C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
912-1665
0e+00
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.
The actual alignment was detected with superfamily member pfam16206:
Pssm-ID: 465066 Cd Length: 827 Bit Score: 1365.19 E-value: 0e+00
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
13-181
3.39e-68
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
:
Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 227.14 E-value: 3.39e-68
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
213-380
1.58e-32
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.
:
Pssm-ID: 463703 Cd Length: 154 Bit Score: 124.14 E-value: 1.58e-32
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
827-909
1.61e-19
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.
:
Pssm-ID: 462756 Cd Length: 84 Bit Score: 84.46 E-value: 1.61e-19
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
912-1665
0e+00
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.
Pssm-ID: 465066 Cd Length: 827 Bit Score: 1365.19 E-value: 0e+00
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
13-181
3.39e-68
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 227.14 E-value: 3.39e-68
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
213-380
1.58e-32
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.
Pssm-ID: 463703 Cd Length: 154 Bit Score: 124.14 E-value: 1.58e-32
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
827-909
1.61e-19
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.
Pssm-ID: 462756 Cd Length: 84 Bit Score: 84.46 E-value: 1.61e-19
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
912-1665
0e+00
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.
Pssm-ID: 465066 Cd Length: 827 Bit Score: 1365.19 E-value: 0e+00
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
13-181
3.39e-68
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 227.14 E-value: 3.39e-68
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
213-380
1.58e-32
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.
Pssm-ID: 463703 Cd Length: 154 Bit Score: 124.14 E-value: 1.58e-32
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
827-909
1.61e-19
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.
Pssm-ID: 462756 Cd Length: 84 Bit Score: 84.46 E-value: 1.61e-19
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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