NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|115532580|ref|NP_001040805|]
View 

Tetraspanin [Caenorhabditis elegans]

Protein Classification

tetraspanin family protein( domain architecture ID 10123253)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886|GO:0097197
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 112-211 1.48e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


:

Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 50.97  E-value: 1.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580 112 FTYSDQVNQLASDDFMYESLSKaaqktippigsLSSDAEVQFWANTQDLFGCCGVYNSTDWsvfwgvtGTNNDLQALHCY 191
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEY-----------YVDDDFQEAMDALQSTFECCGVNGPTDY-------LDLRLLVPSSCC 62

                         90       100
                 ....*....|....*....|....*...
gi 115532580 192 PQH--------FNDGCEKTIRNKISSNA 211
Cdd:cd03127   63 KGTdgncglnlYTEGCLEKLVDFLRSNL 90
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 112-211 1.48e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 50.97  E-value: 1.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580 112 FTYSDQVNQLASDDFMYESLSKaaqktippigsLSSDAEVQFWANTQDLFGCCGVYNSTDWsvfwgvtGTNNDLQALHCY 191
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEY-----------YVDDDFQEAMDALQSTFECCGVNGPTDY-------LDLRLLVPSSCC 62

                         90       100
                 ....*....|....*....|....*...
gi 115532580 192 PQH--------FNDGCEKTIRNKISSNA 211
Cdd:cd03127   63 KGTdgncglnlYTEGCLEKLVDFLRSNL 90
Tetraspanin pfam00335
Tetraspanin family;
62-232 1.39e-06

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 47.31  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580   62 GLFVAAACVLVISFLVAtVSVLRHNSFLLKAYCAMVALMIVVQLVDGLLAFTYSDQVnqlasDDFMYESLSKAAQKTIPP 141
Cdd:pfam00335  47 LLIVLGAVIFLVGFLGC-CGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKL-----SGLLSNWLKKSLEDGYRD 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580  142 IGSLSSDaEVQFWANTQDLFGCCGvynstdwsvfwgvtgtnndlqalhcypqhfndGCEKTIRNKISSNAQYLGAASMGV 221
Cdd:pfam00335 121 WLDLYSC-LNSALDSLQSEFGCCG--------------------------------GCKEKLLEWLRKNLKIIGAGVIAL 167

                         170
                  ....*....|.
gi 115532580  222 LVVEIIASFLA 232
Cdd:pfam00335 168 GVIQLLGIILA 178
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 112-211 1.48e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 50.97  E-value: 1.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580 112 FTYSDQVNQLASDDFMYESLSKaaqktippigsLSSDAEVQFWANTQDLFGCCGVYNSTDWsvfwgvtGTNNDLQALHCY 191
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEY-----------YVDDDFQEAMDALQSTFECCGVNGPTDY-------LDLRLLVPSSCC 62

                         90       100
                 ....*....|....*....|....*...
gi 115532580 192 PQH--------FNDGCEKTIRNKISSNA 211
Cdd:cd03127   63 KGTdgncglnlYTEGCLEKLVDFLRSNL 90
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 112-172 1.29e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 45.43  E-value: 1.29e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115532580 112 FTYSDQVNQLASDDfMYESLSKaaqktippIGSLSSDAEVQFWANTQDLFGCCGVYNSTDW 172
Cdd:cd03165    1 FVFREKVDLTAKDD-LKEGLEL--------YGTRNNRGLTNAWDITQTEFRCCGVTNYTDW 52
Tetraspanin pfam00335
Tetraspanin family;
62-232 1.39e-06

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 47.31  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580   62 GLFVAAACVLVISFLVAtVSVLRHNSFLLKAYCAMVALMIVVQLVDGLLAFTYSDQVnqlasDDFMYESLSKAAQKTIPP 141
Cdd:pfam00335  47 LLIVLGAVIFLVGFLGC-CGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKL-----SGLLSNWLKKSLEDGYRD 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580  142 IGSLSSDaEVQFWANTQDLFGCCGvynstdwsvfwgvtgtnndlqalhcypqhfndGCEKTIRNKISSNAQYLGAASMGV 221
Cdd:pfam00335 121 WLDLYSC-LNSALDSLQSEFGCCG--------------------------------GCKEKLLEWLRKNLKIIGAGVIAL 167

                         170
                  ....*....|.
gi 115532580  222 LVVEIIASFLA 232
Cdd:pfam00335 168 GVIQLLGIILA 178
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 152-211 4.33e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 39.05  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580 152 QFWANTQDLFGCCGVYNSTDW----SVFWGVTGTNN------------------DLQALHCYPQHFNDGCEKTIRNKISS 209
Cdd:cd03156   33 STWNRVMIELKCCGVNGPTDFvdstSFFRQKNEPNSpypescckrnsnsqivdlDCPKLGSPNSYNKKGCYEKLSNPIER 112


                 ..
gi 115532580 210 NA 211
Cdd:cd03156  113 YA 114
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 112-201 1.96e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 36.94  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580 112 FTYSDQVNQLASddfmyESLSKAAQKTIppiGSLSSDAEVQFWANTQDLFGCCGVYNSTDW--SVFWGVTGTNNDL-QAL 188
Cdd:cd03155    1 YTYYQQLEDELK-----ESLKRTMQENY---GQSGEEALTLTVDELQQEFKCCGSNNYTDWqdSEWINSNEANGRLvPDS 72

                         90
                 ....*....|...
gi 115532580 189 HCYPQHFNDGCEK 201
Cdd:cd03155   73 CCKTVVDRCGCLR 85
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 112-215 2.25e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 36.30  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532580 112 FTYSDQVNQLASDDfMYESLSKAaqktippIGSLSSDAEvqfWANTQDLFGCCGVYNSTDWSVF----WGVTGTNNDLQa 187
Cdd:cd03164    1 FVYEKKLNNYVKEG-LTDSLEQY-------HKDNNTSEA---WDMIQSNLQCCGINGTTDWGSGvpssCCSSDTEYKVE- 68

                         90       100
                 ....*....|....*....|....*...
gi 115532580 188 lhcypqhfndGCEKTIRNKISSNAQYLG 215
Cdd:cd03164   69 ----------GCYKKLKNWFESNFLYTG 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH