Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   186 YYVTGFFIAVSVITNVVeTVPCGTVPGSKElpcgeRYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVV 265
Cdd:pfam00520   1 SRYFELFILLLILLNTI-FLALETYFQPEE-----PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   266 AIMPYYIGLVMTNNEDVSGaFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG 345
Cdd:pfam00520  75 VVLPSLISLVLSSVGSLSG-LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   346 S---------SASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGK-------IFGSICSLSGVLVIALPVPVIVSNFSRI 409
Cdd:pfam00520 154 KlktwenpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                  ...
gi 86991434   410 YHQ 412
Cdd:pfam00520 234 TER 236

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   186 YYVTGFFIAVSVITNVVeTVPCGTVPGSKElpcgeRYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVV 265
Cdd:pfam00520   1 SRYFELFILLLILLNTI-FLALETYFQPEE-----PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   266 AIMPYYIGLVMTNNEDVSGaFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG 345
Cdd:pfam00520  75 VVLPSLISLVLSSVGSLSG-LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   346 S---------SASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGK-------IFGSICSLSGVLVIALPVPVIVSNFSRI 409
Cdd:pfam00520 154 KlktwenpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                  ...
gi 86991434   410 YHQ 412
Cdd:pfam00520 234 TER 236

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434    42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEKE--FFFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDEL 118
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 86991434   119 AFYGILPEIIGDC 131
Cdd:pfam02214  81 EFYGLDELALELC 93

voltage-gated potassium channel protein;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  297 IFKFSRHSQGLRILGYTLKSCAselgFLLF--------SLT----MAIIIFATVMFYAEKGSS------ASKFTSIPASF 358
Cdd:PRK10537  98 AITLHFYPWLKFLIGYCIVLLV----ALLIyrrdfdrsSLAagtlFAVISITSLLFYSTFGALylgdgfSPPIESLSTAF 173

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 86991434  359 WYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIA-----LPVPVIVSNFSRI 409
Cdd:PRK10537 174 YFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisaIFGPVIRGNLKRL 229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 85
Cdd:cd18417   1 ATWLPFARAAAVGWLPLAKKPMPKPPSDKKRRNDEILVVNVSGRRFQTWKNTLDRYPDTLLGSSEKEFFYNEDTQEYFFD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 86991434  86 RDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18417  81 RDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  41 LIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF 120
Cdd:cd18380   1 RIVINVSGRRFETWKNTLEKYPDTLLGSTEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECISAYDDELAF 80

                        90       100
                ....*....|....*....|..
gi 86991434 121 YGILPEIIGDCCYEEYKDRKRE 142
Cdd:cd18380  81 FGILPEIIGDCCYEDYRDRKRE 102

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   186 YYVTGFFIAVSVITNVVeTVPCGTVPGSKElpcgeRYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVV 265
Cdd:pfam00520   1 SRYFELFILLLILLNTI-FLALETYFQPEE-----PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   266 AIMPYYIGLVMTNNEDVSGaFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG 345
Cdd:pfam00520  75 VVLPSLISLVLSSVGSLSG-LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434   346 S---------SASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGK-------IFGSICSLSGVLVIALPVPVIVSNFSRI 409
Cdd:pfam00520 154 KlktwenpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                  ...
gi 86991434   410 YHQ 412
Cdd:pfam00520 234 TER 236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEK---EFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDEL 118
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKpgrEFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLREEC 80

                ...
gi 86991434 119 AFY 121
Cdd:cd18187  81 DFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF 120
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKlAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                ..
gi 86991434 121 YG 122
Cdd:cd18317  81 WG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDT-LLGSTEKEFFFNED----TKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAY 114
Cdd:cd18414   3 DRIVINVGGTRHETYRSTLRTLPGTrLAWLAEPDAHSNFDydprADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLY 82

                        90       100       110
                ....*....|....*....|....*....|....*
gi 86991434 115 DDELAFYGILPEIIGDCCYEEYkdRKRENAERLMD 149
Cdd:cd18414  83 EEELAFWGIDETDVEPCCWMTY--RQHRDAEEALD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  44 LNVSGRRFQT-WRTtLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECIS 112
Cdd:cd18378   6 LNVGGVRHEVlWRT-LDRLPRTRLGrlrecNTHESLLelcddYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCVL 84

                        90       100
                ....*....|....*....|....
gi 86991434 113 AYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18378  85 SFSQELEYWGIDEIYLESCCQHRY 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  39 DELIVLNVSGRRFQTWRTTLERYPDT---LLGSTEKEFFFNEDT-------------KEYFFDRDPEVFRCVLNFYRTGK 102
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTrlaLLASSDPQGDCLTQCsqvggsdgspgggNEFFFDRHPGVFAYVLNYYRTGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 86991434 103 LHYPRYECISAYDDELAFYGILPEIIGDCCYEEYkdRKRENAE 145
Cdd:cd18415  81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY--RQHRDAE 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYE 109
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGkllncHSEEAILelcddYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80

                        90       100
                ....*....|....*....|....*...
gi 86991434 110 CISAYDDELAFYGILPEIIGDCCYEEYK 137
Cdd:cd18428  81 CVFSFCQEIEYWGINELFIDSCCSNRYQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLG----STEKEFFFN--ED----TKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18413   4 VVINVGGVKHEVLWRTLDRMPHTRLGklrdSNTHEAIVElcDDyslaDNEYFFDRHPRSFASILNFYRTGKLHLVEEMCV 83

                        90       100
                ....*....|....*....|....*
gi 86991434 112 SAYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18413  84 LAFSDDLEYWGVDELYLESCCQHKY 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYE 109
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAAlfSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDF 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLL--------GSTEKEFFFNED----TKEYFFDRDPEVFRCVLNFYRTGKLHYPRYE 109
Cdd:cd18381   3 IVVNVGGVRQVLYGDVLNRYPETRLaellnclsGGYDAIFSLCDDydpgKREFYFDRDPDAFKCIIEVYYYGEIHMKKGI 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 86991434 110 CISAYDDELAFYGILPEIIGDCCYEEYKDRKRE 142
Cdd:cd18381  83 CPICFKNEMDFWRVDLDFLDECCKCHLSEKREE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18384   1 IRINVGGFRRRLSASALLRFPGTRLGrllacHSEEAILelcddYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                        90       100
                ....*....|....*....|....*
gi 86991434 112 SAYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18384  81 FSFSQEIEYWGINEFFLDSCCSYRY 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18406   1 ERVIINIAGLRFETQLGTLNQFPDTLLGDPDKRMrYFDPLRNEYFFDRNRPSFDGILYFYQSgGKIRRPVNVSIDVFADE 80

                ....
gi 86991434 118 LAFY 121
Cdd:cd18406  81 IRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6); KCNA6, also called voltage-gated potassium channel HBK2 or voltage-gated potassium channel subunit Kv1.6, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA6 is distributed primarily in neurons of central and peripheral nervous systems. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA6 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18407   1 ERLVINISGLRFETQLRTLSIFPDTLLGDPSRRVrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVHVPLDIFLEE 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86991434 118 LAFYGilpeiIGDCCYEEYKDrkrenaerlmDDNDSENNQESMPSLSFRQTMWRAFENPHTS 179
Cdd:cd18407  81 IRFYQ-----LGQEAIETFRE----------DEGFIPEEEKPLPSHHFQRQVWLLFEYPESS 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18423   4 IIINVGGIKYLMPWSTLDEFPLTRLGklkfcSSYEEIVqicddYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREMCA 83

                        90       100
                ....*....|....*....|..
gi 86991434 112 SAYDDELAFYGILPEIIGDCCY 133
Cdd:cd18423  84 LSFQEELTYWGIEEANLERCCL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18411  12 VKLNVGGLAHEVLWRTLDRLPRTRLGklrdcNTHESLMeicddYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 91

                        90       100
                ....*....|....*....|....*
gi 86991434 112 SAYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18411  92 LSFSQELDYWGIDEIYLESCCQARY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18426   1 ININVGGLKRRLSSSTLSKFPDTRLGrllscDSEESILqicddYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80

                        90       100
                ....*....|....*....|....*
gi 86991434 112 SAYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18426  81 FSFSQEIEYWGINEFFLDSCCSYRY 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18405   1 ERVVINVSGLRFETQLKTLAQFPETLLGDPEKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLKRPVNVPFDIFSEE 80

                ....
gi 86991434 118 LAFY 121
Cdd:cd18405  81 VKFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18402   9 ERVVINIAGLRFETQLKTLAQFPNTLLGNPKKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDMFSEE 88

                ....
gi 86991434 118 LAFY 121
Cdd:cd18402  89 IKFY 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEK-EFFFNEDTK-EYFFDRDPEVFRCVLNFYRTGKLHYPR-YECISAYDDEL 118
Cdd:cd18394   5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMFRgDFPTARDSQgNYFIDRDGPLFRYILNFLRTSELTLPVdFKEFDLLRKEA 84

                ....*....
gi 86991434 119 AFYGILPEI 127
Cdd:cd18394  85 DFYQIEPLI 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  38 QDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNE----------DTKEYFFDRDPEVFRCVLNFYRTGKLHYPR 107
Cdd:cd18421   2 RTRHVIINVGGIKYRIPWTTLEEFPLTRLGQLKSCNNFDEimdicddydvTCNEFFFDRNPCAFRTILTFLRAGKLRLLR 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 86991434 108 YECISAYDDELAFYGILPEIIGDCCYEEYKDR 139
Cdd:cd18421  82 EMCALSFQEELLYWGIEEENLEWCCRRRLLQK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  42 IVLNVSGRRFQTWRTTLERYPDTLLGST-EKEFFFNEDTKEYFF-DRDPEVFRCVLNFYRTGKLHYPR-YECISAYDDEL 118
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYPDSMLGAMfSGKFPTKKDSQGNCFiDRDGKIFRYILNFLRTSHLDLPEdFQEMGLLKREA 82

                ....*....
gi 86991434 119 AFYGILPEI 127
Cdd:cd18395  83 DFYQIQPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  44 LNVSGRRFQTWRTTLERYPDTLLG----STEKEFF------FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISA 113
Cdd:cd18425   3 INVGGTSYQISYRVAASYPKTRIGrlatYTDRSRKldlcddYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCPRN 82

                        90       100
                ....*....|....*....|....*.
gi 86991434 114 YDDELAFYGILPEIIGDCCYEEYKDR 139
Cdd:cd18425  83 FLEEINYWGVRIKNTPRCCRISFEER 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86991434  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKE--YFFDRDPEVFRCVLNFYRTGKLHyPRYECISAYdDE 117
Cdd:cd18366   4 EVVPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRHHIPKDSEgrYFIDRDGSYFGYILNFLRDGDLP-PRERARAVY-KE 81

                ....*...
gi 86991434 118 LAFYGILP 125
Cdd:cd18366  82 AQYYGIGP 89