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Conserved domains on  [gi|201027430|ref|NP_001032880|]
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WD repeat-containing protein 43 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11456769)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-305 9.83e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 9.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  20 AFSPDSQaYFALASSDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWAParlqakeshqrkkrkseaigtndqaD--LL 97
Cdd:COG2319  127 AFSPDGK-TLASGSADGTVRLWDLATGKLLRTL--TGH-SGAVTSVAFSP-------------------------DgkLL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  98 ALGTAVGSILLYSTVKGELHSKLisGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCIS 177
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 178 PDGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTtirPNesqpfdgvtGLYFLSGAvHDRLLNVWQVRSenk 255
Cdd:COG2319  256 PDGRLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PD---------GKLLASGS-DDGTVRLWDLAT--- 319

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 201027430 256 eKSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE-------HVLNGH 305
Cdd:COG2319  320 -GKLLRTLTGHTGAVR-SVAFSPDGK---TLASGSDDGTVRLWDlatgellRTLTGH 371
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 472-574 1.90e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.78  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  472 NDFEMLNKVLQTRNVNLIKKTVLRMPLHAVIPLLQELTKRLQGHPNSAVLMVQWLKCVLTIHASYLSTLPDLVHQLGTLY 551
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....
gi 201027430  552 QLMESRVKTFQKLSHLH-GKLILL 574
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNlGALDYL 104
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-305 9.83e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 9.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  20 AFSPDSQaYFALASSDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWAParlqakeshqrkkrkseaigtndqaD--LL 97
Cdd:COG2319  127 AFSPDGK-TLASGSADGTVRLWDLATGKLLRTL--TGH-SGAVTSVAFSP-------------------------DgkLL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  98 ALGTAVGSILLYSTVKGELHSKLisGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCIS 177
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 178 PDGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTtirPNesqpfdgvtGLYFLSGAvHDRLLNVWQVRSenk 255
Cdd:COG2319  256 PDGRLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PD---------GKLLASGS-DDGTVRLWDLAT--- 319

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 201027430 256 eKSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE-------HVLNGH 305
Cdd:COG2319  320 -GKLLRTLTGHTGAVR-SVAFSPDGK---TLASGSDDGTVRLWDlatgellRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-271 8.58e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 8.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  19 CAFSPDSQaYFALASSDGHLRVWETANNRLHQEYVpsAHLSGtCTCLAWAPARlqakeshqrkkrkseaigtndqaDLLA 98
Cdd:cd00200   57 VAASADGT-YLASGSSDKTIRLWDLETGECVRTLT--GHTSY-VSSVAFSPDG-----------------------RILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  99 LGTAVGSILLYSTVKGELHSKLisGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISP 178
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 179 DGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTTIRpnesqpfdgvtglYFLSGAVHDRLLNVWQVRSenke 256
Cdd:cd00200  188 DGEKLLSSSsdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-------------YLLASGSEDGTIRVWDLRT---- 250

                        250
                 ....*....|....*
gi 201027430 257 KSAVMSFTVTDEPVY 271
Cdd:cd00200  251 GECVQTLSGHTNSVT 265
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 472-574 1.90e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.78  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  472 NDFEMLNKVLQTRNVNLIKKTVLRMPLHAVIPLLQELTKRLQGHPNSAVLMVQWLKCVLTIHASYLSTLPDLVHQLGTLY 551
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....
gi 201027430  552 QLMESRVKTFQKLSHLH-GKLILL 574
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNlGALDYL 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-154 1.12e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 201027430   124 GHEKRVNCIQWHQDNDCLYSCSDDKYIVEWS 154
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
124-154 4.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.36e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 201027430  124 GHEKRVNCIQWHQDNDCLYSCSDDKYIVEWS 154
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-305 9.83e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 9.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  20 AFSPDSQaYFALASSDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWAParlqakeshqrkkrkseaigtndqaD--LL 97
Cdd:COG2319  127 AFSPDGK-TLASGSADGTVRLWDLATGKLLRTL--TGH-SGAVTSVAFSP-------------------------DgkLL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  98 ALGTAVGSILLYSTVKGELHSKLisGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCIS 177
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 178 PDGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTtirPNesqpfdgvtGLYFLSGAvHDRLLNVWQVRSenk 255
Cdd:COG2319  256 PDGRLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PD---------GKLLASGS-DDGTVRLWDLAT--- 319

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 201027430 256 eKSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE-------HVLNGH 305
Cdd:COG2319  320 -GKLLRTLTGHTGAVR-SVAFSPDGK---TLASGSDDGTVRLWDlatgellRTLTGH 371
WD40 COG2319
WD40 repeat [General function prediction only];
20-252 7.65e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 7.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  20 AFSPDSQaYFALASSDGHLRVWETANNRLHQEYvpsAHLSGTCTCLAWAParlqakeshqrkkrkseaigtNDQadLLAL 99
Cdd:COG2319  211 AFSPDGK-LLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAFSP---------------------DGR--LLAS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 100 GTAVGSILLYSTVKGELHSKLisGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISPD 179
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 201027430 180 GKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTtirPNesqpfdgvtGLYFLSGAvHDRLLNVWQVRS 252
Cdd:COG2319  342 GKTLASGSddGTVRLWDLATGELLRTLTGHTGAVTSVAFS---PD---------GRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-271 8.58e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 8.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  19 CAFSPDSQaYFALASSDGHLRVWETANNRLHQEYVpsAHLSGtCTCLAWAPARlqakeshqrkkrkseaigtndqaDLLA 98
Cdd:cd00200   57 VAASADGT-YLASGSSDKTIRLWDLETGECVRTLT--GHTSY-VSSVAFSPDG-----------------------RILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  99 LGTAVGSILLYSTVKGELHSKLisGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISP 178
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 179 DGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTTIRpnesqpfdgvtglYFLSGAVHDRLLNVWQVRSenke 256
Cdd:cd00200  188 DGEKLLSSSsdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-------------YLLASGSEDGTIRVWDLRT---- 250

                        250
                 ....*....|....*
gi 201027430 257 KSAVMSFTVTDEPVY 271
Cdd:cd00200  251 GECVQTLSGHTNSVT 265
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 472-574 1.90e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.78  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  472 NDFEMLNKVLQTRNVNLIKKTVLRMPLHAVIPLLQELTKRLQGHPNSAVLMVQWLKCVLTIHASYLSTLPDLVHQLGTLY 551
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....
gi 201027430  552 QLMESRVKTFQKLSHLH-GKLILL 574
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNlGALDYL 104
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-312 6.93e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 6.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  91 NDQADLLALGTAVGSILLYSTVKGELHSKLIsgGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSS 170
Cdd:cd00200   18 SPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 171 VSSLCISPDGKMLLSAGR--TIKLWVLETKEVYRHFTGHATPVSSLRFTtirpnesqPFDGvtglyFLSGAVHDRLLNVW 248
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRdkTIKVWDVETGKCLTTLRGHTDWVNSVAFS--------PDGT-----FVASSSQDGTIKLW 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 201027430 249 QVRSEnkekSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFEHvLNGHCKKPLTS 312
Cdd:cd00200  163 DLRTG----KCVATLTGHTGEVN-SVAFSPDGE---KLLSSSSDGTIKLWDL-STGKCLGTLRG 217
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-249 6.03e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 6.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  19 CAFSPDSQaYFALASSDGHLRVWETANNRlhQEYVPSAHlSGTCTCLAWAPARLQAkeshqrkkrkseAIGTNDqadlla 98
Cdd:cd00200   99 VAFSPDGR-ILSSSSRDKTIKVWDVETGK--CLTTLRGH-TDWVNSVAFSPDGTFV------------ASSSQD------ 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  99 lgtavGSILLYSTVKGELhSKLISGgHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISP 178
Cdd:cd00200  157 -----GTIKLWDLRTGKC-VATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 201027430 179 DGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTTirpnesqpfdgvTGLYFLSGAvHDRLLNVWQ 249
Cdd:cd00200  230 DGYLLASGSedGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP------------DGKRLASGS-ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
65-305 3.33e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 3.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430  65 LAWAPARLQAKESHQRKKRKSEAIGTNDQADLLALGTAVGSILLYSTVKGELHSKLIsgGHEKRVNCIQWHQDNDCLYSC 144
Cdd:COG2319   19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL--GHTAAVLSVAFSPDGRLLASA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 145 SDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISPDGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLRFTtirPN 222
Cdd:COG2319   97 SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSadGTVRLWDLATGKLLRTLTGHSGAVTSVAFS---PD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 223 esqpfdgvtGLYFLSGAvHDRLLNVWQVRSENKEKsavmSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE--- 299
Cdd:COG2319  174 ---------GKLLASGS-DDGTVRLWDLATGKLLR----TLTGHTGAVR-SVAFSPDGK---LLASGSADGTVRLWDlat 235

                        250
                 ....*....|
gi 201027430 300 ----HVLNGH 305
Cdd:COG2319  236 gkllRTLTGH 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-305 3.26e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430 164 WKGDNSSVSSLCISPDGKMLLSAGR--TIKLWVLETKEVYRHFTGHATPVSSLRFTtirpnesqpfdgVTGLYFLSGAVh 241
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAAS------------ADGTYLASGSS- 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 201027430 242 DRLLNVWQVRSENKeksaVMSFTVTDEPVYiDLTLSENKeepvKLAVVC-RDGQVHLFE-------HVLNGH 305
Cdd:cd00200   72 DKTIRLWDLETGEC----VRTLTGHTSYVS-SVAFSPDG----RILSSSsRDKTIKVWDvetgkclTTLRGH 134
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-154 1.12e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 201027430   124 GHEKRVNCIQWHQDNDCLYSCSDDKYIVEWS 154
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
124-154 4.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.36e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 201027430  124 GHEKRVNCIQWHQDNDCLYSCSDDKYIVEWS 154
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-193 1.69e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.69e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 201027430   159 RVKCKWKGDNSSVSSLCISPDGKMLLSAG--RTIKLW 193
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSddGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
163-193 1.68e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.68e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 201027430  163 KWKGDNSSVSSLCISPDGKMLLSAG--RTIKLW 193
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSddGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 95-214 3.27e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201027430   95 DLLALGTAVGSILLYstvkgelhsklisgghekRVNciqWHQdndclyscsddkyivEWSTQMCrvkckwkGDNSSVSSL 174
Cdd:pfam12894   8 DLIALATEDGELLLH------------------RLN---WQR---------------VWTLSPD-------KEDLEVTSL 44

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 201027430  175 CISPDGKMLLSAGR--TIKLWVLETKEVYRHFTGHATPVSSL 214
Cdd:pfam12894  45 AWRPDGKLLAVGYSdgTVRLLDAENGKIVHHFSAGSDLITCL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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