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Conserved domains on  [gi|113677179|ref|NP_001038522|]
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probable methyltransferase-like protein 25 [Danio rerio]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
142-405 1.05e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam13679:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 138  Bit Score: 62.59  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  142 KKAHEVQSMSEVVASLAK----CCRVKQVIDVGSGKGYLCSYLSMR-YNLQVFGIDSSTTNTHGAQERNRKLKkfskAYQ 216
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKelldENGPITIVDHGAGKGYLGFILYYLkYGVRVYGIDTRAELVEKANALAQKLG----FNK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  217 QHRFIEnncvqsndesrehynesdgskncitkqGVEAQTESSALSQQVTrdllasnnaaecpldpsdsdsgssflsllal 296
Cdd:pfam13679  77 RMSFLE---------------------------GTIAGSTPVELPDRVD------------------------------- 98
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  297 dviedvslrvhpsklsaeererrkrenlerkaregkrkdsnsslfspltsyvtaetelktlitelenaVLVGLHTCGDLA 376
Cdd:pfam13679  99 --------------------------------------------------------------------VVTALHACDTAT 110
                         250       260
                  ....*....|....*....|....*....
gi 113677179  377 SSSLRMFRAKQeLRAVCSVGCCYHLLSEE 405
Cdd:pfam13679 111 DDALRFALAKQ-ARAIVLVPCCYHELAEQ 138
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
142-405 1.05e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 62.59  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  142 KKAHEVQSMSEVVASLAK----CCRVKQVIDVGSGKGYLCSYLSMR-YNLQVFGIDSSTTNTHGAQERNRKLKkfskAYQ 216
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKelldENGPITIVDHGAGKGYLGFILYYLkYGVRVYGIDTRAELVEKANALAQKLG----FNK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  217 QHRFIEnncvqsndesrehynesdgskncitkqGVEAQTESSALSQQVTrdllasnnaaecpldpsdsdsgssflsllal 296
Cdd:pfam13679  77 RMSFLE---------------------------GTIAGSTPVELPDRVD------------------------------- 98
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  297 dviedvslrvhpsklsaeererrkrenlerkaregkrkdsnsslfspltsyvtaetelktlitelenaVLVGLHTCGDLA 376
Cdd:pfam13679  99 --------------------------------------------------------------------VVTALHACDTAT 110
                         250       260
                  ....*....|....*....|....*....
gi 113677179  377 SSSLRMFRAKQeLRAVCSVGCCYHLLSEE 405
Cdd:pfam13679 111 DDALRFALAKQ-ARAIVLVPCCYHELAEQ 138
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
166-207 4.26e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 4.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 113677179 166 VIDVGSGKGYLCSYLSMRYNLQVFGIDSSTTNTHGAQERNRK 207
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAE 96
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
142-405 1.05e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 62.59  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  142 KKAHEVQSMSEVVASLAK----CCRVKQVIDVGSGKGYLCSYLSMR-YNLQVFGIDSSTTNTHGAQERNRKLKkfskAYQ 216
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKelldENGPITIVDHGAGKGYLGFILYYLkYGVRVYGIDTRAELVEKANALAQKLG----FNK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  217 QHRFIEnncvqsndesrehynesdgskncitkqGVEAQTESSALSQQVTrdllasnnaaecpldpsdsdsgssflsllal 296
Cdd:pfam13679  77 RMSFLE---------------------------GTIAGSTPVELPDRVD------------------------------- 98
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677179  297 dviedvslrvhpsklsaeererrkrenlerkaregkrkdsnsslfspltsyvtaetelktlitelenaVLVGLHTCGDLA 376
Cdd:pfam13679  99 --------------------------------------------------------------------VVTALHACDTAT 110
                         250       260
                  ....*....|....*....|....*....
gi 113677179  377 SSSLRMFRAKQeLRAVCSVGCCYHLLSEE 405
Cdd:pfam13679 111 DDALRFALAKQ-ARAIVLVPCCYHELAEQ 138
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
166-207 1.47e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 1.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 113677179  166 VIDVGSGKGYLCSYLSMRYNLQVFGIDSSTTNTHGAQERNRK 207
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAE 42
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
166-207 4.26e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 4.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 113677179 166 VIDVGSGKGYLCSYLSMRYNLQVFGIDSSTTNTHGAQERNRK 207
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAE 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
165-236 7.99e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 37.97  E-value: 7.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113677179 165 QVIDVGSGKGYLCSYLSMRYNLQVFGIDSSTTNTHGAQERNRKLKkfskaYQQHRFIENNCVQSNDESREHY 236
Cdd:COG0500   29 RVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAG-----LGNVEFLVADLAELDPLPAESF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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