|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
0e+00 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 516.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLSLAEDPVV---GGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPL 249
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPApprSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 250 PAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVL 329
Cdd:cd17423 241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115497636 330 PELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17423 321 PELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-392 |
5.20e-99 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 299.85 E-value: 5.20e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRplslaedpvvggpgaqitsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPEL 332
Cdd:cd17352 222 FLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 333 VGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17352 302 VGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
13-385 |
2.99e-84 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 261.99 E-value: 2.99e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRplslaedpvvggpgaqitsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17422 161 LVVGALQLNIVVCGALLR-------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPE- 331
Cdd:cd17422 222 YMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEd 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 115497636 332 -LVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 385
Cdd:cd17422 302 dVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
7-385 |
7.80e-73 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 235.41 E-value: 7.80e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 7 PPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTG 86
Cdd:TIGR00892 11 PPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 87 GILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTG--VGLSSfaFAPLFQWLLN 164
Cdd:TIGR00892 91 GLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGspVFLST--LAPLNQYLFE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 165 HYAWRGALLLVSALSLHLVACGALLRPL--------SLAEDPVVGGPGAQIT---------------SLLRHGPFLRYTV 221
Cdd:TIGR00892 169 SFGWRGSFLILGGLLLHCCVCGALMRPVgpsqrvskSKSKEGLPPDGSTKKLskkstaekinrfldfSLFTHRGFLVYLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 222 ALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVILALYP 299
Cdd:TIGR00892 249 GNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGlkWIRPHVQYLFSFALLFNGLTHLLCA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 300 VAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGA 379
Cdd:TIGR00892 329 LAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGS 408
|
....*.
gi 115497636 380 FLLAGS 385
Cdd:TIGR00892 409 IVVSAG 414
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
13-388 |
1.95e-60 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 200.73 E-value: 1.95e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLSLaedpvvggpgaqitSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPLDF--------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASG------WLGDAVPGPVArLLMLWTTLTGVILAlypVAEAPTGLVALTMAYGFTSGALTPVAF 326
Cdd:cd17430 227 FLLSILGFIDIFARPACGvvaglkWVRPRVVYLFS-FAMLFNGLTDLCSA---TAADYGGLVVFCVFFGISYGMVGALQF 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115497636 327 SVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 388
Cdd:cd17430 303 EVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFL 364
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
13-385 |
1.20e-59 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 198.50 E-value: 1.20e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLslaedpvvgGPgaqitsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL---------GP------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDA--VPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLP 330
Cdd:cd17427 226 FLLSILAFVDMFARPSMGLVANSkwIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 115497636 331 ELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 385
Cdd:cd17427 306 DLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVAS 360
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
13-388 |
3.98e-58 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 194.64 E-value: 3.98e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLSLAEdpvvggpgaqitsllrhgpFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDAVPGPVARLL--MLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLP 330
Cdd:cd17424 222 FLMSILGVIDIIGNITFGWLTDRRCLKKYRYFcyLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTS 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 115497636 331 ELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 388
Cdd:cd17424 302 DVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
2.96e-55 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 186.95 E-value: 2.96e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLsSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLSLaedpvvggpgaqitSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPIDF--------------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDAS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPEL 332
Cdd:cd17421 226 FIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDL 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 333 VGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17421 306 VGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEP 365
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
13-385 |
9.01e-52 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 178.15 E-value: 9.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLslaedpvvgGPGAQIT-SLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPA 251
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPI---------GPKPFLDlTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 252 AFLLSVAAISDLVGRVASGWLGDA--VPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVL 329
Cdd:cd17426 232 AFLLSILAFVDMVARPSMGIVANTkwVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 115497636 330 PELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 385
Cdd:cd17426 312 MDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISS 367
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
13-391 |
4.71e-42 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 151.85 E-value: 4.71e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPlslaedpvvggpgaqitsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLP 330
Cdd:cd17425 223 LLLSILGFINIFMRPLAGLLSGlpVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115497636 331 ELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFvVAGAFLLAGSGVLITL 391
Cdd:cd17425 303 DTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVF-YASSIFVVSAALFMGL 362
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-391 |
5.01e-39 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 144.34 E-value: 5.01e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACL-SRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGA 171
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 172 LLLVSALSLHLVACGALLR-------PLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDL 244
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLrrrpadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 245 GWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVILALYPVAEAP-TGLVALTMAYGFTSGALTP 323
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR--RLLAASYALRALGLALLLLLPFPpLALLLFAALFGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115497636 324 VAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITL 391
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
13-392 |
2.90e-38 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 142.67 E-value: 2.90e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGG 87
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 88 ILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYA 167
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 168 WRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITS--------------LLRHGPFLRYTVALTLINTGYFIP 233
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHsrinlflrkifnveIFKRKRYVIWALGIPLALFGYFVP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 234 YVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPG-PVARLLMLWTTLTGVILALYPVAEAPTGLVALTM 312
Cdd:cd17420 241 YVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGvKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 313 AYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17420 321 VMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFIP 400
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
3.20e-38 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 141.51 E-value: 3.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRplslaedpvvggpgaqitsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 F-LLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSG--ALTPVafsVL 329
Cdd:cd17429 222 FpLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGyfSLMPV---VT 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115497636 330 PELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17429 299 EDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLLKP 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-392 |
2.20e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 134.62 E-value: 2.20e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 94 MLLASFATSLTHLyLSIGLLSGSGWALTFTPTLACLSRYF-SRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:COG2223 84 LLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSL-HLVACGALLRPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRD-LGWDPLP 250
Cdd:COG2223 163 LILGILLLvVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 251 AAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAeAPTGLVALTMAYGFTSGALTPVAFSVLP 330
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115497636 331 ELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
13-389 |
2.51e-31 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 123.00 E-value: 2.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRplslaedpvvggpgaqitsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIAL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 F-LLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFsVLPE 331
Cdd:cd17428 222 IpLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPY-VTTK 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 115497636 332 LVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLI 389
Cdd:cd17428 301 TVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-384 |
1.95e-30 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 121.13 E-value: 1.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPlSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:COG2807 175 AVWALLALLALLLWLPLLR-RRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDAVPGpvaRLLMLWTTLTGVILALYPVAEAPTGLVALTMA-YGFTSGALTPVAFSVLPE 331
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGD---RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVlLGLGQGGLFPLALTLIGL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 115497636 332 LVGTGKIYCGL-GLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAG 384
Cdd:COG2807 331 RARTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLM 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
14-384 |
4.85e-30 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 119.64 E-value: 4.85e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFqSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:cd17353 3 WLVLLGAVL-MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 94 MLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALL 173
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 174 LVSALSLHLVACGALL-----------RPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTG--YFIPYVHLVAH 240
Cdd:cd17353 162 ILGIIFLIIIVIGAFLirdppkgwvppGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAglMLIGQAKPIGQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 241 LRdLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVpGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGA 320
Cdd:cd17353 242 EF-AGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115497636 321 LTPVAFSVLPELVGT---GKIYcglGLVQMVESIGGLLGAPLSGYLrDVTGNYTASFVVAGAFLLAG 384
Cdd:cd17353 320 GFALFPALTADFFGTknaGTNY---GLLYTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIAAALSLVA 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-392 |
5.96e-30 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 119.20 E-value: 5.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 6 EPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMT 85
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 86 GGILTALGMLLASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYFS-RRRSLAMGLALTGVGLSSFAFAPLFQWLLN 164
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLL-GLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 165 HYAWRGALLlvsalslhlvacgallrplslaedpVVGGPGAqITSLLRhgpFLRYTVALTLINTGYFIPYVHLVAHLRD- 243
Cdd:COG2271 160 AFGWRAAFL-------------------------ILGLPGL-LLALLR---FWLLALAYFLVYFALYGFLTWLPTYLVEv 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 244 LGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTP 323
Cdd:COG2271 211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115497636 324 VAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLITLP 392
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
13-388 |
2.09e-29 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 117.90 E-value: 2.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTAL 92
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 93 GMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLS----LAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWD- 247
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEppdnQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDa 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 248 PLPAAFLLSVAAISDLVGRVASGWLGDAVPGpvaRLLMLWTTLT----GVILALYPVAEAPTGLVALTMAYGFTSGALTP 323
Cdd:cd17314 241 PSFVTKLMSIYGLFNAFGRLLWGIVADFFGG---RLSTLSILLTilglGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115497636 324 VAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 388
Cdd:cd17314 318 VYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAIL 382
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
1.85e-28 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 115.66 E-value: 1.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGG 87
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 88 ILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYA 167
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 168 WRGALLLVSALSLHLVACGALLRPLSLAEDPVVGG-------PGAQI--TSLLRHGPFLRYTVALTLINTGYFIPYVHLV 238
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKkrkfkcpPLKKIfnFNIWKSTGYRIWAFGIPAALFGYFVPYVHLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 239 AHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWT-TLTGVILALYPVAEAPTGLVALTMAYGFT 317
Cdd:cd17464 241 NHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKVYLQVSSfFFIGLMSMMIPLCHVFGGLIAVCLFMGLF 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115497636 318 SGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17464 321 DGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFIP 395
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
13-392 |
2.61e-26 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 109.12 E-value: 2.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAAR-----VSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGG 87
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 88 ILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLlnhya 167
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 168 wrGALLLVSALSLHLVACGALLRPLSLAedpvvggpgaqiTSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWD 247
Cdd:cd17465 156 --GDAIGLAHTFQVLSLFMFIQIFLSLT------------YKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 248 PLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVA-RLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAF 326
Cdd:cd17465 222 NKREWVLLVCIGASSGIGRLMSGKIGDLIPGLKKiYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMA 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115497636 327 SVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:cd17465 302 PIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFVP 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-353 |
2.06e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.35 E-value: 2.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 7 PPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTG 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 87 GILTALGMLLASFATSLTHLYLSiGLLSGSGWALTFTPTLACLSRYFS-RRRSLAMGLALTGVGLSSFAFAPLFQWLLNH 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 166 YAWRGALLLVSALSLHLVACGALLRPLSLAEDPvvGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRD-L 244
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAAR--ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 245 GWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPV 324
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*....
gi 115497636 325 AFSVLPELVGTGKIYCGLGLVQMVESIGG 353
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
73-388 |
6.32e-20 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 90.76 E-value: 6.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 73 LSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSS 152
Cdd:cd17475 54 LLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 153 FAFAPLFQWLLNHYAWR-GALLLVSALSLHLVACGALLR--PLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTG 229
Cdd:cd17475 134 ALAAALLPPLALHYGWRaAFVVAGLVSILAAVLFWLFYRepPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 230 YFIPYVHLVAHLRD-LGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPG----PVARLLMLWTTLTGVILALYPVAEAP 304
Cdd:cd17475 214 QFALLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrPVLVITAAIAAAALLVLSLLSPGTPL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 305 TGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAG 384
Cdd:cd17475 294 WLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLA 373
|
....
gi 115497636 385 SGVL 388
Cdd:cd17475 374 ALLL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-357 |
3.30e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.16 E-value: 3.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 21 FFQSALVFGVLRSFGVFFVEFVA-AFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASF 99
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 100 ATSLTHLYLSiGLLSGSGWALTFTPTLACLSRYFSR-RRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLVSAL 178
Cdd:pfam07690 82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 179 SLHLVACGALLRPLSLAEDPV----VGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFL 254
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKpaeeARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 255 LSVAAISDLVGRVASGWLGD-AVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELV 333
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 115497636 334 GTGKIYCGLGLVQMVESIGGLLGA 357
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-389 |
5.97e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.85 E-value: 5.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 17 VLSAFFQSALVFGVLRSFgvfFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLL 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPI---LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 97 ASFATSLTHLYLSIgLLSGSGWALTFTPTLACLSRYF-SRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLV 175
Cdd:cd17325 78 FAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 176 SALSLHLVACGALLRPLSLAEDPVVGGPGAQITS---LLRHGPFLRYTVALTLIN---TGYFIPYVHLVAHlRDLGWDPL 249
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSglrLLLRDRRLLALFLAIFVLafaFGALEPFLPLYAA-ELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 250 PAAFLLSVAAISDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVL 329
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRK--PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 330 PELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLI 389
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-389 |
1.94e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.47 E-value: 1.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 20 AFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 100 ATSLTHLYLsIGLLSGSGWALTFTPTLACLSRYFS-RRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLVSAL 178
Cdd:cd06174 81 APSFWLLLL-GRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 179 SLHLVACGALLRPLSLAEDPVVGGPGAQ--------ITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRD-LGWDPL 249
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEAssksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 250 PAAFLLSVAAISDLVGRVASGWLGDaVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVL 329
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 330 PELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLI 389
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-391 |
5.10e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.99 E-value: 5.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 94 MLLASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYF-SRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LlvsalslhlvacgallrplslaedpVVGGPGAQITSLLRHgpFLRYTVALTLINTGYFIPYVHLVAHL-----RDLGWD 247
Cdd:cd17319 161 I-------------------------IEGLLGLLLAVLWWF--YLRQVWGLALGYFGINYALYGLLTWLptylkQARGFS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 248 PLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARL-LMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAF 326
Cdd:cd17319 214 LKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLvIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115497636 327 SVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITL 391
Cdd:cd17319 294 SLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-383 |
1.13e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.95 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 16 VVLSAFFQSALVFGVLrsfGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGML 95
Cdd:COG0738 12 AIYLLFFLWGFATALW---GPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 96 LASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNH---YAWRGAL 172
Cdd:COG0738 89 LFALAPSYPLLLLALFLL-GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLR-PLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRD-LGWDPLP 250
Cdd:COG0738 168 LILAVLLLLLALLFLRSKlPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEAT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 251 AAFLLSVAAISDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLP 330
Cdd:COG0738 248 AALGLSLFWGGMTIGRFLGGFLLKRFGP--VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 115497636 331 ELVGTGKIYcGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLA 383
Cdd:COG0738 326 DGLGKRTAA-AVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-384 |
2.15e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 40 EFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLS---IGLLSGS 116
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAralAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 117 GWALTFtPTLACLSRYfsRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLAE 196
Cdd:cd17324 104 FWAIAA-AYAADLVPP--EKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 197 DPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGW-DPLPAAFLLSVAAISDLVGRVASGWLGDA 275
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGfSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 276 vpGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKiYCGLGLVQMVESIGGLL 355
Cdd:cd17324 261 --GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGAL 337
|
330 340
....*....|....*....|....*....
gi 115497636 356 GAPLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17324 338 GAALGGLVLDHGG-WAGVGWVGAALLLLA 365
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
49-387 |
3.04e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 61.55 E-value: 3.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 49 AARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLThLYLSIGLLSGSGWALTFTPT-LA 127
Cdd:cd06180 33 YAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFA-ALLALRFLAGAASAFVFVFGsNL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 128 CLSRYFSRRRSLAMGLALTGVGLSSF---AFAPLFQWLLNHY--AWRGALLLVsalslhlVACGALLRPLSLAEDPVVGG 202
Cdd:cd06180 112 VLHHATAAGRGHLIGLLFAGVGLGIAlsgLLVPAGLGGGLSWraGWLALALLS-------AVLLLLSFLLLRRGPSAPTE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 203 PGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVAR 282
Cdd:cd06180 185 ASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRAL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 283 LLMLWTTLTGVILALypVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCgLGLVQMVESIGGLLGAPLSGY 362
Cdd:cd06180 265 AANLLVQAVGVLLPL--LSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRA-LALMTASFGVGQILGPLLAGW 341
|
330 340
....*....|....*....|....*
gi 115497636 363 LRDVTGNYTASFVVAGAFLLAGSGV 387
Cdd:cd06180 342 LADATGGFAPALILAAAALVVAALL 366
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
55-392 |
1.84e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 55 IASIGIAVqqfGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYFS 134
Cdd:cd17473 43 LPALFIAL---FAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDYFE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 135 -RRRSLAMGLALTGVGLSSFAFAPLFQWLLNhYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITSLLrH 213
Cdd:cd17473 119 gEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALP-W 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 214 GPFLRYTVALTLINTGYFIPYVHLVAHLRDLGW-DPLPAAFLLSVAAISDLVGRVASGWLGDAVPgpVARLLMLWTTLTG 292
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLG--KRRLLAIGFALMA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 293 VILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTA 372
Cdd:cd17473 275 LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSG 354
|
330 340
....*....|....*....|
gi 115497636 373 SFVVAGAFLLAGSGVLITLP 392
Cdd:cd17473 355 AFLILGVLALVLAIVLLLLR 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
50-385 |
1.40e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.41 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 50 ARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIgLLSGSGWALTFTPTLACL 129
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAAFHPEGARLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 130 SRYFSRRRSLAMGLALTGvGLSSFAFAPLFQWLLnhYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITS 209
Cdd:cd17478 110 SQAAGGRRGLAMSIFSVG-GNLGFALGPLIAAAL--VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 210 LLRHGPFLRYTVALTLINTGYFIPYVHLVA----HLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAvpgpVARLLM 285
Cdd:cd17478 187 RSTLKGVWRALLLLLIIVFLRSWVLSSLTTflpfYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR----FGRRRV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 286 LWTTLTGVILALYPVAEAP-TGLVALTMAYGFTSGALTPV----AFSVLPELVGTGKiycglGLVQMVESIGGLLGAPLS 360
Cdd:cd17478 263 IIASLLLAAPFLLLFLLTPgIWSYILLVLAGFLLFASFPVtvvlAQELLPGNVGLAS-----GLMMGLSFGLGGIGAPVL 337
|
330 340
....*....|....*....|....*
gi 115497636 361 GYLRDVTGnYTASFVVAGAFLLAGS 385
Cdd:cd17478 338 GALADAFG-LESVLLILALLPLLGA 361
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
220-393 |
2.19e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 220 TVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPgpvARLLMLW-TTLTGVILALY 298
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG---RKRLLLLgLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 299 PVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAG 378
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCA 157
|
170
....*....|....*
gi 115497636 379 AFLLAGSGVLITLPH 393
Cdd:cd17325 158 ALALLALVLALLLLP 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-392 |
3.73e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 21 FFQSALVFGVLRSFGVFFVEFVAAFeePAARVSWIASIGIAVQQFGSPVGSALS----TKFGPR-PAVMTGGILTALGML 95
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGL--SAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRrPWILIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 96 LASFATSLTH-----LYLSIGLLSGSGWALTFTPTLA---CLSRYFSRRRSLA---MGLALTGVGLSSFAFAPLFQWLL- 163
Cdd:COG2211 97 LLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYSAlgaELTPDYEERTRLSswrFAFAGLGGLLASVLPPPLVAAFGg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 164 -NHYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLR 242
Cdd:COG2211 177 dAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 243 D-LGWDPLPAAFLLSVAAISDLVGRVASGWLGDAV-PGPVARLLMLWTTLTGVILALYPvAEAPTGLVALTMAYGFTSGA 320
Cdd:COG2211 257 YvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKKAFIIGLLLAALGLLLLFFLG-PGNLWLLLVLAALAGIGLGA 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115497636 321 LTPVAFSVLPELVGTGKIYCG-------LGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLITLP 392
Cdd:COG2211 336 ILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLALFG-YVAGAAQSPSALTGIRLLFFLLP 413
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
68-384 |
4.14e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 4.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 68 PVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTLACLSRYF-SRRRSLAMGLALT 146
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIpPSRRGEGIGYYGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 147 GVGLSSFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRplslaEDPVVGGPGAQITSLLRHGPF----LRYTVA 222
Cdd:cd17489 128 ATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVK-----DPPPVAAEEAEAGTRAFRRLVekkvLPPALI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 223 LTLINTGYFIPYVHLVAHLRDLGWDplPAAFLLSVAAISDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVILALYPVAE 302
Cdd:cd17489 203 LFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGP--KTVIIPGLLLLALGLLLLSFAG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 303 APTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLL 382
Cdd:cd17489 279 SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVL 357
|
..
gi 115497636 383 AG 384
Cdd:cd17489 358 LA 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-392 |
6.70e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 6.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 208 TSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPgpVARLLMLW 287
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 288 TTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVT 367
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|....*
gi 115497636 368 GNYTASFVVAGAFLLAGSGVLITLP 392
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-389 |
2.40e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.22 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 10 GGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFeepaarvsWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGIL 89
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTG--------LLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 90 TALGMLLASFATSLTHLY-------LSIGLLSGSGWAL--TFTPtlaclSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQ 160
Cdd:cd17316 76 FGLATLLIGLLPTPILLLvlrflqgIGIGGEYPGASTYvaEFAP-----SKRRGFALGLLQSGWALGALLAALVASLLIP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 161 WLLNHYAWRGALllvsalslhlvacgallrplslaedpVVGGPGAQITSLLRhGPFLRYTVALTLINTGYFIPYVHLVAH 240
Cdd:cd17316 151 LLSGDWGWRILF--------------------------LIGALPALLALLLR-RRTLLLILLWFFISFGYYGLTTFLPTY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 241 LR-DLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSG 319
Cdd:cd17316 204 LQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVG 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 320 ALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLI 389
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-388 |
1.11e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 50.27 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 52 VSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTLACLSR 131
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE-LFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 132 YFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWrgalllvsalslhlvacgallrpLSLAedpvVGGPGAQITSLL 211
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRW-----------------------LQLA----ISLPGLLFLLLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 212 RHGPflRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLlsvAAISDLVGRVASGWLGDAVP-GPVARLLMLWTTL 290
Cdd:cd17317 159 WWLP--RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFL---SGLVEIPAYFLALLLLDRLGrRWTLSGSLLLAGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 291 TGVILALYPVAEAPTGLVALTMAYGFTSGAltpvaFSVLP----ELVGTGKIYCGLGLVQMVESIGGLLgAPLSGYLRDV 366
Cdd:cd17317 234 ACLVTALLPDDENTLALTLALVGKFAISAA-----FSVIYlytaELYPTVVRNTGVGLCSTVARVGAIL-APFIVLLGKI 307
|
330 340
....*....|....*....|..
gi 115497636 367 tGNYTASFVVAGAFLLAGSGVL 388
Cdd:cd17317 308 -GPLLPLIIFGVLALLGGLLTL 328
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
37-391 |
1.40e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 37 FFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIgLLSGS 116
Cdd:cd17329 22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL-VLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 117 GWALTFTPTLACLSRyFSRRRSLAMGLALTGVGLS-SFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLA 195
Cdd:cd17329 101 GGGLFEPASEAMIAD-VTTPENRTRAFSLLYWAINlGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 196 EDPV--VGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPL-PAAFLLSVAAISDLVGRV-ASGW 271
Cdd:cd17329 180 KRRAaeKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLLLALNALLIVLLQFpVARL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 272 LGDavpGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESI 351
Cdd:cd17329 260 VER---FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 115497636 352 GGLLGAPLSGYLRDvTGNYTASFVVAGAFLLAGSGVLITL 391
Cdd:cd17329 337 GRAIGPLVGGLLLD-LLGPGLPWLILAALGLIAAALLLGL 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-191 |
2.48e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.10 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLrSFGVFFveFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPR--PAVMTGGILTA 91
Cdd:COG2271 183 WLLALAYFLVYFALYGFL-TWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 92 LGMLLASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYFSRR-RSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRG 170
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 115497636 171 ALLLVSALSLHLVACGALLRP 191
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-361 |
2.72e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.09 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 68 PVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLyLSIGLLSGSGWALTFTPTLACLSRYFS-RRRSLAMGLALT 146
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAAAIMPASLALIAATFPgERRGRALGLWGA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 147 GVGLSSFAFAPLFQWLLNHYAWRgalllvsalslhlvACGALLRPLSLAedpvvggpgaqitSLLRHGPFLRYTVALTLI 226
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGWR--------------WIFLINVPIGLV-------------ALLLARTFSGAVLAAFLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 227 NTGYFIPYVHLVAHLRD-LGWDPLPAAFLLSVAAISDLVGRVASGWLGDAV-PGPVARLLMLWTTLTGVILALYPVAEAP 304
Cdd:cd17321 181 GAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFgPRLVLVAGLLLTAVGLLLLALLGADSSV 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 115497636 305 TGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSG 361
Cdd:cd17321 261 WLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-166 |
4.86e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 4.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVaaFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 94 MLLASFATSLTH-LYLSIGLLSGSGWALTFTPTLACLS--------RYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLN 164
Cdd:COG2211 308 LLLLFFLGPGNLwLLLVLAALAGIGLGAILVLPWAMLAdvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
..
gi 115497636 165 HY 166
Cdd:COG2211 388 LF 389
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
225-392 |
8.69e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 8.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 225 LINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVILALYPVAEAP 304
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF-GRK-RLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 305 TGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17489 85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLA 163
|
....*...
gi 115497636 385 SGVLITLP 392
Cdd:cd17489 164 LLLVFLVK 171
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
14-391 |
1.80e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 94 MLLASFATSLTH---LYLSIGLLSGSGWAltftPTLACLSRYFSRR-RSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWR 169
Cdd:cd17312 82 NIFMGFSTSLWFfavLWGLNGLFQSMGWP----PCVKLLGNWFSKKeRGTVYGIWSTSHNFGGILAPILAASLASYYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 170 gallLVSALSLHLVACGALLRPLSLAEDPvvggPGAQITSLlrhGPFLRYTVALTLINTGYFIPYvhlvahlRDLGWDPL 249
Cdd:cd17312 158 ----AAFLVPGIVGLVVAIILFFFLRDSP----PYVWVLSL---AYAFVYIVRYACLDWGPLYLY-------EVKGYSLI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 250 PAAFLLSVAAISDLVGRVASGWLGD-AVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMA-YGFTSGALTPVAFS 327
Cdd:cd17312 220 DAGWFSSLYEVGGIAGTILAGLLSDkLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFlIGFFVGGPINLIGG 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115497636 328 VLPELVGTGKIyCG--LGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITL 391
Cdd:cd17312 300 AAAQDIGRKEA-AGtaTGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
20-383 |
1.86e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 20 AFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASF 99
Cdd:cd17341 4 SWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 100 ATSLTHLYLSIGLLSGSGWAlTFTPTLACLSRYFSRRRS-----LAMGLALTGVGLSSFAFAPLFQWLLN---HYAWRGA 171
Cdd:cd17341 84 AVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVSQLLAPLIAGAIVFdggFVGWRNA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 172 LLLVSALSLHLVACGALLrplsLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDL-----GW 246
Cdd:cd17341 163 FFVPGILLAIAAVLVLLF----GDDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYfktrfGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 247 DPLPAAFLLSVAAISDLVGRVASGWLGDaVPGPVARLLMLWTTLT-GVILALYPVAEAPTGL---VALTMAYGFTSGALT 322
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSD-RFGGRRRLWWLFIVMTiGAALLSLSLPTSGTNLvlfLALFVALGLGAGAGN 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115497636 323 PVAFSVLPeLVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLA 383
Cdd:cd17341 318 GSVFRMVP-FIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVA 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
43-390 |
5.35e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 43 AAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLyLSIGLLSGSGWALTF 122
Cdd:cd17474 27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 123 TPTLACLSRYF-SRRRSLAMGL--ALTGVGLSSFafaPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLAEDPV 199
Cdd:cd17474 106 PLALTLIGDLFeGGERAKAMGLyeAALGLGIAVG---PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 200 VGGPGAQITSLLRHGPFLRYTVALT-LINTGYF--IPYVHLVAHLRdLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAV 276
Cdd:cd17474 183 SSATKLRDLKKALRGRGLLTFLVSAfLYFFLYFafLTYLPFLLELL-YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 277 PGpVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLG 356
Cdd:cd17474 262 FG-ARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
330 340 350
....*....|....*....|....*....|....
gi 115497636 357 APLSGYLRDVTGNYTASFVVAGAFLLAGSGVLIT 390
Cdd:cd17474 341 PLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
251-393 |
1.19e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 251 AAFLLSVAAISDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLP 330
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIER--RRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115497636 331 ELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLPH 393
Cdd:cd17324 114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
48-397 |
1.25e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 48 PAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIGLLSGS-GWALTFTPTL 126
Cdd:cd17335 30 SPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAfFSAPVVPLVD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 127 ACLSRYFSRRRSLAMGLALTGV---GLSSFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGP 203
Cdd:cd17335 110 SITLQYLGEERERYGKQRLWGSigfGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 204 GAQItsLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVpGPVaRL 283
Cdd:cd17335 190 GLLA--LLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRF-GHV-GL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 284 LMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMV-ESIGGLLGAPLSGY 362
Cdd:cd17335 266 LYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLyFGLGGGLGSLIGGY 345
|
330 340 350
....*....|....*....|....*....|....*
gi 115497636 363 LrdvtgnyTASFVVAGAFLLAGSGVLITLPHFFCF 397
Cdd:cd17335 346 L-------YEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-296 |
1.87e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.26 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 94 MLLASFATSLTHLYLSIGLLsGSGWALTFTPTLACLSRYFS-RRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGAL 172
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQ-GIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 173 LLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAA 252
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 115497636 253 FLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILA 296
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-170 |
2.02e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.33 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 16 VVLSAFFQSALVFGVLRSFGVFFVEFVAAFeePAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGML 95
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELGGL--SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115497636 96 LASFATSLTHLYLSIgLLSGSGWALTFTPTLACLSRYFSRR-RSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRG 170
Cdd:cd17325 281 LLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPPEgRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
54-170 |
3.12e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.73 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 54 WIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLyLSIGLLSGSGWALTFTPTLACLSRYF 133
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110
....*....|....*....|....*....|....*...
gi 115497636 134 S-RRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRG 170
Cdd:TIGR00895 135 PkRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-382 |
3.34e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 65 FGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLThLYLSIGLLSGSGWALTFTPTLACLSRYFSRR-RSLAMGL 143
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFVVSESWLNALATNEnRGRVLGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 144 ALTGVGLSSFafapLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVAL 223
Cdd:cd17477 125 YSTVLGLGFA----LGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 224 TLINTGyfiPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGpvaRLLMLWTTLTGVILALYPVAEA 303
Cdd:cd17477 201 GFLEGA---FYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR---RRVLLGCALLGALAALLLPLVP 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 304 PTGLV--ALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFL 381
Cdd:cd17477 275 GLPLAllVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
.
gi 115497636 382 L 382
Cdd:cd17477 355 L 355
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
242-393 |
3.71e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 242 RDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPgpVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGAL 321
Cdd:pfam07690 25 EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115497636 322 TPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLPH 393
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-393 |
4.62e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.29 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 34 FGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLS---I 110
Cdd:cd17371 18 LGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILralA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 111 GLLSGSGWALTFTPTLACL-SRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALL 189
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVpARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 190 R-PLSLAEDPVVGGPGAQITSLLR--HGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFL-----LSVAAIS 261
Cdd:cd17371 178 KePPQWQAARAARRHFADRPSLRElfSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEgsagyLVVTILG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 262 DLVGRVASGWLGDAVPGpvARLLMLWTTLTGVILALY-PVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYC 340
Cdd:cd17371 258 GFLGYLAGGFLADRIGR--RNNFALFALGSAISILLYfFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRAT 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 115497636 341 GLGLVQMVESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLPH 393
Cdd:cd17371 336 AQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-391 |
9.53e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 9.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 41 FVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLS----IGLLSGS 116
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWlllvLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 117 GWALTFTPTLACLSRYFSRRR-SLAMGLALTGVGLSSFAFAPLFQWLlnhYAWRGALLLVSALSLHLVACGALLRPLSLA 195
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQlVRANALNSLATQLARIIGPALGGLL---VALLGPGGAFAINALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 196 EDPVVGGPGAQITSLLRHG-------PFLRYTVALTLINTGYFIPYVHLVAHL--RDLGWDPLPAAFLLSVAAISDLVGR 266
Cdd:cd06173 182 PPAAPGESSSLLLRDLREGlrylrrsPLLRLLLLALALFALLGGALTVLLPLLakEVLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 267 VASGWLGDAVPgpVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQ 346
Cdd:cd06173 262 LLLGRLSKRRR--RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 115497636 347 MVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLITL 391
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
215-389 |
1.95e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 215 PFLRYTVALTLINTGYFiPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVpgpVARLLMLWTTLTGVI 294
Cdd:cd17370 201 AFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI---GRKKLLILGYLSLAL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 295 -LALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGnYTAS 373
Cdd:cd17370 277 aYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PSAA 355
|
170
....*....|....*.
gi 115497636 374 FVVAGAFLLAGSGVLI 389
Cdd:cd17370 356 FLFSAVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
216-388 |
3.32e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 216 FLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPgpvARLLMLWTTLTGVIL 295
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFD---RRRLLILADLLRALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 296 ALYPVAEAPTG------LVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLRDVTGN 369
Cdd:cd06173 78 AAVLALLALLGslslwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157
|
170
....*....|....*....
gi 115497636 370 YTASFVVAGAFLLAGSGVL 388
Cdd:cd06173 158 GGAFAINALSFLLSALLLL 176
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
48-393 |
4.85e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 48 PAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLsIGLLSGSGWALTFTPTLA 127
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 128 CLSRYFS-RRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALllvsalslhlVACGALlrPLSLAedPVVGGpgaq 206
Cdd:cd17365 111 LVSEYAPaRRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----------LLGGVP--PLILL--PLLRG---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 207 itSLLRHGPFLRYTVALTLINTgyFIPYVhlvahLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAvpGPVARLLML 286
Cdd:cd17365 173 --TLLLWVTFFMGLLLVYLLNS--WLPKL-----MVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR--FGPKRVLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 287 WTTLTGVILALYPVAEAPTGLVALTmayGFTSGALTPVAFSVLPELVGTgkIY------CGLGLVQMVESIGGLLGAPLS 360
Cdd:cd17365 242 FFALGAVSLALLGVSPASLVLLYVL---VFLAGACVNGAQVGLYALAAR--FYptevraTGVGWALGVGRLGAILGPLLG 316
|
330 340 350
....*....|....*....|....*....|...
gi 115497636 361 GYLRDVTGNYTASFVVAGAFLLAGSGVLITLPH 393
Cdd:cd17365 317 GLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
216-395 |
4.88e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 216 FLRYTVALTLINTGYFIPYVHLVAHlRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGpvaRLLMLW-TTLTGVI 294
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLH-QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR---KPVMLAgLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 295 LALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGYLrdVTGNYTASF 374
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLF 156
|
170 180
....*....|....*....|..
gi 115497636 375 VV-AGAFLLAGSGVLITLPHFF 395
Cdd:cd17329 157 LAaAVLFLLAALVLLFLLPETR 178
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
42-127 |
5.80e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.79 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 42 VAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIG--LLSG--SG 117
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVgrVLVGigVG 117
|
90
....*....|
gi 115497636 118 WALTFTPTLA 127
Cdd:pfam00083 118 GASVLAPMYI 127
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-166 |
7.47e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 14 WMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVqqfGSPVGSALSTKFGPRPAVMTGGILTALG 93
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGAL---GSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115497636 94 MLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFS-RRRSLAMGLALTGVGLSSFAFAPLFQWLLNHY 166
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
255-384 |
7.95e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 7.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 255 LSVAAISDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELV- 333
Cdd:cd17391 246 FSATGVSSLLSAPRLGKLGDRIGH--HRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITp 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 115497636 334 --GTGKIYcglGLVQMVESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 384
Cdd:cd17391 324 keVAGRIF---GYNQSFQYLGNVAGPLLGSAIAAHFG-YRAVFVVTALLVLLN 372
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-124 |
8.42e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 8.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497636 15 MVVLSAFFQSALVFGVLRSFGVFFVEFVAAF------EEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGI 88
Cdd:cd17321 163 ALLLARTFSGAVLAAFLLGAALGGLLFLLPLylqgvlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
90 100 110
....*....|....*....|....*....|....*...
gi 115497636 89 LTALGMLLASFATSLTHLYLSIG--LLSGSGWALTFTP 124
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPglVLLGLGLGLFATP 280
|
|
| |
