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Conserved domains on  [gi|121583776|ref|NP_001073408|]
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lipase maturation factor 2 [Rattus norvegicus]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 122-585 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 546.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  122 LYFQWDSLLLETGFLAILVAPLRRPSKHKipqgglagALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTY 201
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP--------KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  202 HYETQCLPTPAAWFAHHLPVWLHRLSVVATFLIEIAVPPLFFAPIRRLRLSAFYAQALLQILIIITGNYNFFNLLTLVLT 281
Cdd:pfam06762  73 HYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  282 TALLDDRHLSAEPElrchKKMPTSWPKTLLTSLSLMLELTVYGLLAYGTIYYFGLEVDWQQqivlskttftfhqfsQWLK 361
Cdd:pfam06762 153 LSLLDDAFLYFWTP----ESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENG---------------TFLR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  362 MVTLPTVWLGTASLAWELLIALWRwiqvqgwSRKFFAGIQLSVLGTATVFLFLISLVPYSyvepgthgrLWTGAHRLFSS 441
Cdd:pfam06762 214 RVTLPSIVLGLVSLLSVPVCALLR-------SNKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNAS 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  442 VEHLQLANSYGLFRRMTglGGRPEVVLEGSHDGH-HWTEIEFMYKPGNVSRPPPFLIPHQPRLDWQMWFAALGPHTHSPW 520
Cdd:pfam06762 278 FNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPW 355

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121583776  521 FTSLVLRLLQGKEPVIRLIQnqvaNYPFREQPPTYLRAQRYKYWFSKPGDQSR---WWHRQWVEEFFP 585
Cdd:pfam06762 356 FLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGERRAtgaWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 122-585 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 546.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  122 LYFQWDSLLLETGFLAILVAPLRRPSKHKipqgglagALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTY 201
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP--------KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  202 HYETQCLPTPAAWFAHHLPVWLHRLSVVATFLIEIAVPPLFFAPIRRLRLSAFYAQALLQILIIITGNYNFFNLLTLVLT 281
Cdd:pfam06762  73 HYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  282 TALLDDRHLSAEPElrchKKMPTSWPKTLLTSLSLMLELTVYGLLAYGTIYYFGLEVDWQQqivlskttftfhqfsQWLK 361
Cdd:pfam06762 153 LSLLDDAFLYFWTP----ESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENG---------------TFLR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  362 MVTLPTVWLGTASLAWELLIALWRwiqvqgwSRKFFAGIQLSVLGTATVFLFLISLVPYSyvepgthgrLWTGAHRLFSS 441
Cdd:pfam06762 214 RVTLPSIVLGLVSLLSVPVCALLR-------SNKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNAS 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  442 VEHLQLANSYGLFRRMTglGGRPEVVLEGSHDGH-HWTEIEFMYKPGNVSRPPPFLIPHQPRLDWQMWFAALGPHTHSPW 520
Cdd:pfam06762 278 FNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPW 355

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121583776  521 FTSLVLRLLQGKEPVIRLIQnqvaNYPFREQPPTYLRAQRYKYWFSKPGDQSR---WWHRQWVEEFFP 585
Cdd:pfam06762 356 FLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGERRAtgaWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 122-585 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 546.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  122 LYFQWDSLLLETGFLAILVAPLRRPSKHKipqgglagALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTY 201
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP--------KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  202 HYETQCLPTPAAWFAHHLPVWLHRLSVVATFLIEIAVPPLFFAPIRRLRLSAFYAQALLQILIIITGNYNFFNLLTLVLT 281
Cdd:pfam06762  73 HYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  282 TALLDDRHLSAEPElrchKKMPTSWPKTLLTSLSLMLELTVYGLLAYGTIYYFGLEVDWQQqivlskttftfhqfsQWLK 361
Cdd:pfam06762 153 LSLLDDAFLYFWTP----ESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENG---------------TFLR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  362 MVTLPTVWLGTASLAWELLIALWRwiqvqgwSRKFFAGIQLSVLGTATVFLFLISLVPYSyvepgthgrLWTGAHRLFSS 441
Cdd:pfam06762 214 RVTLPSIVLGLVSLLSVPVCALLR-------SNKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNAS 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583776  442 VEHLQLANSYGLFRRMTglGGRPEVVLEGSHDGH-HWTEIEFMYKPGNVSRPPPFLIPHQPRLDWQMWFAALGPHTHSPW 520
Cdd:pfam06762 278 FNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPW 355

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121583776  521 FTSLVLRLLQGKEPVIRLIQnqvaNYPFREQPPTYLRAQRYKYWFSKPGDQSR---WWHRQWVEEFFP 585
Cdd:pfam06762 356 FLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGERRAtgaWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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