|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
115-951 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 1792.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 115 MRANSLTREPELQKLWEENQVFKRVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDC 194
Cdd:PLN02843 1 MRANSVTREPEIQKLWEENQVYKRVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 195 HGLPIELKVLQSLDQEVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKG 274
Cdd:PLN02843 81 HGLPIELKVLQSLDQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 275 YIYRGRKPVHWSPSSRTALAEAELEYPEGHISKSIYAIFKLVGGAKTS--LLDEFIPNIYLAVWTTTPWTMPANAAVAVN 352
Cdd:PLN02843 161 YIYRGRKPVHWSPSSRTALAEAELEYPEGHVSKSIYVAFPVVSPSETSpeELEEFLPGLSLAIWTTTPWTMPANAAVAVN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 353 AKLQYSVVEVQSFSEDESTVTSNKKKIPGKVLKNQQKLFVIVATDLVPALEAKWGVKLSISKTFLGSDLENCRYTHPIDN 432
Cdd:PLN02843 241 DKLQYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQKLFLIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRYIHPLYN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 433 RDCPVVIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLGEGNTAVVSYLDENM 512
Cdd:PLN02843 321 RESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLGEGNAAVVEALDEAG 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 513 SLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVP 592
Cdd:PLN02843 401 SLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRTWGVP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 593 IPAFYHVKTKEPLMNEETINHVKSIISQKGSDAWWYMSVEDLLPEKYRDKAADYEKGTDTMDVWFDSGSSWAGVLGKREG 672
Cdd:PLN02843 481 IPVFYHVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKASDYEKGTDTMDVWFDSGSSWAGVLGSREG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 673 LSFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEGGKNSKDAPAYGA 752
Cdd:PLN02843 561 LSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEGGKNQKQEPAYGA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 753 DVMRLWVSSVDYTGDVLIGPQILRQMSDIYRKLRGTLRYLLGNLHDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECY 832
Cdd:PLN02843 641 DVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPDNAVPYEDLPSIDKYALFQLENVVNEIEESY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 833 ENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFEyr 912
Cdd:PLN02843 721 DNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQ-- 798
|
810 820 830
....*....|....*....|....*....|....*....
gi 79330394 913 nEDGSAAEFVFELKWPTLNEQWLSFPAEDVLFWQRLLEV 951
Cdd:PLN02843 799 -EDGSAAESVFEAGWPTPNEEWLSFPAEDVDFWSLLLEV 836
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
102-954 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1107.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 102 YKQTVDLPKTGFGMRANSLTREPELQKLWEENQVFKRVSDNNNGG-SFILHDGPPYANGDLHMGHALNKILKDIINRYKL 180
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRpKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 181 LQNYKVQYVPGWDCHGLPIELKVLQSLD-----------QEVRKE-----LTplklrakaakfakaTVKTQMESFKRFGV 244
Cdd:COG0060 81 MRGFDVPYVPGWDCHGLPIELKVEKELGikkkdiekvgiAEFREKcreyaLK--------------YVDEQREDFKRLGV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 245 WADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPEgHISKSIYAIFKLVGGAKTSLL 324
Cdd:COG0060 147 WGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKD-VTSPSIYVKFPVKDEKALLLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 325 DefipNIYLAVWTTTPWTMPANAAVAVNAKLQYSVVEVqsfsedestvtsnkkkipgkvlKNQQKLfvIVATDLVPALEA 404
Cdd:COG0060 226 E----DAYLVIWTTTPWTLPANLAVAVHPDIDYVLVEV----------------------TGGERL--ILAEALVEAVLK 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 405 KWGVK-LSISKTFLGSDLENCRYTHPID-----NRDCPVVIGgDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPV 478
Cdd:COG0060 278 ELGIEdYEVLATFKGAELEGLRYEHPFYyvvgyDRAHPVILG-DYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 479 DDEGKFTEEAGQFRGLSVLgEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAIN 558
Cdd:COG0060 357 DDDGRFTEEAPLFAGLFVK-DANPAIIEDLKERGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIE 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 559 NVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHVKTKEPLMNEETINHVKSIISQKGSDAWWYMSVED-LLPE 637
Cdd:COG0060 436 KVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGELHRTEEVIGSVAELLEEEGADAWFELDLHRpFLDE 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 638 KYR--DKAADYEKGTDTMDVWFDSGSSWAGVLGKREGLSFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGF 715
Cdd:COG0060 516 TLKcpKCGGTMRRVPDVLDVWFDSGSMHFAVLENREELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGF 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 716 VLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSSVDYTGDVLIGPQILRQMSDIYRKLRGTLRYLLGN 795
Cdd:COG0060 596 VLDEDGRKMSKSLGNVVDPQEVID---------KYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLAN 666
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 796 LHDWR-VDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSFTR 874
Cdd:COG0060 667 LDDFDpAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDR 746
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 875 RSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPfeyrnedGSAAEFVFELKWPTLNEQWLSfpAEDVLFWQRLLEVSKL 954
Cdd:COG0060 747 RAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLP-------GEAEESVHLADWPEVDEELID--EELEAKWDLVREVRSA 817
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
112-937 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 917.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 112 GFGMRANSLTREPELQKLWEENQVFKRVSDNNNG-GSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVP 190
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGkPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 191 GWDCHGLPIELKVLQSLDQEVRKELTPLKLRAKAAKFAKATVKT---QMESFKRFGVWADWNNPYLTLDPEYEAAQIEVF 267
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQieeQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 268 GQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPEG---HISKSIYAIFKLVGGAKTsllDEFIPNIYLAVWTTTPWTMP 344
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENykdVKDPSIYVKFPVKKDKKT---YLKVKLSSLLIWTTTPWTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 345 ANAAVAVNAKLQYSVVEVQSFSEdestvtsnkkkipgkvlknqqklFVIVATDLVPALEAKWGVKLSISKTFLGSDLENC 424
Cdd:TIGR00392 238 SNLAIAVHPDFEYALVQDNTKVE-----------------------YFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 425 RYTHPIDNRD------CPVVIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLG 498
Cdd:TIGR00392 295 EYEHPLYDFVsqlkegAPVVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVKD 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 499 EG------NTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAVNRIS 572
Cdd:TIGR00392 375 ADkdiikaNKIIIEQLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFG 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 573 AMTSSRSDWCISRQRTWGVPIPAFYHVKTKEPlMNEETINHVKSIISQKGSDAWWYMSVEDLLPEKYR--DKAADYEKGT 650
Cdd:TIGR00392 455 NWLENRPDWCISRQRYWGIPIPIWYCEDTGEP-IVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLksGDGGEYRRVP 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 651 DTMDVWFDSGSSWAGVLGKREG-----LSFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMS 725
Cdd:TIGR00392 534 DVLDVWFDSGSMPYASIHYPFEnekfkEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMS 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 726 KSLGNVVDPRLVIEggknskdapAYGADVMRLWVSSVDYTGDVLIGPQILRQMSDIYRKLR-GTLRYLL--GNLHDWRVD 802
Cdd:TIGR00392 614 KSLGNVVDPLKVIN---------KYGADILRLYVASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPL 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 803 -NAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSfTRRSCQTVL 881
Cdd:TIGR00392 685 fNSVAVEKFPEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDN-DKRAAQTTL 763
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 79330394 882 STHLLSILRVIAPIVPHLAEDVWQNLPFEYRNEDgsaaefVFELKWPTLNEQWLSF 937
Cdd:TIGR00392 764 YYALLTLVRLLAPFLPHTAEEIYQNLPGGEEEES------VHLNLWPEVDEEFIDE 813
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
126-768 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 620.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 126 LQKLWEENQVFKRVSDNNNG-GSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVL 204
Cdd:pfam00133 2 IYEFWDEQGYFKPELEKRKGkPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 205 QSL---DQEVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRK 281
Cdd:pfam00133 82 KKLgikEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 282 PVHWSPSSRTALAEAELEYPEGHiSKSIYAIFKLVGGAKTSLLdefipniylaVWTTTPWTMPANAAVAVNAKLQYSVve 361
Cdd:pfam00133 162 LVNWSPALNTALSNLEVEYKDVK-GPSIHVAFPLADDEGASLV----------IWTTTPWTLPGNTAVAVNPEFDYVI-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 362 vqsfsedestvtsnkkkipgkvlknqQKLFVIVATDLVPALeAKWGVKLSISKTFLGSDLENCRYTHPIDNRDCPVvIGG 441
Cdd:pfam00133 229 --------------------------TGEGYILAEALLKSL-YKKGTDKKILEDFRGKELEGKEAIHPFVNREIPI-ITD 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 442 DYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLgEGNTAVVSYLDENMSLVMEESYA 521
Cdd:pfam00133 281 DYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRF-DARKKIVELLTEKGLLLKIEPFT 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 522 HKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHVKT 601
Cdd:pfam00133 360 HSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDT 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 602 KEPLMNEETINHVKSIISQKGSDAWWYMSVEDLLpekyRDKAADYEKGTDTMDVWFDSGSSWAGVLG----KREGLS--F 675
Cdd:pfam00133 440 EEVVCRGELFELVAGRFEEEGSIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGwpfvNTEEFKkfF 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 676 PADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVM 755
Cdd:pfam00133 516 PADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID---------KYGADAL 586
|
650
....*....|...
gi 79330394 756 RLWVSSVDYTGDV 768
Cdd:pfam00133 587 RLWLANSDYGRDI 599
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
123-933 |
1.49e-120 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 388.26 E-value: 1.49e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 123 EPELQKLWEENQVFKrVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELK 202
Cdd:TIGR00422 11 EKKWYKKWEKSGFFK-PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIATQVK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 203 VLQSLDQEV-------RKELtpLKLRAKAAKFAKATVKTQMesfKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGY 275
Cdd:TIGR00422 90 VEKKLGAEGktkhdlgREEF--REKIWEWKEESGGTIKNQI---KRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 276 IYRGRKPVHWSPSSRTALAEAELEYPEGHiSKSIYAIFKLVGGAKTslldefipniYLAVWTTTPWTMPANaavavnakl 355
Cdd:TIGR00422 165 IYRGEYLVNWDPKLNTAISDIEVEYKEVK-GKLYYIRYPLANGSKD----------YLVVATTRPETMFGD--------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 356 qysvVEVQSFSEDESTVTSNKKKIpgkvlknqqklfvivatdlvpaleakwgvklsisktflgsdlencryTHPIDNRDC 435
Cdd:TIGR00422 225 ----TAVAVHPEDERYKHLIGKKV-----------------------------------------------ILPLTGRKI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 436 PVvIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLgEGNTAVVSYLDENMSLV 515
Cdd:TIGR00422 254 PI-IADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRF-EARKKIVEDLKEEGLLV 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 516 MEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINN--VKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPI 593
Cdd:TIGR00422 332 KIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEgeIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRI 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 594 PAFYHVKTKEPLMNEEtinhvksiisqkgsdawwymsvEDLLPEKYRDKAA-DYEKGTDTMDVWFDSGSSWAGVLG---- 668
Cdd:TIGR00422 412 PVWYCKECGEVYVAKE----------------------EPLPDDKTNTGPSvELEQDTDVLDTWFSSSLWPFSTLGwpde 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 669 KREGLSF-PADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskda 747
Cdd:TIGR00422 470 TKDLKKFyPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIE-------- 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 748 pAYGADVMRLWVSSVDYTG-DVLIGPQILRQMSDIYRKLRGTLRYLLGNLHDwRVDNAVPYQDLPIIDQHALFQLENVVK 826
Cdd:TIGR00422 542 -KYGADALRFTLASLVTPGdDINFDWKRVESARNFLNKLWNASRFVLMNLSD-DLELSGGEEKLSLADRWILSKLNRTIK 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 827 NIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSftRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQN 906
Cdd:TIGR00422 620 EVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYNGNEAE--KKAARDTLYYVLDKALRLLHPFMPFITEEIWQH 697
|
810 820
....*....|....*....|....*..
gi 79330394 907 LPfeyrnedgSAAEFVFELKWPTLNEQ 933
Cdd:TIGR00422 698 FK--------EGADSIMLQSYPVVDAE 716
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
115-943 |
1.96e-98 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 327.15 E-value: 1.96e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 115 MRANSLTREPELQKLWEENQVFKrvsDNNNGGS--FILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGW 192
Cdd:PRK13208 8 KKYDPEELEEKWQKIWEEEGTYK---FDPDERKpvYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 193 DCHGLPIELKVlqsldQE---VRK-------------ELTplklrakaakfakATVKTQMES-FKRFGVWADWNNPYLTL 255
Cdd:PRK13208 85 DDNGLPTERKV-----EKyygIRKddisreefielcrELT-------------DEDEKKFRElWRRLGLSVDWSLEYQTI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 256 DPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPEGHiSKSIYAIFKLVGGAKtslldefipnIYLAv 335
Cdd:PRK13208 147 SPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE-GKLNYIKFPVEDGEE----------IEIA- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 336 wTTTPWTMPanaavavnaklqySVVEVQSFSEDEstvtsnkkkipgkvlknqqklfvivatdlvpaleakwgvklsiskt 415
Cdd:PRK13208 215 -TTRPELLP-------------ACVAVVVHPDDE---------------------------------------------- 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 416 flgsdlencRYTH--------PIDNRDCPVvIGGDYITTESGTGLVH--TapgHG-QEDYATGLKYGLPLVSPVDDEGKF 484
Cdd:PRK13208 235 ---------RYKHlvgktaivPLFGVEVPI-LADPLVDPDFGTGAVMicT---FGdKTDVTWWRELNLPTRIIIDEDGRM 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 485 TEEAGQFRGLSVLgEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVP 564
Cdd:PRK13208 302 TEAAGKLAGLTIE-EARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYP 380
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 565 ----HQAVNRISAMTSsrsDWCISRQRTWGVPIPAFYHVKTKEPLMNEEtinhvksiisqkgsdawwymsvEDL------ 634
Cdd:PRK13208 381 ehmrVRLENWIEGLNW---DWCISRQRYFGTPIPVWYCKDCGHPILPDE----------------------EDLpvdptk 435
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 635 -LPEKYRD---KAADYEKGTDTMDVWFDSGSSWAGVLG--KREGLS---FPADVYLEGTDQHRGWFQSSLLTSIATQGKA 705
Cdd:PRK13208 436 dEPPGYKCpqcGSPGFEGETDVMDTWATSSITPLIVTGweRDEDLFekvFPMDLRPQGHDIIRTWLFYTILRAYLLTGKL 515
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 706 PYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSS----VDYT---GDVLIGPQILRQM 778
Cdd:PRK13208 516 PWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE---------KYGADAVRYWAASarlgSDTPfdeKQVKIGRRLLTKL 586
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 779 SDIYRklrgtlryLLGNLHDWRVDNAVPyqDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFD 858
Cdd:PRK13208 587 WNASR--------FVLHFSADPEPDKAE--VLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLE 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 859 IAKDRLYtGGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLpfeyrnEDGSaaefVFELKWPTLNEQWLSFP 938
Cdd:PRK13208 657 LVKSRAY-GEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWL------YGGS----VHRASWPEPDEELIDEE 725
|
....*
gi 79330394 939 AEDVL 943
Cdd:PRK13208 726 DEELG 730
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
533-770 |
1.12e-90 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 291.83 E-value: 1.12e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 533 PTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHVKTKEPLMneetin 612
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV------ 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 613 hvksiisqkgsdawwymsvedllpekyrdkaadyEKGTDTMDVWFDSGSSWAGVLGKRE-----GLSFPADVYLEGTDQH 687
Cdd:cd00818 218 ----------------------------------RRVPDVLDVWFDSGSMPYAQLHYPFenedfEELFPADFILEGSDQT 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 688 RGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIeggknskdaPAYGADVMRLWVSSVD-YTG 766
Cdd:cd00818 264 RGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV---------DKYGADALRLWVASSDvYAE 334
|
....
gi 79330394 767 DVLI 770
Cdd:cd00818 335 DLRF 338
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
123-907 |
3.65e-89 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 308.96 E-value: 3.65e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 123 EPELQKLWEENQVFK-RVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIEL 201
Cdd:PLN02882 14 EEKILSLWSEIDAFKtQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 202 KVLQSLDQEVRKELTPLKLRAKAAKFAKATVKTQME---SFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYR 278
Cdd:PLN02882 94 EIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEwekTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 279 GRKPVHWSPSSRTALA--EAELEYPEGHiSKSIYAIFKLVGGAKtslldefipNIYLAVWTTTPWTMPANAAVAVNAKLQ 356
Cdd:PLN02882 174 GFKVMPYSTACKTPLSnfEAGLNYKDVS-DPAVMVSFPIVGDPD---------NASFVAWTTTPWTLPSNLALCVNPNFT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 357 YsvVEVQSFSEDESTVTSNKK--KIPGKVLKNQQKLFVIVATDLVPALEakwgvklsiskTFLGSDLENCRYThPI---- 430
Cdd:PLN02882 244 Y--VKVRNKYTGKVYIVAESRlsALPTAKPKSKKGSKPENAAEGYEVLA-----------KVPGSSLVGKKYE-PLfdyf 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 431 -DNRDCPV-VIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGL-----PLVSPVDDEGKFTEEAGQFRGLSVlGEGNTA 503
Cdd:PLN02882 310 sEFSDTAFrVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKVTDFSGRYV-KDADKD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 504 VVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDaiNNVK--WVP-HQAVNRISAMTSSRSD 580
Cdd:PLN02882 389 IIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLE--NNKQtyWVPdYVKEKRFHNWLENARD 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 581 WCISRQRTWGVPIPAFYH--------VKTKEPL----------MNEETINHVkSIISQKGsdawwymsvedllPEKYRDK 642
Cdd:PLN02882 467 WAVSRSRFWGTPLPIWISddgeevvvIGSIAELeklsgvkvtdLHRHFIDHI-TIPSSRG-------------PEFGVLR 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 643 AADyekgtDTMDVWFDSGS-SWAGV---LGKREGL--SFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFV 716
Cdd:PLN02882 533 RVD-----DVFDCWFESGSmPYAYIhypFENKELFekNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLV 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 717 LDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWvssvdytgdvLIGPQILRQMS-------------DIYR 783
Cdd:PLN02882 608 LAEDGKKMSKSLKNYPDPNEVID---------KYGADALRLY----------LINSPVVRAEPlrfkeegvfgvvkDVFL 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 784 KLRGTLRYLLGNLHDWRVDNAVPYQDLP---------IIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFtIVDLSN 854
Cdd:PLN02882 669 PWYNAYRFLVQNAKRLEVEGGAPFVPLDlaklqnsanVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTN 747
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 79330394 855 FYFDIAKDRL--YTGGTSSftrRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNL 907
Cdd:PLN02882 748 IYVRFNRKRLkgRTGEEDC---RTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNL 799
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
70-920 |
3.79e-83 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 292.26 E-value: 3.79e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 70 NNEFGHSSKRRSRGPVmaAKKASEGEKQEDGKYKQTVDLPKTGFGMRANSLTREPELQKLWEENQVFKRVSD-NNNGGSF 148
Cdd:PTZ00427 27 NGTFFNKRIIRRRGNK--AKFTPSNVRIKTMEGAEMVTVTFTGVSENPNIVEEEEKVLKYWKSIDAFNTSNKlAKNKKAY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 149 ILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQEVRKELTPLKLRAKAAKFA 228
Cdd:PTZ00427 105 IFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 229 KATVKTQME---SFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAEL------- 298
Cdd:PTZ00427 185 GIVLKYSNEwvkTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELnlnykdt 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 299 -------------EYPEGHISKSIYAIFKLVGGAKTSLLDE-----------------FIPNIYLAVWTTTPWTMPANAA 348
Cdd:PTZ00427 265 pdpsiiisfvlcsDFPKVEEECNIEEDKQLLGEKYSVLYNNkrensnngnnnstnnvcYAQHSEILAWTTTPWTLPSNLA 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 349 VAVNAKLQYSVVEvqsfsedesTVTSNKKKIPGKVlknqqKLFVIVAtdlvpalEAKWGVK-LSISKTFLGSDLENCRY- 426
Cdd:PTZ00427 345 LCVNEHFTYLRIH---------HVKSNRVVIVGEC-----RLEWIMK-------ELKWNVEdLKIVNRFKGKELKGLRYk 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 427 ---THPIDNRD----CPVVIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGL--P----LVSPVDDEGKFTEEAGQFRG 493
Cdd:PTZ00427 404 plfTNFYEKYNfkerAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPekniFIDPLDANGYFTNEVEEVQN 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 494 LSVlGEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAV-NRIS 572
Cdd:PTZ00427 484 LYI-KEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIKeKKFH 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 573 AMTSSRSDWCISRQRTWGVPIPAFYHVKTkEPLMNEETINHVKSIISQKGSDAWWYMSVEDLlpEKYRDKAADYEKG--- 649
Cdd:PTZ00427 563 NWIKDAKDWCISRNRYWGTPIPIWADEKM-ETVICVESIKHLEELSGVKNINDLHRHFIDHI--EIKNPKGKTYPKLkri 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 650 TDTMDVWFDSGS-SWAGV----LGKREGLS--FPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGM 722
Cdd:PTZ00427 640 PEVFDCWFESGSmPYAKVhypfSTEKEDFHkiFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGK 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 723 KMSKSLGNVVDPRLVIEggknskdapAYGADVMRLW-VSSVDYTGDVL------IGPQILRQMSDIYRKLR----GTLRY 791
Cdd:PTZ00427 720 KMSKRLKNYPDPLYILD---------KYGADSLRLYlINSVAVRAENLkfqekgVNEVVKSFILPFYHSFRffsqEVTRY 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 792 LLGNLHDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFtIVDLSNFYFDIAKDRLYTG-GTS 870
Cdd:PTZ00427 791 ECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF-IENLTNWYIRLNRDRMRGSlGEE 869
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 79330394 871 SFTRRSCQTVLSTHLLSILrvIAPIVPHLAEDVWQNLP-FEYRNEDGSAAE 920
Cdd:PTZ00427 870 NCLQSLCTTYRTLHLFTVL--MAPFTPFITEYIYQQLRrVKSTNEHNENNE 918
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
123-942 |
1.64e-75 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 265.82 E-value: 1.64e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 123 EPELQKLWEENQVFKrvSDNNNGGSF--ILhdGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDcH-GLPI 199
Cdd:PRK05729 15 EAKWYQKWEEKGYFK--PDDNSKKPFsiVI--PPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaGIAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 200 ELKVLQSLDQE--VRKELTplklrakaakfakatvktqMESF-------------------KRFGVWADWNNPYLTLDPE 258
Cdd:PRK05729 90 QMVVERQLAAEgkSRHDLG-------------------REKFlekvwewkeesggtitnqlRRLGASCDWSRERFTMDEG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 259 YEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPE--GHIsksiYAI-FKLVGGAKtslldefipniYLAV 335
Cdd:PRK05729 151 LSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEvkGKL----WHIrYPLADGSD-----------YLVV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 336 WTTTPWTM---------PanaavavnaklqysvvevqsfsEDEstvtsnkkkipgkvlknqqklfvivatdlvpaleakw 406
Cdd:PRK05729 216 ATTRPETMlgdtavavnP----------------------EDE------------------------------------- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 407 gvklsisktflgsdlencRYTH--------PIDNRDCPVvIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPV 478
Cdd:PRK05729 237 ------------------RYKHligktvilPLVGREIPI-IADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIM 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 479 DDEGKFTEEAGQFRGLSVLgEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAIN 558
Cdd:PRK05729 298 DEDGTINENPGEYQGLDRF-EARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVE 376
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 559 N--VKWVPHQAVNRISA-MTSSRsDWCISRQRTWGVPIPAFYHVKTKEplmneetinHVKSIISQKGSDAWWYmsvedll 635
Cdd:PRK05729 377 NgeIKFVPERWEKTYFHwMENIQ-DWCISRQLWWGHRIPAWYDEDGEV---------YVGREEPEAREKALLT------- 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 636 pekyRDkaadyekgTDTMDVWFdsgSS--WA-GVLG---KREGLS--FPADVYLEGTDqhrgW-----FQSSLLTsiatq 702
Cdd:PRK05729 440 ----QD--------EDVLDTWF---SSalWPfSTLGwpeKTEDLKrfYPTSVLVTGFDiiffWvarmiMMGLHFT----- 499
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 703 GKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSSVDYTG-DVLIGPQILRQmsdi 781
Cdd:PRK05729 500 GQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID---------KYGADALRFTLAALASPGrDIRFDEERVEG---- 566
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 782 YR----KLRGTLRYLLGNLHDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYF 857
Cdd:PRK05729 567 YRnfanKLWNASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYL 646
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 858 DIAKDRLYTGGtssftRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPfeyrneDGSAAEFVFELKWPTLNEQWLSF 937
Cdd:PRK05729 647 ELAKPVLQEAA-----KRATRATLAYVLEQILRLLHPFMPFITEELWQKLA------PLGIEESIMLAPWPEADEAIDEA 715
|
....*
gi 79330394 938 PAEDV 942
Cdd:PRK05729 716 AEAEF 720
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
770-951 |
1.54e-73 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 239.73 E-value: 1.54e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 770 IGPQILRQMSDIYRKLRGTLRYLLGNLHDW-RVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFT 848
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFdPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 849 IVDLSNFYFDIAKDRLYTGGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFEyrnedgSAAEFVFELKWP 928
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGE------KKEESVFLEDWP 154
|
170 180
....*....|....*....|...
gi 79330394 929 TLNEQWLSfpAEDVLFWQRLLEV 951
Cdd:cd07960 155 ELPEEWKD--EELEEKWEKLLAL 175
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
129-914 |
2.41e-72 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 259.54 E-value: 2.41e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 129 LWEENQVFKRVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKV---LQ 205
Cdd:PRK14900 31 FWQERGYFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVekeLK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 206 SLDQEVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHW 285
Cdd:PRK14900 111 KTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINW 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 286 SPSSRTALAEAELEYPEGHiSKSIYAI-FKLVGGAKTslldefipniyLAVWTTTPWTMpanaavavnakLQYSVVEVQS 364
Cdd:PRK14900 191 CPDCRTALSDLEVEHEEAH-QGELWSFaYPLADGSGE-----------IVVATTRPETM-----------LGDTAVAVHP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 365 fsEDESTVTSNKKKIpgkvlknqqklfvivatdlvpaleakwgvklsisktflgsdlencryTHPIDNRDCPVVIGGDYI 444
Cdd:PRK14900 248 --LDPRYMALHGKKV-----------------------------------------------RHPITGRTFPIVADAILV 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 445 TTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLgEGNTAVVSYLDENMslVMEESYAHKY 524
Cdd:PRK14900 279 DPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRF-EARKEVKRLLAEQG--LDRGAKPHVL 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 525 PYDWRTKKPTIF--RATEQWFASVEGFRTATMDAINN--VKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYhVK 600
Cdd:PRK14900 356 PLGRCQRSATILepLLSDQWYVRIEPLARPAIEAVEQgrTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWY-CP 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 601 TKEPLMNEETinhvksiisqkgsdawwymsvedllPEKYRDKA-ADYEKGTDTMDVWFDSGSSWAGVLGKREGLS----- 674
Cdd:PRK14900 435 DGHVTVARET-------------------------PEACSTCGkAELRQDEDVLDTWFSSGLWPFSTMGWPEQTDtlrtf 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 675 FPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIeggknskdaPAYGADV 754
Cdd:PRK14900 490 YPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVIT---------EQYGADA 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 755 MRLWVSSVDYTG-DVLIGPQILRQMSDIYRKLRGTLRYLLGNLHDWrVDNAVPYQDLPII--DQHALFQLENVVKNIQEC 831
Cdd:PRK14900 561 LRFTLAALTAQGrDIKLAKERIEGYRAFANKLWNASRFALMNLSGY-QERGEDPARLARTpaDRWILARLQRAVNETVEA 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 832 YENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYtgGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFEY 911
Cdd:PRK14900 640 LEAFRFNDAANAVYAFVWHELCDWYIELAKEALA--SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQV 717
|
...
gi 79330394 912 RNE 914
Cdd:PRK14900 718 GAS 720
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
123-934 |
7.21e-69 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 246.89 E-value: 7.21e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 123 EPELQKLWEENQVFKRVSDnnnggsfilHDGPPYA------N--GDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDc 194
Cdd:COG0525 13 EAKWYQYWEENGYFKADPD---------SDKEPFTivipppNvtGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 195 H-GLPIELKVLQSLDQE--VRKELTplklrakaakfakatvktqMESF-------------------KRFGVWADWNNPY 252
Cdd:COG0525 83 HaGIATQAVVERQLAEEgkSRHDLG-------------------REKFlervwewkeesggtitnqlRRLGASCDWSRER 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 253 LTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPE--GHIsksiYAI-FKLVGGAKtslldefip 329
Cdd:COG0525 144 FTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEvkGHL----WHIrYPLADGSG--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 330 niYLAVWTTTPWTM---------PanaavavnaklqysvvevqsfsEDEstvtsNKKKIPGKvlknqqklFVIVatdlvp 400
Cdd:COG0525 211 --YIVVATTRPETMlgdtavavhP----------------------EDE-----RYKHLIGK--------TVIL------ 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 401 aleakwgvklsisktflgsdlencrythPIDNRDCPVvIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDD 480
Cdd:COG0525 248 ----------------------------PLVGREIPI-IADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDE 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 481 EGKFTEEAGQFRGLSVLgEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINN- 559
Cdd:COG0525 299 DGTINENAGKYRGLDRF-EARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDg 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 560 -VKWVPHQAVNR-ISAMTSSRsDWCISRQRTWGVPIPAFYHVktkeplmneetinhvksiisqkgsDAWWYMSVEDllPE 637
Cdd:COG0525 378 eIKFVPERWEKTyFHWMENIR-DWCISRQLWWGHRIPAWYCP------------------------DGEVYVARTE--PE 430
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 638 KyRDKAA--DYEKGTDTMDVWFdsgSSWA---GVLGkreglsFPadvylEGTDQHRGWFQSSLL-T-------------- 697
Cdd:COG0525 431 A-CAKAGsvNLTQDEDVLDTWF---SSALwpfSTLG------WP-----EKTEDLKYFYPTSVLvTgfdiiffwvarmim 495
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 698 -SIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRL-WVSSVDYTGDVLIGPQIL 775
Cdd:COG0525 496 mGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID---------KYGADALRFtLAALASPGRDIKFDEERV 566
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 776 RQmsdiYR----KLRGTLRYLLGNLHDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVD 851
Cdd:COG0525 567 EG----YRnfanKLWNASRFVLMNLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNE 642
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 852 LSNFYFDIAKDRLYTGGTSSftRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPfeyrneDGSAAEFVFELKWPTLN 931
Cdd:COG0525 643 FCDWYLELAKPRLYGGDEAA--KRETRATLVYVLEQILRLLHPFMPFITEEIWQKLP------PRKEGESIMLAPWPEAD 714
|
...
gi 79330394 932 EQW 934
Cdd:COG0525 715 EEL 717
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
147-285 |
2.41e-64 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 220.57 E-value: 2.41e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 147 SFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQEVRK---ELTPLKLRAK 223
Cdd:cd00818 2 EFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKdieKMGIAEFNAK 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79330394 224 AAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHW 285
Cdd:cd00818 82 CREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
70-910 |
3.86e-64 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 234.45 E-value: 3.86e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 70 NNEFGHSSKRRSRGPVMAAKKASEGEKQEDGKYKQtvdlPKTGfgmRANSLTREPELQKLWEENQVFKRVSDNNnGGSFI 149
Cdd:PLN02943 20 NPLLLSACRRRAWAPRRAARRFCAAAASENDVFTS----PETA---KSFDFTSEERIYNWWESQGYFKPNFDRG-GDPFV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 150 LHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQE--VRKELTPLKLRAKAAKF 227
Cdd:PLN02943 92 IPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEgiKRTDLGRDEFTKRVWEW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 228 AKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPEgHISK 307
Cdd:PLN02943 172 KEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE-EPGT 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 308 SIYAIFKLVGGaktslldefiPNIYLAVWTTTPWTmpanaavavnaklqysvvevqsfsedestvtsnkkkipgkvlknq 387
Cdd:PLN02943 251 LYYIKYRVAGG----------SEDFLTIATTRPET--------------------------------------------- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 388 qkLFVIVATDLVPALE--AKWGVKLSISKTFLGsdlencrythpidnRDCPVvIGGDYITTESGTGLVHTAPGHGQEDYA 465
Cdd:PLN02943 276 --LFGDVAIAVNPEDDrySKYIGKMAIVPMTYG--------------RHVPI-IADRYVDKDFGTGVLKISPGHDHNDYL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 466 TGLKYGLPLVSPVDDEGKFTEEAGQFRGlsvlgEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFAS 545
Cdd:PLN02943 339 LARKLGLPILNVMNKDGTLNEVAGLYWF-----EAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVT 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 546 VEGFRTATMDAINN--VKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHVKTKeplmNEEtinhvKSIISQKGS 623
Cdd:PLN02943 414 MEPLAEKALKAVENgeLTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKD----CEE-----DYIVARSAE 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 624 DAWwymsveDLLPEKYRDKAADYEKgTDTMDVWFDSGS------SWAGVLGKREGLSFPADVYLEGTDQHRGWFQSSLLT 697
Cdd:PLN02943 485 EAL------EKAREKYGKDVEIYQD-PDVLDTWFSSALwpfstlGWPDVSAEDFKKFYPTTVLETGHDILFFWVARMVMM 557
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 698 SIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSSVDYTGDVLIGPQILRQ 777
Cdd:PLN02943 558 GIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIK---------EFGTDALRFTLALGTAGQDLNLSTERLTS 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 778 MSDIYRKLRGTLRYLLGNLHD------W------RVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQ 845
Cdd:PLN02943 629 NKAFTNKLWNAGKFVLQNLPSqsdtsaWehilacKFDKEESLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIY 708
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79330394 846 RFTIVDLSNFYFDIAKDRLYTGGTSSFTRRScQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFE 910
Cdd:PLN02943 709 DFFWSDFADWYIEASKTRLYHSGDNSALSRA-QAVLLYVFENILKLLHPFMPFVTEELWQALPYR 772
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
128-934 |
5.95e-61 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 225.27 E-value: 5.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 128 KLWEENQVFKRVSD---NNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLP----IE 200
Cdd:PTZ00419 39 EWWEKSGFFKPAEDaksLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAtqvvVE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 201 LKVLQSlDQEVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGR 280
Cdd:PTZ00419 119 KKLMKE-ENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDT 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 281 KPVHWSPSSRTALAEAELEYPE----------GHISK----SIYAIF-KLVGGaktslldefiPNIYLAVWTTTPWTMpa 345
Cdd:PTZ00419 198 RLVNWCCYLKTAISDIEVEFEEiekptkitipGYDKKvevgVLWHFAyPLEDS----------GQEEIVVATTRIETM-- 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 346 naavavnakLQYSVVEVQsfSEDEstvtsNKKKIPGKVLKnqqklfvivatdlvpaleakwgvklsisktflgsdlencr 425
Cdd:PTZ00419 266 ---------LGDVAVAVH--PKDE-----RYKKLHGKELI---------------------------------------- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 426 ytHP-IDNRDCPVVIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLgEGNTAV 504
Cdd:PTZ00419 290 --HPfIPDRKIPIIADDELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRF-DCRRKI 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 505 VSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINN--VKWVPHQAVNRISAMTSSRSDWC 582
Cdd:PTZ00419 367 EEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNgeLKIIPSSHENVWYHWLENIQDWC 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 583 ISRQRTWGVPIPAfYHVKTKEPLMNeetinhvksiisQKGSDAWW----YMSVEDLLPEKYRDKAADY--EKGTDTMDVW 656
Cdd:PTZ00419 447 ISRQLWWGHRIPA-YRVISKGPETD------------PSDEEPWVvarsEEEALEKAKKKFGLSEEDFelEQDEDVLDTW 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 657 FDSGSSWAGVLG---KREGLS--FPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNV 731
Cdd:PTZ00419 514 FSSGLFPFSTLGwpdQTDDLQrfFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNV 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 732 VDPRLVIEG----GKNSK------------------------DAPAYGADVMRLWVSSvdYTGDvliGPQILRQMSDI-- 781
Cdd:PTZ00419 594 IDPLEVIEGislqDLNQKlyegnlpekeikraielqkkefpnGIPECGTDALRFGLLA--YTQQ---GRNINLDINRVvg 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 782 YR----KLRGTLRYLLGNLHDWR------VDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVD 851
Cdd:PTZ00419 669 YRhfcnKLWNAVKFALMKLLKDFnlpnstLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYE 748
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 852 LSNFYFDIAKDRLYTGGTSSfTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFEYRNEDG-SAAEFvfelkwPTL 930
Cdd:PTZ00419 749 LCDVYLELIKPRLSKQSDGE-RKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKSESiSIAKY------PQP 821
|
....
gi 79330394 931 NEQW 934
Cdd:PTZ00419 822 NPGW 825
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
537-767 |
7.34e-45 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 164.51 E-value: 7.34e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 537 RATEQWFASVEGFRTATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPafyhvktkeplmneetinhvks 616
Cdd:cd00668 137 RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---------------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 617 iisqkgsdawwymsvedllpekyrdkaadyekgTDTMDVWFDSGSSWAGVLGKREG-----LSFPADVYLEGTDQHRGWF 691
Cdd:cd00668 195 ---------------------------------EDVFDVWFDSGIGPLGSLGYPEEkewfkDSYPADWHLIGKDILRGWA 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79330394 692 QSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSSVDYTGD 767
Cdd:cd00668 242 NFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE---------KYGADALRYYLTSLAPYGD 308
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
74-934 |
7.71e-43 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 169.69 E-value: 7.71e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 74 GHSSKRRSRGPVMAAKKASEGEKQEDgkykqTVDlPKTGFGMRA----------NSLTREPELQKLWEENQVFKrVSDNN 143
Cdd:PLN02381 53 SDGTNVPKKSEKKSRKRDVEDENPED-----FID-PDTPFGQKKrlssqmakqySPSAVEKSWYAWWEKSGYFG-ADAKS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 144 NGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQE---VRKELTPLKL 220
Cdd:PLN02381 126 SKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRErhlTRHDIGREEF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 221 RAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEY 300
Cdd:PLN02381 206 VSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDY 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 301 peghISKSIYAIFKLVGGAKTslldefipniylavwtttpwtmpanaavavnakLQYSVVevqsfsedestvTSNKKKIP 380
Cdd:PLN02381 286 ----IDIKERTLLKVPGYDKP---------------------------------VEFGVL------------TSFAYPLE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 381 GKVLKnqqklfVIVATDLVPALeakwgvklsISKTFLGSDLENCRY--------THPIDNRDCPVVIGGDYITTESGTGL 452
Cdd:PLN02381 317 GGLGE------IVVATTRIETM---------LGDTAIAIHPDDERYkhlhgkfaVHPFNGRKLPIICDAILVDPNFGTGA 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 453 VHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAG-QFRGLSVLgEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTK 531
Cdd:PLN02381 382 VKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGsEFAGMPRF-AAREAVIEALQKKGLYRGAKNNEMRLGLCSRTN 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 532 ---KPTIfraTEQWFASVEGFRTATMDAINN-----VKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYhVKTKE 603
Cdd:PLN02381 461 dvvEPMI---KPQWFVNCSSMAKQALDAAIDgenkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWY-VTLED 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 604 PLMNEETINHVKSIISQKGSDAWWYMSvedllpEKYRDKAADYEKGTDTMDVWFDSGSSWAGVLGKREGLS-----FPAD 678
Cdd:PLN02381 537 DQLKELGSYNDHWVVARNESDALLEAS------QKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDdlkafYPTS 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 679 VYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEG------------------ 740
Cdd:PLN02381 611 VLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGisleglhkrleegnldpk 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 741 -------GKnSKDAP----AYGADVMRLwvSSVDYTGDV-LIGPQILRQMSdiYR----KLRGTLRYLLGNL-HDWRVDN 803
Cdd:PLN02381 691 elvvakeGQ-KKDFPngiaECGTDALRF--ALVSYTAQSdKINLDILRVVG--YRqwcnKLWNAVRFAMSKLgDDYTPPA 765
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 804 AVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTS-SFTRRSCQTVLS 882
Cdd:PLN02381 766 TLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPEfASERAAAQDTLW 845
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 79330394 883 THLLSILRVIAPIVPHLAEDVWQNLPfeyRNEDGSAAEFVFELKWPTLNEQW 934
Cdd:PLN02381 846 ICLDTGLRLLHPFMPFVTEELWQRLP---QPKDHTRKDSIMISEYPSAVEAW 894
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
148-314 |
1.87e-39 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 148.72 E-value: 1.87e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 148 FILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQEVRKELTpLKLRAKAAKF 227
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIWI-EEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 228 AKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPS---SRTALAEAELEY---- 300
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQwffDMPKFKEKLLKAlrrg 160
|
170
....*....|....*..
gi 79330394 301 ---PEgHISKSIYAIFK 314
Cdd:cd00668 161 kivPE-HVKNRMEAWLE 176
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
528-767 |
1.88e-38 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 147.78 E-value: 1.88e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 528 WRTKKPTIFRATEQWFASVEGFRTATMDAINN--VKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHvktkepl 605
Cdd:cd00817 157 SRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEgdIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC------- 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 606 mneetinhvksiisqKGSDAWWYMSVEDLLPEKYRDKAADYEKG------TDTMDVWFDSGSSWAGVLGKREGLS----- 674
Cdd:cd00817 230 ---------------KDGGHWVVAREEDEAIDKAAPEACVPCGGeelkqdEDVLDTWFSSSLWPFSTLGWPEETKdlkkf 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 675 FPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEGgknskdapaYGADV 754
Cdd:cd00817 295 YPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG---------YGADA 365
|
250
....*....|...
gi 79330394 755 MRLWVSSVDYTGD 767
Cdd:cd00817 366 LRFTLASAATQGR 378
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
123-936 |
1.00e-36 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 149.52 E-value: 1.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 123 EPELQKLWEENQVFKRVSDNNNGGSFILhDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELK 202
Cdd:TIGR00396 7 EEKWQQKWDENKTFKVTDDSSKPKYYIL-SMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAENA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 203 VLQSldqevrkeltplklrAKAAKFAKATVKTQM-ESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRK 281
Cdd:TIGR00396 86 AIKR---------------GIHPAKWTYENIANMkKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 282 PVHWSPSSRTALAEAEL----------------EYPEGHISKSIYA------------------------IFKLVGGAKT 321
Cdd:TIGR00396 151 DVNWCPNDGTVLANEQVdsdgrswrgdtpvekkELKQWFLKITAYAeellndleeldhwpesvkemqrnwIGKSEGVEIT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 322 SLLDEFIPNIylAVWTTTPWTMpanaavavnAKLQYSVVE-----VQSFSEDESTVTSNKKKIPGKVLKNQQKlfvivat 396
Cdd:TIGR00396 231 FKIADHDEKI--TVFTTRPDTI---------FGVTYLALApehplVEKAAENNPKVAAFIKKILNKTVAERTK------- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 397 dlvpALEAKWGVKLSIsKTFlgsdlencrytHPIDNRDCPVVIgGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVS 476
Cdd:TIGR00396 293 ----ATKEKKGVDTGI-KAI-----------HPLTGEKIPIWV-ANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKP 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 477 PVDDEGK-------FTEE-----AGQFRGLSVlGEGNTAVVSYLDENMslvmeesyahkypydwRTKKPTIFRateqwfa 544
Cdd:TIGR00396 356 VIDPAEKdlsltaaYTEDgvlvnSGEFNGLNS-SEARNAIIDMLEKEG----------------KGKRKVNYR------- 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 545 svegFRtatmdainnvkwvphqavnrisamtssrsDWCISRQRTWGVPIPAFY--------HVKTKEPLMNEETINHVKS 616
Cdd:TIGR00396 412 ----LR-----------------------------DWGFSRQRYWGEPIPIIHcedggvvpVPEEDLPVILPEDVVYDGD 458
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 617 IISQKGSDAWWymsVEDLLPEKyrDKAADYEkgTDTMDVWfdSGSSW--AGVLG--------KREGLSF--PADVYLEGT 684
Cdd:TIGR00396 459 GGSPLSRIPEW---VNVTCPSC--GKPALRE--TDTMDTF--AGSSWyyLRYLDpkntdgpfDKEKAEYwlPVDLYIGGI 529
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 685 DQ-----------HRGWFQSSLLTSiatqgKAPYSAVITHGFVL------------------DEKGM------------- 722
Cdd:TIGR00396 530 EHailhllyarffHKFLRDIGYVNT-----KEPFKKLINQGMVLgfyyppngkvpadvlterDEKGKdkaggelvyvgye 604
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 723 KMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWV-------SSVDYTGDVLIGpqILRQMSDIYRklrgtLRY-LLG 794
Cdd:TIGR00396 605 KMSKSKGNGIDPQEIVE---------SYGADALRLFImfmgpiaASLEWNESGLEG--ARRFLDRVWN-----LVYeITG 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 795 NLHDWRVDNavpyQDLPIIDQHALFQLENVVKNIQECYENYQFFK--IFQIIQrftivdLSNFYFDIAKDRLYTGGTSSF 872
Cdd:TIGR00396 669 ELDAASLTV----TALEEAQKELRRDVHKFLKKVTEDLEKRESFNtaISAMME------LLNKLYKAKKEALMLEYLKGF 738
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79330394 873 trrscqtvlsthllsiLRVIAPIVPHLAEDVWQNLpfeyrnedGSAAEFVFELKWPTLNEQWLS 936
Cdd:TIGR00396 739 ----------------VTVLSPFAPHLAEELWEKL--------GSEPFIIDNAKWPVVDETALV 778
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
154-297 |
4.04e-30 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 123.51 E-value: 4.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 154 PPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQE--VRKELTPLKLRAKAAKFAKAT 231
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEgkTRHDLGREEFLEKCWEWKEES 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79330394 232 VKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAE 297
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE 154
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
123-935 |
1.08e-27 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 120.54 E-value: 1.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 123 EPELQKLWEENQVFKrVSDNNNGGSF-ILhDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLP--- 198
Cdd:COG0495 11 EKKWQKYWEENGTFK-ADEDSSKPKYyVL-DMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLPaen 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 199 --IELKV------LQSLDqevrkeltplklrakaakfakatvkTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQM 270
Cdd:COG0495 89 aaIKNGVhpaewtYENIA-------------------------NMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 271 ALKGYIYRGRKPVHWSPSSRTALA-E-----------------------------AE--------LE-YPEG-------H 304
Cdd:COG0495 144 YEKGLAYRKEAPVNWCPVDQTVLAnEqvidgrcwrcgapvekkelpqwflkitdyADellddldkLDgWPEKvktmqrnW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 305 ISKSIYAI--FKLVGGAKTslldefipniyLAVWTTTPWTMpanaavavnaklqYSVvevqSF----SE----DESTVTS 374
Cdd:COG0495 224 IGRSEGAEvdFPVEGSDEK-----------ITVFTTRPDTL-------------FGA----TFmvlaPEhplvKELATPE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 375 NKKKIPGKVLKNQQKlfvivaTDLVPALEAKwgvklsiSKT--FLGsdlencRY-THPIDNRDCPVVIgGDYITTESGTG 451
Cdd:COG0495 276 QNAAVAAFIEEAKKK------SEIERTSETK-------EKTgvFTG------LYaINPLTGEKIPIWI-ADYVLMDYGTG 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 452 LVHTAPGHGQEDYATGLKYGLPL---VSPVD-DEGKFTEEA----------GQFRGLSVlGEGNTAVVSYLDENmslvme 517
Cdd:COG0495 336 AVMAVPAHDQRDFEFAKKYGLPIkqvIAPEDgDDPDILEEAytgdgvlinsGEFDGLDS-EEAKEAIIEWLEEK------ 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 518 esyahkypyDWRTKKpTIFRateqwfasvegFRtatmdainnvkwvphqavnrisamtssrsDWCISRQRTWGVPIPAFY 597
Cdd:COG0495 409 ---------GLGKRK-VNYR-----------LR-----------------------------DWLISRQRYWGEPIPIIH 438
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 598 -------HVKTKE-PLMNEETINhvksiISQKG------SDAWwymsVEDLLPEKyrDKAADYEkgTDTMDVWFDsgSSW 663
Cdd:COG0495 439 cedcgvvPVPEDQlPVELPEDVD-----FDPTGgsplarAPEW----VNVTCPKC--GGPARRE--TDTMDTFVD--SSW 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 664 ----------AGVLGKREGLSF--PADVYLEGTDqH--------RGW----FQSSLLTSiatqgKAPYSAVITHGFVLD- 718
Cdd:COG0495 504 yylrytdphnDEAPFDPEAANYwlPVDQYIGGIE-HailhllyaRFFtkvlRDLGLVSF-----DEPFKRLLTQGMVLEv 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 719 ------EKGM-KMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSSvdytgdvlIGPqiLRQM---SDiyRKLRGT 788
Cdd:COG0495 578 gkdgvvIGGIeKMSKSKGNVVDPDEIIE---------KYGADTLRLFEMF--------AGP--PERDlewSD--SGVEGA 636
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 789 LRYL--LGNL-HDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFK-IFQIIqrftivDLSNfyfDIAKDRL 864
Cdd:COG0495 637 YRFLnrVWRLvVDEAEALKLDVADLSEADKELRRALHKTIKKVTEDIERLRFNTaIAALM------ELVN---ALYKAKD 707
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79330394 865 YTGGTSSFTRRSCQTvlsthllsILRVIAPIVPHLAEDVWQNLPFEyrnedgsaaEFVFELKWPTLNEQWL 935
Cdd:COG0495 708 SGEADRAVLREALET--------LVLLLAPFAPHIAEELWERLGHE---------GSVADAPWPEADEAAL 761
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
814-951 |
2.15e-26 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 105.56 E-value: 2.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 814 DQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSftrrSCQTVLSTHLLSILRVIA 893
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS----RAQTTLYEVLETLLRLLA 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 79330394 894 PIVPHLAEDVWQNlpfeyrnedgsaaEFVFELKWPTLNEQWLSFPAEDVLFWQRLLEV 951
Cdd:pfam08264 77 PFMPFITEELWQK-------------ESIHLAPWPEDAELEEAELEEAFELRQEIVQA 121
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
35-935 |
5.77e-26 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 115.31 E-value: 5.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 35 SNLRRNTPLDSFLAKGRSSVKAFsFLYVSRFST--EPNNEFGHSSKRRSRGPVMA-AKKASEGEKQEDGKYKQTVdlpKT 111
Cdd:PLN02563 3 LQTRAPPPSASSAFRFTSLRLSL-FLVVSSAQTpaSASSYFRRSRRGGVSRSLTRrAFAAPSALTSTTAKTTPAA---KR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 112 GFGMRanslTREPELQKLWEENQVFK--RVSDNNNGGSFILhDGPPYANG-DLHMGHALNKILKDIINRYKLLQNYKVQY 188
Cdd:PLN02563 79 AYPFH----EIEPKWQRYWEENRTFRtpDDVDTSKPKFYVL-DMFPYPSGaGLHVGHPEGYTATDILARYKRMQGYNVLH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 189 VPGWDCHGLPIELKVLQSldqEVRKELTPLklrakaakFAKATVKTQMESfkrFGVWADWNNPYLTLDPEYEAAQIEVFG 268
Cdd:PLN02563 154 PMGWDAFGLPAEQYAIET---GTHPKITTL--------KNIARFRSQLKS---LGFSYDWDREISTTEPEYYKWTQWIFL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 269 QMALKGYIYRGRKPVHWSPSSRTALAEAE--------------------------------------LEYPEG------- 303
Cdd:PLN02563 220 QLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergghpvirkpmrqwmlkitayadrlledlddLDWPESikemqrn 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 304 HISKSIYA--IFKLVGGAKTSlldefiPNIYLAVWTTTPWTMpanaavavnAKLQYSVVE-----VQSFSEDEstvtsNK 376
Cdd:PLN02563 300 WIGRSEGAelDFSVLDGEGKE------RDEKITVYTTRPDTL---------FGATYLVVApehplLSSLTTAE-----QK 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 377 KKIPGKVLKNQQKlfvivaTDLVPALEAKwgvklsiSKT--FLGsdlenCRYTHPIDNRDCPVVIgGDYITTESGTGLVH 454
Cdd:PLN02563 360 EAVEEYVDAASRK------SDLERTELQK-------EKTgvFTG-----SYAINPATGEAIPIWV-ADYVLGSYGTGAIM 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 455 TAPGHGQEDYATGLKYGLPL---VSPVD----DEGKFTEEAG----------QFRGLSVlGEGNTAVVSYLDENmslvme 517
Cdd:PLN02563 421 AVPAHDTRDFEFAQKFDLPIkwvVKPADgnedDAEKAYTGEGvivnssssglDINGLSS-KEAAKKVIEWLEET------ 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 518 ESYAHKYPYDWRtkkptifrateqwfasvegfrtatmdainnvkwvphqavnrisamtssrsDWCISRQRTWGVPIPAFY 597
Cdd:PLN02563 494 GNGKKKVNYKLR--------------------------------------------------DWLFARQRYWGEPIPVVF 523
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 598 HVKTKEPLMNEETinhvksiisqkgsdawwymsveDL---LPEKYR-----------DKAADYEKGTD------------ 651
Cdd:PLN02563 524 LEDSGEPVPVPES----------------------DLpltLPELDDftptgtgepplAKAVSWVNTVDpssgkparretn 581
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 652 TMDVWfdSGSSW------------AGVLGKREGLSFPADVYLEGTDQ---H----RGW---------------FQ----- 692
Cdd:PLN02563 582 TMPQW--AGSCWyylrfmdpknsnALVDKEKEKYWMPVDLYVGGAEHavlHllyaRFWhkvlydigvvstkepFQclvnq 659
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 693 -----------------------SSLLTSIATQGKAPYSAVITHG--FVLDE--------KGMKMSKSLGNVVDPRLVIE 739
Cdd:PLN02563 660 gmilgeveytafkdsdgeyvsadTADRLGELQQEKIPEEKVIKSGdsFVLKDdpsirliaRAHKMSKSRGNVVNPDDVVS 739
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 740 ggknskdapAYGADVMRLWvssvdytgDVLIGPqiLR--------QMSDIYRKLRGTLRYLLGnlhDWRVDNAVPYQDLP 811
Cdd:PLN02563 740 ---------EYGADSLRLY--------EMFMGP--LRdsktwstsGVEGVHRFLGRTWRLVVG---APLPDGSFRDGTVV 797
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 812 IIDQHALFQLENVVKNIQECYENyqffkifqiiqrftiVDLSNFYFDIAKDRLYTGGTSSFTRRScQTVLSTHLLsilrV 891
Cdd:PLN02563 798 TDEEPSLEQLRLLHKCIAKVTEE---------------IESTRFNTAISAMMEFTNAAYKWDKVP-REAIEPFVL----L 857
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....
gi 79330394 892 IAPIVPHLAEDVWQNLpfeyrNEDGSAAefvFElKWPTLNEQWL 935
Cdd:PLN02563 858 LSPYAPHLAEELWFRL-----GHSNSLA---YE-PWPEANPSYL 892
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
161-940 |
1.26e-23 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 107.65 E-value: 1.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 161 LHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPI-------------ELKVLQSLDQEVRKEL----TPLKLRAK 223
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdpeTIELYKSLYGIPEEELekfkDPEYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 224 AAKFAKatvktqmESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELeyPEG 303
Cdd:PRK12300 81 FSEEAK-------EDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDL--LDG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 304 hISKSI--YAIFKLVGGaktslldefiPNIYLAVWTTTP---------WTMPANAavavnaklqYSVVEVqsfsEDESTV 372
Cdd:PRK12300 152 -EEPEIveYTLIKFEES----------EDLILPAATLRPetifgvtnlWVNPDAT---------YVKAEV----DGEKWI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 373 TSNK--KKipgkvLKNQQKlfvivatdlvpaleakwgvKLSISKTFLGSDLENCRYTHPIDNRDCPVvIGGDYITTESGT 450
Cdd:PRK12300 208 VSKEaaEK-----LSFQDR-------------------DVEIIEEIKGSELIGKKVKNPVTGKEVPI-LPADFVDPDNGT 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 451 GLVHTAPGHGQEDYAtGLK------YGLPLVSPV-------------------------DDE----------------GK 483
Cdd:PRK12300 263 GVVMSVPAHAPYDYV-ALRdlkknkELLDVIEPIplievegygefpakevveklgiksqEDPeleeatkevyraefhkGV 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 484 FTEEAGQFRGLSVlGEGNTAVVSYL-DENMSLVMeesyahkypYDWrTKKPTIFRA-TE--------QWFA--SVEGFRT 551
Cdd:PRK12300 342 LKENTGEYAGKPV-REAREKITKDLiEKGIADIM---------YEF-SNRPVYCRCgTEcvvkvvkdQWFIdySDPEWKE 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 552 ATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIP-----------------AFYhvktkeplmneeTINHv 614
Cdd:PRK12300 411 LAHKALDNMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPwdeewiieslsdstiymAYY------------TIAH- 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 615 ksIISQKGsdawwyMSVEDLLPEKYrdkaaDY---EKGtDTMDVWFDSGSSWAGVLGKREGLSF--PADVYLEGTD---- 685
Cdd:PRK12300 478 --KIREYG------IKPEQLTPEFF-----DYvflGKG-DPEEVSKKTGIPKEILEEMREEFLYwyPVDWRHSGKDlipn 543
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 686 -------QHRGWFQSSLLtsiatqgkaPySAVITHGFVLDEkGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLW 758
Cdd:PRK12300 544 hltffifNHVAIFPEEKW---------P-RGIVVNGFVLLE-GKKMSKSKGNVIPLRKAIE---------EYGADVVRLY 603
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 759 V-SSVDYTGDVligpqilrqmsDIYRKLRGTLRYLLGNLHDWrVDNAVPYQD---LPIIDQHALFQLENVVKNIQECYEN 834
Cdd:PRK12300 604 LtSSAELLQDA-----------DWREKEVESVRRQLERFYEL-AKELIEIGGeeeLRFIDKWLLSRLNRIIKETTEAMES 671
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 835 YQFFKIFQIIqrftivdlsnfYFDIAKD-RLYTGGTSSFTRRSCQTVLSThllsILRVIAPIVPHLAEDVWQNLPFEyrn 913
Cdd:PRK12300 672 FQTRDAVQEA-----------FYELLNDlRWYLRRVGEANNKVLREVLEI----WIRLLAPFTPHLAEELWHKLGGE--- 733
|
890 900
....*....|....*....|....*..
gi 79330394 914 edgsaaEFVFELKWPTLNEQWLSFPAE 940
Cdd:PRK12300 734 ------GFVSLEKWPEPDESKIDEEAE 754
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
790-907 |
4.85e-17 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 78.37 E-value: 4.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 790 RYLLGNLHDWRVDNAVPyQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGT 869
Cdd:cd07962 21 RFVLMNLEDDDEPEEDP-ESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKPRLYGEDE 99
|
90 100 110
....*....|....*....|....*....|....*...
gi 79330394 870 SSftRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNL 907
Cdd:cd07962 100 EE--KKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
795-935 |
3.13e-16 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 77.59 E-value: 3.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 795 NLHDWRVDN-AVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFtIVDLSNFYFDIAKDRLYtGGTSSFT 873
Cdd:cd07961 29 NLDGFDPGKdDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDELTNWYIRRNRKRFW-GEEGDDD 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79330394 874 RRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLpfeyRNEDGSAAEFVFELKWPTLNEQWL 935
Cdd:cd07961 107 KLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNL----RRELGDAPESVHLLDWPEVDESLI 164
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
155-285 |
4.63e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 80.37 E-value: 4.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 155 PYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIElkvlQSLDQEVR--KELTplklrakaakfakATV 232
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE----NAAIKIGRdpEDWT-------------EYN 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 79330394 233 KTQM-ESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHW 285
Cdd:cd00812 72 IKKMkEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
710-950 |
2.27e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 79.93 E-value: 2.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 710 VITHGFVLDEkGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWV---SSVDYTGDVligpqilrQMSDIYRKLR 786
Cdd:PRK11893 287 VFAHGFLTLD-GEKMSKSLGNVIDPFDLVD---------EYGVDAVRYFLlreIPFGQDGDF--------SREAFINRIN 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 787 GTLRYLLGNL--------HDWRvDNAVPYQ-DLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIqrFTIVDLSNFYF 857
Cdd:PRK11893 349 ADLANDLGNLaqrtlsmiAKNF-DGKVPEPgALTEADEALLEAAAALLERVRAAMDNLAFDKALEAI--LALVRAANKYI 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 858 D------IAKDRlytggtssftRRSCQTVLSThLLSILRVIA----PIVPHLAEDVWQNLPFEYRNEDGSAAefvfeLKW 927
Cdd:PRK11893 426 DeqapwsLAKTD----------PERLATVLYT-LLEVLRGIAvllqPVMPELAAKILDQLGVEEDENRDFAA-----LSW 489
|
250 260
....*....|....*....|...
gi 79330394 928 PTLNEQwLSFPAEDVLFwQRLLE 950
Cdd:PRK11893 490 GRLAPG-TTLPKPEPIF-PRLEE 510
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
580-928 |
1.46e-14 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 77.85 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 580 DWCISRQRTWGVPIPA-----FYhvktkeplmneetinhVksiisqkgsdawW------YMSVEDLLPEKyRDKAADYEK 648
Cdd:COG0143 225 DLSISRDFDWGIPVPGdpgkvFY----------------V------------WfdaligYISATKGYADD-RGLPEDFEK 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 649 gtdtmdVWFDSGSSWAGVLGK---R-EGLSFPAdvYLEGTdqhrgwfqsslltsiatqGKAPYSAVITHGFVLDEkGMKM 724
Cdd:COG0143 276 ------YWPAPDTELVHFIGKdiiRfHAIIWPA--MLMAA------------------GLPLPKKVFAHGFLTVE-GEKM 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 725 SKSLGNVVDPRLVIEggknskdapAYGADVMRLWVSS-------VDYTGDVLIGpqilRQMSDiyrkLRGTlrylLGNL- 796
Cdd:COG0143 329 SKSRGNVIDPDDLLD---------RYGPDALRYYLLRevpfgqdGDFSWEDFVA----RVNSD----LAND----LGNLa 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 797 HdwRV--------DNAVPYQDLPIIDQHALFQ-LENVVKNIQECYENYQFFKIFQIIqrFTIVDLSNFYFD------IAK 861
Cdd:COG0143 388 S--RTlsmihkyfDGKVPEPGELTEADEELLAeAEAALEEVAEAMEAFEFRKALEEI--MALARAANKYIDetapwkLAK 463
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79330394 862 DRlytggtssfTRRSCQTVLSThLLSILRVIA----PIVPHLAEDVWQNLpfeyrNEDGSAAEFVfELKWP 928
Cdd:COG0143 464 DE---------DPERLATVLYT-LLEALRILAillkPFLPETAEKILEQL-----GLEGDELTWE-DAGWP 518
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
155-279 |
1.51e-12 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 71.26 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 155 PYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQsldqevrKELTPLKLRAKAAKFAKATVKT 234
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQ-------EGLTPKELVDKYHEEFKDDWKW 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 79330394 235 QMESFKRFGvwadwnnpyLTLDPEYEAAQIEVFGQMALKGYIYRG 279
Cdd:TIGR00398 81 LNISFDRFI---------RTTDEEHKEIVQKIFQKLKENGYIYEK 116
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
155-299 |
2.58e-12 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 69.63 E-value: 2.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 155 PYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQsldqevrKELTPLKLRAKAAKFAKatvkt 234
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK-------EGITPEELVDRYHEIHR----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79330394 235 qmESFKRFGVWADwnNPYLTLDPE-YEAAQiEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELE 299
Cdd:pfam09334 76 --EDFKKFNISFD--DYGRTTSERhHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
155-205 |
7.31e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 67.56 E-value: 7.31e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 79330394 155 PYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQ 205
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEE 59
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
155-295 |
8.19e-12 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 68.99 E-value: 8.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 155 PYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELK-------VLQSLDQEVRKeltplklrakaakf 227
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAaekegitPQELVDRIHAE-------------- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 79330394 228 akatvktQMESFKRFGVwaDWNNPYLTLDPE-YEAAQiEVFGQMALKGYIYRGRKPVHWSPSSRTALAE 295
Cdd:COG0143 76 -------FKELFEKLGI--SFDNFIRTTSPEhKELVQ-EIFQRLYDNGDIYKGEYEGWYCPECERFLPD 134
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
580-910 |
5.82e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 66.36 E-value: 5.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 580 DWCISRQR-TWGVPIPafyhvktKEPlmneetiNHVksiisqkgsdawwymsvedllpekyrdkaadyekgtdtMDVWFD 658
Cdd:PRK12267 203 DLSISRTSfDWGIPVP-------FDP-------KHV--------------------------------------VYVWID 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 659 SGSSWAGVLG---KREGLS---FPADVYLEGTDQHRgwFQS----SLLTSIatqGKAPYSAVITHGFVLdEKGMKMSKSL 728
Cdd:PRK12267 231 ALLNYITALGygsDDDELFkkfWPADVHLVGKDILR--FHAiywpIMLMAL---GLPLPKKVFAHGWWL-MKDGKMSKSK 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 729 GNVVDPRLVIEggknskdapAYGADVMRLWV-------SSVDYTGDVLIGpqilRQMSDiyrklrgtlryL---LGNL-- 796
Cdd:PRK12267 305 GNVVDPEELVD---------RYGLDALRYYLlrevpfgSDGDFSPEALVE----RINSD-----------LandLGNLln 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 797 ---------HDWRVDNAVPYQDlpiIDQHALFQLENVVKNIQECYENYQFFK----IFQIIQRftivdlSNFYFD----- 858
Cdd:PRK12267 361 rtvaminkyFDGEIPAPGNVTE---FDEELIALAEETLKNYEELMEELQFSRaleeVWKLISR------ANKYIDetapw 431
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 79330394 859 -IAKD-----RLytggtssftrrscQTVLStHLLSILRVIA----PIVPHLAEDVWQNLPFE 910
Cdd:PRK12267 432 vLAKDegkkeRL-------------ATVMY-HLAESLRKVAvllsPFMPETSKKIFEQLGLE 479
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
523-768 |
1.50e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 60.34 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 523 KYPYDWRtkkptifRATEQWFA--SVEGFRTATMDAINNVKWVPhqavNRISAMtssRSDWC-ISRQRTWGVPIPAFYhv 599
Cdd:cd00812 120 EAPVNWC-------KLLDQWFLkySETEWKEKLLKDLEKLDGWP----EEVRAM---QENWIgCSRQRYWGTPIPWTD-- 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 600 kTKEPLmneetinhvksiisqkgSDAWWYMSVedllpekYRDkaADYEKGTDTMDVWFDsgsswagvlgKREGLSF-PAD 678
Cdd:cd00812 184 -TMESL-----------------SDSTWYYAR-------YTD--AHNLEQPYEGDLEFD----------REEFEYWyPVD 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 679 VYLEGTDQ-----------HRGWFQSSLLTSiatqgkAPYSAVITHGFVLDEkGMKMSKSLGNVVDPRLVIEGgknskda 747
Cdd:cd00812 227 IYIGGKEHapnhllysrfnHKALFDEGLVTD------EPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKK------- 292
|
250 260
....*....|....*....|..
gi 79330394 748 paYGADVMRLWV-SSVDYTGDV 768
Cdd:cd00812 293 --YGADAARLYIlFAAPPDADF 312
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
154-280 |
2.47e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 60.67 E-value: 2.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 154 PPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQsldqevrKELTPLKLRAKaakfakatvk 233
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEE-------AGISPQELADR---------- 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 79330394 234 tQMESFKRFgvWADWNNPY----LTLDPEYEAAQIEVFGQMALKGYIYRGR 280
Cdd:PRK11893 72 -NSAAFKRL--WEALNISYddfiRTTDPRHKEAVQEIFQRLLANGDIYLGK 119
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
427-508 |
6.79e-09 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 56.40 E-value: 6.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 427 THPIDNRDCPVVIGgDYITTESGTGLVHTAPGHGQEDYATGLKYGLPL---VSPVDDEGK-------FTEE-----AGQF 491
Cdd:pfam13603 90 IHPITGEKIPIWIA-NFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIkpvIQPEDGDLDldimteaYTEEgilvnSGEF 168
|
90
....*....|....*..
gi 79330394 492 RGLSvLGEGNTAVVSYL 508
Cdd:pfam13603 169 DGLD-SEEAKEAIIKKL 184
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
155-278 |
7.94e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 59.39 E-value: 7.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 155 PYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVL------QSLDQEVRKEltplklrakaakfa 228
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEkegitpEELIARYHAE-------------- 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 79330394 229 katvktQMESFKRFGVwaDWNNPYLTLDPE-YEAAQiEVFGQMALKGYIYR 278
Cdd:PRK00133 77 ------HKRDFAGFGI--SFDNYGSTHSEEnRELAQ-EIYLKLKENGYIYE 118
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
534-756 |
1.13e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 54.85 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 534 TIFRATEQWFASVEGFRTATMDAINN---VKWvPHQAVNRISAMTSSR-SDWCISRQR-TWGVPIPAFyhvktkeplmne 608
Cdd:cd00814 132 PEWREEEHYFFRLSKFQDRLLEWLEKnpdFIW-PENARNEVLSWLKEGlKDLSITRDLfDWGIPVPLD------------ 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 609 etinhvksiisqkgsdawwymsvedllPEKyrdkaadyekgtdTMDVWFDSGSSWAGVLG---KREGLS------FPADV 679
Cdd:cd00814 199 ---------------------------PGK-------------VIYVWFDALIGYISATGyynEEWGNSwwwkdgWPELV 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 680 YLEGTDQ---HRGWFQSSLLTSiatqGKAPYSAVITHGFVLDEkGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMR 756
Cdd:cd00814 239 HFIGKDIirfHAIYWPAMLLGA----GLPLPTRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLE---------RYGADALR 304
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
793-907 |
2.88e-07 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 50.18 E-value: 2.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 793 LGNL-HdwRV--------DNAVPYQDLPIIDQHALFQL-ENVVKNIQECYENYQFFKIFQIIqrFTIVDLSNFYFD---- 858
Cdd:cd07957 9 LGNLvN--RTlnmaskyfGGVVPEFGGLTEEDEELLEEaEELLEEVAEAMEELEFRKALEEI--MELARAANKYIDetap 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 79330394 859 --IAKDRlytggtssfTRRSCQTVLSThLLSILRVIA----PIVPHLAEDVWQNL 907
Cdd:cd07957 85 wkLAKEE---------DPERLATVLYV-LLELLRILAillsPFMPETAEKILDQL 129
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
156-200 |
2.99e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 54.42 E-value: 2.99e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 79330394 156 YANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIE 200
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQ 58
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
652-909 |
2.60e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.17 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 652 TMDVWFDSGSSWAGVL---GKREGLS------FPADVYLEGTDQ---HRGWFQSSLLTSiatqGKAPYSAVITHGFvLDE 719
Cdd:PLN02224 288 TIYVWFDALLGYISALtedNKQQNLEtavsfgWPASLHLIGKDIlrfHAVYWPAMLMSA----GLELPKMVFGHGF-LTK 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 720 KGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWV-------SSVDYTGDVLIGPQILRQMSDIYRKLRGTLRYL 792
Cdd:PLN02224 363 DGMKMGKSLGNTLEPFELVQ---------KFGPDAVRYFFlrevefgNDGDYSEDRFIKIVNAHLANTIGNLLNRTLGLL 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 793 LGNLHD-WRVDNAVPYQDLPIIDqhalfQLENVVKNIQECYENYQFFKIFQIIqrFTIVDLSNFYFDI-AKDRLYTGGTS 870
Cdd:PLN02224 434 KKNCEStLVEDSTVAAEGVPLKD-----TVEKLVEKAQTNYENLSLSSACEAV--LEIGNAGNTYMDQrAPWFLFKQGGV 506
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 79330394 871 SFTRRSCQTVLsthLLSILRVIA----PIVPHLAEDVWQNLPF 909
Cdd:PLN02224 507 SAEEAAKDLVI---ILEVMRVIAvalsPIAPCLSLRIYSQLGY 546
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
112-199 |
1.81e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 45.45 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 112 GFGMRANSLTREPELQKLWEENQVFKRVSDNNN---GGSFILHDGPPYANGDLHMGHA--LNKIlkDIINRYKLLQNYKV 186
Cdd:PLN02959 8 STARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPpkpGEKFFGNFPYPYMNGLLHLGHAfsLSKL--EFAAAYHRLRGANV 85
|
90
....*....|...
gi 79330394 187 QYVPGWDCHGLPI 199
Cdd:PLN02959 86 LLPFAFHCTGMPI 98
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
713-790 |
2.43e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 44.71 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 713 HGFVLDEkGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMRLWV------SSVDYTgdvligPQILRQMSDIYRKLR 786
Cdd:COG0215 256 NGFLTVN-GEKMSKSLGNFFTVRDLLK---------KYDPEVLRFFLlsahyrSPLDFS------EEALEEAEKALERLY 319
|
....
gi 79330394 787 GTLR 790
Cdd:COG0215 320 NALR 323
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
708-904 |
5.12e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 43.99 E-value: 5.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 708 SAVITHGFV-LDekGMKMSKSLGNVVDPRLVIEggknskdapAYGADVMR--------LWVSSVDYTGDVLIGpqilRQM 778
Cdd:PRK00133 315 TNVFAHGFLtVE--GAKMSKSRGTFIWARTYLD---------HLDPDYLRyylaaklpETIDDLDFNWEDFQQ----RVN 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 779 SD--------IYRKLRGTLRYLLGNLHDWRVDNAVpyqdlpiidqhaLFQLENVVKNIQECYENYQFFKIFQIIqrFTIV 850
Cdd:PRK00133 380 SElvgkvvnfASRTAGFINKRFDGKLPDALADPEL------------LEEFEAAAEKIAEAYEAREFRKALREI--MALA 445
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79330394 851 DLSNFYFD------IAKDrlytggtssfTRRSCQTVLST-----HLLSILrvIAPIVPHLAEDVW 904
Cdd:PRK00133 446 DFANKYVDdnepwkLAKQ----------DGERLQAVCSVglnlfRALAIY--LKPVLPELAERAE 498
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|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
820-907 |
7.02e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 40.27 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79330394 820 QLENVVKNIQECYENYQFFKIFQIIqrftivdlsnfYFDIAKD------RLYTGGTSSFTRRSCQTvlsthllsILRVIA 893
Cdd:cd07959 43 RLNRLIKETTEAYENMQFREALKEG-----------LYELQNDldwyreRGGAGMNKDLLRRFIEV--------WTRLLA 103
|
90
....*....|....
gi 79330394 894 PIVPHLAEDVWQNL 907
Cdd:cd07959 104 PFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
885-907 |
3.70e-03 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 38.35 E-value: 3.70e-03
10 20
....*....|....*....|...
gi 79330394 885 LLSILRVIAPIVPHLAEDVWQNL 907
Cdd:cd07958 95 LETLVLLLAPFAPHIAEELWEEL 117
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