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Conserved domains on  [gi|112984196|ref|NP_001037720|]
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4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor [Rattus norvegicus]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 68-353 3.80e-151

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member PLN02809:

Pssm-ID: 469727  Cd Length: 289  Bit Score: 427.96  E-value: 3.80e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  68 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANR 147
Cdd:PLN02809   3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 148 PIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGS 227
Cdd:PLN02809  83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 228 CDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAV 307
Cdd:PLN02809 163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 112984196 308 AAVGAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLY 353
Cdd:PLN02809 243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 68-353 3.80e-151

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 427.96  E-value: 3.80e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  68 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANR 147
Cdd:PLN02809   3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 148 PIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGS 227
Cdd:PLN02809  83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 228 CDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAV 307
Cdd:PLN02809 163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 112984196 308 AAVGAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLY 353
Cdd:PLN02809 243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 71-352 7.53e-140

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 399.00  E-value: 7.53e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196   71 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIA 150
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  151 AGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDP 230
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  231 AvCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAV 310
Cdd:TIGR01474 161 A-AWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 112984196  311 GAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNL 352
Cdd:TIGR01474 240 ALLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 78-350 2.38e-117

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 341.37  E-value: 2.38e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  78 MRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAF 157
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 158 QSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCdPAVCLPLY 237
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSL-PLPALLLY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 238 FSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQ 317
Cdd:cd13959  160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQE 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112984196 318 IYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLG 350
Cdd:cd13959  240 HRLDLPDPLRSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 72-349 2.23e-75

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 234.74  E-value: 2.23e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  72 QPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPgcFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAA 151
Cdd:COG0382    1 RAYLRLLRLDRPIGILLLLWPTLWALFLAAGG--LPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 152 GDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPL-MKRVTFWPQLALGLTFNWGALLGWSAVKGScDP 230
Cdd:COG0382   79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGS-LP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 231 AVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSG-FGVAMVGALSLVGASSGQTLPYYAAVAA 309
Cdd:COG0382  158 LSAWLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 112984196 310 VG-AHLAHQIYTVD--IHRAEDCWEKFTSNRTVGLLLFLGIVL 349
Cdd:COG0382  238 ALlLLYLSQLWLLRprKKDPARALKLFKLNMLLGLLLFLGIAL 280
UbiA pfam01040
UbiA prenyltransferase family;
89-333 1.69e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 156.62  E-value: 1.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196   89 LYLPCTWSIGLAADPgcFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLT 168
Cdd:pfam01040   1 LLIPALAGLALAAGG--VPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  169 LALGVLLHLNYYSIAMGAASLLLVVTYPL-MKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVcLPLYFSGVMWTLIY 247
Cdd:pfam01040  79 LGLLLLLLLNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA-LLLALALFLWTWAI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  248 DTIYAHQDKKDDALIGLKSTALLF-RENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRA 326
Cdd:pfam01040 158 ALANDLRDREDDRKAGIKTLPVVLgRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237


                  ....*..
gi 112984196  327 EDCWEKF 333
Cdd:pfam01040 238 KKDAKAF 244
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 68-353 3.80e-151

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 427.96  E-value: 3.80e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  68 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANR 147
Cdd:PLN02809   3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 148 PIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGS 227
Cdd:PLN02809  83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 228 CDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAV 307
Cdd:PLN02809 163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 112984196 308 AAVGAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLY 353
Cdd:PLN02809 243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 71-352 7.53e-140

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 399.00  E-value: 7.53e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196   71 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIA 150
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  151 AGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDP 230
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  231 AvCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAV 310
Cdd:TIGR01474 161 A-AWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 112984196  311 GAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNL 352
Cdd:TIGR01474 240 ALLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 78-350 2.38e-117

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 341.37  E-value: 2.38e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  78 MRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAF 157
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 158 QSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCdPAVCLPLY 237
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSL-PLPALLLY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 238 FSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQ 317
Cdd:cd13959  160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQE 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112984196 318 IYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLG 350
Cdd:cd13959  240 HRLDLPDPLRSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 72-349 2.23e-75

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 234.74  E-value: 2.23e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  72 QPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPgcFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAA 151
Cdd:COG0382    1 RAYLRLLRLDRPIGILLLLWPTLWALFLAAGG--LPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 152 GDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPL-MKRVTFWPQLALGLTFNWGALLGWSAVKGScDP 230
Cdd:COG0382   79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGS-LP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 231 AVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSG-FGVAMVGALSLVGASSGQTLPYYAAVAA 309
Cdd:COG0382  158 LSAWLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 112984196 310 VG-AHLAHQIYTVD--IHRAEDCWEKFTSNRTVGLLLFLGIVL 349
Cdd:COG0382  238 ALlLLYLSQLWLLRprKKDPARALKLFKLNMLLGLLLFLGIAL 280
UbiA pfam01040
UbiA prenyltransferase family;
89-333 1.69e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 156.62  E-value: 1.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196   89 LYLPCTWSIGLAADPgcFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLT 168
Cdd:pfam01040   1 LLIPALAGLALAAGG--VPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  169 LALGVLLHLNYYSIAMGAASLLLVVTYPL-MKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVcLPLYFSGVMWTLIY 247
Cdd:pfam01040  79 LGLLLLLLLNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA-LLLALALFLWTWAI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  248 DTIYAHQDKKDDALIGLKSTALLF-RENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRA 326
Cdd:pfam01040 158 ALANDLRDREDDRKAGIKTLPVVLgRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237


                  ....*..
gi 112984196  327 EDCWEKF 333
Cdd:pfam01040 238 KKDAKAF 244
ubiA PRK12873
4-hydroxybenzoate polyprenyltransferase;
71-352 9.58e-42

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 171787 [Multi-domain]  Cd Length: 294  Bit Score: 147.89  E-value: 9.58e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  71 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAadPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIA 150
Cdd:PRK12873   7 LSPWFELLRWNKPTGRLILLIPAGWSLWLT--PSAPPSLLLLLLIILGGLAVSGAGCIANDLWDRRIDRKVERTKNRPLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 151 AGDISAFQSFVFLGAQLTLALGVLLHL----NYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKG 226
Cdd:PRK12873  85 RGKISLKTAYSLLIVLLLLSLFVVLSLpqpsRNLCLSLAFLALPPILIYPSAKRWFAYPQAILALCWGFAVLIPWAAAEG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 227 SCDPAVclPLYFS---GVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPY 303
Cdd:PRK12873 165 SLNGGW--PLLFCwlaTLLWTFGFDTVYAMADRRDDAKIGLNSSALSLGSNALKTVQICYFLTSIFLALAAFIAQVGFIF 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112984196 304 YAAVAavgahlahqIYTVDIHRaeDCWEKFTSNRT-------------VGLLLFLGIVLGNL 352
Cdd:PRK12873 243 WPFWL---------IASIGMQR--DILKLFPEKQSiktignhfsnqviLGSLLLLGLILARG 293
ubiA_other TIGR01475
putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this ...
 106-350 1.31e-22

putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this model represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273646  Cd Length: 282  Bit Score: 96.26  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  106 FPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMG 185
Cdd:TIGR01475  32 LPGLKTLILILIAAVSARTAAMAFNRIIDRAIDARNPRTKNRPLVSGLISKKEARTMIILSLALFLSASYFLNPLAFILS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  186 AASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGV-MWTLIYDTIYAHQDKKDDALIGL 264
Cdd:TIGR01475 112 PLVLLVLIIYPYTKRFTFLCHYVLGSTYGLAPLAGWVAVIGTISFFLVAWLLGIGVgFWIAGFDLIYAIQDYEFDRKNGL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  265 KSTALLFRENTKQWLSG-FGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRAEDCWEK-FTSNRTVGLL 342
Cdd:TIGR01475 192 HSIPARFGIKAALKIASlSHVITFILLLLVGFYVGNGYIALLALILIGLILAYEHYIVDPGDQSKIQRAfFYANGFLSIT 271


                  ....*...
gi 112984196  343 LFLGIVLG 350
Cdd:TIGR01475 272 FLIGVIID 279
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 79-350 1.65e-17

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 81.63  E-value: 1.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  79 RLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGtGAILMRGAGCTINDMWDRDFDKkvERTANRPIAAGDISAFQ 158
Cdd:cd13956    2 RLMRPYTLLYVLAPALAGAALAGAFAGPLPALLLLALL-AVFLGAGAGYALNDYTDRELDA--INKPDRPLPSGRLSPRQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 159 SFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLA-LGLTFNWGALLGWSAVKGSCDPAVCLPLY 237
Cdd:cd13956   79 ALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGWGvLGYATGLALLPGLGAVAAGGLVPLALLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 238 FSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQ 317
Cdd:cd13956  159 LVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAAGLLLAALILVVLLAVAGLLGPLALLALLAVALLALR 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112984196 318 IYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLG 350
Cdd:cd13956  239 ARFARADRLPALPRGFLLLAVYRLLLFAALLLA 271
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 57-244 1.77e-16

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 79.02  E-value: 1.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  57 SLSAAAVVNSAPRPLQPYLRLMrldKPIGTWLLYLpcTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRD 136
Cdd:COG0109    2 SSASASSAASLRSTLRDYLALT---KPRIILLLLF--TALAGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 137 FDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVL-LHLNYYSIAMGAASLLL-VVTY-PLMKRVTFWpqlalgltf 213
Cdd:COG0109   77 IDALMKRTKNRPLPTGRISPREALIFGLVLGVLGLALLaLFVNPLAALLGLLGIFFyVVVYtLWLKRRTPQ--------- 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 112984196 214 N--WGA-------LLGWSAVKGSCDPAvclPLYFSGVM--WT 244
Cdd:COG0109  148 NivIGGaagamppLIGWAAVTGSLSLE---ALLLFLIIflWT 186
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 78-231 1.95e-15

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 75.55  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  78 MRLDKPIGTWLLYLpcTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAF 157
Cdd:cd13957    1 LELTKPRITLLVLL--TALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 158 QSFVFLGAQLTLALGVLLHL-NYYSIAMGAASLLL-VVTYPLMKRVTFWpqlalgltFN--WGA-------LLGWSAVKG 226
Cdd:cd13957   79 HALIFGLVLGILGLALLALFvNPLTALLGLLGIFLyVFVYTPLKKRTTP--------LNtvIGGiagaippLIGWAAATG 150


                 ....*
gi 112984196 227 SCDPA 231
Cdd:cd13957  151 SLDLG 155
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 99-231 1.31e-14

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 73.64  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  99 LAADPGCFPDWYML-SLFGTGaiLMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHL 177
Cdd:PRK04375  34 LLAPPGVPPLLLLLlTLLGIA--LVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPREALIFGLVLGVLGFLLLGLF 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 112984196 178 -NYYSIAMGAASLLL-VVTYPL-MKRVTfwPQ------LAlgltfnwGA---LLGWSAVKGSCDPA 231
Cdd:PRK04375 112 vNPLAAWLTLAGIFFyVVVYTLwLKRRT--PQniviggAA-------GAmppLIGWAAVTGSLSWE 168
ubiA PRK13106
prenyltransferase; Reviewed
 74-274 4.68e-14

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 72.07  E-value: 4.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  74 YLRLMRLDKPigtwLLYLPCTWSIGLAADPGcFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGD 153
Cdd:PRK13106  18 ILRFLRIEQT----FFSLPMAYLGAFVAIKG-IPPISTLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRPLVTGA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 154 ISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVC 233
Cdd:PRK13106  93 IKISEAKALITAGLILFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLASIQGLAVFSGAVAVLGLYANSLI 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 112984196 234 LPLY-------FSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFREN 274
Cdd:PRK13106 173 QVLLrvpwlfvIGTILWAAGFDLYNHIPDAEFDREMGLHSFAVVLGKW 220
ubiA PRK12886
prenyltransferase; Reviewed
 108-298 1.94e-13

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 70.10  E-value: 1.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 108 DWYMLSLFGTgailmRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAA 187
Cdd:PRK12886  45 DWILMAMVGA-----RTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPLCLYLSPP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 188 SLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCD-PAVCLPLyfsGVM-WTLIYDTIYAHQDKKDDALIGLK 265
Cdd:PRK12886 120 ALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIRGTIElPAILLGL---AVLfWVAGFDILYALQDLEFDRKEGLH 196

                        170       180       190
                 ....*....|....*....|....*....|....
gi 112984196 266 STALLFRENTKQWLS-GFGVAMVGALSLVGASSG 298
Cdd:PRK12886 197 SIPAKLGVNGSLWIArVFHLLMIGFLFALGISAG 230
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 73-244 3.81e-13

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 68.81  E-value: 3.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196   73 PYLRLMrldKPIGTWLLYLPCTWSIGLAADPGCFPDWYML-SLFGTGaiLMRGAGCTINDMWDRDFDKKVERTANRPIAA 151
Cdd:TIGR01473   2 DYLQLT---KPRIISLLLITAFAGMWLAPGGALVNPPLLLlTLLGTT--LAAASANAFNMYIDRDIDKKMKRTRNRPLVT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  152 GDISAFQSFVFLGAQLTLALGVLL-HLNYYSIAMGAASLLL-VVTY-PLMKRVTFWPQLALGLTFNWGALLGWSAVKGSC 228
Cdd:TIGR01473  77 GRISPREALAFGLLLGVLGVAILAaFVNPLAALLGLFGIFFyVIVYtIWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSI 156

                         170
                  ....*....|....*..
gi 112984196  229 DP-AVCLPLYFsgVMWT 244
Cdd:TIGR01473 157 SLgAWLLFAII--FLWQ 171
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
107-266 1.11e-10

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 61.66  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 107 PDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGA 186
Cdd:PRK12888  36 VHWADLLLVTVAMVGARTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRTAWTGALVALAVFLGAAALLNPLCLALAP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 187 ASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCD-PAVCLPLYFSgvMWTLIYDTIYAHQDKKDDALIGLK 265
Cdd:PRK12888 116 LAVAPLVVYPYAKRFTNFPHAILGLAQAVGPVGAWIAVTGTWSwPAVLLGLAVG--LWIGGFDLIYACQDAEVDRRIGVR 193


                 .
gi 112984196 266 S 266
Cdd:PRK12888 194 S 194
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
129-354 1.87e-10

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 61.18  E-value: 1.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 129 INDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLA 208
Cdd:PRK12874  66 FNRLVDRDIDKDNPRTANRPSVDGRISVKSMVLFIVLNALIFIGVSYFINPLAFKLSFPFLIVLGGYSYFKRFSSLAHLV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 209 LGLTFNWGALLGWSAVKGSCDP-AVCLPLyfsGVM-WTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGF--GV 284
Cdd:PRK12874 146 LGLSLGLAPIAGVVAVLGEIPLwSVFLAL---GVMfWVAGFDLLYSLQDMEFDKKRGLHSIPSKFGEKATLFISRLfhLL 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112984196 285 AMVGALSLVGASSGQTLPYYAAVAAVGAHLA-HQIYTVD---IHRAedcweKFTSNRTVGLLLFLGIVLGNLYK 354
Cdd:PRK12874 223 AVLFWLLFVWCAHLGLFAYLGVIVSALILLYeHYLVRKDfkkIDKA-----FFTLNGYLGIVFFIFIVLDVLFK 291
ubiA PRK12876
prenyltransferase; Reviewed
 109-266 1.28e-09

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 58.60  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 109 WYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAAS 188
Cdd:PRK12876  46 IKTISLGGSAFFCARTVGIIVNQIIDCAIDKKNPRTSSRVLPAKLLSINFSMLLLTLCSFLFLSLCWLLNPLCFSLAVLS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 189 LLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGScdpAVCLPLYFSGVMWTLIY-------DTIYAHQDKKDDAL 261
Cdd:PRK12876 126 TLLMIIYPYTKRVTFLCHWILGLVYYLAILMNFFAIIET---PLSFSLFCMASLWGISFgmiiaanDIIYAIQDLEFDRK 202


                 ....*
gi 112984196 262 IGLKS 266
Cdd:PRK12876 203 EGLFS 207
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 129-195 5.92e-05

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 44.39  E-value: 5.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112984196 129 INDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTY 195
Cdd:cd13963   52 LNDLLDLEADRLHPTKRNRPIASGRLSIPAALALAVVLLLAGLALALLLSPAFLLVLLAYLVLNLAY 118
ubiA PRK12882
prenyltransferase; Reviewed
 120-289 9.40e-05

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 43.81  E-value: 9.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 120 ILMRGAGCTINDMWDRDFDkKVERtANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYP-LM 198
Cdd:PRK12882  48 FLATGAGNAINDYFDREID-RINR-PDRPIPSGAVSPRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAeTL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 199 KRVTFWPQLAL----GLTFNWGAllgwsAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFREN 274
Cdd:PRK12882 126 KGTPGLGNASVayltGSTFLFGG-----AAVGTEGLLALLVLFALAALATLAREIIKDVEDIEGDRAEGARTLPILIGVR 200

                        170
                 ....*....|....*.
gi 112984196 275 TKQWL-SGFGVAMVGA 289
Cdd:PRK12882 201 KALYVaAAFLLVAVAA 216
ubiA PRK12895
prenyltransferase; Reviewed
 99-266 2.00e-04

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 42.88  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  99 LAADPGCFPDWYMLSLFGtgAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLN 178
Cdd:PRK12895  28 IAAGHYIHPIKILLILIA--AVSARTSAMSINRIEGLRYDMINPRKKDWALVSGRIKMREAIAFTIIFIAIFEICTFLLN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 179 YYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGS--CDPAVCLpLYFSGVMWTLIYDTIYAHQDK 256
Cdd:PRK12895 106 RLVFILSPIVIFLFIIDPFLKRYTAWRHIYMGSIIGLGVLAGYLAVIPAfpYNLLIYI-IFISSSLWIAGFDIIYVIPDI 184

                        170
                 ....*....|
gi 112984196 257 KDDALIGLKS 266
Cdd:PRK12895 185 EYDKINGLKT 194
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 119-243 7.24e-04

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 41.03  E-value: 7.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 119 AILMRGAGCTINDMWDRDFDKkVERtANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPL- 197
Cdd:cd13964   41 SVLLYAAGMVLNDVFDAELDA-RER-PERPIPSGRVSRGAALALGAGLLAAGVALAALVGRLSGLVALLLAAAILLYDAw 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 112984196 198 MKRVTFWPqLALGLTFNWGALLGWSAVKGSCDP-----AVCLPLYFSGVMW 243
Cdd:cd13964  119 LKHTPLGP-LLMGLCRGLNLLLGASAAAAGGLGpallaALALGVYIAGVTY 168
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 73-303 1.46e-03

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 39.79  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  73 PYLRLMRLDKP----IGTWLLYlpctwsIGLAADPGCFPDWYMLSLFGTGAILMrGAGCTINDMWDRDFDkKVERTaNRP 148
Cdd:cd13961    1 AYLELIRPPNLlmaaLAQYLGA------LFALGPLLSLNDLELLLLFLSVFLIA-AAGYIINDYFDVEID-RINKP-DRP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 149 IAAGDIS---AFQSFVFLGAqLTLALGVLLHLNYYSIAMGAASLLLVVTYPLmKRVTFWPQLA----LGLTFnwgaLLGW 221
Cdd:cd13961   72 IPSGRISrreALILSILLNA-LGLILAFLLSPLALLIALLNSLLLWLYSHKL-KRTPLIGNLLvallTGLPF----LFGG 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 222 SAVKGSCDPAVCLPLyFSGVMwTLIYDTIYAHQDKKDDALIGLKSTALLF-RENTKQWLSGFGVAMVGALSLVGASSGQT 300
Cdd:cd13961  146 LAAGNLLLIILLLAL-FAFLI-TLGREIVKDIEDVEGDRAEGARTLPIVYgIKKAKKIAALLLLLAILLSPLPYLLGGLG 223


                 ...
gi 112984196 301 LPY 303
Cdd:cd13961  224 ILY 226
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 97-195 2.27e-03

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 39.42  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196  97 IGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWD--RDFDKKVERTANRPIAAGDISAFQ----SFVFLGAQLTLA 170
Cdd:cd13962   20 TALAYYLGGFFNWLLFLLALLAALLLQIGVNLANDYFDykKGTDTEPRSGPSRVLVSGLLSPRQvlraALVLLLLAALLG 99

                         90       100
                 ....*....|....*....|....*
gi 112984196 171 LGVLLHLNYYSIAMGAASLLLVVTY 195
Cdd:cd13962  100 LYLVALGGWLLLLLGLLGILAGYFY 124
PLN02776 PLN02776
prenyltransferase
 128-238 2.79e-03

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 39.34  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984196 128 TINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVL-LHLNYYSIAMGAASLLL-VVTYPLMKRVTFWP 205
Cdd:PLN02776  47 TLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVAWAVVVGAAGVALLaYKTNMLTAGLGAGNILLyAFVYTPLKQIHPAN 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 112984196 206 qlalgltfNW-GA-------LLGWSAVKGSCDP-AVCLP--LYF 238
Cdd:PLN02776 127 --------TWvGAvvgaippLMGWAAASGQLDAgAMVLAaaLYF 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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