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Conserved domains on  [gi|115532662|ref|NP_001040846|]
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Cytokinesis defective protein 7 [Caenorhabditis elegans]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 12196753)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Caenorhabditis elegans cytokinesis defective protein 7

Gene Ontology:  GO:0005515
PubMed:  27521773|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 31-123 1.99e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


:

Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.46  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662    31 ISCGNRSFFVNPGWLAELSPYFADELYV--RKPNVQRYVIDQATPDE---VLEFLRCITFCPMRKpltvkNVSLVLTFAN 105
Cdd:smart00225   4 LVVGGKKFHAHKAVLAAHSPYFKALFSSdfKESDKSEIYLDDVSPEDfraLLNFLYTGKLDLPEE-----NVEELLELAD 78

                           90
                   ....*....|....*...
gi 115532662   106 RFEMRPVQARCENFIAQN 123
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96
 
Name Accession Description Interval E-value
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 31-123 1.99e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.46  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662    31 ISCGNRSFFVNPGWLAELSPYFADELYV--RKPNVQRYVIDQATPDE---VLEFLRCITFCPMRKpltvkNVSLVLTFAN 105
Cdd:smart00225   4 LVVGGKKFHAHKAVLAAHSPYFKALFSSdfKESDKSEIYLDDVSPEDfraLLNFLYTGKLDLPEE-----NVEELLELAD 78

                           90
                   ....*....|....*...
gi 115532662   106 RFEMRPVQARCENFIAQN 123
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 33-123 3.71e-04

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 38.78  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662   33 CGNRSFFVNPGWLAELSPYFaDELYVRKP---NVQRYVIDQATPDEVLEFLRCI-TFCPMRKpltvKNVSLVLTFANRFE 108
Cdd:pfam00651  17 VGDKEFRAHKAVLAACSPYF-KALFSGQEsesSVSEITLDDVSPEDFEALLEFMyTGKLISE----ENVDDLLAAADKLQ 91

                          90
                  ....*....|....*
gi 115532662  109 MRPVQARCENFIAQN 123
Cdd:pfam00651  92 IPSLVDKCEEFLIKS 106
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 26-116 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 37.32  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662  26 WRKFEISCGNRSFFVNPGWLAELSPYFADELY--VRKPNVQRYVIDQATPDEVLEFLRCITFCPMRkpLTVKNVSLVLTF 103
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTgsMIESNLKEVTLEDVEPEIFETVLKYMYTGQVT--LSEENVLDLLML 83

                         90
                 ....*....|...
gi 115532662 104 ANRFEMRPVQARC 116
Cdd:cd18314   84 ASKYQVPDLEKLC 96
 
Name Accession Description Interval E-value
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 31-123 1.99e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.46  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662    31 ISCGNRSFFVNPGWLAELSPYFADELYV--RKPNVQRYVIDQATPDE---VLEFLRCITFCPMRKpltvkNVSLVLTFAN 105
Cdd:smart00225   4 LVVGGKKFHAHKAVLAAHSPYFKALFSSdfKESDKSEIYLDDVSPEDfraLLNFLYTGKLDLPEE-----NVEELLELAD 78

                           90
                   ....*....|....*...
gi 115532662   106 RFEMRPVQARCENFIAQN 123
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 33-123 3.71e-04

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 38.78  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662   33 CGNRSFFVNPGWLAELSPYFaDELYVRKP---NVQRYVIDQATPDEVLEFLRCI-TFCPMRKpltvKNVSLVLTFANRFE 108
Cdd:pfam00651  17 VGDKEFRAHKAVLAACSPYF-KALFSGQEsesSVSEITLDDVSPEDFEALLEFMyTGKLISE----ENVDDLLAAADKLQ 91

                          90
                  ....*....|....*
gi 115532662  109 MRPVQARCENFIAQN 123
Cdd:pfam00651  92 IPSLVDKCEEFLIKS 106
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 26-116 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 37.32  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532662  26 WRKFEISCGNRSFFVNPGWLAELSPYFADELY--VRKPNVQRYVIDQATPDEVLEFLRCITFCPMRkpLTVKNVSLVLTF 103
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTgsMIESNLKEVTLEDVEPEIFETVLKYMYTGQVT--LSEENVLDLLML 83

                         90
                 ....*....|...
gi 115532662 104 ANRFEMRPVQARC 116
Cdd:cd18314   84 ASKYQVPDLEKLC 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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