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Conserved domains on  [gi|118026935|ref|NP_001071160|]
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alpha-1,2-mannosyltransferase ALG9 isoform d [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 1-311 1.27e-82

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 259.99  E-value: 1.27e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935    1 MMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLV 72
Cdd:pfam03901 113 WALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935   73 --MKHRWKSFF--HWSLMALILFLVP--VVVIDSYYYGKLVIAPLNIVLYNVFTpHGPDLYGTEPWYFYLINGFLNFNVA 146
Cdd:pfam03901 193 rlRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVLS-NGSSFYGTHPWYFYFSNGLPNILGP 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  147 FALALLVLPltslmeYLLQRFHVQNLghpyWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQkcyhfv 226
Cdd:pfam03901 272 FLLAFILGP------LVLLLRKVSRL----SQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS------ 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  227 fQRYRLEHYTVTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPS 306
Cdd:pfam03901 336 -RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGMECYSTPS 409


                  ....*
gi 118026935  307 SFLLP 311
Cdd:pfam03901 410 SFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 1-311 1.27e-82

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 259.99  E-value: 1.27e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935    1 MMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLV 72
Cdd:pfam03901 113 WALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935   73 --MKHRWKSFF--HWSLMALILFLVP--VVVIDSYYYGKLVIAPLNIVLYNVFTpHGPDLYGTEPWYFYLINGFLNFNVA 146
Cdd:pfam03901 193 rlRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVLS-NGSSFYGTHPWYFYFSNGLPNILGP 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  147 FALALLVLPltslmeYLLQRFHVQNLghpyWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQkcyhfv 226
Cdd:pfam03901 272 FLLAFILGP------LVLLLRKVSRL----SQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS------ 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  227 fQRYRLEHYTVTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPS 306
Cdd:pfam03901 336 -RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGMECYSTPS 409


                  ....*
gi 118026935  307 SFLLP 311
Cdd:pfam03901 410 SFFLH 414
PLN02816 PLN02816
mannosyltransferase
 97-220 1.96e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 53.11  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  97 VIDSYYYGKLVIAPLNIVLYNvFTPHGPDLYGTEPWYFYLINGFLnfnvafalallvlpltsLMEYLLQRFHVQNLGHPY 176
Cdd:PLN02816 256 LLDRLMYGSWVIVPLNFLKFN-FLSSGGDYYGTHPWHWYFTQGFL-----------------VMLFTFTPFSIAGIIKSK 317

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 118026935 177 WLTLAPMYIWFI-IFFIQPHKEERFLFPVYPLICLCGAVALSALQ 220
Cdd:PLN02816 318 NQKLSALILWVLaIYSILGHKEFRFVLPVLPIALIFSGYAFAQME 362
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 1-311 1.27e-82

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 259.99  E-value: 1.27e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935    1 MMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLV 72
Cdd:pfam03901 113 WALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935   73 --MKHRWKSFF--HWSLMALILFLVP--VVVIDSYYYGKLVIAPLNIVLYNVFTpHGPDLYGTEPWYFYLINGFLNFNVA 146
Cdd:pfam03901 193 rlRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVLS-NGSSFYGTHPWYFYFSNGLPNILGP 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  147 FALALLVLPltslmeYLLQRFHVQNLghpyWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQkcyhfv 226
Cdd:pfam03901 272 FLLAFILGP------LVLLLRKVSRL----SQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS------ 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  227 fQRYRLEHYTVTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPS 306
Cdd:pfam03901 336 -RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGMECYSTPS 409


                  ....*
gi 118026935  307 SFLLP 311
Cdd:pfam03901 410 SFFLH 414
PLN02816 PLN02816
mannosyltransferase
 97-220 1.96e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 53.11  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026935  97 VIDSYYYGKLVIAPLNIVLYNvFTPHGPDLYGTEPWYFYLINGFLnfnvafalallvlpltsLMEYLLQRFHVQNLGHPY 176
Cdd:PLN02816 256 LLDRLMYGSWVIVPLNFLKFN-FLSSGGDYYGTHPWHWYFTQGFL-----------------VMLFTFTPFSIAGIIKSK 317

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 118026935 177 WLTLAPMYIWFI-IFFIQPHKEERFLFPVYPLICLCGAVALSALQ 220
Cdd:PLN02816 318 NQKLSALILWVLaIYSILGHKEFRFVLPVLPIALIFSGYAFAQME 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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