|
Name |
Accession |
Description |
Interval |
E-value |
| ZnMc_ADAMTS_like |
cd04273 |
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ... |
436-644 |
1.08e-113 |
|
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.
:
Pssm-ID: 239801 Cd Length: 207 Bit Score: 358.47 E-value: 1.08e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 436 KWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSIGNPIHITVVRLIILEDEEKDLKITHHADDTLKNFCRWQ 515
Cdd:cd04273 1 RYVETLVVADSKMVEFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 516 KNVNMKGDDHPQHHDTAILLTRKDLCaTMNHPCETLGLSHVAGLCHPQLSCSVSEDTGLPLAFTVAHELGHSFGIQHDGT 595
Cdd:cd04273 81 KKLNPPNDSDPEHHDHAILLTRQDIC-RSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 114052955 596 GNDCESIGKRPFIMSPQLLYDRGiPLTWSRCSREYITRFLDRGWGLCLD 644
Cdd:cd04273 160 GNSCGPEGKDGHIMSPTLGANTG-PFTWSKCSRRYLTSFLDTGDGNCLL 207
|
|
| Pep_M12B_propep |
pfam01562 |
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ... |
247-387 |
3.71e-37 |
|
Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.
:
Pssm-ID: 460254 Cd Length: 128 Bit Score: 136.68 E-value: 3.71e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 247 DIVHPVRVDAGgsflsyelwpRVLRKRDVSAAQASSAFYQLQYQGRELLFNLTTNPYLLAPGFVSEIRRRSNLSNVHIQT 326
Cdd:pfam01562 1 EVVIPVRLDPS----------RRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPPV 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114052955 327 SVPTCHLLGDVQDpeLEGGFAAISACDGLRGVFQLSNEDYFIEPLdEVPAQPGHAQPHMVY 387
Cdd:pfam01562 71 QTDHCYYQGHVEG--HPDSSVALSTCSGLRGFIRTENEEYLIEPL-EKYSREEGGHPHVVY 128
|
|
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
894-1003 |
2.33e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
:
Pssm-ID: 461796 Cd Length: 115 Bit Score: 122.30 E-value: 2.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 894 TVSRTFKEAEGMGYVDVGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYQVAGTTFTYTRKGN-W 971
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 114052955 972 ETLTSPGPTTEPVWIQLLFQ---ERNPGVHYKYTI 1003
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
659-723 |
1.19e-24 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
:
Pssm-ID: 465496 Cd Length: 68 Bit Score: 98.57 E-value: 1.19e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114052955 659 PGVLYDVNHQCRLQYGPSSAYCEDV-DNVCYTLWCSVGT--TCHSKMDAAVDGTSCGKNKWCLNGECV 723
Cdd:pfam17771 1 PGQLYSADEQCRLIFGPGSTFCPNGdEDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
736-788 |
5.19e-14 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
:
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 68.00 E-value: 5.19e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 114052955 736 WSGWSAWSVCSRSCGVGVRSSERQCTQPVPKNKGKYCVGERKRYRLCNLQACP 788
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1695-1750 |
7.73e-14 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 67.48 E-value: 7.73e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1695 WVVGPWGQCSAPCGGGVQRRLVKCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1750
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1018-1072 |
1.09e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 67.09 E-value: 1.09e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1018 WHYGPWSKCPVTCGTGVQRQSLYCMEKQAGIVDEGH-CDHLSRPRDRKRkCNEEPC 1072
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1588-1643 |
8.65e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 61.70 E-value: 8.65e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1588 WRAGNWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCqPGPTKPPTRQLCGTQPC 1643
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1139-1187 |
6.54e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 59.00 E-value: 6.54e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1139 WGVGNWSQCSVTCGAGIRQRSVLCI---NNTGVP---CDGAERPITETFCFLQPC 1187
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1537-1585 |
5.31e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 56.69 E-value: 5.31e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1537 WQVGNWSQCSTTCGLGAIWRLVRCSSG------NDEDCTLSSRPQPARHCHLRPC 1585
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| ADAMTS_CR_3 super family |
cl41950 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
794-892 |
4.97e-08 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
The actual alignment was detected with superfamily member pfam19236:
Pssm-ID: 437068 Cd Length: 115 Bit Score: 53.17 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 794 FRHTQCSQFDSMLYK-----GKLHKW---VPVLNDENPCELHCRPFNYSNREKLRDAVMDGTPCYQGRISRD----ICID 861
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 114052955 862 GICKKVGCDFELDSGAEEDRCGVCRGDGSTC 892
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1646-1692 |
5.72e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 50.91 E-value: 5.72e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1646 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNTRPCNTHPC 1692
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1216-1525 |
7.78e-08 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 7.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1216 PHQPVPRPS----------PASSPKPVSISNAIDEEDPELDPPGPvfvddfyydynfinfhedlsygsfeeshsdlvdig 1285
Cdd:PHA03247 2570 PPRPAPRPSepavtsrarrPDAPPQSARPRAPVDDRGDPRGPAPP----------------------------------- 2614
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1286 gqTVPPhirPTEPPSDSPvPTAGAPGAEEEGiQGSWSPSPllseashsPPVLLENTPVNPLANFLTEEESPIGAPELGLP 1365
Cdd:PHA03247 2615 --SPLP---PDTHAPDPP-PPSPSPAANEPD-PHPPPTVP--------PPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1366 SVSW-PPASVD--GMVTSVA----PGNPDELLVREDTQSQPSTPWSDRNKLSKDGNPLGPTSPALPKSPF----PTQPSS 1434
Cdd:PHA03247 2680 PQRPrRRAARPtvGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggPARPAR 2759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1435 PSNSTTQASLSPDAVEVS------TGWNVALDPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQSP-GLLPRPAQETQTNS 1507
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAgpprrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAP 2839
|
330
....*....|....*...
gi 114052955 1508 SKDPAvqPLQPSLVEDGA 1525
Cdd:PHA03247 2840 PPPPG--PPPPSLPLGGS 2855
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1076-1129 |
1.15e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 50.14 E-value: 1.15e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 114052955 1076 WWVGDWQPCSRSCGpGGFFRRAVFCTRSVGLDEQRalePSACGHLPRPLAEIPC 1129
Cdd:pfam19030 1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGGSIVP---DSECSAQKKPPETQSC 50
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ZnMc_ADAMTS_like |
cd04273 |
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ... |
436-644 |
1.08e-113 |
|
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.
Pssm-ID: 239801 Cd Length: 207 Bit Score: 358.47 E-value: 1.08e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 436 KWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSIGNPIHITVVRLIILEDEEKDLKITHHADDTLKNFCRWQ 515
Cdd:cd04273 1 RYVETLVVADSKMVEFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 516 KNVNMKGDDHPQHHDTAILLTRKDLCaTMNHPCETLGLSHVAGLCHPQLSCSVSEDTGLPLAFTVAHELGHSFGIQHDGT 595
Cdd:cd04273 81 KKLNPPNDSDPEHHDHAILLTRQDIC-RSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 114052955 596 GNDCESIGKRPFIMSPQLLYDRGiPLTWSRCSREYITRFLDRGWGLCLD 644
Cdd:cd04273 160 GNSCGPEGKDGHIMSPTLGANTG-PFTWSKCSRRYLTSFLDTGDGNCLL 207
|
|
| Pep_M12B_propep |
pfam01562 |
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ... |
247-387 |
3.71e-37 |
|
Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.
Pssm-ID: 460254 Cd Length: 128 Bit Score: 136.68 E-value: 3.71e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 247 DIVHPVRVDAGgsflsyelwpRVLRKRDVSAAQASSAFYQLQYQGRELLFNLTTNPYLLAPGFVSEIRRRSNLSNVHIQT 326
Cdd:pfam01562 1 EVVIPVRLDPS----------RRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPPV 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114052955 327 SVPTCHLLGDVQDpeLEGGFAAISACDGLRGVFQLSNEDYFIEPLdEVPAQPGHAQPHMVY 387
Cdd:pfam01562 71 QTDHCYYQGHVEG--HPDSSVALSTCSGLRGFIRTENEEYLIEPL-EKYSREEGGHPHVVY 128
|
|
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
894-1003 |
2.33e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 122.30 E-value: 2.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 894 TVSRTFKEAEGMGYVDVGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYQVAGTTFTYTRKGN-W 971
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 114052955 972 ETLTSPGPTTEPVWIQLLFQ---ERNPGVHYKYTI 1003
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| Reprolysin |
pfam01421 |
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ... |
436-647 |
3.42e-31 |
|
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.
Pssm-ID: 426256 [Multi-domain] Cd Length: 200 Bit Score: 122.02 E-value: 3.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 436 KWVETLVVADSKMVEYHGQPQ--VESYVLTIMNMVAGLYhdpsigNPIHITVVrLIILE---DEEKdLKITHHADDTLKN 510
Cdd:pfam01421 1 KYIELFIVVDKQLFQKMGSDTtvVRQRVFQVVNLVNSIY------KELNIRVV-LVGLEiwtDEDK-IDVSGDANDTLRN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 511 FCRWQKNVNMKgddhPQHHDTAILLTRKDLCATmnhpceTLGLSHVAGLCHPQLSCSVSED---TGLPLAFTVAHELGHS 587
Cdd:pfam01421 73 FLKWRQEYLKK----RKPHDVAQLLSGVEFGGT------TVGAAYVGGMCSLEYSGGVNEDhskNLESFAVTMAHELGHN 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 588 FGIQHDGTGNDCESIGKRPFIMSPQLLYDrgIPLTWSRCSREYITRFLDRGWGLCLDDRP 647
Cdd:pfam01421 143 LGMQHDDFNGGCKCPPGGGCIMNPSAGSS--FPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
659-723 |
1.19e-24 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Pssm-ID: 465496 Cd Length: 68 Bit Score: 98.57 E-value: 1.19e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114052955 659 PGVLYDVNHQCRLQYGPSSAYCEDV-DNVCYTLWCSVGT--TCHSKMDAAVDGTSCGKNKWCLNGECV 723
Cdd:pfam17771 1 PGQLYSADEQCRLIFGPGSTFCPNGdEDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
736-788 |
5.19e-14 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 68.00 E-value: 5.19e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 114052955 736 WSGWSAWSVCSRSCGVGVRSSERQCTQPVPKNKGKYCVGERKRYRLCNLQACP 788
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1695-1750 |
7.73e-14 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 67.48 E-value: 7.73e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1695 WVVGPWGQCSAPCGGGVQRRLVKCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1750
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1018-1072 |
1.09e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 67.09 E-value: 1.09e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1018 WHYGPWSKCPVTCGTGVQRQSLYCMEKQAGIVDEGH-CDHLSRPRDRKRkCNEEPC 1072
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1588-1643 |
8.65e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 61.70 E-value: 8.65e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1588 WRAGNWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCqPGPTKPPTRQLCGTQPC 1643
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1139-1187 |
6.54e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 59.00 E-value: 6.54e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1139 WGVGNWSQCSVTCGAGIRQRSVLCI---NNTGVP---CDGAERPITETFCFLQPC 1187
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1537-1585 |
5.31e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 56.69 E-value: 5.31e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1537 WQVGNWSQCSTTCGLGAIWRLVRCSSG------NDEDCTLSSRPQPARHCHLRPC 1585
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| ADAMTS_CR_3 |
pfam19236 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
794-892 |
4.97e-08 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
Pssm-ID: 437068 Cd Length: 115 Bit Score: 53.17 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 794 FRHTQCSQFDSMLYK-----GKLHKW---VPVLNDENPCELHCRPFNYSNREKLRDAVMDGTPCYQGRISRD----ICID 861
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 114052955 862 GICKKVGCDFELDSGAEEDRCGVCRGDGSTC 892
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1646-1692 |
5.72e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 50.91 E-value: 5.72e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1646 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNTRPCNTHPC 1692
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1216-1525 |
7.78e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 7.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1216 PHQPVPRPS----------PASSPKPVSISNAIDEEDPELDPPGPvfvddfyydynfinfhedlsygsfeeshsdlvdig 1285
Cdd:PHA03247 2570 PPRPAPRPSepavtsrarrPDAPPQSARPRAPVDDRGDPRGPAPP----------------------------------- 2614
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1286 gqTVPPhirPTEPPSDSPvPTAGAPGAEEEGiQGSWSPSPllseashsPPVLLENTPVNPLANFLTEEESPIGAPELGLP 1365
Cdd:PHA03247 2615 --SPLP---PDTHAPDPP-PPSPSPAANEPD-PHPPPTVP--------PPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1366 SVSW-PPASVD--GMVTSVA----PGNPDELLVREDTQSQPSTPWSDRNKLSKDGNPLGPTSPALPKSPF----PTQPSS 1434
Cdd:PHA03247 2680 PQRPrRRAARPtvGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggPARPAR 2759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1435 PSNSTTQASLSPDAVEVS------TGWNVALDPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQSP-GLLPRPAQETQTNS 1507
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAgpprrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAP 2839
|
330
....*....|....*...
gi 114052955 1508 SKDPAvqPLQPSLVEDGA 1525
Cdd:PHA03247 2840 PPPPG--PPPPSLPLGGS 2855
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1076-1129 |
1.15e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 50.14 E-value: 1.15e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 114052955 1076 WWVGDWQPCSRSCGpGGFFRRAVFCTRSVGLDEQRalePSACGHLPRPLAEIPC 1129
Cdd:pfam19030 1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGGSIVP---DSECSAQKKPPETQSC 50
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
737-787 |
7.40e-06 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 44.72 E-value: 7.40e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 114052955 737 SGWSAWSVCSRSCGVGVRSSERQCTQPVPknKGKYCVGERKRYRLCNLQAC 787
Cdd:pfam00090 1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1018-1073 |
8.04e-06 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 44.89 E-value: 8.04e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1018 WHYGPWSKCPVTCGTGVQRQSLYCmEKQAGIVDEGHCDHlsrPRDRKRKCNEEPCP 1073
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1137-1187 |
1.41e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 44.11 E-value: 1.41e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1137 SSWGvgNWSQCSVTCGAGIRQRSVLCINNT----GVPCDGAERpiTETFCFLQPC 1187
Cdd:smart00209 2 SEWS--EWSPCSVTCGGGVQTRTRSCCSPPpqngGGPCTGEDV--ETRACNEQPC 52
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1692-1751 |
7.11e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 42.19 E-value: 7.11e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1692 CTQWvvGPWGQCSAPCGGGVQRRLVKCVNtqtGLAEEDSDLCSHEAwpESSRPCATEDCE 1751
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1648-1692 |
6.09e-03 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 36.80 E-value: 6.09e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 114052955 1648 TSSWRECSEACGGGEQQRLVTC--PEPGLCEESLRPNN--TRPCNTHPC 1692
Cdd:smart00209 4 WSEWSPCSVTCGGGVQTRTRSCcsPPPQNGGGPCTGEDveTRACNEQPC 52
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1591-1643 |
6.52e-03 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 36.41 E-value: 6.52e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 114052955 1591 GNWSKCSRNCGGGSATRDVQCVDtrdlrPLRPFHCQPGPTKPPTRQLCGTQPC 1643
Cdd:smart00209 5 SEWSPCSVTCGGGVQTRTRSCCS-----PPPQNGGGPCTGEDVETRACNEQPC 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ZnMc_ADAMTS_like |
cd04273 |
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ... |
436-644 |
1.08e-113 |
|
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.
Pssm-ID: 239801 Cd Length: 207 Bit Score: 358.47 E-value: 1.08e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 436 KWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSIGNPIHITVVRLIILEDEEKDLKITHHADDTLKNFCRWQ 515
Cdd:cd04273 1 RYVETLVVADSKMVEFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 516 KNVNMKGDDHPQHHDTAILLTRKDLCaTMNHPCETLGLSHVAGLCHPQLSCSVSEDTGLPLAFTVAHELGHSFGIQHDGT 595
Cdd:cd04273 81 KKLNPPNDSDPEHHDHAILLTRQDIC-RSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 114052955 596 GNDCESIGKRPFIMSPQLLYDRGiPLTWSRCSREYITRFLDRGWGLCLD 644
Cdd:cd04273 160 GNSCGPEGKDGHIMSPTLGANTG-PFTWSKCSRRYLTSFLDTGDGNCLL 207
|
|
| Pep_M12B_propep |
pfam01562 |
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ... |
247-387 |
3.71e-37 |
|
Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.
Pssm-ID: 460254 Cd Length: 128 Bit Score: 136.68 E-value: 3.71e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 247 DIVHPVRVDAGgsflsyelwpRVLRKRDVSAAQASSAFYQLQYQGRELLFNLTTNPYLLAPGFVSEIRRRSNLSNVHIQT 326
Cdd:pfam01562 1 EVVIPVRLDPS----------RRRRSLASESTYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPPV 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114052955 327 SVPTCHLLGDVQDpeLEGGFAAISACDGLRGVFQLSNEDYFIEPLdEVPAQPGHAQPHMVY 387
Cdd:pfam01562 71 QTDHCYYQGHVEG--HPDSSVALSTCSGLRGFIRTENEEYLIEPL-EKYSREEGGHPHVVY 128
|
|
| ZnMc_ADAM_like |
cd04267 |
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ... |
438-636 |
5.36e-36 |
|
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.
Pssm-ID: 239795 Cd Length: 192 Bit Score: 135.63 E-value: 5.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 438 VETLVVADSKMVEYHgQPQVES---YVLTIMNMVAGLYHDPSIGNPIHITVVRLIILEDEEKDLKITHHADDTLKNFCRW 514
Cdd:cd04267 3 IELVVVADHRMVSYF-NSDENIlqaYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSFW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 515 QKNVnmkgddhPQHHDTAILLTRKDLCAtmnhpCETLGLSHVAGLCHPQLSCSVSEDTGLPL--AFTVAHELGHSFGIQH 592
Cdd:cd04267 82 RAEG-------PIRHDNAVLLTAQDFIE-----GDILGLAYVGSMCNPYSSVGVVEDTGFTLltALTMAHELGHNLGAEH 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 114052955 593 DGTGNDCESIGKRP-FIMSPQLlyDRGIPLTWSRCSREYITRFLD 636
Cdd:cd04267 150 DGGDELAFECDGGGnYIMAPVD--SGLNSYRFSQCSIGSIREFLD 192
|
|
| ZnMc_adamalysin_II_like |
cd04269 |
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ... |
436-643 |
7.42e-34 |
|
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.
Pssm-ID: 239797 [Multi-domain] Cd Length: 194 Bit Score: 129.66 E-value: 7.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 436 KWVETLVVADSKMVEYHGQ--PQVESYVLTIMNMVAGLYHdpsignPIHITVVrLIILE---DEEKdLKITHHADDTLKN 510
Cdd:cd04269 1 KYVELVVVVDNSLYKKYGSnlSKVRQRVIEIVNIVDSIYR------PLNIRVV-LVGLEiwtDKDK-ISVSGDAGETLNR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 511 FCRWQKNVNmkgdDHPQHHDTAILLTRKDLCATmnhpceTLGLSHVAGLCHPQLSCSVSEDTG---LPLAFTVAHELGHS 587
Cdd:cd04269 73 FLDWKRSNL----LPRKPHDNAQLLTGRDFDGN------TVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHN 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 588 FGIQHDGTGNDCESigkRPFIMSPQLLYdrgIPLTWSRCSREYITRFLDRGWGLCL 643
Cdd:cd04269 143 LGMEHDDGGCTCGR---STCIMAPSPSS---LTDAFSNCSYEDYQKFLSRGGGQCL 192
|
|
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
894-1003 |
2.33e-32 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 122.30 E-value: 2.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 894 TVSRTFKEAEGMGYVDVGLIPAGAREILIEEVAEAANFLALRSeDPDKYFLNGGWTIQ-WNGDYQVAGTTFTYTRKGN-W 971
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*
gi 114052955 972 ETLTSPGPTTEPVWIQLLFQ---ERNPGVHYKYTI 1003
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFI 114
|
|
| Reprolysin |
pfam01421 |
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ... |
436-647 |
3.42e-31 |
|
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.
Pssm-ID: 426256 [Multi-domain] Cd Length: 200 Bit Score: 122.02 E-value: 3.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 436 KWVETLVVADSKMVEYHGQPQ--VESYVLTIMNMVAGLYhdpsigNPIHITVVrLIILE---DEEKdLKITHHADDTLKN 510
Cdd:pfam01421 1 KYIELFIVVDKQLFQKMGSDTtvVRQRVFQVVNLVNSIY------KELNIRVV-LVGLEiwtDEDK-IDVSGDANDTLRN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 511 FCRWQKNVNMKgddhPQHHDTAILLTRKDLCATmnhpceTLGLSHVAGLCHPQLSCSVSED---TGLPLAFTVAHELGHS 587
Cdd:pfam01421 73 FLKWRQEYLKK----RKPHDVAQLLSGVEFGGT------TVGAAYVGGMCSLEYSGGVNEDhskNLESFAVTMAHELGHN 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 588 FGIQHDGTGNDCESIGKRPFIMSPQLLYDrgIPLTWSRCSREYITRFLDRGWGLCLDDRP 647
Cdd:pfam01421 143 LGMQHDDFNGGCKCPPGGGCIMNPSAGSS--FPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
|
|
| ADAMTS_CR_2 |
pfam17771 |
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ... |
659-723 |
1.19e-24 |
|
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.
Pssm-ID: 465496 Cd Length: 68 Bit Score: 98.57 E-value: 1.19e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114052955 659 PGVLYDVNHQCRLQYGPSSAYCEDV-DNVCYTLWCSVGT--TCHSKMDAAVDGTSCGKNKWCLNGECV 723
Cdd:pfam17771 1 PGQLYSADEQCRLIFGPGSTFCPNGdEDVCSKLWCSNPGgsTCTTKNLPAADGTPCGNKKWCLNGKCV 68
|
|
| ZnMc_salivary_gland_MPs |
cd04272 |
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ... |
438-643 |
7.59e-19 |
|
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.
Pssm-ID: 239800 Cd Length: 220 Bit Score: 87.41 E-value: 7.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 438 VETLVVADSKMVEYHGQ-PQVESYVLTIMNMVAGLYHDpsIGNP-IHITVVRLIILEDEEKDLKITHHADD------TLK 509
Cdd:cd04272 3 PELFVVVDYDHQSEFFSnEQLIRYLAVMVNAANLRYRD--LKSPrIRLLLVGITISKDPDFEPYIHPINYGyidaaeTLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 510 NFcrwqkNVNMKGDDHPQHHDTAILLTRKDLCATMNHPCET--LGLSHVAGLCHpQLSCSVSEDTGLPL--AFTVAHELG 585
Cdd:cd04272 81 NF-----NEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTgtGGYAYVGGACT-ENRVAMGEDTPGSYygVYTMTHELA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 586 HSFGIQHDGTGnDCESIGKRP----------FIMSpqllYDRGIP--LTWSRCSREYITRFLDRGWGLCL 643
Cdd:cd04272 155 HLLGAPHDGSP-PPSWVKGHPgsldcpwddgYIMS----YVVNGErqYRFSQCSQRQIRNVFRRLGASCL 219
|
|
| ZnMc |
cd00203 |
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ... |
526-635 |
1.03e-14 |
|
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.
Pssm-ID: 238124 [Multi-domain] Cd Length: 167 Bit Score: 73.71 E-value: 1.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 526 PQHHDTAILLTRKDlcatmnHPCETLGLSHVAGLCHPQLSCSVSEDTGLP---LAFTVAHELGHSFGIQHDGTGNDCESI 602
Cdd:cd00203 49 IDKADIAILVTRQD------FDGGTGGWAYLGRVCDSLRGVGVLQDNQSGtkeGAQTIAHELGHALGFYHDHDRKDRDDY 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 114052955 603 GKRP-----------FIMSPQLL-YDRGIPLTWSRCSREYITRFL 635
Cdd:cd00203 123 PTIDdtlnaedddyySVMSYTKGsFSDGQRKDFSQCDIDQINKLY 167
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
736-788 |
5.19e-14 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 68.00 E-value: 5.19e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 114052955 736 WSGWSAWSVCSRSCGVGVRSSERQCTQPVPKNKGKYCVGERKRYRLCNLQACP 788
Cdd:smart00209 1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1695-1750 |
7.73e-14 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 67.48 E-value: 7.73e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1695 WVVGPWGQCSAPCGGGVQRRLVKCVNTqTGLAEEDSDLCSHEAWPESSRPCATEDC 1750
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQK-GGGSIVPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1018-1072 |
1.09e-13 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 67.09 E-value: 1.09e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1018 WHYGPWSKCPVTCGTGVQRQSLYCMEKQAGIVDEGH-CDHLSRPRDRKRkCNEEPC 1072
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQS-CNLKPC 55
|
|
| Reprolysin_5 |
pfam13688 |
Metallo-peptidase family M12; |
434-612 |
5.68e-13 |
|
Metallo-peptidase family M12;
Pssm-ID: 372673 Cd Length: 191 Bit Score: 69.37 E-value: 5.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 434 KEKWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSignPIHITVVRLIILEDEEKDLKI---THHADDTLKN 510
Cdd:pfam13688 1 STRTVALLVAADCSYVAAFGGDAAQANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPacsTGDSSDRLSE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 511 FCRWQKNvnmkgdDHPQHHDTAILLTRKDlcatmnhpCETLGLSHVAGLCHPQLSCSVSEDTGLP--------LAFTVAH 582
Cdd:pfam13688 78 FQDFSAW------RGTQNDDLAYLFLMTN--------CSGGGLAWLGQLCNSGSAGSVSTRVSGNnvvvstatEWQVFAH 143
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 114052955 583 ELGHSFGIQHDGT----------GNDCESIGKRpFIMSPQ 612
Cdd:pfam13688 144 EIGHNFGAVHDCDsstssqccppSNSTCPAGGR-YIMNPS 182
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1588-1643 |
8.65e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 61.70 E-value: 8.65e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1588 WRAGNWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCqPGPTKPPTRQLCGTQPC 1643
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1139-1187 |
6.54e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 59.00 E-value: 6.54e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1139 WGVGNWSQCSVTCGAGIRQRSVLCI---NNTGVP---CDGAERPITETFCFLQPC 1187
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1537-1585 |
5.31e-10 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 56.69 E-value: 5.31e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1537 WQVGNWSQCSTTCGLGAIWRLVRCSSG------NDEDCTLSSRPQPARHCHLRPC 1585
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| ADAMTS_CR_3 |
pfam19236 |
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ... |
794-892 |
4.97e-08 |
|
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.
Pssm-ID: 437068 Cd Length: 115 Bit Score: 53.17 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 794 FRHTQCSQFDSMLYK-----GKLHKW---VPVLNDENPCELHCRPFNYSNREKLRDAVMDGTPCYQGRISRD----ICID 861
Cdd:pfam19236 5 FMSQQCARTDGQPLRsspggASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDgtlsLCVL 84
|
90 100 110
....*....|....*....|....*....|.
gi 114052955 862 GICKKVGCDFELDSGAEEDRCGVCRGDGSTC 892
Cdd:pfam19236 85 GSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1646-1692 |
5.72e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 50.91 E-value: 5.72e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1646 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEESLRPNNTRPCNTHPC 1692
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1216-1525 |
7.78e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 7.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1216 PHQPVPRPS----------PASSPKPVSISNAIDEEDPELDPPGPvfvddfyydynfinfhedlsygsfeeshsdlvdig 1285
Cdd:PHA03247 2570 PPRPAPRPSepavtsrarrPDAPPQSARPRAPVDDRGDPRGPAPP----------------------------------- 2614
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1286 gqTVPPhirPTEPPSDSPvPTAGAPGAEEEGiQGSWSPSPllseashsPPVLLENTPVNPLANFLTEEESPIGAPELGLP 1365
Cdd:PHA03247 2615 --SPLP---PDTHAPDPP-PPSPSPAANEPD-PHPPPTVP--------PPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1366 SVSW-PPASVD--GMVTSVA----PGNPDELLVREDTQSQPSTPWSDRNKLSKDGNPLGPTSPALPKSPF----PTQPSS 1434
Cdd:PHA03247 2680 PQRPrRRAARPtvGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggPARPAR 2759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1435 PSNSTTQASLSPDAVEVS------TGWNVALDPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQSP-GLLPRPAQETQTNS 1507
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAgpprrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAP 2839
|
330
....*....|....*...
gi 114052955 1508 SKDPAvqPLQPSLVEDGA 1525
Cdd:PHA03247 2840 PPPPG--PPPPSLPLGGS 2855
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
1076-1129 |
1.15e-07 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 50.14 E-value: 1.15e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 114052955 1076 WWVGDWQPCSRSCGpGGFFRRAVFCTRSVGLDEQRalePSACGHLPRPLAEIPC 1129
Cdd:pfam19030 1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGGSIVP---DSECSAQKKPPETQSC 50
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1277-1588 |
7.38e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1277 SHSDLVDIGGQTVPPHIRPTEPPSDSPVPTAGAPGaeeegiqGSWSPSPLLSEASHSPPV-----LLENTPVNPLANFLT 1351
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA-------RQASPALPAAPAPPAVPAgpatpGGPARPARPPTTAGP 2766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1352 EEESPIGAPELGLP-SVSWPPASVDGMVTSVAPGNPDEllvrEDTQSQPSTPWSDRNKLSKDGNPLGPTSPALPKSPFPT 1430
Cdd:PHA03247 2767 PAPAPPAAPAAGPPrRLTRPAVASLSESRESLPSPWDP----ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1431 QPSSPSNSTTQASLSPdavevstGWNVALDPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQS-------PGLLPRPAQET 1503
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAP-------GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfalppdqPERPPQPQAPP 2915
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1504 QTNSSKDPAVQPL-QPSLVEDGAP-------TDLLPAKNASWQVGNWSQCSTTCGLGAIWRLvRCSSGNDEDCTLSSRPQ 1575
Cdd:PHA03247 2916 PPQPQPQPPPPPQpQPPPPPPPRPqpplaptTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF-RVPQPAPSREAPASSTP 2994
|
330
....*....|...
gi 114052955 1576 PARHCHLRPCAAW 1588
Cdd:PHA03247 2995 PLTGHSLSRVSSW 3007
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
737-787 |
7.40e-06 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 44.72 E-value: 7.40e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 114052955 737 SGWSAWSVCSRSCGVGVRSSERQCTQPVPknKGKYCVGERKRYRLCNLQAC 787
Cdd:pfam00090 1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
|
|
| TSP1_spondin |
pfam19028 |
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ... |
737-787 |
7.58e-06 |
|
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.
Pssm-ID: 465948 Cd Length: 52 Bit Score: 44.58 E-value: 7.58e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 114052955 737 SGWSAWSVCSRSCGVGVRSSERQCTQPvPKNKGKYCVGERKRyRLCNLQAC 787
Cdd:pfam19028 4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPCPELLER-RPCNLPPC 52
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1018-1073 |
8.04e-06 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 44.89 E-value: 8.04e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 114052955 1018 WHYGPWSKCPVTCGTGVQRQSLYCmEKQAGIVDEGHCDHlsrPRDRKRKCNEEPCP 1073
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| Reprolysin_2 |
pfam13574 |
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ... |
550-632 |
1.33e-05 |
|
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.
Pssm-ID: 372637 Cd Length: 193 Bit Score: 48.01 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 550 TLGLSHVAGLCHPQLSCsVSEDTGLPLAFT-------------VAHELGHSFGIQHDGTG--NDCESI----------GK 604
Cdd:pfam13574 86 ELGLAYVGQICQKGASS-PKTNTGLSTTTNygsfnyptqewdvVAHEVGHNFGATHDCDGsqYASSGCernaatsvcsAN 164
|
90 100
....*....|....*....|....*...
gi 114052955 605 RPFIMSPQllYDRGIPLtWSRCSREYIT 632
Cdd:pfam13574 165 GSFIMNPA--SKSNNDL-FSPCSISLIC 189
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1137-1187 |
1.41e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 44.11 E-value: 1.41e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 1137 SSWGvgNWSQCSVTCGAGIRQRSVLCINNT----GVPCDGAERpiTETFCFLQPC 1187
Cdd:smart00209 2 SEWS--EWSPCSVTCGGGVQTRTRSCCSPPpqngGGPCTGEDV--ETRACNEQPC 52
|
|
| Reprolysin_3 |
pfam13582 |
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ... |
481-593 |
2.90e-05 |
|
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.
Pssm-ID: 463926 [Multi-domain] Cd Length: 122 Bit Score: 45.05 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 481 IHITVVRLIILED-EEKDLKIThhADDTLKNFCRWqknvNMKGDDHPQHhDTAILLTRKDlcatmnhPCETLGLSHVAGL 559
Cdd:pfam13582 20 IRLQLAAIIITTSaDTPYTSSD--ALEILDELQEV----NDTRIGQYGY-DLGHLFTGRD-------GGGGGGIAYVGGV 85
|
90 100 110
....*....|....*....|....*....|....*..
gi 114052955 560 CHPQLSCSVSED---TGLPLAFTVAHELGHSFGIQHD 593
Cdd:pfam13582 86 CNSGSKFGVNSGsgpVGDTGADTFAHEIGHNFGLNHT 122
|
|
| ZnMc_TACE_like |
cd04270 |
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ... |
441-649 |
4.72e-05 |
|
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
Pssm-ID: 239798 [Multi-domain] Cd Length: 244 Bit Score: 46.98 E-value: 4.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 441 LVVADSKMVEYHGQPQVESYVLTIMNMVAG---LYHDPSIGNP----IHITVVRLIIL-EDEEKDLKITHHAddtlKNFC 512
Cdd:cd04270 6 LLVADHRFYKYMGRGEEETTINYLISHIDRvddIYRNTDWDGGgfkgIGFQIKRIRIHtTPDEVDPGNKFYN----KSFP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 513 RWQKNVNMKGDDHPQHHD---TAILLTRKDLcaTMNhpceTLGLSHVA--------GLCHPQLSCSV----SEDTGLPLA 577
Cdd:cd04270 82 NWGVEKFLVKLLLEQFSDdvcLAHLFTYRDF--DMG----TLGLAYVGsprdnsagGICEKAYYYSNgkkkYLNTGLTTT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 578 F-------------TVAHELGHSFGIQHDGTGNDC---ESIGKRpFIMSPQLLY-DRGIPLTWSRCSREYITRFLDRGWG 640
Cdd:cd04270 156 VnygkrvptkesdlVTAHELGHNFGSPHDPDIAECapgESQGGN-YIMYARATSgDKENNKKFSPCSKKSISKVLEVKSN 234
|
....*....
gi 114052955 641 LCLDDRPSK 649
Cdd:cd04270 235 SCFVERSQS 243
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1692-1751 |
7.11e-05 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 42.19 E-value: 7.11e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1692 CTQWvvGPWGQCSAPCGGGVQRRLVKCVNtqtGLAEEDSDLCSHEAwpESSRPCATEDCE 1751
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1287-1535 |
5.78e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1287 QTVPPH---IRPTEP--------PSDSPVPTAG-APGAEEEGIQGSWSPSPLLSEASHSPPVLLENTPvnplANFLTEEE 1354
Cdd:PHA03247 2566 RSVPPPrpaPRPSEPavtsrarrPDAPPQSARPrAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP----AANEPDPH 2641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1355 SPIGAPELGLPSVSWPPASVDGMVTSVAPGNPdellvredtqSQPSTPwsdrnklskdgnPLGPTSPALPKS-------- 1426
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRA----------AQASSP------------PQRPRRRAARPTvgsltsla 2699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1427 ---PFPTQPSSPSNSTTQASLSPDAVEVSTGWNVALdPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQSPGLLPRPAQET 1503
Cdd:PHA03247 2700 dppPPPPTPEPAPHALVSATPLPPGPAAARQASPAL-PAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260 270
....*....|....*....|....*....|..
gi 114052955 1504 QTNSSKDPAVQPLQPSLVEDGAPTDLLPAKNA 1535
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
|
|
| PTZ00441 |
PTZ00441 |
sporozoite surface protein 2 (SSP2); Provisional |
1144-1443 |
7.76e-04 |
|
sporozoite surface protein 2 (SSP2); Provisional
Pssm-ID: 240420 [Multi-domain] Cd Length: 576 Bit Score: 44.18 E-value: 7.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1144 WSQCSVTCGAGIRQRSvlcinntgvpcdgaeRPITETFCflqpcqystyivdtgasgsgssSPELFNEVDFDPHQPVPRP 1223
Cdd:PTZ00441 246 WTPCSVTCGKGTHSRS---------------RPILHEGC----------------------TTHMVEECEEEECPVEPEP 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1224 SPASSPKPVSisnaideedPELDPPGPvfVDDfyyDYNFINFHEDLSYGSFEESHS--------------DLVDIGGQTV 1289
Cdd:PTZ00441 289 LPVPAPVPPT---------PEDDNPRP--TDD---EFAVPNFNEGLDVPDNPQDPVpppnegkdgnpneeNLFPPGDDEV 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1290 PPHirPTEPPSDSPVPTAGAPGAEEEGIQGSWSPSPLLSEASHSPPV-----LLENTPVNP---LANFLTEEESP----I 1357
Cdd:PTZ00441 355 PDE--SNVPPNPPNVPGGSNSEFSSDVENPPNPPNPDIPEQEPNIPEdsnkeVPEDVPMEPeddRDNNFNEPKKPenkgD 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114052955 1358 GAPELGLPSVSWPPASVDGMVTSVAPGNPDEllvREDTQSQP-STPWSDRNKLSKDGNplgptspaLPKSPFPTQPSSPS 1436
Cdd:PTZ00441 433 GQNEPVIPKPLDNERDQSNKNKQVNPGNRHN---SEDRYTRPhGRNNENRNYNNKNSD--------IPKHPERSEHEQPE 501
|
....*..
gi 114052955 1437 NSTTQAS 1443
Cdd:PTZ00441 502 DKKKKSS 508
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
739-787 |
1.79e-03 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 38.20 E-value: 1.79e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 114052955 739 WSA--WSVCSRSCGVGVRSSERQCTQPVPK--NKGKYCVGERK--RYRLCNLQAC 787
Cdd:pfam19030 1 WVAgpWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
1144-1187 |
1.84e-03 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 37.78 E-value: 1.84e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 114052955 1144 WSQCSVTCGAGIRQRSVLCINNT--GVPCDGaerPITET-FCFLQPC 1187
Cdd:pfam00090 6 WSPCSVTCGKGIQVRQRTCKSPFpgGEPCTG---DDIETqACKMDKC 49
|
|
| TSP1_spondin |
pfam19028 |
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ... |
1645-1692 |
4.62e-03 |
|
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.
Pssm-ID: 465948 Cd Length: 52 Bit Score: 36.87 E-value: 4.62e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 114052955 1645 PWytSSWRECSEACGGGEQQR---LVTCPEPG--LCEESLRpnnTRPCNTHPC 1692
Cdd:pfam19028 5 EW--SEWSECSVTCGGGVQTRtrtVIVEPQNGgrPCPELLE---RRPCNLPPC 52
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1648-1692 |
6.09e-03 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 36.80 E-value: 6.09e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 114052955 1648 TSSWRECSEACGGGEQQRLVTC--PEPGLCEESLRPNN--TRPCNTHPC 1692
Cdd:smart00209 4 WSEWSPCSVTCGGGVQTRTRSCcsPPPQNGGGPCTGEDveTRACNEQPC 52
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
1591-1643 |
6.52e-03 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 36.41 E-value: 6.52e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 114052955 1591 GNWSKCSRNCGGGSATRDVQCVDtrdlrPLRPFHCQPGPTKPPTRQLCGTQPC 1643
Cdd:smart00209 5 SEWSPCSVTCGGGVQTRTRSCCS-----PPPQNGGGPCTGEDVETRACNEQPC 52
|
|
| TSP_1 |
pfam00090 |
Thrombospondin type 1 domain; |
1645-1692 |
6.96e-03 |
|
Thrombospondin type 1 domain;
Pssm-ID: 459668 [Multi-domain] Cd Length: 49 Bit Score: 36.24 E-value: 6.96e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 114052955 1645 PWytSSWRECSEACGGGEQQRLVTC----PEPGLCEESLRPnnTRPCNTHPC 1692
Cdd:pfam00090 2 PW--SPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIE--TQACKMDKC 49
|
|
| TSP1_CCN |
pfam19035 |
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ... |
1538-1585 |
7.72e-03 |
|
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.
Pssm-ID: 465952 Cd Length: 44 Bit Score: 36.16 E-value: 7.72e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 114052955 1538 QVGNWSQCSTTCGLGAIwrlVRCSSGNDEdCTLSsrpQPARHCHLRPC 1585
Cdd:pfam19035 4 QSTEWSPCSKTCGMGVS---TRVSNDNAE-CKLV---TETRLCQLRPC 44
|
|
| |
