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Conserved domains on  [gi|115532974|ref|NP_001041007|]
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Juxtamembrane domain-associated catenin [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 313-403 1.30e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  313 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 392
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 115532974  393 QDGLGHPSMSS 403
Cdd:cd00063    79 GGGESPPSESV 89
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
205-476 2.25e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  205 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 283
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  284 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 363
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  364 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 443
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 115532974  444 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 476
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 528-619 2.37e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  528 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 606
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 115532974  607 SGCSQPSPPSDFV 619
Cdd:cd00063    80 GGESPPSESVTVT 92
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 722-761 2.32e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 2.32e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 115532974   722 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 761
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 691-898 4.60e-07

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.72  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  691 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 770
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  771 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 845
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115532974  846 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 898
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 964-999 4.07e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 115532974   964 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 999
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 313-403 1.30e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  313 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 392
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 115532974  393 QDGLGHPSMSS 403
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
205-476 2.25e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  205 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 283
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  284 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 363
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  364 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 443
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 115532974  444 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 476
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 313-397 1.07e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 67.64  E-value: 1.07e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974    313 PLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVyGSRDWIVANEQlVQENVFTVESLRPNGVYEFRVRGKN 392
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 115532974    393 QDGLG 397
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 205-294 2.39e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  205 PSAPGVPDVVDAGIGEVTVVWSAPlQSNGGEVRGYQIEMREFPDGEWESMGVDHlLKDTTCRVTNLT-SHEVQFRVSAYG 283
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTP-GSETSYTLTGLKpGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 115532974  284 RTGFGPASNPS 294
Cdd:cd00063    79 GGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 528-619 2.37e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  528 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 606
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 115532974  607 SGCSQPSPPSDFV 619
Cdd:cd00063    80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
315-400 3.00e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 3.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   315 APGRPTVIAVDGQGVLLEWTPPvaDVHSSPPQGYQVEYR-VYGSRDWivaNEQLV--QENVFTVESLRPNGVYEFRVRGK 391
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRpKNSGEPW---NEITVpgTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 115532974   392 NQDGLGHPS 400
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 205-288 1.04e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.04e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974    205 PSAPGVPDVVDAGIGEVTVVWSAPLQSNG-GEVRGYQIEMREfPDGEWESMGVDHllKDTTCRVTNLT-SHEVQFRVSAY 282
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYRE-EGSEWKEVNVTP--SSTSYTLTGLKpGTEYEFRVRAV 77


                    ....*.
gi 115532974    283 GRTGFG 288
Cdd:smart00060   78 NGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 722-761 2.32e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 2.32e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 115532974   722 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 761
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 722-762 3.49e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 3.49e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 115532974    722 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSF 762
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 691-898 4.60e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.72  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  691 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 770
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  771 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 845
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115532974  846 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 898
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
fn3 pfam00041
Fibronectin type III domain;
428-507 9.20e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.79  E-value: 9.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   428 PPGQPQMVEVGDDVVKLEWAPSVQN----ARYIVEYREVGDPE-WHTANyDPIVQNGIQVEGLHRNSTYEFCVISIVDNI 502
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEpWNEIT-VPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 115532974   503 ASQPS 507
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
526-613 1.71e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   526 PAPNILEapeFLEVDGDKITICWL-PAQSQLPVMGYDVEFRDL--QQDDRWYKVNDQPVFackMTVGDLIMDHDYQFRVL 602
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTpPPDGNGPITGYEVEYRPKnsGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 115532974   603 AHNASGCSQPS 613
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 534-610 2.52e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 2.52e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115532974    534 PEFLEVDGDKITICWLPAQSQlPVMGYDVEFR--DLQQDDRWYKVNDQPVfACKMTVGDLIMDHDYQFRVLAHNASGCS 610
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDD-GITGYIVGYRveYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 766-807 5.47e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 5.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 115532974   766 NDANKLAVMEADGVRLIAEVLRTThDASVKEEAAAALWNLSS 807
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
733-831 2.41e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  733 GGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANklAVMEADGVRLIAEVLrTTHDASVKEEAAAALWNLSSADMLK 812
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQ--AVIDANLIPPLIHLL-SSAEYKIKKEACWAISNATSGGLNR 403

                          90
                  ....*....|....*....
gi 115532974  813 PVILESateILSQQVIAPV 831
Cdd:COG5064   404 PDIIRY---LVSQGFIKPL 419
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 964-999 4.07e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 115532974   964 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 999
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 766-807 4.57e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 4.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 115532974    766 NDANKLAVMEADGVRLIAEVLRTTHDaSVKEEAAAALWNLSS 807
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDE-EVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 313-403 1.30e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  313 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 392
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 115532974  393 QDGLGHPSMSS 403
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
205-476 2.25e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  205 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 283
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  284 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 363
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  364 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 443
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 115532974  444 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 476
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 313-397 1.07e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 67.64  E-value: 1.07e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974    313 PLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVyGSRDWIVANEQlVQENVFTVESLRPNGVYEFRVRGKN 392
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 115532974    393 QDGLG 397
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 205-294 2.39e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  205 PSAPGVPDVVDAGIGEVTVVWSAPlQSNGGEVRGYQIEMREFPDGEWESMGVDHlLKDTTCRVTNLT-SHEVQFRVSAYG 283
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTP-GSETSYTLTGLKpGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 115532974  284 RTGFGPASNPS 294
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
276-513 2.51e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.19  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  276 QFRVSAYGRTGFGPASNPslpvkipISETDLATsagAPLAPGRPTVIAVDGQGVLLEWTP-PVADVhssppQGYQVEYRV 354
Cdd:COG3401   206 YYRVAATDTGGESAPSNE-------VSVTTPTT---PPSAPTGLTATADTPGSVTLSWDPvTESDA-----TGYRVYRSN 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  355 YGSRDW-IVANeqlVQENVFTVESLRPNGVYEFRVRGKNQDGLghPSMSSGGVairpaapqrhvparKVSESVQPPGQPQ 433
Cdd:COG3401   271 SGDGPFtKVAT---VTTTSYTDTGLTNGTTYYYRVTAVDAAGN--ESAPSNVV--------------SVTTDLTPPAAPS 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  434 MVEV---GDDVVKLEWAPSVQN--ARYIVEYREVGDPEWHTANyDPIVQNGIQVEGLHRNSTYEFCVISI-VDNIASQPS 507
Cdd:COG3401   332 GLTAtavGSSSITLSWTASSDAdvTGYNVYRSTSGGGTYTKIA-ETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPS 410


                  ....*.
gi 115532974  508 ETSDII 513
Cdd:COG3401   411 EEVSAT 416
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 428-513 1.67e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  428 PPGQPQMVEVGDDVVKLEWAPSVQNAR----YIVEYREVGDPEWHTANYDPIVQNGIQVEGLHRNSTYEFCVISIVDNIA 503
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGpitgYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|
gi 115532974  504 SQPSETSDII 513
Cdd:cd00063    83 SPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 528-619 2.37e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  528 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 606
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 115532974  607 SGCSQPSPPSDFV 619
Cdd:cd00063    80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
315-400 3.00e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 3.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   315 APGRPTVIAVDGQGVLLEWTPPvaDVHSSPPQGYQVEYR-VYGSRDWivaNEQLV--QENVFTVESLRPNGVYEFRVRGK 391
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRpKNSGEPW---NEITVpgTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 115532974   392 NQDGLGHPS 400
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
214-636 3.72e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.33  E-value: 3.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  214 VDAGIGEVTVVWSAPLQSNGGEVRGYQIEMREFPDGEWESMGVDHLLKDTTCRVTNLTSHEVQFRVSAYGRTGFGPASNP 293
Cdd:COG3401    34 KTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  294 SLPVKIPISETDLATSAGAPLAPGRPTVIAVDG-QGVLLEWTPPVADVHSSPPQGYQVEYRVYGSRDWIVANEQLVQENV 372
Cdd:COG3401   114 SDEVPSPAVGTATTATAVAGGAATAGTYALGAGlYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  373 FTVESLRPNGVYEFRVRGKNQDGLGHPSmssggvairpaapqrhvPARKVSESVQPPGQPQMVEV---GDDVVKLEWAPS 449
Cdd:COG3401   194 DGGGDIEPGTTYYYRVAATDTGGESAPS-----------------NEVSVTTPTTPPSAPTGLTAtadTPGSVTLSWDPV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  450 VQN--ARYIVEYREVGDPEW------HTANY-DPIVQNGiqveglhrnSTYEFCVISI-VDNIASQPSETSdiihlrpTC 519
Cdd:COG3401   257 TESdaTGYRVYRSNSGDGPFtkvatvTTTSYtDTGLTNG---------TTYYYRVTAVdAAGNESAPSNVV-------SV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  520 NTSALRPApnileAPEFLEV---DGDKITICWLPAqSQLPVMGYDVEfRDLQQDDRWYKVN---DQPVFackmTVGDLIM 593
Cdd:COG3401   321 TTDLTPPA-----APSGLTAtavGSSSITLSWTAS-SDADVTGYNVY-RSTSGGGTYTKIAetvTTTSY----TDTGLTP 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 115532974  594 DHDYQFRVLAHNASGCSqpSPPSDFVHIEPSTNRFSSDTMESP 636
Cdd:COG3401   390 GTTYYYKVTAVDAAGNE--SAPSEEVSATTASAASGESLTASV 430
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
178-395 8.47e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 8.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  178 ASDHDSEDRSAPPPAPASRFLHEdsgipsapgVPDVVDAGIGEVTVV--WSAPLQSNGgevrgYQIEMREfPDGEWESMG 255
Cdd:COG4733   518 AIDAGAFDDVPPQWPPVNVTTSE---------SLSVVAQGTAVTTLTvsWDAPAGAVA-----YEVEWRR-DDGNWVSVP 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  256 VDHllkDTTCRVTNLTSHEVQFRVSAYGRtgFGPASNPSLPvkipiSETDLATSAGAPLAPGRPTVIAVDGqGVLLEWTP 335
Cdd:COG4733   583 RTS---GTSFEVPGIYAGDYEVRVRAINA--LGVSSAWAAS-----SETTVTGKTAPPPAPTGLTATGGLG-GITLSWSF 651

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115532974  336 PV-ADVhssppQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKNQDG 395
Cdd:COG4733   652 PVdADT-----LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 205-288 1.04e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.04e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974    205 PSAPGVPDVVDAGIGEVTVVWSAPLQSNG-GEVRGYQIEMREfPDGEWESMGVDHllKDTTCRVTNLT-SHEVQFRVSAY 282
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYRE-EGSEWKEVNVTP--SSTSYTLTGLKpGTEYEFRVRAV 77


                    ....*.
gi 115532974    283 GRTGFG 288
Cdd:smart00060   78 NGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 722-761 2.32e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 2.32e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 115532974   722 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 761
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 722-762 3.49e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 3.49e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 115532974    722 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSF 762
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 691-898 4.60e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.72  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  691 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 770
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  771 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 845
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115532974  846 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 898
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
fn3 pfam00041
Fibronectin type III domain;
428-507 9.20e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.79  E-value: 9.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   428 PPGQPQMVEVGDDVVKLEWAPSVQN----ARYIVEYREVGDPE-WHTANyDPIVQNGIQVEGLHRNSTYEFCVISIVDNI 502
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEpWNEIT-VPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 115532974   503 ASQPS 507
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 428-498 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 4.09e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532974    428 PPGQPQMVEVGDDVVKLEWAPSVQNA--RYIVEYREVG---DPEWHTANYDPIvQNGIQVEGLHRNSTYEFCVISI 498
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYreeGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
526-613 1.71e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   526 PAPNILEapeFLEVDGDKITICWL-PAQSQLPVMGYDVEFRDL--QQDDRWYKVNDQPVFackMTVGDLIMDHDYQFRVL 602
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTpPPDGNGPITGYEVEYRPKnsGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 115532974   603 AHNASGCSQPS 613
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
201-339 2.02e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  201 DSGIPSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGvdHLLKDTTCRVTNLTS-HEVQFRV 279
Cdd:COG3401   323 DLTPPAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNVYRSTSGGGTYTKIA--ETVTTTSYTDTGLTPgTTYYYKV 397

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  280 SAYGRTgfGPASNPSLPVKIPISETDLATSAGAPLAPGRPTVIAVDGQGVLLEWTPPVAD 339
Cdd:COG3401   398 TAVDAA--GNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSA 455
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 534-610 2.52e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 2.52e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115532974    534 PEFLEVDGDKITICWLPAQSQlPVMGYDVEFR--DLQQDDRWYKVNDQPVfACKMTVGDLIMDHDYQFRVLAHNASGCS 610
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDD-GITGYIVGYRveYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 766-807 5.47e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 5.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 115532974   766 NDANKLAVMEADGVRLIAEVLRTThDASVKEEAAAALWNLSS 807
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 306-391 1.54e-03

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 39.29  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974   306 LATSAGAPLAPGRPTVIAVDGQGVLlEWTPpvaDVHSSPPQGYQVEYRVYGSRDWI-VANEQLVQENV--FTVESLRPNG 382
Cdd:pfam01108   15 SAAGGPSLPAPQNVTFQSTNFKNIL-TWEP---GPNSPPDVVYTVQYKIYGSGDWKnVPNCTNITRTEcdLTDETSDLTE 90


                   ....*....
gi 115532974   383 VYEFRVRGK 391
Cdd:pfam01108   91 TYYARVRAV 99
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
733-831 2.41e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532974  733 GGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANklAVMEADGVRLIAEVLrTTHDASVKEEAAAALWNLSSADMLK 812
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQ--AVIDANLIPPLIHLL-SSAEYKIKKEACWAISNATSGGLNR 403

                          90
                  ....*....|....*....
gi 115532974  813 PVILESateILSQQVIAPV 831
Cdd:COG5064   404 PDIIRY---LVSQGFIKPL 419
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 964-999 4.07e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 115532974   964 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 999
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 766-807 4.57e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 4.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 115532974    766 NDANKLAVMEADGVRLIAEVLRTTHDaSVKEEAAAALWNLSS 807
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDE-EVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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