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Conserved domains on  [gi|85662402|ref|NP_001034243|]
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cadherin-8 isoform 1 precursor [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-387 9.05e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 9.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANI 360
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 85662402 361 HIDPRFSsrgpfkdTATVKIVVEDADE 387
Cdd:cd11304  78 GGPPLSS-------TATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 395-492 1.16e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 395 TYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 85662402 474 HSQISRVPVAIKVLDVNDN 492
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-272 2.29e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 171 PYHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQP--YFSIEPETAIIKTALPnMDREAKEEYLVVIQAKD 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 85662402 249 MGGHSggLSGTTTLTVTLTDVNDN 272
Cdd:cd11304  77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 7.41e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 7.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402     87 TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 499-602 2.10e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 499 EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFlYSLLPEMVNNPnFTIkknEDNSLSILAKhNGFNRQKQEVYLLPIVI 578
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGL-FSI---DPSTGEITTA-KPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 85662402 579 SDSGNPPLSSTSTLTIRVCGcSND 602
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLD-VND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-387 9.05e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 9.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANI 360
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 85662402 361 HIDPRFSsrgpfkdTATVKIVVEDADE 387
Cdd:cd11304  78 GGPPLSS-------TATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 395-492 1.16e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 395 TYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 85662402 474 HSQISRVPVAIKVLDVNDN 492
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-272 2.29e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 171 PYHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQP--YFSIEPETAIIKTALPnMDREAKEEYLVVIQAKD 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 85662402 249 MGGHSggLSGTTTLTVTLTDVNDN 272
Cdd:cd11304  77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 7.41e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 7.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402     87 TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-163 1.14e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402  81 LVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQ 158
Cdd:cd11304  15 VVLTVSaTDPDSGENgEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD-GGGPPLSSTATVTITVL 93


                ....*
gi 85662402 159 DINDN 163
Cdd:cd11304  94 DVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 499-602 2.10e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 499 EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFlYSLLPEMVNNPnFTIkknEDNSLSILAKhNGFNRQKQEVYLLPIVI 578
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGL-FSI---DPSTGEITTA-KPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 85662402 579 SDSGNPPLSSTSTLTIRVCGcSND 602
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLD-VND 97
Cadherin pfam00028
Cadherin domain;
281-383 8.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 8.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANI 360
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 85662402   361 HIDPRFSsrgpfkdTATVKIVVE 383
Cdd:pfam00028  77 GGPPLSS-------TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 5.74e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 5.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    414 TARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 85662402    493 AP 494
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 299-389 2.98e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 2.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    299 KANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSsrgpfkdTATV 378
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPE----TGEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TATV 69

                           90
                   ....*....|..
gi 85662402    379 KIVVEDA-DEPP 389
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
172-253 3.83e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   172 YHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQPY--FSIEPETAIIKTALPnMDREAKEEYLVVIQAKDM 249
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ....
gi 85662402   250 GGHS 253
Cdd:pfam00028  77 GGPP 80
Cadherin pfam00028
Cadherin domain;
500-597 8.18e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 8.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   500 YEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFlYSLLPEMVNNpNFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIVIS 579
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGG-NFRI--DPDTGDISTTKP--LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 85662402   580 DSGNPPLSSTSTLTIRVC 597
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-274 1.53e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    190 TATDADDpvyGNSAKLVYSILEG--QPYFSIEPETAIIKTALPnMDREAKEEYLVVIQAKDMGGHSggLSGTTTLTVTLT 267
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITVL 74


                   ....*..
gi 85662402    268 DVNDNPP 274
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
396-487 5.11e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   396 YLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHtDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNH 474
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 85662402   475 SQISRVPVAIKVL 487
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
75-158 3.54e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    75 SGPEPILVGRLHTDLDPGSKkIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFI 154
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 85662402   155 IKVQ 158
Cdd:pfam00028  89 ITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 518-602 1.86e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 1.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    518 SAMDKDDPKNGHFFlYSLLPEMVNNPnFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVC 597
Cdd:smart00112   1 SATDADSGENGKVT-YSILSGNDDGL-FSI--DPETGEITTTKP--LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*
gi 85662402    598 GCsND 602
Cdd:smart00112  75 DV-ND 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-387 9.05e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 9.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANI 360
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 85662402 361 HIDPRFSsrgpfkdTATVKIVVEDADE 387
Cdd:cd11304  78 GGPPLSS-------TATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 395-492 1.16e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 395 TYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 85662402 474 HSQISRVPVAIKVLDVNDN 492
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-272 2.29e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 171 PYHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQP--YFSIEPETAIIKTALPnMDREAKEEYLVVIQAKD 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 85662402 249 MGGHSggLSGTTTLTVTLTDVNDN 272
Cdd:cd11304  77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 7.41e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 7.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402     87 TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-163 1.14e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402  81 LVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQ 158
Cdd:cd11304  15 VVLTVSaTDPDSGENgEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD-GGGPPLSSTATVTITVL 93


                ....*
gi 85662402 159 DINDN 163
Cdd:cd11304  94 DVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 499-602 2.10e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402 499 EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFlYSLLPEMVNNPnFTIkknEDNSLSILAKhNGFNRQKQEVYLLPIVI 578
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGL-FSI---DPSTGEITTA-KPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 85662402 579 SDSGNPPLSSTSTLTIRVCGcSND 602
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLD-VND 97
Cadherin pfam00028
Cadherin domain;
281-383 8.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 8.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANI 360
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 85662402   361 HIDPRFSsrgpfkdTATVKIVVE 383
Cdd:pfam00028  77 GGPPLSS-------TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 5.74e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 5.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    414 TARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 85662402    493 AP 494
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 299-389 2.98e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 2.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    299 KANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSsrgpfkdTATV 378
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPE----TGEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TATV 69

                           90
                   ....*....|..
gi 85662402    379 KIVVEDA-DEPP 389
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
172-253 3.83e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   172 YHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQPY--FSIEPETAIIKTALPnMDREAKEEYLVVIQAKDM 249
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ....
gi 85662402   250 GGHS 253
Cdd:pfam00028  77 GGPP 80
Cadherin pfam00028
Cadherin domain;
500-597 8.18e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 8.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   500 YEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFlYSLLPEMVNNpNFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIVIS 579
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGG-NFRI--DPDTGDISTTKP--LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 85662402   580 DSGNPPLSSTSTLTIRVC 597
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-274 1.53e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    190 TATDADDpvyGNSAKLVYSILEG--QPYFSIEPETAIIKTALPnMDREAKEEYLVVIQAKDMGGHSggLSGTTTLTVTLT 267
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITVL 74


                   ....*..
gi 85662402    268 DVNDNPP 274
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
396-487 5.11e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402   396 YLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHtDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNH 474
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 85662402   475 SQISRVPVAIKVL 487
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
75-158 3.54e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    75 SGPEPILVGRLHTDLDPGSKkIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFI 154
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 85662402   155 IKVQ 158
Cdd:pfam00028  89 ITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 518-602 1.86e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 1.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402    518 SAMDKDDPKNGHFFlYSLLPEMVNNPnFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVC 597
Cdd:smart00112   1 SATDADSGENGKVT-YSILSGNDDGL-FSI--DPETGEITTTKP--LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*
gi 85662402    598 GCsND 602
Cdd:smart00112  75 DV-ND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 70-163 2.73e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.96  E-value: 2.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85662402  70 VLEEFSGPEpiLVGRLHTDLDPGSKKIKYILS--GDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPl 147
Cdd:cd00031   6 AVEGRSRGS--FRVSIPTDLIASSGEIIKISAagKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP- 82

                        90
                ....*....|....*.
gi 85662402 148 EPPSEFIIKVQDINDN 163
Cdd:cd00031  83 QTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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