NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|112983748|ref|NP_001037765|]
View 

V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IgV_VISTA cd20980
Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell ...
 34-179 5.56e-99

Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA); The members here are composed of the immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA; also known as B7-H5, PD-1H, Gi24, Dies1, SISP1 and DD1alpha). VISTA is an immune checkpoint protein involved in the regulation of T cell activity and inhibits the T cell response against cancer. VISTA is a type I transmembrane protein with a single IgV domain with sequence homology to the IgV domains of the members of B7 family. VISTA is the only B7 family member that lacks an IgC domain. VISTA is primarily expressed in white blood cells and its transcription is partially controlled by p53. Similar to PD-1/PD-L1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune system. Unlike the B7 family members, VISTA contains 10 beta-strands, instead of the nine that typically comprises of an IgV fold. Moreover, human VISTA contains the 21-residue extended loop between stands C and C', which does not align with any B7 family structure.


:

Pssm-ID: 409572  Cd Length: 147  Bit Score: 287.59  E-value: 5.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748  34 KVTTPYSLYVCPEGQNVTLTCRILDSVSKGHDANFLKTWFLSSRGEVQVCKEHRPIRNF-ISHHQHHRSHPAVNASHDQP 112
Cdd:cd20980    1 KVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLtFQDLHLHHGGQAANTSHDLA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112983748 113 QKHGLEIAYDNHGNFSITLHNVTLSDSGLYCCLVIEVKHHHPERRLYGYMELQVQTGKGSASTCTAY 179
Cdd:cd20980   81 QRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEQRLYGAMELQVQTGKDAPSTCVAY 147
 
Name Accession Description Interval E-value
IgV_VISTA cd20980
Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell ...
 34-179 5.56e-99

Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA); The members here are composed of the immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA; also known as B7-H5, PD-1H, Gi24, Dies1, SISP1 and DD1alpha). VISTA is an immune checkpoint protein involved in the regulation of T cell activity and inhibits the T cell response against cancer. VISTA is a type I transmembrane protein with a single IgV domain with sequence homology to the IgV domains of the members of B7 family. VISTA is the only B7 family member that lacks an IgC domain. VISTA is primarily expressed in white blood cells and its transcription is partially controlled by p53. Similar to PD-1/PD-L1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune system. Unlike the B7 family members, VISTA contains 10 beta-strands, instead of the nine that typically comprises of an IgV fold. Moreover, human VISTA contains the 21-residue extended loop between stands C and C', which does not align with any B7 family structure.


Pssm-ID: 409572  Cd Length: 147  Bit Score: 287.59  E-value: 5.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748  34 KVTTPYSLYVCPEGQNVTLTCRILDSVSKGHDANFLKTWFLSSRGEVQVCKEHRPIRNF-ISHHQHHRSHPAVNASHDQP 112
Cdd:cd20980    1 KVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLtFQDLHLHHGGQAANTSHDLA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112983748 113 QKHGLEIAYDNHGNFSITLHNVTLSDSGLYCCLVIEVKHHHPERRLYGYMELQVQTGKGSASTCTAY 179
Cdd:cd20980   81 QRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEQRLYGAMELQVQTGKDAPSTCVAY 147
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 36-147 2.34e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 57.08  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748   36 TTPYSLYVcPEGQNVTLTCRILDSVSKGHdanFLKTWFLSSRGEvqvcKEHRPIRNFISHHQHHRSHPAVNASHDQPQkh 115
Cdd:pfam07686   1 QTPREVTV-ALGGSVTLPCTYSSSMSEAS---TSVYWYRQPPGK----GPTFLIAYYSNGSEEGVKKGRFSGRGDPSN-- 70

                          90       100       110
                  ....*....|....*....|....*....|..
gi 112983748  116 gleiaydnhGNFSITLHNVTLSDSGLYCCLVI 147
Cdd:pfam07686  71 ---------GDGSLTIQNLTLSDSGTYTCAVI 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-146 1.37e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748    38 PYSLYVcPEGQNVTLTCRildsVSKGHDANFlkTWFlssrgevqvckehRPIRNFISHHQHHRSHPavnashdqpqkhgl 117
Cdd:smart00410   1 PPSVTV-KEGESVTLSCE----ASGSPPPEV--TWY-------------KQGGKLLAESGRFSVSR-------------- 46

                           90       100
                   ....*....|....*....|....*....
gi 112983748   118 eiaydNHGNFSITLHNVTLSDSGLYCCLV 146
Cdd:smart00410  47 -----SGSTSTLTISNVTPEDSGTYTCAA 70
 
Name Accession Description Interval E-value
IgV_VISTA cd20980
Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell ...
 34-179 5.56e-99

Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA); The members here are composed of the immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA; also known as B7-H5, PD-1H, Gi24, Dies1, SISP1 and DD1alpha). VISTA is an immune checkpoint protein involved in the regulation of T cell activity and inhibits the T cell response against cancer. VISTA is a type I transmembrane protein with a single IgV domain with sequence homology to the IgV domains of the members of B7 family. VISTA is the only B7 family member that lacks an IgC domain. VISTA is primarily expressed in white blood cells and its transcription is partially controlled by p53. Similar to PD-1/PD-L1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune system. Unlike the B7 family members, VISTA contains 10 beta-strands, instead of the nine that typically comprises of an IgV fold. Moreover, human VISTA contains the 21-residue extended loop between stands C and C', which does not align with any B7 family structure.


Pssm-ID: 409572  Cd Length: 147  Bit Score: 287.59  E-value: 5.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748  34 KVTTPYSLYVCPEGQNVTLTCRILDSVSKGHDANFLKTWFLSSRGEVQVCKEHRPIRNF-ISHHQHHRSHPAVNASHDQP 112
Cdd:cd20980    1 KVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLtFQDLHLHHGGQAANTSHDLA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112983748 113 QKHGLEIAYDNHGNFSITLHNVTLSDSGLYCCLVIEVKHHHPERRLYGYMELQVQTGKGSASTCTAY 179
Cdd:cd20980   81 QRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEQRLYGAMELQVQTGKDAPSTCVAY 147
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 36-147 2.34e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 57.08  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748   36 TTPYSLYVcPEGQNVTLTCRILDSVSKGHdanFLKTWFLSSRGEvqvcKEHRPIRNFISHHQHHRSHPAVNASHDQPQkh 115
Cdd:pfam07686   1 QTPREVTV-ALGGSVTLPCTYSSSMSEAS---TSVYWYRQPPGK----GPTFLIAYYSNGSEEGVKKGRFSGRGDPSN-- 70

                          90       100       110
                  ....*....|....*....|....*....|..
gi 112983748  116 gleiaydnhGNFSITLHNVTLSDSGLYCCLVI 147
Cdd:pfam07686  71 ---------GDGSLTIQNLTLSDSGTYTCAVI 93
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 123-146 8.53e-05

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 41.29  E-value: 8.53e-05
                         10        20
                 ....*....|....*....|....
gi 112983748 123 NHGNFSITLHNVTLSDSGLYCCLV 146
Cdd:cd20982   67 SKGDVSLTIENVTLADSGIYCCRI 90
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
 46-145 3.23e-04

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 39.03  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748  46 EGQNVTLTCRildsVSKGHDANFlkTWfLSSRGEVQVCKEHRPIRNfiSHHQhhrshpAVNASHDQpqkhgleiaydnhg 125
Cdd:cd05717   10 EGETLTLKCQ----VSLRDDSSL--QW-LNPNGQTIYFNDKRALRD--SRYQ------LLNHSASE-------------- 60

                         90       100
                 ....*....|....*....|
gi 112983748 126 nFSITLHNVTLSDSGLYCCL 145
Cdd:cd05717   61 -LSISVSNVTLSDEGVYTCL 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-146 1.37e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748    38 PYSLYVcPEGQNVTLTCRildsVSKGHDANFlkTWFlssrgevqvckehRPIRNFISHHQHHRSHPavnashdqpqkhgl 117
Cdd:smart00410   1 PPSVTV-KEGESVTLSCE----ASGSPPPEV--TWY-------------KQGGKLLAESGRFSVSR-------------- 46

                           90       100
                   ....*....|....*....|....*....
gi 112983748   118 eiaydNHGNFSITLHNVTLSDSGLYCCLV 146
Cdd:smart00410  47 -----SGSTSTLTISNVTPEDSGTYTCAA 70
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 113-145 4.08e-03

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 36.17  E-value: 4.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 112983748 113 QKHGLEI--AYDNHGNF--------SITLHNVTLSDSGLYCCL 145
Cdd:cd05846   49 KKYGVKIqpSYVRRISFtssglnstSITIWNVTLEDEGCYKCL 91
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 121-146 4.66e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.38  E-value: 4.66e-03
                         10        20
                 ....*....|....*....|....*.
gi 112983748 121 YDNHGNFSITLHNVTLSDSGLYCCLV 146
Cdd:cd00096   33 RSELGNGTLTISNVTLEDSGTYTCVA 58
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 37-146 6.43e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 35.45  E-value: 6.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983748  37 TPYSLYVCPEGQNVTLTCRIldsvsKGHDANFLKTWflssrgevqvCKE----HRPIRNFISHHQHHRShpavnASHDQP 112
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPY-----PPKYASSRKYW----------CKWgsegCQTLVSSEGVVPGGRI-----SLTDDP 61

                         90       100       110
                 ....*....|....*....|....*....|....
gi 112983748 113 QkhgleiaydnHGNFSITLHNVTLSDSGLYCCLV 146
Cdd:cd05716   62 D----------NGVFTVTLNQLRKEDAGWYWCGV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH