calcium and integrin-binding family member 3 isoform 2 [Mus musculus]
EF-hand domain-containing protein( domain architecture ID 12144783)
EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction
List of domain hits
Name | Accession | Description | Interval | E-value | ||
EF-hand_7 | pfam13499 | EF-hand domain pair; |
80-147 | 4.13e-09 | ||
EF-hand domain pair; : Pssm-ID: 463900 [Multi-domain] Cd Length: 67 Bit Score: 50.33 E-value: 4.13e-09
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Name | Accession | Description | Interval | E-value | |||
EF-hand_7 | pfam13499 | EF-hand domain pair; |
80-147 | 4.13e-09 | |||
EF-hand domain pair; Pssm-ID: 463900 [Multi-domain] Cd Length: 67 Bit Score: 50.33 E-value: 4.13e-09
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PTZ00184 | PTZ00184 | calmodulin; Provisional |
30-148 | 5.80e-08 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 48.99 E-value: 5.80e-08
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
84-146 | 2.28e-07 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 45.62 E-value: 2.28e-07
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FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
54-142 | 1.24e-05 | |||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 42.47 E-value: 1.24e-05
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Name | Accession | Description | Interval | E-value | |||
EF-hand_7 | pfam13499 | EF-hand domain pair; |
80-147 | 4.13e-09 | |||
EF-hand domain pair; Pssm-ID: 463900 [Multi-domain] Cd Length: 67 Bit Score: 50.33 E-value: 4.13e-09
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PTZ00184 | PTZ00184 | calmodulin; Provisional |
30-148 | 5.80e-08 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 48.99 E-value: 5.80e-08
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
84-146 | 2.28e-07 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 45.62 E-value: 2.28e-07
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PTZ00183 | PTZ00183 | centrin; Provisional |
28-150 | 3.56e-06 | |||
centrin; Provisional Pssm-ID: 185503 [Multi-domain] Cd Length: 158 Bit Score: 44.29 E-value: 3.56e-06
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FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
54-142 | 1.24e-05 | |||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 42.47 E-value: 1.24e-05
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FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
44-146 | 7.98e-05 | |||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 40.16 E-value: 7.98e-05
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EFh_PI-PLCeta | cd16205 | EF-hand motif found in phosphoinositide phospholipase C eta (PI-PLC-eta); PI-PLC-eta isozymes ... |
30-151 | 9.09e-04 | |||
EF-hand motif found in phosphoinositide phospholipase C eta (PI-PLC-eta); PI-PLC-eta isozymes represent a class of neuron-specific metazoan PI-PLCs that are most abundant in the brain, particularly in the hippocampus, habenula, olfactory bulb, cerebellum, and throughout the cerebral cortex. They are phosphatidylinositol 4,5-bisphosphate-hydrolyzing enzymes that are more sensitive to Ca2+ than other PI-PLC isozymes. They function as calcium sensors activated by small increases in intracellular calcium concentrations. They are also activated through G-protein-coupled receptor (GPCR) stimulation, and further mediate GPCR signalling pathways. PI-PLC-eta isozymes contain an N-terminal pleckstrin homology (PH) domain, four atypical EF-hand motifs, a PLC catalytic core domain, a C2 domain, and a unique C-terminal tail that terminates with a PDZ-binding motif, a potential interaction site for other signaling proteins. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. The C-terminal tail harbors a number of proline-rich motifs which may interact with SH3 (Src homology 3) domain-containing proteins, as well as many serine/threonine residues, suggesting possible regulation of interactions by protein kinases/phosphatases. There are two PI-PLC-eta isozymes (1-2). Aside from the PI-PLC-eta isozymes identified in mammals, their eukaryotic homologs are also present in this family. Pssm-ID: 320035 [Multi-domain] Cd Length: 141 Bit Score: 37.36 E-value: 9.09e-04
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PRK00977 | PRK00977 | exodeoxyribonuclease VII small subunit; Provisional |
100-143 | 5.31e-03 | |||
exodeoxyribonuclease VII small subunit; Provisional Pssm-ID: 179195 Cd Length: 80 Bit Score: 34.11 E-value: 5.31e-03
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Blast search parameters | ||||
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