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Conserved domains on  [gi|112293289|ref|NP_001036203|]
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somatotropin precursor [Macaca mulatta]

Protein Classification

somatotropin_like domain-containing protein( domain architecture ID 10178929)

somatotropin_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
35-215 1.31e-94

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


:

Pssm-ID: 198435  Cd Length: 180  Bit Score: 273.94  E-value: 1.31e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  35 LFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQtSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPA-AFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289 115 PVQFLRSVFANSLVYGTSySDVYDLLKDLEEGIQTLMGRLEDGSSRTGQIFKQTYSKFDTNSHNNDALLKNYGLLYCFRK 194
Cdd:cd10285   80 PVQFLSSVFTNQLHFGSS-DRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYSKFDVNLRSDEALLKNYGLLSCFKK 158
                        170       180
                 ....*....|....*....|..
gi 112293289 195 DMDKIETFLRIVQCRS-VEGSC 215
Cdd:cd10285  159 DMHKVETYLRVMKCRRfPESNC 180
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
35-215 1.31e-94

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 273.94  E-value: 1.31e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  35 LFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQtSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPA-AFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289 115 PVQFLRSVFANSLVYGTSySDVYDLLKDLEEGIQTLMGRLEDGSSRTGQIFKQTYSKFDTNSHNNDALLKNYGLLYCFRK 194
Cdd:cd10285   80 PVQFLSSVFTNQLHFGSS-DRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYSKFDVNLRSDEALLKNYGLLSCFKK 158
                        170       180
                 ....*....|....*....|..
gi 112293289 195 DMDKIETFLRIVQCRS-VEGSC 215
Cdd:cd10285  159 DMHKVETYLRVMKCRRfPESNC 180
Hormone_1 pfam00103
Somatotropin hormone family;
22-215 5.08e-64

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 197.60  E-value: 5.08e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289   22 QEGSAFPT---------IPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQkySFLQnpQTSLCFSESIPTPSNREE 92
Cdd:pfam00103  10 ENVASCPScapdnvgcrMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKG--YFIR--RTTSCHTNSIHTPENREK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289   93 TQQKSNLELLRISLLLIQSWLEPVQFLR----SVFANSLVYGTSYSDVYDLLKDLEEGIQTLMGRLEDgSSRTGQIFKQT 168
Cdd:pfam00103  86 AQQTSNEELLKWSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVID-PERTENEAYPA 164
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 112293289  169 YSKFD--TNSHNNDALLKNYGLLYCFRKDMDKIETFLRIVQCR-SVEGSC 215
Cdd:pfam00103 165 WSGLSslTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRlIYKDSC 214
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
35-215 1.31e-94

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 273.94  E-value: 1.31e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  35 LFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQtSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPA-AFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289 115 PVQFLRSVFANSLVYGTSySDVYDLLKDLEEGIQTLMGRLEDGSSRTGQIFKQTYSKFDTNSHNNDALLKNYGLLYCFRK 194
Cdd:cd10285   80 PVQFLSSVFTNQLHFGSS-DRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYSKFDVNLRSDEALLKNYGLLSCFKK 158
                        170       180
                 ....*....|....*....|..
gi 112293289 195 DMDKIETFLRIVQCRS-VEGSC 215
Cdd:cd10285  159 DMHKVETYLRVMKCRRfPESNC 180
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
35-215 8.19e-74

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 221.22  E-value: 8.19e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  35 LFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKysflQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10284    1 LFDRAIPHAERVYHLSSEAYAEFEEKYIPGENP----PNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289 115 PVQFLRSVFAN----SLVYGTSYSDVYDLLKDLEEGIQTLMGRLEDgSSRTGQIFKQTYSKFDTnsHNNDALLKNYGLLY 190
Cdd:cd10284   77 PLLHLHTVLANskgtSLALLPKAKQVSEMLKLLEDGVETLSERIKD-LPLEFNSVGALWSVDET--HNSLRRMHDYDLLS 153
                        170       180
                 ....*....|....*....|....*
gi 112293289 191 CFRKDMDKIETFLRIVQCRSVEGSC 215
Cdd:cd10284  154 CFKKDAHKVETYLKILKCRRFEHSC 178
Hormone_1 pfam00103
Somatotropin hormone family;
22-215 5.08e-64

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 197.60  E-value: 5.08e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289   22 QEGSAFPT---------IPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQkySFLQnpQTSLCFSESIPTPSNREE 92
Cdd:pfam00103  10 ENVASCPScapdnvgcrMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKG--YFIR--RTTSCHTNSIHTPENREK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289   93 TQQKSNLELLRISLLLIQSWLEPVQFLR----SVFANSLVYGTSYSDVYDLLKDLEEGIQTLMGRLEDgSSRTGQIFKQT 168
Cdd:pfam00103  86 AQQTSNEELLKWSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVID-PERTENEAYPA 164
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 112293289  169 YSKFD--TNSHNNDALLKNYGLLYCFRKDMDKIETFLRIVQCR-SVEGSC 215
Cdd:pfam00103 165 WSGLSslTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRlIYKDSC 214
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
22-215 8.56e-23

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 91.46  E-value: 8.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  22 QEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPkeqkySFLQNPQTSL---CFSESIPTPSNREETQQKSN 98
Cdd:cd10286   10 DTGGRCCSISLEKLLDRAIQHAELIYRVSEESCTLFEEMFIP-----FSVRALLIQEgnaCSTKTVSIPTSKTEIQQISD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  99 LELLRISLLLIQSWLEPVQFLRSVFAN------SLVYGTSYsdVYDLLKDLEEGIQTLMGR-LEDGSSRTGQIFKQTYSK 171
Cdd:cd10286   85 KWLLHSVLILVQFWIDPLVDLQTSLDRydnapsALLNKTKW--MSTKLMNLEQGVLVLIRKmLGEGMLLNNESPADTLDH 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 112293289 172 FDTnSHNNDALLKNYGLLYCFRKDMDKIETFLRIVQCRSVEG-SC 215
Cdd:cd10286  163 FVM-SDMLESVLRDYTLLSCFKKDAHKVETFLKLLKCRQTDRlNC 206
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
30-214 1.43e-20

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 85.39  E-value: 1.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  30 IPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSflqnPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLI 109
Cdd:cd10288   13 LSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVD----RALTSCHTSSLTTPENKEQAQQIKNEDLLKLIISLL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289 110 QSWLEPVQFLRSVFANSL-VYGTSYSDVydllKDLEEGIQTLMGRLEDGSSR--TGQIFKQTYS-----KFDTNSHNNDA 181
Cdd:cd10288   89 RSWNEPLKHLVTELSSMKgAPDTILSKA----KEIEEKNKELLEGLKRILSRvqPGIEENEDYPvwsglPSLQSSDEDSR 164
                        170       180       190
                 ....*....|....*....|....*....|...
gi 112293289 182 LLKNYGLLYCFRKDMDKIETFLRIVQCRSVEGS 214
Cdd:cd10288  165 LFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGN 197
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
32-215 3.67e-13

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 65.28  E-value: 3.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289  32 LSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQnpqtslCFSESIPTPSNREETQQKSNLELLRISLLLIQS 111
Cdd:cd10287    1 VADLFDRVIQHSSRMHSLSSELHWELEQYFLPSRNIRRKRK------CHTAGILTPNGKENAQKLEREELTEVILRLLGA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293289 112 WLEPVQFLRSVFANSLVYgTSYS-----DVYDLLKDLEEGIQTLMGRL----EDGSSRTGQIFKQTYSKFDTNSHNndaL 182
Cdd:cd10287   75 WREPLSHFHQSMGHDKDF-NSYSpgkakQMSDMVHELRDGVEKVTEKMqllgVISNSLGGLSPEDAGPSAISGHLD---A 150
                        170       180       190
                 ....*....|....*....|....*....|....
gi 112293289 183 LKNYGLLYCFRKDMDKIETFLRIVQCRSV-EGSC 215
Cdd:cd10287  151 MSDYDLLHCFRRDSNKVQNYLKILKCRIFpESSC 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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