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Conserved domains on  [gi|1937906781|ref|NP_001032431|]
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Krueppel-like factor 11 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 40-383 1.49e-101

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


:

Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 303.84  E-value: 1.49e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781  40 LEQTDIEAVEALVCMSSWGQRSQ------VRPLTPVSDSGDVTTavlMDTAAPDLPKDFHSFSTLCITPPQSPELMEPTG 113
Cdd:cd21584     1 LEQNDLEAVEALVCMSSWGQRSQkgdllkIRPLTPASDSCDSLT---LHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 114 TPVPSqvinsqgcmatalppsptggprtlskgeppepssesSCRAVMTSVIRHTGESPAPtcfptgptqeqpasdsrggq 193
Cdd:cd21584    78 TAPPP------------------------------------PCRAMATSVIRHTADSSPP-------------------- 101

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 194 dplldhlealqdtrladgllvtnlvscqpclhksgglfpidkgqqtvwptavqtclpknpesdlsrkttpfisVPVSSPP 273
Cdd:cd21584   102 -------------------------------------------------------------------------VPVPSPP 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 274 VLCQMIPVAGQNGMLSAFLRPPtQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGNT 353
Cdd:cd21584   109 VLCQMIPVSGQSGMISAFLQPP-ALSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVMTLGNT 187

                         330       340       350
                  ....*....|....*....|....*....|
gi 1937906781 354 KLLPLAPAPVFVASSQNCAPQVDFSRRRNY 383
Cdd:cd21584   188 KLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
381-438 1.63e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1937906781 381 RNYVCNFPGCRKTyfKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHT 438
Cdd:COG5048    32 RPDSCPNCTDSFS--RLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 443-465 5.47e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 5.47e-05
                          10        20
                  ....*....|....*....|...
gi 1937906781 443 FVCPVCDRRFMRSDHLTKHARRH 465
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 40-383 1.49e-101

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 303.84  E-value: 1.49e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781  40 LEQTDIEAVEALVCMSSWGQRSQ------VRPLTPVSDSGDVTTavlMDTAAPDLPKDFHSFSTLCITPPQSPELMEPTG 113
Cdd:cd21584     1 LEQNDLEAVEALVCMSSWGQRSQkgdllkIRPLTPASDSCDSLT---LHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 114 TPVPSqvinsqgcmatalppsptggprtlskgeppepssesSCRAVMTSVIRHTGESPAPtcfptgptqeqpasdsrggq 193
Cdd:cd21584    78 TAPPP------------------------------------PCRAMATSVIRHTADSSPP-------------------- 101

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 194 dplldhlealqdtrladgllvtnlvscqpclhksgglfpidkgqqtvwptavqtclpknpesdlsrkttpfisVPVSSPP 273
Cdd:cd21584   102 -------------------------------------------------------------------------VPVPSPP 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 274 VLCQMIPVAGQNGMLSAFLRPPtQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGNT 353
Cdd:cd21584   109 VLCQMIPVSGQSGMISAFLQPP-ALSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVMTLGNT 187

                         330       340       350
                  ....*....|....*....|....*....|
gi 1937906781 354 KLLPLAPAPVFVASSQNCAPQVDFSRRRNY 383
Cdd:cd21584   188 KLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
381-438 1.63e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1937906781 381 RNYVCNFPGCRKTyfKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHT 438
Cdd:COG5048    32 RPDSCPNCTDSFS--RLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-426 2.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.09e-05
                          10        20
                  ....*....|....*....|....*...
gi 1937906781 399 HLKAHLRTHTGEKPFTCswDGCDKKFAR 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 443-465 5.47e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 5.47e-05
                          10        20
                  ....*....|....*....|...
gi 1937906781 443 FVCPVCDRRFMRSDHLTKHARRH 465
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
249-353 1.81e-03

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 40.69  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 249 LPKNPESDlSRKTTPFISVPVSsPPVLCQMIPVAGQNG-MLSAFLRPPTQLPAGTIKPILPQAASMSQP----------V 317
Cdd:pfam16014  11 LRKKPATE-GAKPKPDIHVAVA-PPVTVAVEALPGQNSeQQTASASPPSQHPAQAIPTILAPAAPPSQPsvvlstlpaaM 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1937906781 318 FMGPPVPQGTVMLVLPQStfpQPAACPSSVMAIGNT 353
Cdd:pfam16014  89 AVTPPIPASMANVVAPPT---QPAASSTAACAVSSV 121
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
294-382 2.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 294 PPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGNTKLLPLAPAPVFVASSQNCAP 373
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRP 449


                  ....*....
gi 1937906781 374 QVDFSRRRN 382
Cdd:PRK14971  450 AQFKEEKKI 458
ZnF_C2H2 smart00355
zinc finger;
443-465 4.57e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 4.57e-03
                           10        20
                   ....*....|....*....|...
gi 1937906781  443 FVCPVCDRRFMRSDHLTKHARRH 465
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 40-383 1.49e-101

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 303.84  E-value: 1.49e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781  40 LEQTDIEAVEALVCMSSWGQRSQ------VRPLTPVSDSGDVTTavlMDTAAPDLPKDFHSFSTLCITPPQSPELMEPTG 113
Cdd:cd21584     1 LEQNDLEAVEALVCMSSWGQRSQkgdllkIRPLTPASDSCDSLT---LHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 114 TPVPSqvinsqgcmatalppsptggprtlskgeppepssesSCRAVMTSVIRHTGESPAPtcfptgptqeqpasdsrggq 193
Cdd:cd21584    78 TAPPP------------------------------------PCRAMATSVIRHTADSSPP-------------------- 101

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 194 dplldhlealqdtrladgllvtnlvscqpclhksgglfpidkgqqtvwptavqtclpknpesdlsrkttpfisVPVSSPP 273
Cdd:cd21584   102 -------------------------------------------------------------------------VPVPSPP 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 274 VLCQMIPVAGQNGMLSAFLRPPtQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGNT 353
Cdd:cd21584   109 VLCQMIPVSGQSGMISAFLQPP-ALSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVMTLGNT 187

                         330       340       350
                  ....*....|....*....|....*....|
gi 1937906781 354 KLLPLAPAPVFVASSQNCAPQVDFSRRRNY 383
Cdd:cd21584   188 KLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 41-383 1.27e-75

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 237.52  E-value: 1.27e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781  41 EQTDIEAVEALVCMSSWGQRSQV-----RPLTPVSDSGDvttavlmDTAAPDLPKDFHSFSTLCITPPQSPELMEPTGTP 115
Cdd:cd21974     1 EQGDLEAVEALVSMSSWWKRRQKrlrkpRPLTPSSDSSD-------EDDAPESPKDFHSLSSLCMTPPYSPPFFEASHSP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 116 VPsqvinsqgcmATALPPSPTGGPRTLSKGEPPEPSSESsCRAVMTSVIRHTGESPaptcfptgptqeqpasdsrggqdp 195
Cdd:cd21974    74 SV----------ASLHPPSAASSQPPPEPESSEPPAASP-QRAQATSVIRHTADPV------------------------ 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 196 lldhlealqdtrladgllvtnlvscqpclhksgglfpidkgqqtvwptavqtclpknpesdlsrkttpfisvPVSSPPVL 275
Cdd:cd21974   119 ------------------------------------------------------------------------PVSPPPVL 126

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 276 CQMIPVAGQNGMLSAFLRPPTQLPAGTIKPILPQAasmsQPVFMGPPVPQGTVMLVLPQSTFPQPAAcPSSVMAIGNTKL 355
Cdd:cd21974   127 CQMLPVSSSSGVIVAFLKAPQQPSPQPQKPALPQP----QVVLVGGQVPQGPVMLVVPQPAVPQPYV-QPTVVTPGGTKL 201

                         330       340
                  ....*....|....*....|....*...
gi 1937906781 356 LPLAPAPVFVASSQNCAPQVDFSRRRNY 383
Cdd:cd21974   202 LPIAPAPGFIPSGQSSAPQPDFSRRRNH 229
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 40-382 2.47e-26

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 107.38  E-value: 2.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781  40 LEQTDIEAVEALVCMSS-WGQRS----QVRPLTPVSDSGDvttavlmDTAAPdLPKDFHSFSTLCITPPQSPELMEPTGT 114
Cdd:cd21572     1 MGAGDMEAVEALMSMTKhWKTRSfrlrHFRPLTPSSDSSE-------DDDLP-SPADFHDSPPFCMTPPYSPPHFEATHP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 115 PvpsqvinsqgcmaTALPPSPTGGPRTLSKGEPPEPSSESScRAVMTSVIRHTgespaptcfptgptqeqpasdsrggqd 194
Cdd:cd21572    73 P-------------SAATLHPPAAQPPEEQHLSAETAASQQ-RFQCTSVIRHT--------------------------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 195 plldhlealqdtrlADGLLVtnlvSCQPClhksgglfpidkgqqtvwptavqtclpknPESDLSRKTTPFISVPVSSPPV 274
Cdd:cd21572   112 --------------ADAQPC----SCSSC-----------------------------PSSPSVVPSVPAGVAGVSPVPV 144

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 275 LCQMIPVAGQNGMLSAFLRPPTQLPagtikpilPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGnTK 354
Cdd:cd21572   145 YCQILPVSSSSTTVVAAQAPLPQPQ--------QQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGG-TK 215

                         330       340
                  ....*....|....*....|....*....
gi 1937906781 355 LLPLAPAPVFVASSQNC-APQVDFSRRRN 382
Cdd:cd21572   216 LAAIAPAPGHTPSEQRKsPPQPEVSRVRS 244
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
381-438 1.63e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1937906781 381 RNYVCNFPGCRKTyfKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHT 438
Cdd:COG5048    32 RPDSCPNCTDSFS--RLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-426 2.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.09e-05
                          10        20
                  ....*....|....*....|....*...
gi 1937906781 399 HLKAHLRTHTGEKPFTCswDGCDKKFAR 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 443-465 5.47e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 5.47e-05
                          10        20
                  ....*....|....*....|...
gi 1937906781 443 FVCPVCDRRFMRSDHLTKHARRH 465
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 409-467 3.40e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1937906781 409 GEKPFTCSWDGCDKKFARSDELSRHR-------RTH------------TGEKKFVCPVCDRRFMRSDHLTKHaRRHMT 467
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 413-437 9.67e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1937906781 413 FTCswDGCDKKFARSDELSRHRRTH 437
Cdd:pfam00096   1 YKC--PDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
373-461 1.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 373 PQVDFSRRRNYVCNFPGCRKTYFKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHTgEKKFVCPVCDRRF 452
Cdd:COG5048   377 QYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSF 455


                  ....*....
gi 1937906781 453 MRSDHLTKH 461
Cdd:COG5048   456 RRDLDLSNH 464
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
249-353 1.81e-03

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 40.69  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 249 LPKNPESDlSRKTTPFISVPVSsPPVLCQMIPVAGQNG-MLSAFLRPPTQLPAGTIKPILPQAASMSQP----------V 317
Cdd:pfam16014  11 LRKKPATE-GAKPKPDIHVAVA-PPVTVAVEALPGQNSeQQTASASPPSQHPAQAIPTILAPAAPPSQPsvvlstlpaaM 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1937906781 318 FMGPPVPQGTVMLVLPQStfpQPAACPSSVMAIGNT 353
Cdd:pfam16014  89 AVTPPIPASMANVVAPPT---QPAASSTAACAVSSV 121
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
294-382 2.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 294 PPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQSTFPQPAACPSSVMAIGNTKLLPLAPAPVFVASSQNCAP 373
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRP 449


                  ....*....
gi 1937906781 374 QVDFSRRRN 382
Cdd:PRK14971  450 AQFKEEKKI 458
ZnF_C2H2 smart00355
zinc finger;
443-465 4.57e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 4.57e-03
                           10        20
                   ....*....|....*....|...
gi 1937906781  443 FVCPVCDRRFMRSDHLTKHARRH 465
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 385-461 5.61e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.24  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906781 385 CNFPGCRKTYFKSSHLKAHLRTHTGE------KPFTCSWDGCDKKFARSDELSRHRRTHTGEKK-FVCPVCDRRFMRSDH 457
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHRS 81


                  ....
gi 1937906781 458 LTKH 461
Cdd:pfam15909  82 LFKH 85
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 443-465 6.87e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.16  E-value: 6.87e-03
                          10        20
                  ....*....|....*....|...
gi 1937906781 443 FVCPVCDRRFMRSDHLTKHARRH 465
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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