Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s)

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 116007442   477 CSLCHRPVLmagthlYCIIRLECGHVYHKPCIQGELLKNCNEC 519
Cdd:smart00184   1 CPICLEEYL------KDPVILPCGHTFCRSCIRKWLESGNNTC 37

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007442  267 EIVVHQLE--HNQEYLYWYLDSLLKKDPSNV--FQKKLISLYAIFDR-NKLLPFLKRSKDYDIQEALVICKQENFYPEIV 341
Cdd:pfam00637  11 SRVVKLFEkaGLLEELISYLESALKEDSRENpaLQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAKLCEKADLYEEAV 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 116007442  342 YLLGCMGgvEASEALNiIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEI 395
Cdd:pfam00637  91 ILYKKIG--NWKEAIS-LLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRF 141

RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 41 (Vps41) and similar proteins; Vps41, also known as S53, is a protein involved in trafficking of proteins from the late Golgi to the vacuole. It interacts with caspase-8, suggesting a potential role of Vps41 beyond lysosomal trafficking. It has been identified as a potential therapeutic target for human Parkinson's disease (PD). Vps41 and the soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein VAMP7 are specifically involved in the fusion of the trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes. Vps41 is a specific subunit of the lysosomal tethering complex HOPS (homotypic vacuole fusion and protein sorting) that also includes Vps39 and a Class C Vps core complex composed of Vps11, Vps16, Vps18, and Vps33. HOPS operates at the lysosomal vacuole, controls all traffic from late endosomes into the vacuole and interacts with the Rab7/Ypt7-GTP form. The HOPS-specific Vps39 and Vps41 subunits belong to the class B Vps. They form a subcomplex that interacts with Rab7/Ypt7 and is are required for homotypic and heterotypic late endosome fusion. Vps41 contains an N-terminal WD40 repeat, one or two clathrin repeats and a C3H2C3-type RING-H2 finger domain close to its C-terminus.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 116007442 474 EQLCSLCHRPVLMAGTHLYC-IIRLECGHVYHKPCIQGELLKNCNECN 520
Cdd:cd16690    2 EQICEACHRPLLVSDLRKAFnVVVFFCRHAFHEDCLPAQNVEFCNICS 49

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007442  267 EIVVHQLE--HNQEYLYWYLDSLLKKDPSNV--FQKKLISLYAIFDR-NKLLPFLKRSKDYDIQEALVICKQENFYPEIV 341
Cdd:pfam00637  11 SRVVKLFEkaGLLEELISYLESALKEDSRENpaLQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAKLCEKADLYEEAV 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 116007442  342 YLLGCMGgvEASEALNiIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEI 395
Cdd:pfam00637  91 ILYKKIG--NWKEAIS-LLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRF 141

RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 41 (Vps41) and similar proteins; Vps41, also known as S53, is a protein involved in trafficking of proteins from the late Golgi to the vacuole. It interacts with caspase-8, suggesting a potential role of Vps41 beyond lysosomal trafficking. It has been identified as a potential therapeutic target for human Parkinson's disease (PD). Vps41 and the soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein VAMP7 are specifically involved in the fusion of the trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes. Vps41 is a specific subunit of the lysosomal tethering complex HOPS (homotypic vacuole fusion and protein sorting) that also includes Vps39 and a Class C Vps core complex composed of Vps11, Vps16, Vps18, and Vps33. HOPS operates at the lysosomal vacuole, controls all traffic from late endosomes into the vacuole and interacts with the Rab7/Ypt7-GTP form. The HOPS-specific Vps39 and Vps41 subunits belong to the class B Vps. They form a subcomplex that interacts with Rab7/Ypt7 and is are required for homotypic and heterotypic late endosome fusion. Vps41 contains an N-terminal WD40 repeat, one or two clathrin repeats and a C3H2C3-type RING-H2 finger domain close to its C-terminus.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 116007442 474 EQLCSLCHRPVLMAGTHLYC-IIRLECGHVYHKPCIQGELLKNCNECN 520
Cdd:cd16690    2 EQICEACHRPLLVSDLRKAFnVVVFFCRHAFHEDCLPAQNVEFCNICS 49