NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|118150442|ref|NP_001071200|]
View 

1-acyl-sn-glycerol-3-phosphate acyltransferase beta [Danio rerio]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 60-263 1.27e-56

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 180.59  E-value: 1.27e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  60 RVIRFLVRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVF 139
Cdd:COG0204   14 RLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 140 INRKKTSDAKNVMsDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFsSYSKFYLRKEKEFKS 219
Cdd:COG0204   94 VDRSKRRAALRAL-RQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAI-DGTERALPKGFLPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 118150442 220 GTITLKVLPKIETKGLTADDVTTLSDQAFGVMRSAFMEISGQSA 263
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 60-263 1.27e-56

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 180.59  E-value: 1.27e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  60 RVIRFLVRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVF 139
Cdd:COG0204   14 RLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 140 INRKKTSDAKNVMsDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFsSYSKFYLRKEKEFKS 219
Cdd:COG0204   94 VDRSKRRAALRAL-RQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAI-DGTERALPKGFLPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 118150442 220 GTITLKVLPKIETKGLTADDVTTLSDQAFGVMRSAFMEISGQSA 263
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 66-246 8.42e-54

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 172.46  E-value: 8.42e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  66 VRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKT 145
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 146 SDAKNVMsDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFSSYSKFYLRKEKEFKSGTITLK 225
Cdd:cd07989   81 RSAREAL-REAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                        170       180
                 ....*....|....*....|...
gi 118150442 226 VLPKIETKGL--TADDVTTLSDQ 246
Cdd:cd07989  160 IGEPIPPEGLelAEEDRKELREK 182
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 78-204 2.11e-42

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 141.26  E-value: 2.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442   78 QVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPD---RCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNVMSD 154
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEY 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 118150442  155 AAKTMLTDKIrLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFS 204
Cdd:pfam01553  83 LVELLREGKL-VVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 74-204 2.96e-40

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 135.94  E-value: 2.96e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442   74 GLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNvMS 153
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIAT-AL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 118150442  154 DAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFS 204
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 91-202 2.04e-34

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 120.54  E-value: 2.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442    91 YVIISNHQSSLDVLGMVEILPD---RCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNVMSDAAKtMLTDKIRLW 167
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVE-LLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 118150442   168 VFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIV 202
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVA 114
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 31-264 5.47e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 107.79  E-value: 5.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  31 FYVAYMMLLAVIAIPICILKS-----GGRDIENMRVIRFLVRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLG 105
Cdd:PRK15018   2 LYIFRLIITVIYSILVCVFGSiyclfSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 106 MVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNVMSDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKK 185
Cdd:PRK15018  82 ASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 186 GAFHLAIQAQVPIIPIVFSSYS-KFYLRKekeFKSGTITLKVLPKIETKGLTADDVTTLSDQAFGVMRSAFMEISGQSAQ 264
Cdd:PRK15018 162 GAFHAAIAAGVPIIPVCVSTTSnKINLNR---LHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAE 238
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 60-263 1.27e-56

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 180.59  E-value: 1.27e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  60 RVIRFLVRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVF 139
Cdd:COG0204   14 RLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 140 INRKKTSDAKNVMsDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFsSYSKFYLRKEKEFKS 219
Cdd:COG0204   94 VDRSKRRAALRAL-RQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAI-DGTERALPKGFLPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 118150442 220 GTITLKVLPKIETKGLTADDVTTLSDQAFGVMRSAFMEISGQSA 263
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 66-246 8.42e-54

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 172.46  E-value: 8.42e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  66 VRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKT 145
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 146 SDAKNVMsDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFSSYSKFYLRKEKEFKSGTITLK 225
Cdd:cd07989   81 RSAREAL-REAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                        170       180
                 ....*....|....*....|...
gi 118150442 226 VLPKIETKGL--TADDVTTLSDQ 246
Cdd:cd07989  160 IGEPIPPEGLelAEEDRKELREK 182
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 78-204 2.11e-42

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 141.26  E-value: 2.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442   78 QVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPD---RCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNVMSD 154
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEY 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 118150442  155 AAKTMLTDKIrLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFS 204
Cdd:pfam01553  83 LVELLREGKL-VVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 74-204 2.96e-40

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 135.94  E-value: 2.96e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442   74 GLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNvMS 153
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIAT-AL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 118150442  154 DAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFS 204
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 91-202 2.04e-34

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 120.54  E-value: 2.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442    91 YVIISNHQSSLDVLGMVEILPD---RCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNVMSDAAKtMLTDKIRLW 167
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVE-LLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 118150442   168 VFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIV 202
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVA 114
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 31-264 5.47e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 107.79  E-value: 5.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  31 FYVAYMMLLAVIAIPICILKS-----GGRDIENMRVIRFLVRHVKYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLG 105
Cdd:PRK15018   2 LYIFRLIITVIYSILVCVFGSiyclfSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 106 MVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNVMSDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKK 185
Cdd:PRK15018  82 ASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 186 GAFHLAIQAQVPIIPIVFSSYS-KFYLRKekeFKSGTITLKVLPKIETKGLTADDVTTLSDQAFGVMRSAFMEISGQSAQ 264
Cdd:PRK15018 162 GAFHAAIAAGVPIIPVCVSTTSnKINLNR---LHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAE 238
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 62-210 5.50e-18

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 79.38  E-value: 5.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  62 IRFLVRHvkYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVL----GMVEILPDRCTMIAKKELIWAGTVgmICWLGGI 137
Cdd:cd06551    1 FRYLLLN--FFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLilflLLERGLRRDVYGLMDEELLERYPF--FTRLGAF 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118150442 138 vFINRKKTSDAKNVMSDAAKTMLTDKIRLWVFPEGTR-NQNGGLLPFKKGAFHLAIQAQVPIIPIVFsSYSKFY 210
Cdd:cd06551   77 -SVDRDSPRSAAKSLKYVARLLSKPGSVVWIFPEGTRtRRDKRPLQFKPGVAHLAEKAGVPIVPVAL-RYTFEL 148
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 78-254 1.31e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 73.61  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  78 QVSGWEHL-QTEGPYVIISNHQSSLDVLGMVEIlpDRC-TMIAKKELIWAGTVGMICWLGGIVFINRkktSDAKNVMSDA 155
Cdd:PLN02901  38 EVEGLENLpSPDEPAVYVSNHQSFLDIYTLFHL--GRPfKFISKTSIFLIPIIGWAMYMTGHIPLKR---MDRRSQLECL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 156 AKTM--LTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQAQVPIIPIVFSSYSKFYLR-KEKEFKSGTITLKVLPKIEt 232
Cdd:PLN02901 113 KRCMelLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNgKEGILNPGSVKVVIHPPIE- 191

                        170       180
                 ....*....|....*....|..
gi 118150442 233 kGLTADDvttLSDQAFGVMRSA 254
Cdd:PLN02901 192 -GSDADE---LCNEARKVIAES 209
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 71-174 2.47e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 69.57  E-value: 2.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  71 YFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILP-----DRCTMIAKKELIWAGTVGMICWLGGIVFINRKKT 145
Cdd:cd07990    6 WLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADrfgrlGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWE 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 118150442 146 SDaKNVMSDAAKTMLTDKIRLWV--FPEGTR 174
Cdd:cd07990   86 KD-EKTIKRQLKRLKDSPEPFWLliFPEGTR 115
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 88-202 5.81e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 68.79  E-value: 5.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  88 EGPYVIISNHQSSLDVLGMVEILPdrCTMIAKKELIWAGTVGMICWLGGIVFINRKKTSDAKNV---MSDAAKTMltDKI 164
Cdd:cd07991   23 EAPRIIVANHTSFIDPLILFSDLF--PSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVveeIKERATDP--NWP 98

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 118150442 165 RLWVFPEGTRNQNGGLLPFKKGAFhlaiQAQVPIIPIV 202
Cdd:cd07991   99 PILIFPEGTTTNGKALIMFKKGAF----EPGVPVQPVA 132
PRK14014 PRK14014
putative acyltransferase; Provisional
 70-133 6.68e-09

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 55.63  E-value: 6.68e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118150442  70 KYFLGLRYQVSGWEHLQTEGPYVIISNHQSSLDVLGMVEILPDRCTMI---AKKELIWAGTVGMICW 133
Cdd:PRK14014  68 RLLPRTQWDVEGLEGLSKKGWYLVISNHQSWVDILVLQYVFNRRIPMLkffLKQELIWVPFLGLAWW 134
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 77-214 7.60e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 50.68  E-value: 7.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  77 YQVSGWehlQTEGP------YVII-SNHQSSLD-VLGMVEI--LPDRCTMIAKKELIWAGTVGMICWLGGIVfINRKKTS 146
Cdd:cd07988    5 LRLSGW---RIEGEppnkpkFVVIgAPHTSNWDfVLGLLAAfaLGLKISFLGKHSLFKPPLGPFMRWLGGIP-VDRSRAG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118150442 147 DAKNVMSDAAKTmlTDKIRLWVFPEGTRNQNGgllPFKKGAFHLAIQAQVPIIPIVFSsyskfYLRKE 214
Cdd:cd07988   81 GLVEQVVEEFRR--REEFVLAIAPEGTRSKVD---KWKTGFYHIARGAGVPILLVYLD-----YKRKT 138
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 79-215 1.55e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 50.72  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  79 VSGWEHLQTEGPYVIISNHQSSL-DVLGMVEILPDRCTMIAKKELIWAGTVGMICWLGGIVFINRKKTS-DAKNVMSDAA 156
Cdd:cd07992   18 VVGRENVPKDGPVIFLGNHPNALiDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRPKDLaRGGIGKISNA 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 118150442 157 KTM------LTDKIRLWVFPEGTRNQNGGLLPFKKGAFHLAIQA------QVPIIPIvfssySKFYLRKEK 215
Cdd:cd07992   98 AVFdavgeaLKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVPV-----GLNYEDKSR 163
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
31-228 2.21e-06

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 48.81  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442   31 FYVAYMMLLAVIAIPICILKSGGRDIenmrvIRFLVRhvkyfLGLRYQVSGWEHLQTEGPYVIIS-NHQSSLDVLGMVEI 109
Cdd:PRK06814  405 LFIALANLIVAILILRLLPTNLLRDI-----FSILFR-----AFYRVEVKGLENLQKAGKKAVIAaNHVSFLDGPLLAAY 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  110 LPDRCTM-----IAKKeliWagtvgmicWLGGIVFINRKKTSDAKNVMsdAAKTM---LTDKIRLWVFPEGTRNQNGGLL 181
Cdd:PRK06814  475 LPEEPTFaidtdIAKA---W--------WVKPFLKLAKALPVDPTNPM--ATRTLikeVQKGEKLVIFPEGRITVTGSLM 541

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 118150442  182 PFKKGAFHLAIQAQVPIIPIV-----FSSYSKF--YLRKEKEFKsgtITLKVLP 228
Cdd:PRK06814  542 KIYDGPGMIADKAGAMVVPVRidglqFTHFSRLknQVRRKWFPK---VTVTILP 592
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 73-204 5.29e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 46.09  E-value: 5.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  73 LGLRYQVSGWEHLQTEGPYVIISNHQ-SSLDVLGMVEIL----PDrCTMIAKKELIWAGTvgMICWLGGIVFINRKKTSd 147
Cdd:cd07986    6 VQLEVDVSGLENIPKDGPVVIVANHPfGILDGLILADLLgsvrPD-VRILANQLLSKIPE--LRDLFIPVDPLEGRAAL- 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118150442 148 AKNVMS-DAAKTMLTDKIRLWVFPEGT----RNQNGGL--LPFKKGAFHLAIQAQVPIIPIVFS 204
Cdd:cd07986   82 AKNRESlREALRHLKNGGALIIFPAGRvstaSPPFGRVsdRPWNPFVARLARKAKAPVVPVYFS 145
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 60-212 5.40e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 47.61  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442   60 RVIRFLVRHVKYflglRYQVSGWEHLQTEGPYVIISNHQSSLD--VLGMVEILPDRCTMIA----KKELIWagtvgmICW 133
Cdd:PRK08633  416 RFLLLLLMHTRY----RLRVEGRENIPAKGGALLLGNHVSWIDwaLLQAASPRPIRFVMERsiyeKWYLKW------FFK 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  134 LGGIVFInrkkTSDAKNVMSDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKGaFHLAIQ-AQVPIIPivfssyskFYLR 212
Cdd:PRK08633  486 LFGVIPI----SSGGSKESLEFIRKALDDGEVVCIFPEGAITRNGQLNEFKRG-FELIVKgTDVPIIP--------FYIR 552
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 68-204 1.62e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 41.89  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  68 HVKYFLGlrYQVSGWEHLQTEGPYVIISNHqSSLDVLGMV------EILPDR--CTMIAKkelIWAGTVGM---ICWLGG 136
Cdd:cd07987    1 HRKYFRV--YEVRGLENIPDEGPALLVHPH-GGLPIDGALlaaaflLLFPGRlpRALADH---FLFPLPGLrdlLRRLGA 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 118150442 137 IVfinrkktSDAKNVMSdaaktMLTDKIRLWVFPEGTR-------NQNGGLLPFKKGAFHLAIQAQVPIIPiVFS 204
Cdd:cd07987   75 VP-------GSRENCVR-----LLREGELVLIFPGGARealkskrEEYYLLWKKRKGFARLALRAGAPIVP-VFT 136
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 134-222 4.08e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 40.63  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442 134 LGGIvFINRKKTSD--AKNVMSDAAKTMLTDKIRLWVFPEGTRNQNGGLLPFKKG-------AFHLAIQAQVPIIPIVFs 204
Cdd:cd07993   71 LGAF-FIRRSFGKDplYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGllsvvveAYLKGSVPDVLIVPVSI- 148

                         90       100
                 ....*....|....*....|....*....
gi 118150442 205 SYSK-----FYLR------KEKEFKSGTI 222
Cdd:cd07993  149 SYDRvleeeLYAEellgppKPKESLSGLL 177
PLN02833 PLN02833
glycerol acyltransferase family protein
 91-190 8.21e-03

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 37.06  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118150442  91 YVIISNHQSSLDVLGMVEILPdrCTMIAKKELIWAGTV--GMICWLGGIVFiNRKKTSDaKNVMSDAAKTMLT--DKIRL 166
Cdd:PLN02833 165 QVFVANHTSMIDFIVLEQMTP--FAVIMQKHPGWVGFLqnTILESVGCIWF-NRTEAKD-REVVAKKLRDHVQdpDRNPL 240

                         90       100
                 ....*....|....*....|....
gi 118150442 167 WVFPEGTRNQNGGLLPFKKGAFHL 190
Cdd:PLN02833 241 LIFPEGTCVNNEYTVMFKKGAFEL 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH