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Conserved domains on  [gi|112983998|ref|NP_001037746|]
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uncharacterized protein C10orf62 homolog [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5569 super family cl39257
Family of unknown function (DUF5569); This is a family of unknown function found in mammals.
 1-208 3.56e-82

Family of unknown function (DUF5569); This is a family of unknown function found in mammals.


The actual alignment was detected with superfamily member pfam17729:

Pssm-ID: 465472  Cd Length: 225  Bit Score: 247.62  E-value: 3.56e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998    1 MLWAQRKKRKATTETTED--KPAESHRP-NDSWIKSHFSRLSEEKLPAYRRVSSCGY----SPEGKHGEANTTLHVDTVT 73
Cdd:pfam17729   1 MLWIQRKRRKAVRESPGDedKSPESHKAkNESWIKSHFSRLSEEKLPTHHYASASGSatapQPESGSGEASTTIHMETFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998   74 TKHGEGGVALHRDSFASKQKISGTSVSKEMQRESGKSPSMENDTWAAVAACTKEIDAKGHHVANSVLQRSPEYHRTGHAE 153
Cdd:pfam17729  81 TRHGEGGTALHRESFTSKQKMSGSSVTKETHRESGKSSSTDEATWAAVAACTKEIDTKGRQLANSMLQRATVYQHSGHLE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 112983998  154 SRNISPEDLKALEEVELKLKGNFLTHRETVVAGANQAHTVY----NQSHHGNQSHQNHN 208
Cdd:pfam17729 161 SKDINQEELKALEEVEIKLKGNFLTQRENTVAGANHTHTFYshhgHQGHHSHSNHQSHS 219
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 165-302 1.16e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.95  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998  165 LEEVELKLKGNfLTHRETVVAGANQAHTVYNQSHHGNQ-----SHQNHNTYPCHQNNQSRSVHYQGHHPSHL-------- 231
Cdd:pfam09770 196 LEEVEAAMRAQ-AKKPAQQPAPAPAQPPAAPPAQQAQQqqqfpPQIQQQQQPQQQPQQPQQHPGQGHPVTILqrpqspqp 274

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112983998  232 -SHQGYPSYSSHQNHPGHPSQQGHSSHSNQQGHLGLSSQQGHPSQSSHqSHQGQPGHPNHQSHSLVNRRNQI 302
Cdd:pfam09770 275 dPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSFGRQAPI 345
 
Name Accession Description Interval E-value
DUF5569 pfam17729
Family of unknown function (DUF5569); This is a family of unknown function found in mammals.
 1-208 3.56e-82

Family of unknown function (DUF5569); This is a family of unknown function found in mammals.


Pssm-ID: 465472  Cd Length: 225  Bit Score: 247.62  E-value: 3.56e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998    1 MLWAQRKKRKATTETTED--KPAESHRP-NDSWIKSHFSRLSEEKLPAYRRVSSCGY----SPEGKHGEANTTLHVDTVT 73
Cdd:pfam17729   1 MLWIQRKRRKAVRESPGDedKSPESHKAkNESWIKSHFSRLSEEKLPTHHYASASGSatapQPESGSGEASTTIHMETFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998   74 TKHGEGGVALHRDSFASKQKISGTSVSKEMQRESGKSPSMENDTWAAVAACTKEIDAKGHHVANSVLQRSPEYHRTGHAE 153
Cdd:pfam17729  81 TRHGEGGTALHRESFTSKQKMSGSSVTKETHRESGKSSSTDEATWAAVAACTKEIDTKGRQLANSMLQRATVYQHSGHLE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 112983998  154 SRNISPEDLKALEEVELKLKGNFLTHRETVVAGANQAHTVY----NQSHHGNQSHQNHN 208
Cdd:pfam17729 161 SKDINQEELKALEEVEIKLKGNFLTQRENTVAGANHTHTFYshhgHQGHHSHSNHQSHS 219
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 165-302 1.16e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.95  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998  165 LEEVELKLKGNfLTHRETVVAGANQAHTVYNQSHHGNQ-----SHQNHNTYPCHQNNQSRSVHYQGHHPSHL-------- 231
Cdd:pfam09770 196 LEEVEAAMRAQ-AKKPAQQPAPAPAQPPAAPPAQQAQQqqqfpPQIQQQQQPQQQPQQPQQHPGQGHPVTILqrpqspqp 274

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112983998  232 -SHQGYPSYSSHQNHPGHPSQQGHSSHSNQQGHLGLSSQQGHPSQSSHqSHQGQPGHPNHQSHSLVNRRNQI 302
Cdd:pfam09770 275 dPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSFGRQAPI 345
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 189-274 3.56e-04

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 41.57  E-value: 3.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998 189 QAHTVYNQSHHGNQSHQNHNTYPCHQNNQSRSVHYQGHHPSHLSHQGYPSYSSHQNHPGHPSQQGHSSHSNQQGHLGlss 268
Cdd:cd22056  217 HPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFREPMRVH--- 293


                 ....*.
gi 112983998 269 QQGHPS 274
Cdd:cd22056  294 HQGHPG 299
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 188-292 2.02e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998  188 NQAHTVYNQSHHGNQSHQNHNTYPCHQNN-----QSRSVHYQGHHPshLSHQGYPSYSSHQNHPGHPSQQGHSShSNQQG 262
Cdd:TIGR01628 376 MQLQPRMRQLPMGSPMGGAMGQPPYYGQGpqqqfNGQPLGWPRMSM--MPTPMGPGGPLRPNGLAPMNAVRAPS-RNAQN 452

                          90       100       110
                  ....*....|....*....|....*....|
gi 112983998  263 HLGLSSQQGHPSQSSHQSHQGQPGHPNHQS 292
Cdd:TIGR01628 453 AAQKPPMQPVMYPPNYQSLPLSQDLPQPQS 482
 
Name Accession Description Interval E-value
DUF5569 pfam17729
Family of unknown function (DUF5569); This is a family of unknown function found in mammals.
 1-208 3.56e-82

Family of unknown function (DUF5569); This is a family of unknown function found in mammals.


Pssm-ID: 465472  Cd Length: 225  Bit Score: 247.62  E-value: 3.56e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998    1 MLWAQRKKRKATTETTED--KPAESHRP-NDSWIKSHFSRLSEEKLPAYRRVSSCGY----SPEGKHGEANTTLHVDTVT 73
Cdd:pfam17729   1 MLWIQRKRRKAVRESPGDedKSPESHKAkNESWIKSHFSRLSEEKLPTHHYASASGSatapQPESGSGEASTTIHMETFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998   74 TKHGEGGVALHRDSFASKQKISGTSVSKEMQRESGKSPSMENDTWAAVAACTKEIDAKGHHVANSVLQRSPEYHRTGHAE 153
Cdd:pfam17729  81 TRHGEGGTALHRESFTSKQKMSGSSVTKETHRESGKSSSTDEATWAAVAACTKEIDTKGRQLANSMLQRATVYQHSGHLE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 112983998  154 SRNISPEDLKALEEVELKLKGNFLTHRETVVAGANQAHTVY----NQSHHGNQSHQNHN 208
Cdd:pfam17729 161 SKDINQEELKALEEVEIKLKGNFLTQRENTVAGANHTHTFYshhgHQGHHSHSNHQSHS 219
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 165-302 1.16e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.95  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998  165 LEEVELKLKGNfLTHRETVVAGANQAHTVYNQSHHGNQ-----SHQNHNTYPCHQNNQSRSVHYQGHHPSHL-------- 231
Cdd:pfam09770 196 LEEVEAAMRAQ-AKKPAQQPAPAPAQPPAAPPAQQAQQqqqfpPQIQQQQQPQQQPQQPQQHPGQGHPVTILqrpqspqp 274

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112983998  232 -SHQGYPSYSSHQNHPGHPSQQGHSSHSNQQGHLGLSSQQGHPSQSSHqSHQGQPGHPNHQSHSLVNRRNQI 302
Cdd:pfam09770 275 dPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSFGRQAPI 345
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 189-274 3.56e-04

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 41.57  E-value: 3.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998 189 QAHTVYNQSHHGNQSHQNHNTYPCHQNNQSRSVHYQGHHPSHLSHQGYPSYSSHQNHPGHPSQQGHSSHSNQQGHLGlss 268
Cdd:cd22056  217 HPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFREPMRVH--- 293


                 ....*.
gi 112983998 269 QQGHPS 274
Cdd:cd22056  294 HQGHPG 299
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 188-292 2.02e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998  188 NQAHTVYNQSHHGNQSHQNHNTYPCHQNN-----QSRSVHYQGHHPshLSHQGYPSYSSHQNHPGHPSQQGHSShSNQQG 262
Cdd:TIGR01628 376 MQLQPRMRQLPMGSPMGGAMGQPPYYGQGpqqqfNGQPLGWPRMSM--MPTPMGPGGPLRPNGLAPMNAVRAPS-RNAQN 452

                          90       100       110
                  ....*....|....*....|....*....|
gi 112983998  263 HLGLSSQQGHPSQSSHQSHQGQPGHPNHQS 292
Cdd:TIGR01628 453 AAQKPPMQPVMYPPNYQSLPLSQDLPQPQS 482
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 210-285 2.78e-03

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 38.87  E-value: 2.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 112983998 210 YPCHQNNQSRSVHYQGHHPSHlsHQGYPSYSSHQNHPGHPSQQGHSSHSNQQgHLGLSSQQGHPSQSSHQSHQGQP 285
Cdd:cd22056  205 GQQKPKHQMHSVHPQAFTHHQ--AAGPGALQGRGGRGGPDCHLLHSSHHHHH-HHHLQYQYMNAPYPPHYAHQGAP 277
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 202-293 7.13e-03

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 37.80  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983998  202 QSHQNHNTYPCHQNNQSRSVHYQGHHPShlshQGYPSYSSHQNHPGHPSQQghSSHSNQQGHLGLSSQQGHPSQSSHQSH 281
Cdd:pfam05110  85 QEKPDQPFFPDKTSGLPPSFHTSSHSQP----MGPPSSSSPSVSSSQSQKK--SQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          90
                  ....*....|..
gi 112983998  282 QGQPGHPNHQSH 293
Cdd:pfam05110 159 RSKGGQESHSSS 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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