value: 9.79e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757   34 DEDLIILTYPKSGTNWLIEIVCLIQTKGDPKWIQSVP---NWERSPWLE---------SKSGYSVLTSKEGPRLMTSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHlfnNHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  102 IHLFSKSFFSSKAKVIYLIRNPRDVLVSGYFFWANTNLVKNLESLGIYFEQFLKGNVRYGSWFEHIHGWLSMRERNNFLV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  182 LYYEDMKKDAKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNYSLIKEDQItnglKLMRKGTTGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVS----PFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 124486757  262 QTEAFDKVFQDKMVGFP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 9.79e-98

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 287.32  E-value: 9.79e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757   34 DEDLIILTYPKSGTNWLIEIVCLIQTKGDPKWIQSVP---NWERSPWLE---------SKSGYSVLTSKEGPRLMTSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHlfnNHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  102 IHLFSKSFFSSKAKVIYLIRNPRDVLVSGYFFWANTNLVKNLESLGIYFEQFLKGNVRYGSWFEHIHGWLSMRERNNFLV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  182 LYYEDMKKDAKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNYSLIKEDQItnglKLMRKGTTGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVS----PFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 124486757  262 QTEAFDKVFQDKMVGFP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 17-276 1.16e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 89.98  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  17 WVQKEIVEDVHNK--FVVKDEDLIILTYPKSGTNWLIEIVCLI--QTKGDpkwIQSVPNWERSP-----WLESKSGY--- 84
Cdd:PLN02164  60 WLQPLLEGLLHAQefFQARPNDFLVCSYPKTGTTWLKALTFAIanRSRFD---DSSNPLLKRNPhefvpYIEIDFPFfps 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  85 -SVLTSKEGPrLMTSHLPIHLFSKSFFSSKAKVIYLIRNPRDVLVSGY-FFWANTNLVKNLESLGIYFEQFLKGNVRYGS 162
Cdd:PLN02164 137 vDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWtFLHKERSQQGPLNSLEESFDMFCRGLSVYGP 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757 163 WFEHIHG-WLSMRER-NNFLVLYYEDMKKDAKGTIKKICDFLGKNLGPDE-----LDLVLKYSSFQAMKENNMSNYSLIK 235
Cdd:PLN02164 216 YLDHVLGyWKAYQENpDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDR 295

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 124486757 236 EDQ--ITNGLKLMRKGTTGDWKNHFTVAQTEAFDKVFQDKMVG 276
Cdd:PLN02164 296 EDRpaVYANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKG 338
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-216 3.78e-06

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 46.93  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  38 IILTYPKSGTNWLIEivCLIQTK--GDPK-WIQ--SVPNWERSPWLESKSGYS------VLTSKEGP------RLMTSHL 100
Cdd:COG4424   10 VICATPRSGSTLLCE--LLNATGvaGCPGeYFNppFIPEWARGFLLGDRDRDPdeylraIRRAGTTPngvfgfKLFWDQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757 101 P-----IHLFSKSFfsSKAKVIYLIRnpRDVL---VSGYF------FWANTNLVKNLESLGIY-FEQFLKgnvrygsWFE 165
Cdd:COG4424   88 PrllqrALRLLAAF--PDLKFIHLTR--RDKLaqaVSLVIaqqtgqWHSDADDALAPTAPPEYdAEEIAR-------LLE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124486757 166 HIH----GWLSMRERNN--FLVLYYEDMKKDAKGTIKKICDFLGKNLGPDELDLVLK 216
Cdd:COG4424  157 ALQdfeaRWEAWFARTGitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 9.79e-98

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 287.32  E-value: 9.79e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757   34 DEDLIILTYPKSGTNWLIEIVCLIQTKGDPKWIQSVP---NWERSPWLE---------SKSGYSVLTSKEGPRLMTSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHlfnNHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  102 IHLFSKSFFSSKAKVIYLIRNPRDVLVSGYFFWANTNLVKNLESLGIYFEQFLKGNVRYGSWFEHIHGWLSMRERNNFLV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  182 LYYEDMKKDAKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNYSLIKEDQItnglKLMRKGTTGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVS----PFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 124486757  262 QTEAFDKVFQDKMVGFP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 17-276 1.16e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 89.98  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  17 WVQKEIVEDVHNK--FVVKDEDLIILTYPKSGTNWLIEIVCLI--QTKGDpkwIQSVPNWERSP-----WLESKSGY--- 84
Cdd:PLN02164  60 WLQPLLEGLLHAQefFQARPNDFLVCSYPKTGTTWLKALTFAIanRSRFD---DSSNPLLKRNPhefvpYIEIDFPFfps 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  85 -SVLTSKEGPrLMTSHLPIHLFSKSFFSSKAKVIYLIRNPRDVLVSGY-FFWANTNLVKNLESLGIYFEQFLKGNVRYGS 162
Cdd:PLN02164 137 vDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWtFLHKERSQQGPLNSLEESFDMFCRGLSVYGP 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757 163 WFEHIHG-WLSMRER-NNFLVLYYEDMKKDAKGTIKKICDFLGKNLGPDE-----LDLVLKYSSFQAMKENNMSNYSLIK 235
Cdd:PLN02164 216 YLDHVLGyWKAYQENpDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDR 295

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 124486757 236 EDQ--ITNGLKLMRKGTTGDWKNHFTVAQTEAFDKVFQDKMVG 276
Cdd:PLN02164 296 EDRpaVYANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKG 338
Sulfotransfer_3 pfam13469
Sulfotransferase family;
37-203 9.30e-14

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 67.70  E-value: 9.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757   37 LIILTYPKSGTNWLIEIVCLI-QTKGDPKWIQSVPNWERSPWLESKSGYSVLTSKEGPRLMTSHLPIHLFS----KSFFS 111
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHpDVRPPEETWFVIPRILALLQAWGKSLEALARVPSYARWLCDKSPSHLFHldllLKAFP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  112 sKAKVIYLIRNPRDVLVSGYFfwanTNLVKNLESLGIYFEQFLKGNVRYgsWFEHIHGWLSMRER---NNFLVLYYEDMK 188
Cdd:pfam13469  81 -DAKFIHLHRDPVDTVISSYC----SLFGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARARvppGRFLDVRYEDLV 153

                         170
                  ....*....|....*
gi 124486757  189 KDAKGTIKKICDFLG 203
Cdd:pfam13469 154 ADPEGTLRRILEFLG 168
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-216 3.78e-06

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 46.93  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757  38 IILTYPKSGTNWLIEivCLIQTK--GDPK-WIQ--SVPNWERSPWLESKSGYS------VLTSKEGP------RLMTSHL 100
Cdd:COG4424   10 VICATPRSGSTLLCE--LLNATGvaGCPGeYFNppFIPEWARGFLLGDRDRDPdeylraIRRAGTTPngvfgfKLFWDQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486757 101 P-----IHLFSKSFfsSKAKVIYLIRnpRDVL---VSGYF------FWANTNLVKNLESLGIY-FEQFLKgnvrygsWFE 165
Cdd:COG4424   88 PrllqrALRLLAAF--PDLKFIHLTR--RDKLaqaVSLVIaqqtgqWHSDADDALAPTAPPEYdAEEIAR-------LLE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124486757 166 HIH----GWLSMRERNN--FLVLYYEDMKKDAKGTIKKICDFLGKNLGPDELDLVLK 216
Cdd:COG4424  157 ALQdfeaRWEAWFARTGitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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