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Conserved domains on  [gi|442621894|ref|NP_001034077|]
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uncharacterized protein Dmel_CG34041, isoform F [Drosophila melanogaster]

Protein Classification

prolyl 4-hydroxylase subunit alpha( domain architecture ID 10551023)

prolyl 4-hydroxylase catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P4Ha_N pfam08336
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are ...
 260-391 1.50e-25

Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.


:

Pssm-ID: 462433  Cd Length: 135  Bit Score: 101.97  E-value: 1.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621894  260 SKSKVINILKIQENVVKYLENYIYALETKLKTIDEALIDLATYHIQFERDKLAIASSPVASYSLIHHMQSDWTHWQLFLQ 339
Cdd:pfam08336   1 SVSGLEKLLELERELIDNLENYIEELEEKLDTLKRFLEELKREHEKADEDPEEYLSNPLNAFSLIKRLHQDWPKWEKLMK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442621894  340 EDPGKDELASLMSIKKY---LPTKNDISEVCHGISKMLNAYLMTAQDIANGVILG 391
Cdd:pfam08336  81 TNQAVGFLEQLTEMRSRllkLPTDEDLEGAAEALLRLQDTYNLDPSDLANGNLNG 135
P4Ha_N pfam08336
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are ...
 29-138 9.53e-24

Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.


:

Pssm-ID: 462433  Cd Length: 135  Bit Score: 96.96  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621894   29 SSTKMKAYLDLDTRLKTQLRGYSEDLQDHISTLNRYIDDRKSELDKVGKDPEVYLGNPLNSFSLLHHLHFDWPAWRKLME 108
Cdd:pfam08336   1 SVSGLEKLLELERELIDNLENYIEELEEKLDTLKRFLEELKREHEKADEDPEEYLSNPLNAFSLIKRLHQDWPKWEKLMK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 442621894  109 KPLATEY---ITEIQEMWSEMPTKDEYTNSIKA 138
Cdd:pfam08336  81 TNQAVGFleqLTEMRSRLLKLPTDEDLEGAAEA 113
LapB super family cl34526
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 435-505 5.05e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG2956:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 5.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442621894 435 YNKSKEWLNvAISMLESSAYWDPivPSADLYLKLAEVYVKQQNWTLALETVEFALKSNPRNAQLIRMQKRL 505
Cdd:COG2956  120 YEQEGDWEK-AIEVLERLLKLGP--ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187
 
Name Accession Description Interval E-value
P4Ha_N pfam08336
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are ...
 260-391 1.50e-25

Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.


Pssm-ID: 462433  Cd Length: 135  Bit Score: 101.97  E-value: 1.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621894  260 SKSKVINILKIQENVVKYLENYIYALETKLKTIDEALIDLATYHIQFERDKLAIASSPVASYSLIHHMQSDWTHWQLFLQ 339
Cdd:pfam08336   1 SVSGLEKLLELERELIDNLENYIEELEEKLDTLKRFLEELKREHEKADEDPEEYLSNPLNAFSLIKRLHQDWPKWEKLMK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442621894  340 EDPGKDELASLMSIKKY---LPTKNDISEVCHGISKMLNAYLMTAQDIANGVILG 391
Cdd:pfam08336  81 TNQAVGFLEQLTEMRSRllkLPTDEDLEGAAEALLRLQDTYNLDPSDLANGNLNG 135
P4Ha_N pfam08336
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are ...
 29-138 9.53e-24

Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.


Pssm-ID: 462433  Cd Length: 135  Bit Score: 96.96  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621894   29 SSTKMKAYLDLDTRLKTQLRGYSEDLQDHISTLNRYIDDRKSELDKVGKDPEVYLGNPLNSFSLLHHLHFDWPAWRKLME 108
Cdd:pfam08336   1 SVSGLEKLLELERELIDNLENYIEELEEKLDTLKRFLEELKREHEKADEDPEEYLSNPLNAFSLIKRLHQDWPKWEKLMK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 442621894  109 KPLATEY---ITEIQEMWSEMPTKDEYTNSIKA 138
Cdd:pfam08336  81 TNQAVGFleqLTEMRSRLLKLPTDEDLEGAAEA 113
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 435-505 5.05e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 5.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442621894 435 YNKSKEWLNvAISMLESSAYWDPivPSADLYLKLAEVYVKQQNWTLALETVEFALKSNPRNAQLIRMQKRL 505
Cdd:COG2956  120 YEQEGDWEK-AIEVLERLLKLGP--ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187
 
Name Accession Description Interval E-value
P4Ha_N pfam08336
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are ...
 260-391 1.50e-25

Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.


Pssm-ID: 462433  Cd Length: 135  Bit Score: 101.97  E-value: 1.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621894  260 SKSKVINILKIQENVVKYLENYIYALETKLKTIDEALIDLATYHIQFERDKLAIASSPVASYSLIHHMQSDWTHWQLFLQ 339
Cdd:pfam08336   1 SVSGLEKLLELERELIDNLENYIEELEEKLDTLKRFLEELKREHEKADEDPEEYLSNPLNAFSLIKRLHQDWPKWEKLMK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442621894  340 EDPGKDELASLMSIKKY---LPTKNDISEVCHGISKMLNAYLMTAQDIANGVILG 391
Cdd:pfam08336  81 TNQAVGFLEQLTEMRSRllkLPTDEDLEGAAEALLRLQDTYNLDPSDLANGNLNG 135
P4Ha_N pfam08336
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are ...
 29-138 9.53e-24

Prolyl 4-Hydroxylase alpha-subunit, N-terminal region; The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.


Pssm-ID: 462433  Cd Length: 135  Bit Score: 96.96  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621894   29 SSTKMKAYLDLDTRLKTQLRGYSEDLQDHISTLNRYIDDRKSELDKVGKDPEVYLGNPLNSFSLLHHLHFDWPAWRKLME 108
Cdd:pfam08336   1 SVSGLEKLLELERELIDNLENYIEELEEKLDTLKRFLEELKREHEKADEDPEEYLSNPLNAFSLIKRLHQDWPKWEKLMK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 442621894  109 KPLATEY---ITEIQEMWSEMPTKDEYTNSIKA 138
Cdd:pfam08336  81 TNQAVGFleqLTEMRSRLLKLPTDEDLEGAAEA 113
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 435-505 5.05e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 5.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442621894 435 YNKSKEWLNvAISMLESSAYWDPivPSADLYLKLAEVYVKQQNWTLALETVEFALKSNPRNAQLIRMQKRL 505
Cdd:COG2956  120 YEQEGDWEK-AIEVLERLLKLGP--ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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