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Conserved domains on  [gi|81158095|ref|NP_001032231|]
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protocadherin gamma-A3 precursor [Rattus norvegicus]

Protein Classification

protocadherin( domain architecture ID 11175791)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 27-109 6.70e-43

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 150.37  E-value: 6.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    27 QIRYSVPEELDKGSYVGNISKDLGLEPHELAERGVRIISRGRSQLFSLDPRSGSLVTAGRIDREELCAQSAPCVVSFNIL 106
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 81158095   107 VED 109
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-769 5.79e-40

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 141.89  E-value: 5.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   685 DLTLYLVVAVAAVSCIFLAFVIVLLALRLRRWHSSRLLQASGNgLAGIPASHFVGVDGVQAFLQTYSQEVSLTAGSRKSH 764
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 81158095   765 LIFPQ 769
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 243-340 9.28e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 9.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 243 EYRVSVLENVPVGTRLTTVNATDPDEGFNAQVSYILdkMPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQDG- 321
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                        90       100
                ....*....|....*....|
gi 81158095 322 -PGLFSRAKILVTVLDVNDN 340
Cdd:cd11304  79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 1.52e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.52e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 453 SYLAYIPENNARGASIFSVTAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITAR 532
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLF-SIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 81158095 533 DSGNPPLSSNSTLSLFVLDKNDN 555
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 352-445 1.16e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 1.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 352 SVPEEAPAGREIALINVHDRDSGQNGQVSVFVLGNLP---FTLEKSidqYYRLVTARSLDHEKESQYNISLRATDGGSPP 428
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 81158095 429 LSTETHITLHVTDINDN 445
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 808-902 7.19e-24

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 98.17  E-value: 7.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   808 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMILASA--SEAADGSSTLGGGTGTMGLSARYGPQFTLQH 884
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTVSSATpePEAGEVSPPVGAGVNSNSWTFRYGPGNPKQP 81

                          90
                  ....*....|....*....
gi 81158095   885 VPD-YRQNVYIPGSNATLT 902
Cdd:pfam15974  82 VPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-663 4.57e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.57e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 576 PRSAEPGYLVTKVVAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 654
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 81158095 655 VTLTIAVAD 663
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 134-235 2.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 134 ELEIKIGELTVPGTRFPLKTAFDPDVGMNSLQNYKL---NSNDYFSLavnsvidDAKYPELVLERALDREKKAVHQLDLI 210
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 81158095 211 ASDGGDPAHTGKLCIQVIVLDANDN 235
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 27-109 6.70e-43

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 150.37  E-value: 6.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    27 QIRYSVPEELDKGSYVGNISKDLGLEPHELAERGVRIISRGRSQLFSLDPRSGSLVTAGRIDREELCAQSAPCVVSFNIL 106
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 81158095   107 VED 109
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-769 5.79e-40

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 141.89  E-value: 5.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   685 DLTLYLVVAVAAVSCIFLAFVIVLLALRLRRWHSSRLLQASGNgLAGIPASHFVGVDGVQAFLQTYSQEVSLTAGSRKSH 764
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 81158095   765 LIFPQ 769
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 243-340 9.28e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 9.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 243 EYRVSVLENVPVGTRLTTVNATDPDEGFNAQVSYILdkMPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQDG- 321
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                        90       100
                ....*....|....*....|
gi 81158095 322 -PGLFSRAKILVTVLDVNDN 340
Cdd:cd11304  79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 1.52e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.52e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 453 SYLAYIPENNARGASIFSVTAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITAR 532
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLF-SIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 81158095 533 DSGNPPLSSNSTLSLFVLDKNDN 555
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 352-445 1.16e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 1.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 352 SVPEEAPAGREIALINVHDRDSGQNGQVSVFVLGNLP---FTLEKSidqYYRLVTARSLDHEKESQYNISLRATDGGSPP 428
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 81158095 429 LSTETHITLHVTDINDN 445
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 808-902 7.19e-24

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 98.17  E-value: 7.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   808 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMILASA--SEAADGSSTLGGGTGTMGLSARYGPQFTLQH 884
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTVSSATpePEAGEVSPPVGAGVNSNSWTFRYGPGNPKQP 81

                          90
                  ....*....|....*....
gi 81158095   885 VPD-YRQNVYIPGSNATLT 902
Cdd:pfam15974  82 VPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-663 4.57e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.57e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 576 PRSAEPGYLVTKVVAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 654
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 81158095 655 VTLTIAVAD 663
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 262-342 9.89e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 9.89e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    262 NATDPDEGFNAQVSYILDkmPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQDG--PGLFSRAKILVTVLDVND 339
Cdd:smart00112   1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTATVTITVLDVND 78


                   ...
gi 81158095    340 NAP 342
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
244-335 1.69e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   244 YRVSVLENVPVGTRLTTVNATDPDEGFNAQVSYilDKMPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQD--G 321
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY--SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsgG 78

                          90
                  ....*....|....
gi 81158095   322 PGLFSRAKILVTVL 335
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-557 6.80e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 6.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    472 TAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITARDSGNPPLSSNSTLSLFVLD 551
Cdd:smart00112   1 SATDADSGENGKVTYSI----LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 81158095    552 KNDNSP 557
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 134-235 2.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 134 ELEIKIGELTVPGTRFPLKTAFDPDVGMNSLQNYKL---NSNDYFSLavnsvidDAKYPELVLERALDREKKAVHQLDLI 210
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 81158095 211 ASDGGDPAHTGKLCIQVIVLDANDN 235
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 367-447 2.61e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    367 NVHDRDSGQNGQVSVFVLGN---LPFTLEKSIDQyyrLVTARSLDHEKESQYNISLRATDGGSPPLSTETHITLHVTDIN 443
Cdd:smart00112   1 SATDADSGENGKVTYSILSGnddGLFSIDPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 81158095    444 DNPP 447
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
352-440 9.90e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 9.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   352 SVPEEAPAGREIALINVHDRDSGQNGQVSVFVLGNLP---FTLEKSIDQyyrLVTARSLDHEKESQYNISLRATDGGSPP 428
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 81158095   429 LSTETHITLHVT 440
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
454-550 2.54e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   454 YLAYIPENNARGASIFSVTAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITARD 533
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI----LGGGPGGNF-RIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 81158095   534 SGNPPLSSNSTLSLFVL 550
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-663 4.00e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 4.00e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81158095    589 VAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTIAVAD 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
576-661 4.02e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 4.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   576 PRSAEPGYLVTKVVAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 654
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 81158095   655 VTLTIAV 661
Cdd:pfam00028  85 ATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 153-237 6.11e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 6.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    153 TAFDPDVGMNSLQNYKLNSND---YFSLavnsvidDAKYPELVLERALDREKKAVHQLDLIASDGGDPAHTGKLCIQVIV 229
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNddgLFSI-------DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 81158095    230 LDANDNPP 237
Cdd:smart00112  74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-126 5.56e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 5.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095  27 QIRYSVPEELDKGSYVGNIS---KDLGlephELAERGVRIISRGRSQLFSLDPRSGSLVTAGRIDREELcaqsapCVVSF 103
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSatdPDSG----ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTL 70

                        90       100
                ....*....|....*....|....*...
gi 81158095 104 NILVEDKLKIF-----EVEVDISDINDN 126
Cdd:cd11304  71 TVTATDGGGPPlsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 62-128 1.93e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.93e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81158095     62 RIISRGRSQLFSLDPRSGSLVTAGRIDREELcaqsapCVVSFNILVEDKLKIF-----EVEVDISDINDNAP 128
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREEQ------PEYTLTVEATDGGGPPlsstaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
136-230 2.69e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   136 EIKIGELTVPGTRFPLKTAFDPDVGMNSLQNYKL---NSNDYFSLAVNSviddakyPELVLERALDREKKAVHQLDLIAS 212
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDT-------GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 81158095   213 DGGDPAHTGKLCIQVIVL 230
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 27-109 6.70e-43

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 150.37  E-value: 6.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    27 QIRYSVPEELDKGSYVGNISKDLGLEPHELAERGVRIISRGRSQLFSLDPRSGSLVTAGRIDREELCAQSAPCVVSFNIL 106
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 81158095   107 VED 109
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-769 5.79e-40

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 141.89  E-value: 5.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   685 DLTLYLVVAVAAVSCIFLAFVIVLLALRLRRWHSSRLLQASGNgLAGIPASHFVGVDGVQAFLQTYSQEVSLTAGSRKSH 764
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 81158095   765 LIFPQ 769
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 243-340 9.28e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 9.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 243 EYRVSVLENVPVGTRLTTVNATDPDEGFNAQVSYILdkMPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQDG- 321
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                        90       100
                ....*....|....*....|
gi 81158095 322 -PGLFSRAKILVTVLDVNDN 340
Cdd:cd11304  79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 1.52e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.52e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 453 SYLAYIPENNARGASIFSVTAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITAR 532
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLF-SIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 81158095 533 DSGNPPLSSNSTLSLFVLDKNDN 555
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 352-445 1.16e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 1.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 352 SVPEEAPAGREIALINVHDRDSGQNGQVSVFVLGNLP---FTLEKSidqYYRLVTARSLDHEKESQYNISLRATDGGSPP 428
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 81158095 429 LSTETHITLHVTDINDN 445
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 808-902 7.19e-24

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 98.17  E-value: 7.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   808 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMILASA--SEAADGSSTLGGGTGTMGLSARYGPQFTLQH 884
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTVSSATpePEAGEVSPPVGAGVNSNSWTFRYGPGNPKQP 81

                          90
                  ....*....|....*....
gi 81158095   885 VPD-YRQNVYIPGSNATLT 902
Cdd:pfam15974  82 VPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-663 4.57e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.57e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 576 PRSAEPGYLVTKVVAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 654
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 81158095 655 VTLTIAVAD 663
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 262-342 9.89e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 9.89e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    262 NATDPDEGFNAQVSYILDkmPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQDG--PGLFSRAKILVTVLDVND 339
Cdd:smart00112   1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTATVTITVLDVND 78


                   ...
gi 81158095    340 NAP 342
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
244-335 1.69e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   244 YRVSVLENVPVGTRLTTVNATDPDEGFNAQVSYilDKMPGKIAQIFHLNSVTGDVSILKSLDYEDAVFYEIKIEAQD--G 321
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY--SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsgG 78

                          90
                  ....*....|....
gi 81158095   322 PGLFSRAKILVTVL 335
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-557 6.80e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 6.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    472 TAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITARDSGNPPLSSNSTLSLFVLD 551
Cdd:smart00112   1 SATDADSGENGKVTYSI----LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 81158095    552 KNDNSP 557
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 134-235 2.20e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095 134 ELEIKIGELTVPGTRFPLKTAFDPDVGMNSLQNYKL---NSNDYFSLavnsvidDAKYPELVLERALDREKKAVHQLDLI 210
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 81158095 211 ASDGGDPAHTGKLCIQVIVLDANDN 235
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 367-447 2.61e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    367 NVHDRDSGQNGQVSVFVLGN---LPFTLEKSIDQyyrLVTARSLDHEKESQYNISLRATDGGSPPLSTETHITLHVTDIN 443
Cdd:smart00112   1 SATDADSGENGKVTYSILSGnddGLFSIDPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 81158095    444 DNPP 447
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
352-440 9.90e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 9.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   352 SVPEEAPAGREIALINVHDRDSGQNGQVSVFVLGNLP---FTLEKSIDQyyrLVTARSLDHEKESQYNISLRATDGGSPP 428
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 81158095   429 LSTETHITLHVT 440
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
454-550 2.54e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   454 YLAYIPENNARGASIFSVTAQDPDTDKNAQITYSLaedtLQGVPLSSFvSINSNTGVLYALCSFDYEQFRDLQLHITARD 533
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI----LGGGPGGNF-RIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 81158095   534 SGNPPLSSNSTLSLFVL 550
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-663 4.00e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 4.00e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81158095    589 VAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTIAVAD 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
576-661 4.02e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 4.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   576 PRSAEPGYLVTKVVAVDKDSGQNSWLSYRLIKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 654
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 81158095   655 VTLTIAV 661
Cdd:pfam00028  85 ATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 153-237 6.11e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 6.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    153 TAFDPDVGMNSLQNYKLNSND---YFSLavnsvidDAKYPELVLERALDREKKAVHQLDLIASDGGDPAHTGKLCIQVIV 229
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNddgLFSI-------DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 81158095    230 LDANDNPP 237
Cdd:smart00112  74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-126 5.56e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 5.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095  27 QIRYSVPEELDKGSYVGNIS---KDLGlephELAERGVRIISRGRSQLFSLDPRSGSLVTAGRIDREELcaqsapCVVSF 103
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSatdPDSG----ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTL 70

                        90       100
                ....*....|....*....|....*...
gi 81158095 104 NILVEDKLKIF-----EVEVDISDINDN 126
Cdd:cd11304  71 TVTATDGGGPPlsstaTVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 28-126 2.88e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 52.35  E-value: 2.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095  28 IRYSVPEELDKGSYVGNISKDLGlephELAERGVRIISRGRS---QLFSLDPRSGSLVTAGRIDREELCAQ--SAPCVVS 102
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDKGVHyiSVSAASL 77

                        90       100
                ....*....|....*....|....
gi 81158095 103 FNILVEDKLkifEVEVDISDINDN 126
Cdd:cd00031  78 GANVPQTSS---VFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 62-128 1.93e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.93e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81158095     62 RIISRGRSQLFSLDPRSGSLVTAGRIDREELcaqsapCVVSFNILVEDKLKIF-----EVEVDISDINDNAP 128
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREEQ------PEYTLTVEATDGGGPPlsstaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
136-230 2.69e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095   136 EIKIGELTVPGTRFPLKTAFDPDVGMNSLQNYKL---NSNDYFSLAVNSviddakyPELVLERALDREKKAVHQLDLIAS 212
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDT-------GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 81158095   213 DGGDPAHTGKLCIQVIVL 230
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
 475-555 7.56e-03

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 36.94  E-value: 7.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81158095    475 DPDTDknaQITYSLAedTLQGVPLSSFVSINSNTGVLYALCSFDYEQfrDLQLHITARDSGNppLSSNSTLSLFVLDKND 554
Cdd:smart00736  26 DADGD---TLTYSAT--LSDGSALPSWLSFDSDTGTLSGTPTNSDVG--SLSLKVTATDSSG--ASASDTFTITVVNTND 96


                   .
gi 81158095    555 N 555
Cdd:smart00736  97 A 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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